Delayed acyclovir therapy and death among neonates with herpes simplex virus infection

Pediatrics

Volumn 128, Issue 6, 2011, Pages 1153-1160

  Shah, Samir S ^a,b,c   Aronson, Paul L ^a,b   Mohamad, Zeinab ^a   Lorch, Scott A ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Acyclovir; Herpes simplex virus; Neonate; Therapy

Indexed keywords

ACICLOVIR;

ANTIVIRAL THERAPY; ARTICLE; CHILD DEATH; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HERPES SIMPLEX; HOSPITAL ADMISSION; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEWBORN; OBSERVATIONAL STUDY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SCORING SYSTEM;

EID: 83155176205     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2011-0177     Document Type: Article

References (25)

1. Cohen DM, Lorch SA, King RL, Hodinka RL, Cohn KA, Shah SS. Factors influencing the decision to test young infants for herpes simplex virus infection. Pediatr Infect Dis J. 2007;26(12):1156-1158 (Pubitemid 350190953)
2. Caviness AC, Demmler GJ, Almendarez Y, Selwyn BJ. The prevalence of neonatal herpes simplex virus infection compared with serious bacterial illness in hospitalized neonates. J Pediatr. 2008;153(2):164-169
3. Whitley RJ, Nahmias AJ, Soong SJ, Galasso GG, Fleming CL, Alford CA. Vidarabine therapy of neonatal herpes simplex virus infection. Pediatrics. 1980;66(4):495-501 (Pubitemid 10018429)
4. Kimberlin DW, Lin CY, Jacobs RF, et al. Natural history of neonatal herpes simplex virus infections in the acyclovir era. Pediatrics. 2001;108(2):223-229
5. Whitley RJ, Corey L, Arvin A, et al. Changing presentation of herpes simplex virus infection in neonates. J Infect Dis. 1988;158(1): 109-116
6. Kimura H, Futamura M, Kito H, et al. Detection of viral DNA in neonatal herpes simplex virus infections: frequent and prolonged presence in serum and cerebrospinal fluid. J Infect Dis. 1991;164(2):289-293
7. Troendle-Atkins J, Demmler GJ, Buffone GJ. Rapid diagnosis of herpes simplex virus encephalitis by using the polymerase chain reaction. J Pediatr. 1993;123(3):376-380 (Pubitemid 23258158)
8. Lakeman FD, Whitley RJ. Diagnosis of herpes simplex encephalitis: application of polymerase chain reaction to cerebrospinal fluid from brain-biopsied patients and correlation with disease. J Infect Dis. 1995; 171(4):857-863
9. Shah SS, Volk J, Mohamad Z, Hodinka RL, Zorc JJ. Herpes simplex virus testing and hospital length of stay in neonates and young infants. J Pediatr. 2010;156(5): 738-743
10. Kimberlin DW, Lin CY, Jacobs RF, et al. Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. Pediatrics. 2001;108(2):230-238
11. Kimberlin DW. When should you initiate acyclovir therapy in a neonate? J Pediatr. 2008; 153(2):155-156 (Pubitemid 351970576)
12. Long SS. In defense of empiric acyclovir therapy in certain neonates. J Pediatr. 2008; 153(2):157-158 (Pubitemid 351970580)
13. Whitley R, Arvin A, Prober C, et al. Predictors of morbidity and mortality in neonates with herpes simplex virus infections. N Engl J Med. 1991;324(7):450-454
14. Mongelluzzo J, Mohamad Z, Ten Have TR, Shah SS. Corticosteroids and mortality in children with bacterial meningitis. JAMA. 2008;299(17):2048 -2055
15. Shah SS, Hall M, Srivastava R, Subramony A, Levin JE. Intravenous immunoglobulin in children with streptococcal toxic shock syndrome. Clin Infect Dis. 2009;49(9): 1369-1376
16. Rosenbaum PR, Rubin DB. The central role of the propensity score in observational studies for causal effects. Biometrika. 1983; 70(1):41-55
17. Stürmer T, Joshi M, Glynn RJ, Avorn J, Rothman KJ, Schneeweiss S. A review of the application of propensity score methods yielded increasing use, advantages in specific settings, but not substantially different estimates compared with conventional multivariable methods. J Clin Epidemiol. 2006; 59(5):437-447
18. Weitzen S, Lapane KL, Toledano AY, Hume AL, Mor V. Principles for modeling propensity scores in medical research: a systematic literature review. Pharmacoepidemiol Drug Saf. 2004;13(12):841-853 (Pubitemid 40003819)
19. Imbens GW. Nonparametric estimation of average treatment effects under heterogeneity: a review. Rev Econ Stat. 2004; 86(1):4-29 (Pubitemid 38422764)
20. Greenland S. Introduction to regression modeling. In: Rothman KJ, Greenland S, eds. Modern Epidemiology. 3rd ed. Philadelphia, PA: Lippincott, Williams & Wilkins; 2008: 446-451
21. Pickering LK, ed. Red Book: 2003 Report of the Committee on Infectious Diseases. 26th ed. Elk Grove Village, IL: American Academy of Pediatrics; 2003:344-353
22. Whitley RJ, Nahmias AJ, Visintine AM, Fleming CL, Alford CA. The natural history of herpes simplex virus infection of mother and newborn. Pediatrics. 1980;66(4):489-494 (Pubitemid 10018428)
23. Caviness AC, Demmler GJ, Selwyn BJ. Clinical and laboratory features of neonatal herpes simplex virus infection: a case-control study. Pediatr Infect Dis J. 2008;27(5): 425-430
24. Davis KL, Shah SS, Frank G, Eppes SC. Why are young infants tested for herpes simplex virus? Pediatr Emerg Care. 2008;24(10): 673-678
25. O'Riordan DP, Golden WC, Aucott SW. Herpes simplex virus infections in preterm infants. Pediatrics. 2006;118(6). Available at: www. pediatrics.org/cgi/content/full/118/6/ e1612