Breath biomarkers in environmental health science: Exploring patterns in the human exposome

Journal of Breath Research

Volumn 5, Issue 4, 2011, Pages

  Pleil, Joachim D ^a   Stiegel, Matthew A ^b   Sobus, Jon R ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b IL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,4 TRIMETHYLBENZENE; 1,3,5 TRIMETHYLBENZENE; 4 ETHYLTOLUENE; BENZENE; BIOLOGICAL MARKER; DECANE; DODECANE; ETHYLBENZENE; FUEL; META XYLENE; NONANE; ORTHO XYLENE; PARA XYLENE; TOLUENE; UNCLASSIFIED DRUG; UNDECANE;

ARTICLE; BREATH ANALYSIS; CLUSTER ANALYSIS; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; ENVIRONMENTAL HEALTH; EXPIRED AIR; HUMAN; PRIORITY JOURNAL; SPIROMETRY; EXHALATION; METHODOLOGY; PHYSIOLOGY; REVIEW;

BIOLOGICAL MARKERS; BREATH TESTS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; EXHALATION; HUMANS;

EID: 83155165230     PISSN: 17527155     EISSN: 17527163     Source Type: Journal    
DOI: 10.1088/1752-7155/5/4/046005     Document Type: Article

References (29)

1. Cao W and Duan Y 2006 Breath analysis: potential for clinical diagnosis and exposure assessment Clin. Chem. 52 800-11 (Pubitemid 43673257)
2. Domany E 2003 Cluster analysis of gene expression data J. Stat. Phys. 110 1117-39
3. Hubbard H F, Sobus J R, Pleil J D, Madden M C and Tabucchi S 2009 Application of novel method to measure endogenous VOCs in exhaled breath condensate before and after exposure to diesel exhaust J. Chromatogr. B 877 3652-8
4. Kettenring J R 2006 The practice of cluster analysis J. Classification 23 3-30
5. Lahiri D K 2011 An integrated approach to genome studies Science 331 47
6. Lindstrom A B and Pleil J D 1996 A methodological approach for exposure assessment studies in residences using volatile organic compound contaminated water J. Air Waste Manag. Assoc. 46 1058-66 (Pubitemid 26380449)
7. Lindstrom A B and Pleil J D 2002 A review of the USEPA's single breath canister (SBC) method for exhaled volatile organic biomarkers Biomarkers 7 189-208 (Pubitemid 34678836)
8. Pauling L, Robinson A B, Teranishi R and Cary P 1971 Quantitative analysis of urine vapor and breath by gas-liquid partition chromatography Proc. Natl Acad. Sci. USA 68 2374-6
9. Phillips M, Herrera J, Krishnan S, Zain M, Greenberg J and Cataneo R N 1999 Variation in volatile organic compounds in the breath of normal humans J. Chromatogr. B Biomed. Sci. Appl. 729 75-88 (Pubitemid 29264111)
10. Pleil J D 2008 The role of exhaled breath biomarkers in environmental health science J. Toxicol. Environ. Health B Crit. Rev. 11 613-26
11. Pleil J D 2009 Influence of systems biology response and environmental exposure level on between-subject variability in breath and blood biomarkers Biomarkers 14 560-71
12. Pleil J D, Fisher J W and Lindstrom A B 1998b Comparison of human blood and breath levels of trichloroethylene from controlled inhalation exposure Environ. Health Perspect. 106 573-80 (Pubitemid 28495433)
13. Pleil J D, Hubbard H F, Sobus J R and Madden M C 2008 Volatile polar metabolites in exhaled breath condensate (EBC): collection and analysis J. Breath Res. 2 026001
14. Pleil J D and Lindstrom A B 1997 Exhaled human breath measurement for assessing exposure to halogenated volatile organic compounds Clin. Chem. 43 (5) 723-30 (Pubitemid 27208772)
15. Pleil J D and Lindstrom A B 1998a Sample timing and mathematical considerations for modeling breath elimination of volatile organic compounds Risk Anal. 18 585-602
16. Pleil J D and Lorber M N 2007 Relative congener scaling of polychlorinated Dibenzo-p-dioxins and Dibenzofurans to estimate building fire contributions in air, surface wipes, and dust samples Environ. Sci. Technol. 41 7286-93 (Pubitemid 350071636)
17. Pleil J D and Sheldon L S 2011 Adapting concepts from systems biology to develop systems exposure event networks for exposure science research Biomarkers 16 99-105
18. Pleil J D, Stiegel M A, Madden M C and Sobus J R 2011a Heat map visualization of complex environmental and biomarker measurements Chemosphere 84 716-23
19. Pleil J D, Stiegel M A, Sobus J R, Liu Q and Madden M C 2011b Interpreting the breath biomarker exposome for environmental and intelligence applications J. Breath Res. 5 037104
20. Pleil J D, Stiegel M A, Sobus J R, Tabucchi S, Ghio A J and Madden M C 2010 Cumulative exposure assessment for trace-level polycyclic aromatic hydrocarbons (PAHs) using human blood and plasma analysis J. Chromatogr. B 878 1753-60
21. Rappaport S M 2011 Implications of the exposome for exposure science J. Exposure Sci. Environ. Epidemiol. 21 5-9
22. Rappaport S M and Smith M T 2010 Environment and disease risk Science 330 460-1
23. Rioux J D and Abbas A K 2005 Paths to understanding the genetic basis of autoimmune disease Nature 435 584-9 (Pubitemid 40825497)
24. Sawyer K, Samet J D, Ghio A J, Pleil J D and Madden M C 2008 Responses measured in the exhaled breath of human volunteers acutely exposed to ozone and diesel exhaust J. Breath Res. 2 037019
25. Smith M T and Rappaport S M 2009 Building exposure biology centers to put the E intro 'G x E' interaction studies Environ. Health Perspect. 117 (8) A334-5
26. Sobus J R, Pleil J D, McClean M D, Herrick R F and Rappaport S M 2010 Biomarker variance component estimation for exposure surrogate selection and toxicokinetic inference Toxicol. Lett. 199 247-53
27. Sobus J R, Tan Y M, Pleil J D and Sheldon L S 2011 A biomonitoring framework to support exposure and risk assessments Sci. Total Environ. at press (doi:10.1016/j.scitotenv.2011.07.046)
28. Wild C P 2005 Complementing the genome with an 'exposome': the outstanding challenge of environmental exposure measurement in molecular epidemiology Cancer Epidemiol., Biomarkers Prev. 14 1847-50 (Pubitemid 41161186)
29. Wild C P 2011 How much of a contribution do exposures experienced between conception and adolescence make to the burden of cancer in adults? Cancer Epidemiol., Biomarkers Prev. 20 580-1