Nuclear factor kappa B (NF-κB): A novel cause for diabetes, coronary artery disease and cancer initiation and promotion?

Medical Hypotheses

Volumn 78, Issue 1, 2012, Pages 29-32

  Rial, Nathaniel S ^a,b   Choi, Kwan ^a   Nguyen, Tam ^a   Snyder, Branden ^a   Slepian, Marvin J ^a,c,d  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c Mel and Enid Zuckerman College of Public Health ^*  (United States)

^d Director of Interventional Cardiology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; ROSUVASTATIN;

ARTERIOSCLEROSIS; ARTICLE; BREAST CANCER; CANCER RISK; CARDIOVASCULAR DISEASE; CHRONIC LYMPHATIC LEUKEMIA; CORONARY ARTERY DISEASE; CYTOPLASM; DIABETES MELLITUS; ENDOTHELIUM; EPIDEMIC; EPITHELIUM; HEALTH CARE; HUMAN; HYPOTHESIS; IMMOBILIZATION; INFLAMMATION; LEUKOCYTE; LIPID DIET; LUNG CANCER; MACROPHAGE; MOLECULE; MONOCYTE; OBESITY; PANCREAS CANCER; PERIODONTAL DISEASE; PROSTATE CANCER; RISK FACTOR; SMOKING; STROMA; TUMOR PROMOTION; UNITED STATES;

BODY MASS INDEX; CORONARY ARTERY DISEASE; DIABETES MELLITUS, TYPE 2; HUMANS; INFLAMMATION; MODELS, BIOLOGICAL; NEOPLASMS; NF-KAPPA B; OBESITY; PERIODONTAL DISEASES; RISK FACTORS;

EID: 83155192179     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.09.034     Document Type: Article

References (43)

