Aspirin may do wonders by the induction of immunological self-tolerance against autoimmune atherosclerosis

Medical Hypotheses

Volumn 78, Issue 1, 2012, Pages 171-173

  Hussain, Muzammal ^a   Javeed, Aqeel ^a   Ashraf, Muhammad ^a   Riaz, Amjad ^a   Mushtaq, Muhammad Hassan ^a  

^a UNIVERSITY OF VETERINARY AND ANIMAL SCIENCES   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; COLECALCIFEROL; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; ATHEROSCLEROSIS; CD4+ CD25+ T LYMPHOCYTE; CELL ACTIVITY; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ASPIRIN; ATHEROSCLEROSIS; AUTOIMMUNE DISEASES; DENDRITIC CELLS; HUMANS; LYMPHOCYTE ACTIVATION; SELF TOLERANCE; T-LYMPHOCYTES, REGULATORY;

EID: 83155192117     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.10.019     Document Type: Article

References (34)

1. Leaberry B.A. Aspirin for the prevention of cardiovascular disease: systematic review. J Nurs Care Qual 2010, 25:17-21.
2. Toth P.P. An urgent matter-identifying your patients' cardiovascular risk improving their outcomes. Atherosclerosis: the underlying disease. J Fam Pract 2009, 58:S19-25.
3. Robinson J.G., Fox K.M., Bullano M.F., Grandy S. Atherosclerosis profile and incidence of cardiovascular events: a population-based survey. BMC Cardiovasc Disord 2009, 9:46.
4. Blasi C. The autoimmune origin of atherosclerosis. Atherosclerosis 2008, 201:17-32.
5. Sherer Y., Shoenfeld Y. Mechanisms of disease: atherosclerosis in autoimmune diseases. Nat Clin Pract 2006, 2:99-106.
6. Jaichander P., Selvarajan K., Garelnabi M., Parthasarathy S. Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res 2008, 49:2142-2148.
7. Liu H., Jiang D., Zhang S., Ou B. Aspirin inhibits fractalkine expression in atherosclerotic plaques and reduces atherosclerosis in ApoE gene knockout mice. Cardiovasc Drug Ther/Sponsored Int Soc Cardiovasc Pharmacother 2010, 24:17-24.
8. Lu L., Liu H., Peng J., et al. Regulations of the key mediators in inflammation and atherosclerosis by aspirin in human macrophages. Lipid Health Dis 2010, 9:16.
9. Hua Y., Xue J., Sun F., Zhu L., Xie M. Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology 2009, 83:18-25.
10. George J., Harats D., Gilburd B., et al. Adoptive transfer of beta(2)-glycoprotein I-reactive lymphocytes enhances early atherosclerosis in LDL receptor-deficient mice. Circulation 2000, 102:1822-1827.
11. Daugherty A., Rateri D.L. T lymphocytes in atherosclerosis: the yin-yang of Th1 and Th2 influence on lesion formation. Circ Res 2002, 90:1039-1040.
12. Song L., Leung C., Schindler C. Lymphocytes are important in early atherosclerosis. J Clin Invest 2001, 108:251-259.
13. Gotsman I., Gupta R., Lichtman A.H. The influence of the regulatory T lymphocytes on atherosclerosis. Arterioscler Thromb Vasc Biol 2007, 27:2493-2495.
14. Taleb S., Tedgui A., Mallat Z. Regulatory T-cell immunity and its relevance to atherosclerosis. J Intern Med 2008, 263:489-499.
15. Lourenco E.V., La Cava A. Natural regulatory T cells in autoimmunity. Autoimmunity 2010, 44:33-42.
16. Wing K., Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010, 11:7-13.
17. Sakaguchi S. Regulatory T cells: history and perspective. Methods Mol Biol (Clifton, NJ) 2011, 707:3-17.
18. van Es T., van Puijvelde G.H., Foks A.C., et al. Vaccination against Foxp3(+) regulatory T cells aggravates atherosclerosis. Atherosclerosis 2010, 209:74-80.
19. Entin-Meer M., Afek A., George J. Regulatory T-cells FoxP3 and atherosclerosis. Adv Exp Med Biol 2009, 665:106-114.
20. Paulson K.E., Zhu S.N., Chen M., Nurmohamed S., Jongstra-Bilen J., Cybulsky M.I. Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis. Circ Res 2010, 106:383-390.
21. Hjerpe C., Johansson D., Hermansson A., Hansson G.K., Zhou X. Dendritic cells pulsed with malondialdehyde modified low density lipoprotein aggravate atherosclerosis in Apoe(-/-) mice. Atherosclerosis 2010, 209:436-441.
22. Niessner A., Weyand C.M. Dendritic cells in atherosclerotic disease. Clin Immunol (Orlando, Fla) 2010, 134:25-32.
23. Hermansson A., Johansson D.K., Ketelhuth D.F., Andersson J., Zhou X., Hansson G.K. Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice. Circulation 2011.
24. Maldonado R.A., von Andrian U.H. How tolerogenic dendritic cells induce regulatory T cells. Adv Immunol 2010, 108:111-165.
25. Mahnke K., Schmitt E., Bonifaz L., Enk A.H., Jonuleit H. Immature but not inactive: the tolerogenic function of immature dendritic cells. Immunol Cell Biol 2002, 80:477-483.
26. Takeda M., Yamashita T., Sasaki N., et al. Oral administration of an active form of vitamin D3 (calcitriol) decreases atherosclerosis in mice by inducing regulatory T cells and immature dendritic cells with tolerogenic functions. Arterioscler Thromb Vasc Biol 2010, 30:2495-2503.
27. Phadke K., Carroll J., Nanda S. Effects of various anti-inflammatory drugs on type II collagen-induced arthritis in rats. Clin Exp Immunol 1982, 47:579-586.
28. Yamazaki R., Kusunoki N., Matsuzaki T., Hashimoto S., Kawai S. Aspirin and sodium salicylate inhibit proliferation and induce apoptosis in rheumatoid synovial cells. J Pharm Pharmacol 2002, 54:1675-1679.
29. Zhang L., Bertucci A.M., Smith K.A., Xu L., Datta S.K. Hyperexpression of cyclooxygenase 2 in the lupus immune system and effect of cyclooxygenase 2 inhibitor diet therapy in a murine model of systemic lupus erythematosus. Arthritis Rheum 2007, 56:4132-4141.
30. Buckland M., Jago C., Fazekesova H., George A., Lechler R., Lombardi G. Aspirin modified dendritic cells are potent inducers of allo-specific regulatory T-cells. Int Immunopharmacol 2006, 6:1895-1901.
31. Buckland M., Jago C.B., Fazekasova H., et al. Aspirin-treated human DCs up-regulate ILT-3 and induce hyporesponsiveness and regulatory activity in responder T cells. Am J Transplant 2006, 6:2046-2059.
32. Buckland M., Lombardi G. Aspirin and the induction of tolerance by dendritic cells. Handbook Exp Pharmacol 2009, 197-213.
33. Hernandez A., Burger M., Blomberg B.B., et al. Inhibition of NF-kappa B during human dendritic cell differentiation generates anergy and regulatory T-cell activity for one but not two human leukocyte antigen DR mismatches. Hum Immunol 2007, 68:715-729.
34. Javeed A., Zhang B., Qu Y., et al. The significantly enhanced frequency of functional CD4+CD25+Foxp3+ T regulatory cells in therapeutic dose aspirin-treated mice. Transpl Immunol 2009, 20:253-260.