Prostaglandin F2α and control of reproduction in female swine: A review

Theriogenology

Volumn 77, Issue 1, 2012, Pages 1-11

  De Rensis, F ^a   Saleri, R ^a   Tummaruk, P ^b   Techakumphu, M ^b   Kirkwood, R N ^c  

^a UNIVERSITY OF PARMA   (Italy)

^b CHULALONGKORN UNIVERSITY   (Thailand)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN RECEPTOR;

ANIMAL; ANIMAL DISEASE; ARTIFICIAL INSEMINATION; CORPUS LUTEUM; DRUG EFFECT; ESTRUS CYCLE; FEMALE; LUTEOLYSIS; METABOLISM; PHYSIOLOGY; PREGNANCY; PUERPERIUM; REPRODUCTION; REVIEW; SWINE;

ANIMALS; CORPUS LUTEUM; DINOPROST; ESTROUS CYCLE; FEMALE; INSEMINATION, ARTIFICIAL; LUTEOLYSIS; POSTPARTUM PERIOD; PREGNANCY; RECEPTORS, PROSTAGLANDIN; REPRODUCTION; SWINE;

SUIDAE;

EID: 83055188044     PISSN: 0093691X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.theriogenology.2011.07.035     Document Type: Review

References (135)

1. Schomberg D.W. Demonstration in vitro of luteolytic activity in pig uterine flushing. J Endocrinol 1967, 38:359-361.
2. Christenson R.K., Day B.N. Luteolytic effects of endometrial extracts in the pig. J Anim Sci 1972, 34:620-625.
3. Bazer F.W., Geisert R.D., Thatcher W.W., Roberts R.M. The establishment and maintenance of pregnancy. Control of Pig Reproduction 1982, 227-253. Butterworth Scientific, London. D.J.A. Cole, G.A. Foxcroft (Eds.).
4. Gleeson A.R., Thorburn G.D., Cox R.I. Prostaglandin F concentrations in the utero-ovarian venous plasma of the sow during the late luteal phase of the oestrous cycle. Prostaglandins 1974, 5:521-529.
5. 2 positive feedback loop in the porcine endometrium. Endocrinology 2009, 150:3823-3832.
6. Niswender G.D., Dzuik P.J., Kaltenbach C.C., Norton H.W. Local effects of embryo and uterus on corpora lutea in gilts. J Anim Sci 1970, 30:225-234.
7. Ginther O.J. Internal regulation of physiological processes through local venoarterial pathways: a review. J Anim Sci 1974, 39:550-564.
8. The European Agency for the Evaluation of Medicinal Products. Dinoprost tromethamine report EMEA. http://www.emea.europa.eu/pdfs/vet/mrls/dinoprost.pdf.
9. The European Agency for the Evaluation of Medicinal Products. Cloprostenol and R-cloprostenol summary report April 1997, EMEA.
10. Kral J., Mysikowa S., Bilek P., Borovicka A., Pichcova D., Seik B. Luteolytic effect of d-cloprostenol and its residue in milk and organs. Biol Chem Vet 1989, 25:293-300.
11. 2α receptors in bovine corpus luteum and myometrial cell membranes. J Vet Pharm Ther 2008, 17:455-458.
12. Re G., Badino P., Novelli A., Vallisneri A., Girardi C. Specific binding of DL-cloprostenol and D-cloprostenol to PGF2alfa receptors in bovine corpus luteum and myometrial membranes. J Vet Pharmacol Therap 1994, 17:455-458.
13. Kimball F.A., Lauderdale J.W. Comparison of luteolytic effectiveness of several prostaglandin analogs in heifers and relative binding affinity for bovine luteal prostaglandin binding sites. Prostaglandins 1976, 12:985-995.
14. Connor L., Phillips G.D., Palmer W.M. Effects of prostaglandin on the estrous cycle and hormone levels in the gilt. Can J Anim Sci 1976, 56:661-669.
15. Anderson L.E., Wu Y.L., Wiltbank M.C. Prostaglandin F2a receptor in the corpus luteum: recent information on the gene, messenger ribonucleic acid, and protein. Biol Reprod 2001, 64:1041-1047.
16. Anderson L.L., Butcher R.L., Melampy R.M. Subtotal hysterectomy and ovarian function in gilts. Endocrinology 1961, 69:571-580.
17. Horton E.W., Poyser N.L. Uterine luteolytic hormone: a physiological role for prostaglandin F2a. Physiol Rev 1976, 56:595-651.
18. Moeljono M.P., Thatcher W.W., Bazer F.W., Frank M., Owens L.J., Wilcox C.J. A study of prostaglandin F2a as the luteolysin in swine: II. Characterization and comparison of prostaglandin F2a, estrogen and progestin concentration in utero-ovarian vein plasma of non pregnant and pregnant gilts. Prostaglandin 1977, 14:543-555.
