Chronic lymphocytic leukemia with central nervous system involvement: Report of two cases with a comprehensive literature review

Journal of Neuro-Oncology

Volumn 106, Issue 1, 2012, Pages 185-200

  Moazzam, Alan A ^a   Drappatz, Jan ^b   Kim, Ryan Y ^a   Kesari, Santosh ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Brain; Chronic lymphocytic leukemia; CNS; Leptomeningeal metastases; Leukemia

Indexed keywords

ALEMTUZUMAB; CYCLOPHOSPHAMIDE; FLUDARABINE; METHOTREXATE; PREDNISOLONE; RITUXIMAB; STEROID; TEMOZOLOMIDE; VINCRISTINE;

ADULT; ALLOGENEIC STEM CELL TRANSPLANTATION; CANCER MORTALITY; CASE REPORT; CENTRAL NERVOUS SYSTEM LEUKEMIA; CHRONIC LYMPHATIC LEUKEMIA; CORRELATION ANALYSIS; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EARLY DIAGNOSIS; FEMALE; HUMAN; HUMAN TISSUE; LEUKEMIA RELAPSE; LYMPH NODE BIOPSY; MALE; MULTIPLE CYCLE TREATMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; PROGNOSIS; REVIEW; RISK FACTOR; TREATMENT RESPONSE;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CENTRAL NERVOUS SYSTEM NEOPLASMS; COMBINED MODALITY THERAPY; FATAL OUTCOME; FEMALE; FLOW CYTOMETRY; GAIT DISORDERS, NEUROLOGIC; HUMANS; HYPESTHESIA; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LEUKEMIC INFILTRATION; LEUKOCYTE COUNT; MAGNETIC RESONANCE IMAGING; MIDDLE AGED; TOMOGRAPHY, X-RAY COMPUTED; TUMOR MARKERS, BIOLOGICAL;

EID: 83055194635     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/s11060-011-0636-z     Document Type: Review

References (71)

1. Akintola-Ogunremi O, Whitney C, Mathur SC, Finch CN (2002) Chronic lymphocytic leukemia presenting with symptomatic central nervous system involvement. Ann Hematol 81(7):402-404 (Epub 13 Jun 2002) (Pubitemid 36067650)
2. K Almhanna N Wongchaowart J Sweetenham 2009 Intracerebral Hodgkin's lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma: a case report and literature review Cancer Invest 27 215 220 19235595 10.1080/07357900802189824
3. A Bagic V Lupu C Kessler C Tornatore 2007 Isolated Richter's transformation of the brain J Neurooncol 83 325 328 17570037 10.1007/s11060-007-9334-2 (Pubitemid 46952246)
4. M Barcos W Lane GA Gomez T Han A Freeman H Preisler E Henderson 1987 An autopsy study of 1206 acute, chronic leukemias (1958 to 1982) Cancer 60 4 827 837 3474054 10.1002/1097-0142(19870815)60:4<827::AID-CNCR2820600419>3.0. CO;2-A 1:STN:280:DyaL2s3ktl2msQ%3D%3D (Pubitemid 17126293)
5. KM Bayliss BD Kueck CA Hanson WG Matthaeus UA Almagro 1990 Richter's syndrome presenting as primary central nervous system lymphoma. Transformation of an identical clone Am J Clin Pathol 93 1 117 123 2294692 1:STN:280: DyaK3c7gt1eguw%3D%3D (Pubitemid 20038949)
6. M Bojsen-Miller JL Nielsen 1983 CNS involvement in leukaemia Acta Pathol Microbiol Immunol Scand A 91 209 216
7. W Boogerd TM Vroom 1986 Meningeal involvement as the initial symptom of B cell chronic lymphocytic leukemia Eur Neurol 25 461 464 3491759 10.1159/000116053 1:STN:280:DyaL2s%2FotVCktA%3D%3D (Pubitemid 17179403)