1. US Mortality Data 2006. National Center for Health Statistics. 2009; Center for Disease Control and Prevention.
2. Cancer Fact Sheet 2006.
3. The top ten leading causes of death by broad income group 2008.
4. Cancer Statistics 2009.
5. Humphrey L.L., Fu R., Buckley D.I., Freeman M., Helfand M. Periodontal disease and coronary heart disease incidence. a systematic review and metaanalysis. J Gen Intern Med Dec 2008, 23(12):2079-2086.
6. Ridker P.M., Cook N.R., Lee I.M., et al. A randomized trial of low-dose aspirin in the primary prevention of cardiovascular disease in women. N Engl J Med Mar 31 2005, 352(13):1293-1304.
7. Tangrea J.A., Albert P.S., Lanza E., et al. Non-steroidal anti-inflammatory drug use is associated with reduction in recurrence of advanced and non-advanced colorectal adenomas (United States). Cancer Causes Control Jun 2003, 14(5):403-411.
8. Zernecke A., Bidzhekov K., Ozuyaman B., et al. CD73/ecto-5'-nucleotidase protects against vascular inflammation and neointima formation. Circulation May 2 2006, 113(17):2120-2127.
9. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation Mar 5 2002, 105(9):1135-1143.
10. Demaria S, Pikarsky E, Karin M, et al. Cancer and inflammation: promise for biologic therapy. J Immunother. May;33(4):335-351.
11. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. Mar 19 2010 ;140(6):883-899.
12. Karin M. NF-kappaB as a critical link between inflammation and cancer. Cold Spring Harb Perspect Biol Nov 2009, 1:a000141. (5).
13. Terzic J, Grivennikov S, Karin E, Karin M. Inflammation and colon cancer. Gastroenterology. Jun 2010; 138(6):2101-2114.
14. Baker RG, Hayden MS, Ghosh S. NF-kappaB, inflammation, and metabolic disease. Cell Metab. Jan 5 2011; 13(1):11-22 e2105.
15. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. Feb 2011; 11(2):98-107.
16. Shehzad A, Ha T, Subhan F, Lee YS. New mechanisms and the antiinflammatory role of curcumin in obesity and obesity-related metabolic diseases. Eur J Nutr. Apr 2011; 50(3):151-161.
17. Zernecke A., Shagdarsuren E., Weber C. Chemokines in atherosclerosis: an update. Arterioscler Thromb Vasc Biol Nov 2008, 28(11):1897-1908.
18. Baker A.R., Harte A.L., Howell N., et al. Epicardial adipose tissue as a source of nuclear factor-kappaB and c-Jun N-terminal kinase mediated inflammation in patients with coronary artery disease. J Clin Endocrinol Metab Jan 2009, 94(1):261-267.
19. Libby P. Inflammation in atherosclerosis. Nature Dec 19-26 2002, 420(6917):868-874.
20. Libby P. What have we learned about the biology of atherosclerosis? The role of inflammation. Am J Cardiol Oct 11 2001, 88(7(B)):3J-6J.
21. Ridker P.M., Danielson E., Fonseca F.A., et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med Nov 20 2008, 359(21):2195-2207.
22. Balkwill F., Mantovani A. Inflammation and cancer: back to Virchow? Lancet Feb 17 2001, 357(9255):539-545.
23. Karin M., Cao Y., Greten F.R., Li Z.W. NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer Apr 2002, 2(4):301-310.
24. Huang S., Pettaway C.A., Uehara H., Bucana C.D., Fidler I.J. Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene Jul 12 2001, 20(31):4188-4197.
25. Franzoso G., Bours V., Park S., Tomita-Yamaguchi M., Kelly K., Siebenlist U. The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa Bmediated inhibition. Nature Sep 24 1992, 359(6393):339-342.
26. Neri A., Chang C.C., Lombardi L., et al. B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-kappa B p50. Cell Dec 20 1991, 67(6):1075-1087.
27. Willis T.G., Jadayel D.M., Du M.Q., et al. Bcl10 is involved in t(1;14)(p22;q32) of MALT B cell lymphoma and mutated in multiple tumor types. Cell Jan 8 1999, 96(1):35-45.
28. Davis R.E., Brown K.D., Siebenlist U., Staudt L.M. Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells. J Exp Med Dec 17 2001, 194(12):1861-1874.
29. Annunziata C.M., Davis R.E., Demchenko Y., et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell Aug 2007, 12(2):115-130.
30. Rial N.S., Lazennec G., Prasad A.R., Krouse R.S., Lance P., Gerner E.W. Regulation of deoxycholate induction of CXCL8 by the adenomatous polyposis coli gene in colorectal cancer. Int J Cancer May 15 2009, 124(10):2270-2280.
31. Rial N.S., Meyskens F.L., Gerner E.W. Polyamines as mediators of APCdependent intestinal carcinogenesis and cancer chemoprevention. Essays Biochem 2009, 46:111-124.
32. Gerner E.W., Meyskens F.L. Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation. Clin Cancer Res Feb 1 2009, 15(3):758-761.
33. Palapattu G.S., Sutcliffe S., Bastian P.J., et al. Prostate carcinogenesis and inflammation: emerging insights. Carcinogenesis Jul 2005, 26(7):1170-1181.
34. Luo J.L., Tan W., Ricono J.M., et al. Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature Apr 5 2007, 446(7136):690-694.
35. Ali S., Lazennec G. Chemokines: novel targets for breast cancer metastasis. Cancer Metastasis Rev Dec 2007, 26(3-4):401-420.
36. Freund A., Jolivel V., Durand S., et al. Mechanisms underlying differential expression of interleukin-8 in breast cancer cells. Oncogene Aug 12 2004, 23(36):6105-6114.
37. Lazennec G, Richmond A. Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol Med. Mar 2010; 16(3):133-144.
38. Lowe G.D. Dental disease, coronary heart disease and stroke, and inflammatory markers: what are the associations, and what do they mean? Circulation Mar 9 2004, 109(9):1076-1078.
39. Janket S.J., Qvarnstrom M., Meurman J.H., Baird A.E., Nuutinen P., Jones J.A. Asymptotic dental score and prevalent coronary heart disease. Circulation Mar 9 2004, 109(9):1095-1100.
40. Sakurai K., Wang D., Suzuki J., et al. High incidence of actinobacillus actinomycetemcomitans infection in acute coronary syndrome. Int Heart J Nov 2007, 48(6):663-675.
41. Hujoel P.P., Drangsholt M., Spiekerman C., Derouen T.A. Examining the link between coronary heart disease and the elimination of chronic dental infections. J Am Dent Assoc Jul 2001, 132(7):883-889.
42. Payne JB, Golub LM, Stoner JA, et al. The effect of subantimicrobial-dosedoxycycline periodontal therapy on serum biomarkers of systemic inflammation: a randomized, double-masked, placebo-controlled clinical trial. J Am Dent Assoc. Mar 2011; 142(3):262-273.
43. Teles R, Wang CY. Mechanisms involved in the association between peridontal diseases and cardiovascular disease. Oral Dis. Jul 2011; 17(5): 450-461.