19. Gadsby J.E., Balapure A.K., Britt J.H., Fitz T.A. Prostaglandin F2 alfa receptors on enzyme dissociated pig luteal cells throughout the estrous cycle. Endocrinology 1990, 126:787-795.
20. Gadsby J.E., Lovdal J.A., Britt J.H., Fitz T.A. Prostaglandin F2 alpha receptor concentrations in corpora lutea of cycling, pregnant, and pseudopregnant pigs. Biol Reprod 1993, 49:604-608.
21. Wiltbank M.C., Shiaom T.F., Bergfelt D.R., Ginther O.J. Prostaglandin F2a receptors in the early bovine corpus luteum. Biol Reprod 1995, 52:74-78.
22. Wiltbank M.C., Diskin M.G., Flores J.A., Niswender G.D. Regulation of the corpus luteum by protein kinase C. II. Inhibition of lipoprotein-stimulated steroidogenesis by PGF2a. Biol Reprod 1990, 42:239-245.
23. Wiltbank M.C., Buthrie P.B., Mattson M.P., Kate S.B., Niswender G.D. Hormonal regulation of free intracellular calcium concentrations in small and large ovine cells. Biol Reprod 1989, 41:771-778.
24. Diaz F.J., Crenshaw T.D., Wiltbank M.C. Prostaglandin F2a induces distinct physiological responses in porcine corpora lutea after acquisition of luteolytic capacity. Biol Reprod 2000, 63:1504-1512.
25. 2α receptor in bovine preovulatory follicles. Endocrinology 1996, 137:3348-3355.
26. Diaz F.J., Wiltbank M.C. Acquisition of luteolytic capacity: changes in prostaglandin F2a regulation of steroid hormone receptors and estradiol biosynthesis in pig corpora lutea. Biol Reprod 2004, 70:1333-1339.
27. Levy N., Kobayashi S., Roth Z., Wolfenson D., Miyamoto A., Meidan R. Administration of prostaglandin F2a during the early bovine luteal phase does not alter the expression of ET-1 and of its type A receptor: a possible cause for corpus luteum refractoriness. Biol Reprod 2000, 63:377-382.
28. Diaz F.J., Wiltbank M.C. Acquisition of luteolytic capacity involves differential regulation by prostaglandin F2a of genes involved in progesterone biosynthesis in the porcine corpus luteum. Domest Anim Endocrinol 2005, 28:172-189.
29. Rexroad C.E., Guthrie H.D. Prostaglandin F2 alpha and progesterone release in vitro by ovine luteal tissue during induced luteolysis. Adv Exp Med Biol 1979, 112:639-644.
30. Guthrie H.D., Rexroad C.E., Bolt D.J. In vitro release of progesterone and prostaglandins F and E by porcine luteal and endometrial tissue during induced luteolysis. Adv Exp Med Biol 1979, 112:627-632.
31. 2α regulates distinct physiological changes in early and mid-cycle bovine corpora lutea. Biol Reprod 1998, 58:346-352.
32. Slomczynska M., Krok M., Pierscinski A. Localization of the progesterone receptor in the porcine ovary. Acta Histochem 2000, 102:183-191.
33. Slomczynska M., Wozniak J. Differential distribution of estrogen receptor-beta and estrogen receptor-alpha in the porcine ovary. Exp Clin Endocrinol Diabetes 2001, 109:238-244.
34. Ford S.P., Christenson L.K. Direct effects of oestradiol-17B and prostaglandin E-2 in protecting pig corpora lutea from a luteolytic dose of prostaglandin F-2alfa. J Reprod Fertil 1991, 93:203-209.
35. Jarry H., Einspanier A., Kanngiesser L., Dietrich M., Pitzel L., Holtz W., Wuttke W. Release and effects of oxytocin on estradiol and progesterone secretion in porcine corpora lutea as measured by an in vivo microdialysis system. Endocrinology 1990, 126:2350-2358.
36. Gregoraszczuk E.L., Oblonczyk K. Effect of a specific aromatase inhibitor on oestradiol secretion by porcine corpora lutea at various stages of the luteal phase. Reprod Nutr Dev 1996, 36:65-72.