8. L Boumsell A Bernard EL Reinherz, et al. 1981 Surface antigens on malignant Sezary and T-CLL cells correspond to those of mature T cells Blood 57 526 530 6970053 1:STN:280:DyaL3M7htVKruw%3D%3D (Pubitemid 11154621)
9. JH Bower JE Hammack SK McDonnell A Tefferi 1997 The neurologic complications of B-cell chronic lymphocytic leukemia Neurology 48 2 407 412 9040730 1:STN:280:DyaK2s7ptlWgug%3D%3D (Pubitemid 27087612)
10. WG Brick M Majmundar LK Hendricks AM Kallab RE Burgess AP Jillella 2002 Leukemic leptomeningeal involvement in stage 0 and stage 1 chronic lymphocytic leukemia Leuk Lymphoma 43 1 199 201 11908730 10.1080/10428190210191 1:STN:280:DC%2BD387nsFyrsw%3D%3D (Pubitemid 34223992)
11. Caligaris-Cappio F, Ghia P (2008) Novel insights in chronic lymphocytic leukemia: are we getting closer to understanding the pathogenesis of the disease? J Clin Oncol 26(27):4497-4503 (Epub 28 Jul 2008)
12. J Cash KM Fehir MS Pollack 1987 Meningeal involvement in early stage chronic lymphocytic leukemia Cancer 59 798 800 3802037 10.1002/1097- 0142(19870215)59:4<798::AID-CNCR2820590423>3.0.CO;2-B 1:STN:280: DyaL2s7gt1GisA%3D%3D (Pubitemid 17018760)
13. N Chiorazzi KR Rai M Ferrarini 2005 Chronic lymphocytic leukemia N Engl J Med 352 8 804 815 15728813 10.1056/NEJMra041720 1:CAS:528:DC%2BD2MXhsFCiu74%3D (Pubitemid 40271175)
14. V Conesa A Mompel J Ruiz A Gómez P Fernandez J Lucas I Aranda 1999 Fulminant brain lymphoid infiltration in a patient with chronic lymphocytic leukemia Am J Hematol 60 2 167 168 9929115 10.1002/(SICI)1096-8652(199902)60: 2<167::AID-AJH18>3.0.CO;2-W 1:STN:280:DyaK1M7is1Wqtw%3D%3D (Pubitemid 29047443)
15. SC Cramer JA Glaspy JT Efird DN Louis 1996 Chronic lymphocytic leukemia and the central nervous system: a clinical and pathological study Neurology 46 19 25 8559372 1:STN:280:DyaK287ktlWmsQ%3D%3D (Pubitemid 26156096)
16. JN Currie S Lessell IM Lessell JS Weiss DM Albert EM Benson 1988 Optic neuropathy in chronic lymphocytic leukemia Arch Ophthalmol 106 5 654 660 3358732 1:STN:280:DyaL1c7pt1Cqsw%3D%3D
17. GE Davies 1982 Meningeal leukemia complicating chronic lymphocytic leukemia Cancer 50 3 605 606 6980044 10.1002/1097-0142(19820801)50:3<605:: AID-CNCR2820500338>3.0.CO;2-8 1:STN:280:DyaL383jtlemtg%3D%3D
18. RV Diwan VG Diwan EM Bellon 1982 Brain involvement in chronic lymphocytic leukemia J Comput Assist Tomogr 6 4 812 814 7119204 10.1097/00004728-198208000- 00030 1:STN:280:DyaL3s%2Fgslykuw%3D%3D (Pubitemid 12097830)
19. MA Elliott L Letendre C Li JD Hoyer JE Hammack 1999 Chronic lymphocytic leukaemia with symptomatic diffuse central nervous system infiltration responding to therapy with systemic fludarabine Br J Haematol 104 689 694 10192427 10.1046/j.1365-2141.1999.01245.x 1:STN:280:DyaK1M3gs1Kntw%3D%3D (Pubitemid 29143485)
20. JS Fain F Naeim DP Becker, et al. 1992 Chronic lymphocytic leukemia presenting as a pituitary mass lesion Can J Neurol Sci 19 239 242 1623453 1:STN:280:DyaK38zitlCmtg%3D%3D
21. B Garicochea MG Cliquet N Melo A del Giglio PE Dorlhiac-Llacer DA Chamone 1997 Leptomeningeal involvement in chronic lymphocytic leukemia identified by polymerase chain reaction in stored slides: a case report Mod Pathol 10 5 500 503 9160317 1:STN:280:DyaK2szgsVSgsA%3D%3D (Pubitemid 27244239)
