Effects of the topical application of an ethylacetate fraction from Vernonia scorpioides on excisional wounds infected with Staphylococcus aureus in rats

Revista Brasileira de Farmacognosia

Volumn 22, Issue 1, 2011, Pages 123-130

  Kreuger, Maria Regina Orofino ^a   Farias, Bruna Gonçalves ^a   Moreira, Janaína ^a   Blind, Luise Zozula ^b   Amoah, Solomon Kweku Sagoe ^c   Leite, Andreia Siqueira ^c   Biavatti, Maique Weber ^c   van Hoof, Tom ^d   D́herde, Katharina ^d   Cruz, Alexandre Bella ^a  

^a UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

^b UNIVERSIDADE TECNOLÓGICA FEDERAL DO PARANÁ   (Brazil)

^c FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^d GHENT UNIVERSITY   (Belgium)

Author keywords

Vernonia scorpioides ethyl acetate fraction wound healing staphylococcus aureus

Indexed keywords

ACETIC ACID ETHYL ESTER; CINNAMIC ACID DERIVATIVE; FLAVONOID; GLAUCOLIDE; HIRSUTINOLIDE; POLYACETYLENE; RIFAMYCIN B; SESQUITERPENE LACTONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG STRUCTURE; EPITHELIUM; EXTRACELLULAR MATRIX; GRANULATION TISSUE; HISTOPATHOLOGY; IN VITRO STUDY; MEDICINAL PLANT; NONHUMAN; RAT; STAPHYLOCOCCUS INFECTION; TISSUE NECROSIS; VERNONIA; VERNONIA SCORPIOIDE; WOUND HEALING; WOUND INFECTION;

EID: 83155192407     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0102-695X2011005000192     Document Type: Article

References (30)