37. Duffy D.M., Chaffin C.L., Stouffer R.L. Expression of estrogen receptor alpha and beta in the rhesus monkey corpus luteum during the menstrual cycle: regulation by luteinizing hormone and progesterone. Endocrinology 2000, 141:1711-1717.
38. Auletta F.J., Caldwell B.V., Speroff L. Estrogen-induced luteolysis in the rhesus monkey: reversal with indomethacin. Prostaglandins 1976, 11:745-752.
39. Karsch F.J., Sutton G.P. An intra-ovarian site for the luteolytic action of estrogen in the rhesus monkey. Endocrinology 1976, 98:553-561.
40. Conley A.J., Ford S.P. Direct luteotrophic effect of oestradiol-17 beta on pig corpora lutea. J Reprod Fertil 1989, 87:125-131.
41. Qiu Y., Waters C.E., Lewis A.E., Langman M.J., Eggo M.C. Oestrogen-induced apoptosis in colonocytes expressing oestrogen receptor beta. J Endocrinol 2002, 174:369-377.
42. Kuranaga E., Kanuka H., Furuhata Y., Yonezawa T., Suzuki M., Nishihara M., Takahashi M. Requirement of the Fas ligand-expressing luteal immune cells for regression of corpus luteum. FEBS Lett 2000, 472:137-142.
43. Roughton S.A., Lareu R.R., Bittles A.H., Dharmarajan A.M. Fas and Fas ligand messenger ribonucleic acid and protein expression in the rat corpus luteum during apoptosis-mediated luteolysis. Biol Reprod 1999, 60:797-804.
44. Taniguchi H., Yokomizo Y., Okuda K. Fas-Fas ligand system mediates luteal cell death in bovine corpus luteum. Biol Reprod 2002, 66:754-759.
45. 2α. Biol Reprod 2000, 63:1229-1236.
46. Arosh J.A., Banu S.K., Chapdelaine P., Madore E., Sirois J., Fortier M.A. Prostaglandin biosynthesis, transport, and signalling in corpus luteum: a basis for autoregulation of luteal function. Endocrinology 2004, 145:2551-2560.
47. Goravanahally M.P., Salem J., Yao E.K., Inskeep E.K., Flores J.A. Differential gene expression in the bovine corpus luteum during transition from early phase to midphase and its potential role in acquisition of luteolytic sensitivity to prostaglandin F2 alpha. Biol Reprod 2009, 80:980-988.
48. Acosta T.J., Bah M.B., Korzekwa A., Woclawek-Potocka I., Markiewicz W., Jaroszewski J.J., Okuda K., Skarzynski D.J. Acute changes in circulating concentrations of progesterone and nitric oxide and partial pressure of oxygen during prostaglandin F2alpha-induced luteolysis in cattle. J Reprod Dev 2009, 55:149-155.
49. Tenhagen B.A., Kuchenbush S., Heuwieser W. Timing of ovulation and fertility of heifers after synchronization of oestrus with GnRH and prostaglandin F2α. Reprod Dom Anim 2005, 40:62-67.
50. De Rensis F., Peter A. The control of follicular dynamics by PGF2a, GnRH, hCG and estrus synchronization in cattle. Reprod Dom Anim 1999, 34:49-59.
51. Menchaca A., Miller V., Gil J., Pinczak A., Laca M., Rubianes E. Prostaglandin F2alfa treatment associated with timed artificial insemination in ewes. Reprod Dom Anim 2004, 39:352-355.
52. Rubianes E., Menchaca A. The pattern and manipulation of ovarian follicular growth in goats. Anim Reprod Sci 2003, 78:271-287.
53. Bacci M.L., Barazzoni A.M., Forni A., Costerbosa G.L. In situ detection of apoptosis in regressing corpus luteum of pregnant sow: evidence of an early presence of DNA fragmentation. Domest Anim Endocrinol 1996, 13:361-372.
54. Moeljono W.W., Thatcher W.W., Bazer F.W., Frank M., Owens L.J., Wilcox C.J. A study of prostaglandin F2alpha as the luteolysin in swine: II. Characterization and comparison of prostaglandin F, estrogens and progestin concentrations in utero-ovarian vein plasma of nonpregnant and pregnant gilts. Prostaglandins 1977, 14:543-555.
55. Tai H.H., Ensor C.M., Tong M., Zhou H., Yan F. Prostaglandin catabolizing enzymes. Prostaglandins Other Lipid Mediat 2002, 68-69:483-493.
56. 2α in pigs with luteolysis blocked by pregnancy, estradiol benzoate or human chorionic gonadotropin. J Anim Sci 1981, 52:330-339.