22. M Garofalo Jr R Murali I Halperin K Magardician HF Moussouris JC Masdeu 1989 Chronic lymphocytic leukemia with hypothalamic invasion Cancer 64 8 1714 1716 2790684 10.1002/1097-0142(19891015)64:8<1714::AID-CNCR2820640826>3.0. CO;2-G (Pubitemid 19251144)
23. El' Getaz GI Miller 1979 Spinal cord involvement in chronic lymphocytic leukemia Cancer 43 1858 1861 445372 10.1002/1097-0142(197905)43:5<1858::AID- CNCR2820430539>3.0.CO;2-E 1:STN:280:DyaE1M7ovFehug%3D%3D (Pubitemid 9203737)
24. M Gobbi PL Tazzari D Raspadori M Cavo S Pileri S Tura 1985 Meningeal leukemia complicating prolymphocytoid transformation of B-chronic lymphocytic leukemia Acta Haematol 74 4 205 207 3939061 10.1159/000206219 1:STN:280:DyaL283jvVansA%3D%3D (Pubitemid 16081702)
25. H Hagberg O Lannemyr S Acosta G Birgegard H Hagberg 1997 Successful treatment of syndrome of inappropriate antidiuretic secretion (SIADH) in 2 patients with CNS involvement of chronic lymphocytic leukaemia Eur J Haematol 58 207 208 9150717 10.1111/j.1600-0609.1997.tb00950.x 1:STN:280: DyaK2s3psFSltw%3D%3D (Pubitemid 27183473)
26. Hanse MC, Van't Veer MB, van Lom K, van den Bent MJ (2008) Incidence of central nervous system involvement in chronic lymphocytic leukemia and outcome to treatment. J Neurol. 255(6):828-830 (Epub 30 Apr 2008)
27. MA Hoffman E Valderrama A Fuchs M Friedman K Rai 1995 Leukemic meningitis in B-cell prolymphocytic leukemia. A clinical, pathologic, and ultrastructural case study and a review of the literature Cancer 75 5 1100 1103 7850707 10.1002/1097-0142(19950301)75:5<1100::AID-CNCR2820750508>3.0.CO;2-Q 1:STN:280:DyaK2M7ltlGrsw%3D%3D
28. U Kaiser 2003 Cerebral involvement as the initial manifestation of chronic lymphocytic leukaemia Acta Haematol 109 193 195 12853692 10.1159/000070969 (Pubitemid 36829018)
29. M Kalac V Suvic-Krizanic S Ostojic I Kardum-Skelin B Barsic B Jaksica 2007 Central nervous system involvement of previously undiagnosed chronic lymphocytic leukemia in a patient with neuroborreliosis Int J Hematol 85 4 323 325 17483076 10.1532/IJH97.E0618 1:STN:280:DC%2BD2s3ntlClug%3D%3D (Pubitemid 47182059)
30. LM Kernoff PJ Coghlan 1983 Prolymphocytic leukaemia with leukaemic meningitis and extralymphoid tumours: a case report S Afr Med J 64 8 290 292 6603668 1:STN:280:DyaL3s3ns1Wmtw%3D%3D
31. S Knop U Herrlinger U Ernemann L Kanz H Hebart 2005 Fludarabine may induce durable remission in patients with leptomeningeal involvement of chronic lymphocytic leukemia Leuk Lymphoma 46 11 1593 1598 16236614 10.1080/ 10428190500178472 1:CAS:528:DC%2BD2MXhtFahtLjN (Pubitemid 41700992)
32. S Korsager B Laurson TM Mortensen 1982 Dementia and central nervous system involvement in chronic lymphocytic leukemia Scand J Haematol 29 283 286 7178833 10.1111/j.1600-0609.1982.tb00595.x 1:STN:280:DyaL3s%2Fpt1yksg%3D%3D (Pubitemid 12037574)
