Central nervous system involvement of previously undiagnosed chronic lymphocytic leukemia in a patient with neuroborreliosis

International Journal of Hematology

Volumn 85, Issue 4, 2007, Pages 323-325

  Kalac, Matko ^a,d   Suvic Krizanic, V ^b   Ostojic, S ^a   Kardum Skelin, I ^a   Barsic, B ^c   Jaksic, B ^a  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b Dr Ivo Pedisic County Hospital   (Croatia)

^c Croatia   (Croatia)

^d University of Zagreb   (Croatia)

Author keywords

Central nervous system; Chronic lymphocytic leukemia; Neuroborreliosis

Indexed keywords

ANTIINFECTIVE AGENT; CHLORAMBUCIL; CLOXACILLIN; DEXAMETHASONE; GELATINASE B;

ADULT; ARTICLE; B LYMPHOCYTE; BLOOD BRAIN BARRIER; BORRELIA INFECTION; CASE REPORT; CELL CLONE; CELL COUNT; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CHRONIC LYMPHATIC LEUKEMIA; CYTOLOGY; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LEUKOCYTE MIGRATION; LYMPHOCYTE; MALE; MENINX; NEUROBORRELIOSIS; SYMPTOMATOLOGY; SYSTEMIC THERAPY;

ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTINEOPLASTIC AGENTS, HORMONAL; BLOOD-BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CHLORAMBUCIL; DEXAMETHASONE; ENZYME ACTIVATION; HUMANS; INJECTIONS, SPINAL; LEUKEMIA, B-CELL, CHRONIC; LEUKEMIC INFILTRATION; LYME NEUROBORRELIOSIS; MALE; MATRIX METALLOPROTEINASE 9; MIDDLE AGED;

EID: 34547512902     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1532/IJH97.E0618     Document Type: Article

References (21)

1. Kipps TJ. Chronic lymphocytic leukemia and related diseases. In: Lichtman MA, Beutler E, Kaushansky K, Seligsohn U, Kipps TJ, Prchal JT, eds. Williams Hematology Seventh Edition. New York, NY: McGraw-Hill; 2005:1343-1385.
2. Majumdar G. Chronic lymphocytic leukaemia with cerebral infiltration. Leuk Lymphoma. 1998;28:603-605.
3. Elliott MA, Letendre L, Li CY, Hoyer JD, Hammack JE. Chronic lymphocytic leukaemia with symptomatic diffuse central nervous system infiltration responding to therapy with systemic fludarabine. Br J Haematol. 1999;104:689-694.
4. Remkova A, Bezayova T, Vyskocil M. B cell lymphocytic leukemia with meningeal infiltration by T lymphocytes. Eur J Intern Med. 2003;14:49-52.
5. Akintola-Ogunremi O, Whitney C, Mathur SC, Finch CN. Chronic lymphocytic leukemia presenting with symptomatic central nervous system involvement. Ann Hematol. 2002;81:402-404.
6. Rothe G, Schmitz G. Consensus protocol for the flow cytometric immunophenotyping of haematopoietic malignancies: Working Group on Flow Cytometry and Image Analysis. Leukemia. 1996;10:877-895.
7. Owen RG, Johnson RJ, Rawstron AC, et al. Assessment of IgH strategies in multiple myeloma. J Clin Pathol. 1996;49:672-675.
8. Greig NH, Genka S, Daly EM, Sweeney DJ, Rapoport SI. Physicochemical and pharmacokinetic parameters of seven lipophilic chlorambucil esters designed for brain penetration. Cancer Chemother Pharmacol. 1990;25:311-319.
9. Greig NH, Sweeney DJ, Rapoport SI. Comparative brain and plasma pharmacokinetics and anticancer activities of chlorambucil and melphalan in the rat. Cancer Chemother Pharmacol. 1988;21:1-8.
10. Nowakowski GS, Call TG, Cook RJ, Kurtin PJ, Zent CS. Is the presence of a monoclonal B-cell population in the cerebrospinal fluid diagnostic of CNS involvement by a lymphoid malignancy? [abstract]. Blood. 102. Abstract 3445.
11. Yuschenko M, Weber F, Maeder M, et al. Matrix metalloproteinase-9 (MMP-9) in human cerebrospinal fluid (CSF): elevated levels are primarily related to CSF cell count. J Neuroimmunol. 2000;110:244-251.
12. Grab DJ, Perides G, Dumler JS, et al. Borrelia burgdorferi, host-derived proteases, and the blood-brain barrier. Infect Immun. 2005;5:1014-1022.
13. Paul R, Lorenzl S, Koedel U, et al. Matrix metalloproteinases contribute to the blood-brain barrier disruption during bacterial meningitis. Ann Neurol. 1998;44:592-600.
14. Petrides G, Charness ME, Tanner LM, et al. Matrix metalloproteinases in the cerebrospinal fluid of patients with Lyme borreliosis. J Infect Dis. 1998;177:401-408.
15. Kuwabara H, Kanamori H, Takasaki H, et al. Involvement of central nervous system in prolymphocytoid transformation of chronic lymphocytic leukemia. Leuk Lymphoma. 2003;44:1235-1237.
16. Johnson SA. Nucleoside analogues in the treatment of haematologic malignancies. Expert Opin Pharmacother. 2001;2:929-943.
17. Mowatt L, Matthews T, Anderson I. Sustained visual recovery after treatment with intrathecal methotrexate in a case of optic neuropathy caused by chronic lymphocytic leukemia. J Neuroophthalmol. 2005;25:113-115.
18. Szawarsi P, Chapman CS. A woman who couldn't speak: report of methotrexate neurotoxicity. Postgrad Med J. 2005;81:194-195.
19. Marmont AM. Leukemic meningitis in B-cell chronic lymphocytic leukemia: resolution following intrathecal methotrexate. Blood. 2000;96:776-777.
20. Brick WG, Majumundar M, Hendricks LK, Kallab AM, Burgess RE, Jillella AP. Leukemic leptomeningeal involvement in stage 0 and stage 1 chronic lymphocytic leukemia. Leuk Lymphoma. 2002;43:199-201.
21. Schmidt-Hieber M, Thiel E, Keilholz U. Spinal paraparesis due to leukemic meningitis in early-stage chronic lymphocytic leukemia. Leuk Lymphoma. 2005;46:619-621.