57. McCracken J.A., Glew M.E., Scaramuzzi R.J. Corpus luteum regression induced by prostaglandin in F2-alpha. J Clin Endocrinol Metab 1970, 30:544-546.
58. McCracken J.A., Carlson J.S., Glew M.E., Goding J.R., Baird D.T., Gréen K., Samuelsson B. Prostaglandin F2 identified as a luteolytic hormone in sheep. Nat New Biol 1972, 238:129-134.
59. Inskeep E.K., Murdoch W.J. Relation of ovarian functions to uterine and ovarian secretion of prostaglandins during the estrous cycle and early pregnancy in the ewe and cow. Int Rev Physiol 1980, 22:325-356.
60. Thorburn G.D., Cox R.J., Currie W.B., Restall B.J., Schneider W. Prostaglandin F and progesterone concentrations in the utero-ovarian venous plasma of the ewe during the oestrous cycle and early pregnancy. J Reprod Fertil 1973, 18(Suppl):151-158.
61. Nancarrow C.D., Buckmaster J., Chamley W., Cox R.I., Cumming I.A., Cummins L., Drinan J.P., Findlay J.K., Goding J.R., Restall B.J., Schneider W., Thorburn G.D. Hormonal changes around oestrus in the cow. J Reprod Fertil 1973, 32:320-321.
62. Peterson A.J., Fairclough R.J., Payne E., Smith J.F. Hormonal changes around bovine luteolysis. Prostaglandins 1975, 10:675-684.
63. Kindahl H., Edqvist L.E., E.Granström E., Bane A. The release of prostaglandin F2alpha as reflected by 15-keto-13, 14-dihydroprostaglandin F2alpha in the peripheral circulation during normal luteolysis in heifers. Prostaglandins 1976, 11:871-878.
64. Schramm W., Bovaird L., Glew M.E., Schramm G., McCracken J.A. Corpus luteum regression induced by ultra-low pulses of prostaglandin F2 alpha. Prostaglandins 1983, 26:347-364.
65. 2α during the oestrus cycle. Acta Vet Scand 1981, 77(Suppl):143-158.
66. Diehl J.R., Day B.N. Effect of prostaglandin F2alfa on luteal function in swine. J Anim Sci 1974, 39:392-396.
67. Guthrie H.D., Polge C. Luteal function and oestrus in gilts treated with a synthetic analogue of Prostaglandin F2α (ICI79.939) at various times during the oestrus cycle. J Reprod Fertil 1976, 48:423-425.
68. 2α in hysterectomized gilts. Prostaglandins 1976, 11:737-743.
69. Bridges G.A., Helser L.A., Grum D.E., Mussard M.L., Day M.L. Decreasing the interval between GnRH and PGF2a from 7 to 5 days and lengthening proestrus increases timed-AI pregnancy rates in beef cows. Theriogenology 2008, 69:843-851.
70. Kasimanickam R., Day M.L., Rudolph J.S., Hall J.B., Whittier W.D. Two doses of prostaglandin improve pregnancy rates to timed-AI in a 5-day progesterone-based synchronization protocol in beef cows. Theriogenology 2009, 71:762-767.
71. Adams G.P., Nasser L.F., Bo G.A., Garcia A., Del Campo M.R., Mapletoft R.J. Superovulatory response of ovarian follicles of Wave 1 versus Wave 2 in heifers. Theriogenology 1994, 42:1103-1113.
72. Whittier W.D., Kasimanickam R.K., Currin J.F., Schramm H.H., Vlcek M. Effect of timing of second prostaglandin F2alpha administration in a 5-day, progesterone-based Co-Synch protocol on AI pregnancy rates in beef cows. Theriogenology 2010, 74:1002-1009.
73. Estill C.T., Britt J.H., Gadsby J.E. Repeated administration of prostaglandin F2α during the early luteal phase causes premature luteolysis in the pig. Biol Reprod 1993, 49:181-185.
74. Estill C.T., Britt J.H., Gadsby J.E. Does increased PGF2α induce luteolysis during early diestrus in the pig?. Prostaglandins 1995, 49:255-267.
75. Kuge T., Iwata H., Kuwayama T., Domeki I., Shioya Y., Monji Y. Induction of estrus by prostaglandin F2alfa administration in the vagina vestibules of miniature pig. J Reprod Dev 2006, 52:391-396.
76. Cushman R.A., Davis P.E., Boonyaprakob U., Hedgpeth V.S., Burns P.J., Britt J.H. Technical note: use of slow-release estradiol and prostaglandin F2alpha to induce pseudopregnancy and control estrus in gilts. J Anim Sci 1999, 77:2883-2885.