33. H Kuwabara H Kanamori H Takasaki M Takabayashi S Yamaji N Tomita K Fujimaki S Fujisawa Y Ishigatsubo 2003 Involvement of central nervous system in prolymphocytoid transformation of chronic lymphocytic leukemia Leuk Lymphoma 44 7 1235 1237 12916878 10.1080/1042819031000079177 1:CAS:528:DC%2BD3sXivFOhu70%3D (Pubitemid 36609119)
34. PK Lane RM Townsend JH Beckstead L Corash 1988 Central nervous system involvement in a patient with chronic lymphocytic leukemia and non-Hodgkin's lymphoma (Richter's syndrome), with concordant cell surface immunoglobulin isotypic and immunophenotypic markers Am J Clin Pathol 89 254 259 3341285 1:STN:280:DyaL1c7jtVygtw%3D%3D (Pubitemid 18057182)
35. Lange CP, Brouwer RE, Brooimans R, Vecht ChJ (2007) Leptomeningeal disease in chronic lymphocytic leukemia. Clin Neurol Neurosurg 109(10):896-901 (Epub 12 Sep 2007) (Pubitemid 47600472)
36. MK Liepman ML Votaw 1981 Meningeal leukemia complicating chronic lymphocytic leukemia Cancer 47 2482 2484 6895047 10.1002/1097-0142(19810515)47: 10<2482::AID-CNCR2820471028>3.0.CO;2-O 1:STN:280:DyaL38%2FgtFOksw%3D%3D (Pubitemid 11127641)
37. A Lopez Guillermo F Cervantes J Blade, et al. 1989 Central nervous system involvement demonstrated by immunological study in prolymphocytic variant of chronic lymphocytic leukemia Acta Haematol 81 109 111 2496549 10.1159/000205537 1:STN:280:DyaL1M3isV2ksQ%3D%3D (Pubitemid 19099987)
38. P Mahe B Moreau S Bonnemain D Letortorec S Menegali D Bourdin D De Lajartre JL Harousseau 1994 Isolated Richter's syndrome of the brain: two recent cases Nouv Rev Fr Hematol 36 383 385 7892133 1:STN:280:DyaK2M7pvFWrsw%3D%3D (Pubitemid 24352500)
39. G Majumdar 1998 Chronic lymphocytic leukaemia with cerebral infiltration Leuk Lymphoma 28 5-6 603 605 9613992 1:STN:280:DyaK1c3nsVSksQ%3D%3D (Pubitemid 28203912)
40. AM Marmont 2000 Leukemic meningitis in B-cell chronic lymphocytic leukemia: resolution following intrathecal methotrexate Blood 96 776 777 10950515 1:CAS:528:DC%2BD3cXltVGgs70%3D (Pubitemid 30463407)
41. K Miller H Budke A Orazi 1997 Leukemic meningitis complicating early stage chronic lymphocytic leukemia Arch Pathol Lab Med 121 524 527 9167611 1:STN:280:DyaK2szhtVCntg%3D%3D (Pubitemid 27215158)
42. C Morrison S Shah IW Flinn 1998 Leptomeningeal involvement in chronic lymphocytic leukemia Cancer Pract 6 223 228 9767335 10.1046/j.1523-5394.1998. 006004223.x 1:STN:280:DyaK1cvktVegug%3D%3D (Pubitemid 28328397)
43. L Mowatt T Matthews I Anderson 2005 Sustained visual recovery after treatment with intrathecal methotrexate in a case of optic neuropathy caused by chronic lymphocytic leukemia J Neuroophthalmol 25 2 113 115 15937434 10.1097/01.WNO.0000165104.01237.3F (Pubitemid 40791655)
44. K Ng J Nash BE Woodcock 1991 High grade lymphoma of the cerebellum: a rare complication of chronic lymphatic leukaemia Clin Lab Haematol 13 1 93 97 2060268 10.1111/j.1365-2257.1991.tb00256.x 1:STN:280:DyaK3M3osVGltw%3D%3D
45. BP O'Neill TM Habermann PM Banks JR O'Fallon JD Earle 1989 Primary central nervous system lymphoma as a variant of Richter's syndrome in two patients with chronic lymphocytic leukemia Cancer 64 6 1296 1300 2766225 10.1002/1097-0142(19890915)64:6<1296::AID-CNCR2820640621>3.0.CO;2-E (Pubitemid 19217109)