1. Bardón A, Borkosky S, Ybarra MI, Montanaro S, Cartagena E 2007. Bioactive plants from Argentina and Bolivia. Fitoterapia 78: 227-231.
2. Bowling FL, Jude EB, Boulton AJ 2009. MRSA and diabetic foot wounds: contaminating or infecting organisms? Curr Diabetes Rep 9: 440-444.
3. Buskuhl H, Blind LZ, Oliveira FL, Freitas RA, Barison A, Campos FR, Corilo Y, Eberlin MN, Caramori GF, Biavatti MW 2010. Sesquiterpene lactones from Vernonia scorpioides and their in vitro cytotoxicity. Phytochemistry 71: 1539-1544.
4. Buskuhl H, Freitas RA, Delle Monache F, Barison A, Campos FR, Corilo Y, Eberlin MN, Biavatti MW 2009. A new polyacetylene from Vernonia scorpioides (Lam.) Pers. (Asteraceae) and its in vitro antitumoral activity. J Brazil Chem Soc 20: 1327-1333.
5. Campos MP, Cechinel Filho V, Silva RZ, Yunes RA, Monache FD, Bella Cruz A 2007. Antibacterial activity of extract, fractions and four compounds extracted from Piper solmsianum C.DC. var. solmsianum. Z Naturforsch 62: 173-178.
6. Cabrera AL, Klein RM 1980. Compostas: 3. Tribo: Vernoniae. Fl Ilustr Catarin 354-355.
7. Challand S, Willcox M 2009. A clinical trial of the traditional medicine Vernonia amygdalina in the treatment of uncomplicated malaria. J Altern Complem Med 15: 1231-1237.
8. Chung IL, Moon HI 2009. Antiplasmodial activities of sesquiterpene lactone from Carpesium cernum. J Enzym Inhib Med Ch 24: 131-135.
9. Dalazen P, Molon A, Biavatti MW, Kreuger MRO 2005. Effects of topical application of extract from Vernonia scorpioides on excisional wounds in mice. Rev Bras Farmacogn 15: 82-87.
10. Daróczy J 2006. Quality control in chronic wound management: the role of local povidone-iodine (Betadine) therapy. Dermatology 212: 82-87.
11. Durai R, Ng PC, Hoque H 2010. Methicillin-resistant Staphylococcus aureus: an update. AORN J 91: 599-606.
12. Fatima SS, Rajasekhar MD, Kumar KV, Kumar MT, Babu KR, Rao CA 2010. Antidiabetic and antihyperlipidemic activity of ethyl acetate:isopropanol (1:1) fraction of Vernonia anthelmintica seeds in streptozotocin induced diabetic rats. Food Chem Toxicol 8: 495-501.
13. Feltenstein MW, Schühly W, Warnick JE, Fischer NH, Sufka KJ 2004. Anti-inflammatory and anti-hyperalgesic effects of sesquiterpene lactones from Magnolia and Bear's foot. Pharmacol Biochem Be 79: 299-302.
14. Freire MFI, Abreu HS, Cruz LCH, Freire RB 1996. Inhibition of fungal growth by extracts of Vernonia scorpioides (Lam.) Pers. Rev Microbiol 27: 1-6.
15. Harrington AT, Mahlen SD, Clarridge 3rd JE 2010. Significantly larger numbers of methicillin-resistant Staphylococcus aureus bacteria are recovered from polymicrobial respiratory and wound sites by use of chromogenic primary media than by use of conventional culture. J Clin Microbiol 48: 1350-1353.
16. Kreuger MRO, Biavatti MW, Pacheco E, D'ávila Junior RR, Blind LZ 2009. Cytotoxic activity of the subfraction 2125 from Vernonia scorpioides against Sarcoma 180 tumor cells in mice. Rev Bras Farmacogn 19: 353-357.
17. Lans C, Harper T, Georges K, Bridgewater E 2001. Medicinal and ethnoveterinary remedies of hunters in Trinidad. BMC Complem Altern M 30: 1-10.
18. Lee KH, Huang ES, Piantadosi C, Pagano JS, Geissman TA 1971. Cytotoxicity of Sesquiterpene Lactones. Cancer Res 31: 1649-1654.
19. Leite SN, Palhano G, Almeida S, Biavatti MW 2002. Wound healing activity and systemic effects of Vernonia scorpioides extract in guinea pig. Fitoterapia 73: 496-500.
20. Lipsky BA, Berendt AR, Deery HG, Embil JM, Joseph WS, Karchmer AW, LeFrock JL, Lew DP, Mader JT, Norden C, Tan JS 2006. Diagnosis and treatment of diabetic foot infections. Plast Reconstr Surg 117: 212S-238S.
21. Lopes JLC 1991. Sesquiterpene lactones from Vernonia. Mem I Oswaldo Cruz 86: 227-230.
22. NCCLS 2006. National committee for clinical Laboratory Standards: Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, Approved Standard, 7th ed., Approved Standard M7-A7, Wayne, Pennsylvania.
23. Nicolau DP, Stein GE 2010. Therapeutic options for diabetic foot infections: a review with an emphasis on tissue penetration characteristics. J Am Podiat Med Assn 100: 52-63.
24. Ntutelaa S, Smitha P, Matikab L, Mukindad J, Arendseb H, Allieb N, Estesf DM, Mabuselae W, Folba P, Steync L, Johnsone Q, Folkg WR, Sycede J, Jacobsb M 2009. Efficacy of Artemisia afra phytotherapy in experimental tuberculosis. Tuberculosis 89: 33-40.
25. Okigbo RN, Mmeka EC 2008. Antimicrobial effects of three tropical plant extracts on Staphylococcus aureus, Escherichia coli and Candida albicans. Afr J Tradit Complem 5: 226-229.
26. Oyugi DA, Luo X, Lee KS, Hill B, Izevbigie EB 2009. Activity markers of the anti-breast carcinoma cell growth fractions of Vernonia amygdalina extracts. Exp Biol Med 234: 410-417.
27. Pagno T, Blind LZ, Biavatti MW, Kreuger MRO 2006. Cytotoxic activity of the dichloromethane fraction from Vernonia scorpioides (Lam.) Pers. (Asteraceae) against Ehrlich's tumor cells in mice. Braz J Med Biol Res 39: 1483-1491.
28. Pattanayak SP, Sunita P 2008. Wound healing, anti-microbial and antioxidant potential of Dendrophthoe falcata (L.f) Ettingsh, J Ethnopharmacol 120: 241-247.
29. Pratheeshkumar P, Kuttan G 2010. Modulation of immune response by Vernonia cinerea L. inhibits the proinflammatory cytokine profile, iNOS, and COX-2 expression in LPS-stimulated macrophages. Immunopharm Immunot 6: 1-11.
30. Saroglou V, Karioti A, Rancic A, Dimas K, Koukoulitsa C, Zervou M, Skaltsa H 2010. Sesquiterpene Lactones from Anthemis melanolepis and their antibacterial and cytotoxic activities. Prediction of their pharmacokinetic profile. J Nat Prod 73: 242-246.