77. Puglisi T.A., Rampacek G.B., Kraeling R.R., Kiser T.E. Corpus luteum susceptibility to prostaglandin F2 alpha (PGF2 alpha) luteolysis in hysterectomized prepuberal and mature gilts. Prostaglandins 1979, 18:257-264.
78. ten Haff W., Thacker P.A., Kirkwood R.N. Effect of injecting gonadotrophins during the luteal phase of the estrous cycle on the inter-estrus interval of gilts. Can J Anim Sci 2002, 82:457-459.
79. Davis D.L., Blair R.M. Studies of uterine secretions and products of primary cultures of endometrial cells in pigs. J Reprod Fertil 1993, 48(Suppl):143-155.
80. Sales K.J., Jabbour H.N. Cyclooxygenase enzymes and prostaglandins in reproductive tract physiology and pathology. Prostaglandins Other Lipid Mediat 2003, 71:97-117.
81. 2. Prostaglandins 1994, 47:61-75.
82. Blitck A., Waclawik A., Kaczmarek M.M., Kiewisk J., Ziecik A.J. Effect of estrus induction on prostaglandin content and prostaglandin synthesis enzyme expression in the uterus of early pregnant pigs. Theriogenology 2010, 73:1244-1256.
83. Bazer F.W., Thatcher W.W. Theory of maternal recognition of pregnancy in swine based on estrogen controlled endocrine versus exocrine secretion of prostaglandin F2alfa, by the uterine endometrium. Prostaglandins 1977, 14:397-400.
84. Spencer T.E., Burghardt R.C., Johnson G.A., Bazer F.W. Conceptus signals for establishment and maintenance of pregnancy. Anim Reprod Sci 2004, 82-83:537-550.
85. Kraeling R.R., Rampacek G.B., Ball G.D. Estradiol inhibition of PGF2 luteolysis in the pig. J Anim Sci 1975, 41(suppl 1):363.
86. Meites F.D., Webster H.D., Young F.W., Thorp J.F., Hatch R.N. Effects of corpora lutea removal and replacement with progesterone on pregnancy in goats. J Anim Sci 1951, 10:411-416.
87. Agarwal S.P., Agarwal V.K., Kanaujia A.S. Steroid hormones in pregnant goats. Indian J Anim Sci 1998, 58:1050-1056.
88. Wango E.O., Heap R.B., Wooding F.B. Progesterone and 5 beta-pregnanediol production by isolated foetal placental binucleate cells from sheep and goats. J Endocrinol 1991, 129:283-289.
89. Perry J.S., Heap R.B., Burton R.D., Gadsby J.E. Endocrinology of the blastocyst and its role in the establishment of pregnancy. J Reprod Fertil 1976, 25(Suppl):85-87.
90. Cates W.F. Minimum daily exogenous progesterone requirement for implantation in the bovine species. PhD Thesis University of Minnesota 1963.
91. Wenkof M.S. The use of prostaglandins in reproduction. Can Vet J 1975, 4:100-105.
92. Hammond D., Matty G. A farrowing management system using cloprostenol to control the time of parturition. Vet Rec 1980, 106:72-75.
93. Holtz W., Hartman F.J., Welp C. Induction of parturition in swine with prostaglandin analogue and oxytocin. Theriogenology 1983, 19:583-592.
94. Guthrie H.D. Control of time of parturition in pigs. J Reprod Fertil 1985, 33(Suppl):229-244.
95. Cameron R.D.A., Kieran P.J., Martin I. The efficacy in inducing batch farrowing and the impact on sow behaviour of the prostaglandins cloprostenol and dinoprost. Proc 16th IPVS Congress 2000, 386.
96. Keïta A., Driancourt M.A., Pommier P., Pagot E., Hervé V. Induction of parturition in sows using luprostiol and cloprostenol: efficacy and safety evaluation. Proc 17th IPVS Congress 2002, 475.
97. Balogh G., Bilkei G. Increasing the predictability of farrowing in swine with oxytocin or a parasympathomimetic agent after inducing parturition by cloprostenol. Pig J 2003, 52:98-105.
98. De Rensis F., Sottocorona M., Kirkwood R.N. Effect of prostaglandin and dexamethasone injection on farrowing and piglet neonatal growth. Vet Rec 2002, 14:330-331.
99. Kaeoket K. The effect of dose and route of administration of R-Cloprostenol on the parturient response of sows. Reprod Dom Anim 2006, 41:472-476.