46. K Oshimi M Akahoshi N Hagiwara M Tanaka H Mizoguchi 1985 A case of T-cell chronic lymphocytic leukemia with an unusual phenotype and central nervous system involvement Cancer 55 1937 1942 3872161 10.1002/1097-0142(19850501)55: 9<1937::AID-CNCR2820550918>3.0.CO;2-1 1:STN:280:DyaL2M7ltFKgtQ%3D%3D (Pubitemid 15116950)
47. E Pastor E Grau E Real 1997 Leukemic meningitis in a patient with B-cell prolymphocytic leukemia Haematologica 82 4 511 512 9299880 1:STN:280: DyaK2svksVOhsw%3D%3D
48. WN Patton MP Carey MR Fletcher EB Rolfe D Spooner PR Richardson IM Franklin 1992 Diffuse intracerebral involvement in B-cell chronic lymphocytic leukaemia: a case report Clin Lab Haematol 14 149 154 1633685 1:STN:280:DyaK38zjvFahsg%3D%3D
49. I Perez Fernandez F Salgado Ordonez 1998 Infiltration of the central nervous system as a presentation form of early stage chronic lymphocytic leukemia Am J Hematol 58 339 342 9692402 10.1002/(SICI)1096-8652(199808)58: 4<339::AID-AJH17>3.0.CO;2-2 1:STN:280:DyaK1czlsFWgsg%3D%3D (Pubitemid 28346025)
50. S Pohar C deMetz S Poppema J Hugh 1993 Chronic lymphocytic leukemia with CNS involvement J Neuro-Oncol 16 35 37 10.1007/BF01324832 1:STN:280: DyaK2c%2FhsFagug%3D%3D (Pubitemid 23223540)
51. M Półtorak A Członkowska K Nowicka 1983 Chronic lymphocytic leukemia: study of cell subsets in cerebrospinal fluid and peripheral blood Eur Neurol 22 4 289 292 6884398 10.1159/000115573 (Pubitemid 13070499)
52. L Poplawska-Szczyglowska J Walewski B Pienkowska-Grela G Rymkiewicz O Mioduszewska 1999 Chronic lymphocytic leukaemia presenting with central nervous system involvement Med Oncol 16 65 68 10382945 10.1007/BF02787361 1:STN:280:DyaK1MzhtVeiug%3D%3D (Pubitemid 29238384)
53. A Remkova T Bezayova M Vyskocil 2003 B cell chronic lymphocytic leukemia with meningeal infiltration by T lymphocytes Eur J Int Med 14 49 52 10.1016/S0953-6205(02)00207-8 (Pubitemid 36120568)
54. E Reske-Nielsen JH Petersen H Sogaard KB Jensen 1974 Leukemia of the central nervous system [letter] Lancet 1 211 212 4129892 10.1016/S0140-6736(74) 92511-2 1:STN:280:DyaE2c%2Foslehug%3D%3D
55. T Robak J Gora-Tybor K Tybor K Jamroziak P Robak R Kordek P Rieske A Majos H Urbanska-Rys 2004 Richter's syndrome in the brain first manifested as an ischaemic stroke Leuk Lymphoma 45 6 1261 1267 15360010 10.1080/ 10428190310001638823 (Pubitemid 38584912)
56. P Rubin NL Harris 1993 Case records of the Massachusetts general hospital: case 4. A 73-year-old man with severe facial pain, visual loss, decreased ocular motility, and an orbital mass N Engl J Med 328 266 275 10.1056/NEJM199301283280409 (Pubitemid 23035314)
57. P Ruiz M Moezzi W Chamizo P Ganjei CC Whitcomb LC Rey 1992 Central nervous system expression of a monoclonal paraprotein in a chronic lymphocytic leukemia patient Acta Haematol 88 37 40 1414160 10.1159/000204593 1:STN:280:DyaK3s%2FjsVSitw%3D%3D
58. AD Rye RN Stitson MJ Dyer 2001 Pituitary infiltration in B-cell chronic lymphocytic leukaemia Br J Haematol 115 718 11843801 10.1046/j.1365-2141.2001. 03210.x 1:STN:280:DC%2BD387htVCrug%3D%3D (Pubitemid 34042885)
59. M Schmidt-Hieber E Thiel U Keilholz 2005 Spinal paraparesis due to leukemic meningitis in early-stage chronic lymphocytic leukemia Leuk Lymphoma 46 4 619 621 16019494 10.1080/14767050400029681 (Pubitemid 40584882)
60. AK Singh RPH Thompson 1986 Leukaemic meningitis in chronic lymphocytic leukemia Acta Haematol 75 113 115 3090818 10.1159/000206098 1:STN:280: DyaL283ptF2lsg%3D%3D (Pubitemid 16071289)
61. MP Stagg CH Gumbart 1987 Chronic lymphocytic leukemic meningitis as a cause of the syndrome of inappropriate secretion of antidiuretic hormone Cancer 60 191 192 3594356 10.1002/1097-0142(19870715)60:2<191::AID- CNCR2820600212>3.0.CO;2-2 1:STN:280:DyaL2s3ktlylsw%3D%3D (Pubitemid 17092255)
62. LM Staudt 2003 Molecular diagnosis of the hematologic cancers N Engl J Med 348 18 1777 1785 12724484 10.1056/NEJMra020067 1:CAS:528: DC%2BD3sXjtlWqsrg%3D (Pubitemid 36514709)
63. JP Steinberg M Pecora JL Lokey 1985 Leukemic meningitis in B-cell chronic lymphocytic leukemia Cancer Treat Rep 69 687 688 3874689 1:STN:280: DyaL2M3lsVGhug%3D%3D (Pubitemid 15031687)
64. AK Sullivan JC Vera LM Jerry G Rowden B Bain 1978 Small lymphocyte T-cell leukemia in the adult Cancer 42 2920 2927 310337 10.1002/1097-0142(197812)42: 6<2920::AID-CNCR2820420656>3.0.CO;2-I 1:STN:280:DyaE1M%2Fotl2gug%3D%3D (Pubitemid 9107575)
65. A Tefferi RL Phyliky 1992 A clinical update on chronic lymphocytic leukemia. I. Diagnosis and prognosis Mayo Clin Proc 67 349 353 1548950 1:STN:280:DyaK387psVyguw%3D%3D
66. R Thiruvengadam ZP Bernstein 1992 Central nervous system involvement in prolymphocytic transformation of chronic lymphocytic leukemia Acta Haematol 87 163 164 1642098 10.1159/000204747 1:STN:280:DyaK38zltFOitA%3D%3D
67. van den Bent MJ, Lamers CH, van't Veer MB, Sillevis Smitt PA, Bolhuis RL, Gratama JW (2002) Increased levels of soluble CD27 in the cerebrospinal fluid are not diagnostic for leptomeningeal involvement by lymphoid malignancies. Ann Hematol 81(4):187-191 (Epub 26 Mar 2002) (Pubitemid 36067605)
68. E Viadana IDJ Bross JW Pickren 1978 An autopsy study of the metastatic patterns of human leukemias Oncology 35 87 96 274679 10.1159/000225262 1:STN:280:DyaE1c7nslyntQ%3D%3D (Pubitemid 8323093)
69. ML Wang LY Shih P Dunn MC Kuo 2000 Meningeal involvement in B-cell chronic lymphocytic leukemia: report of two cases J Formos Med Assoc 99 10 775 778 11061073 1:STN:280:DC%2BD3crgvFGiuw%3D%3D
70. N Watanabe T Takahashi N Sugimoto Y Tanaka M Kurata A Matsushita A Maeda K Nagai K Nasu 2005 Excellent response of chemotherapy-resistant B-cell-type chronic lymphocytic leukemia with meningeal involvement to rituximab Int J Clin Oncol 10 357 361 16247665 10.1007/s10147-005-0496-7 (Pubitemid 41507212)
71. Y Yamamoto M Tsujimoto Y Konoike H Nakamine T Morii H Kimura 2004 Richter's syndrome presenting as a nasal lymphoma Leuk Lymphoma 45 9 1919 1923 15223655 10.1080/1042819042000219430 (Pubitemid 38997162)