100. 2α on the parturient response of sows. J Swine Health Prod 1996, 4:123-126.
101. Kirkwood R.N., Aherne F.X. Improving the predictability of cloprostenol-induced farrowing in sows. Swine Health Prod 1998, 6:219-221.
102. Oxenreider S.L., McClure R.C., Day B.N. Arteries and veins of the internal genitalia of female swine. J Reprod Fertil 1965, 9:19-27.
103. Stefanczyk-Krzymowska S., Chlopek J., Grzegorzewski W., Radomski M. Local transfer of prostaglandin E2 into the ovary and its retrograde transfer into the uterus in early pregnant sows. Exp Physiol 2005, 90:807-814.
104. Burne T.H.J., Murfitt P.J.E., Gilbert G.L. Behavioural responses to intramuscular injections of prostaglandin F2α in female pigs. Pharmacol Biochem Behav 2000, 66:789-796.
105. Burne T.H.J., Murfitt P.J.E., Gilbert C.L. Deprivation of straw bedding alters PGF2α-induced nesting behaviour in female pigs. Appl Anim Behav Sci 2000, 69:215-225.
106. Burne T.H.J., Murfitt P.J.F., Gilbert C.K. Influence of environmental temperature on PGF2α-induced nest building in female pigs. Appl Anim Behav Sci 2001, 71:293-304.
107. Gilbert C.L. Endocrine regulation of periparturient behaviour in pigs. Reprod 2001, 58(Suppl.):263-267.
108. Widowski T.M., Curtis S.E., Dziuk P.J., Wagner W.C., Sherwood O.D. Behavioral and endocrine responses of sows to prostaglandin F2 alpha and cloprostenol. Biol Reprod 1990, 43:290-297.
109. Klopfenstein C., Farmer C., Martineau G.P. Diseases of the mammary glands and lactation problems. Diseases of Swine 2006, 833-860. Iowa State University Press, Ames. 9th ed. B.E. Straw, J.J. Zimmerman, D.J. Taylor (Eds.).
110. De Passillé A., Rushen J., Foxcroft G., Aherne F., Schaefer A. Performance of young pigs: relationships with periparturient progesterone, prolactin and insulin of sows. J Anim Sci 1993, 71:179-184.
111. Gerjets I., Kemper N. Coliform mastitis in sows: A review. J Swine Health Prod 2009, 17:97-105.
112. Kirkwood R. Influence of postpartum cloprostenol injection on sow and litter performance. Swine Health Prod 1999, 7:121-122.
113. Einarsson S., Viring S., Lindell J.O. The effect of prostaglandin F2 alpha and oxytocin on porcine myometrium in vitro. Zuchthygiene 1975, 10:135-139.
114. Lorenzo J., Imaz M., Fernandez de Aragon J., Gilbert J., Simon X. Effect of Lutalyse™ (Dinolytic™) sterile solution administered during the lactation period on several reproduction parameters of sows. Proc 12th IPVS Congress 1992, 496.
115. Flaus L., Gilette G. Use of Dinolytic™ sterile solution (PGF2a) in sows between 36 and 48 h post-farrowing. Proc 13th IPVS Congress 1994, 382.
116. 2α on neonatal survival. Proc 14th IPVS Congress 1996, 629.
117. 2α immediately postpartum on subsequent reproductive performance. Swine Health Prod 1996, 4:73-78.
118. 2α(dinoprost tromethamine) 24 hrs post-farrowing and its effects on the weaning to service interval, fertility and the effects of antibiotic treatments in sows of different parities. Proc. 15th IPVS Congress 1988, 89.
119. Lauderdale J., Hanson B., Chenault J. The effect of injecting 2 ml Lutalyse™/Dinolytic™ sterile solution (dinoprost tromethamine) into post-partum sows on number of piglets born and born alive per litter in the subsequent farrowing. Proc. 15th IPVS Congress 1988, 215.
120. Koketsu Y., Dial G.D., King V.L. Returns to service after mating and removal of sows for reproductive reasons from commercial swine farms. Theriogenology 1997, 47:1347-1363.
121. Koketsu Y., Dial G. Interactions between the associations of parity, lactation length, and weaning-to-conception interval with subsequent litter size in swine herds using early weaning. Prev Vet Med 1998, 37:113-120.
122. 2α on return to oestrus and pregnancy rates in dairy cows. Vet J 1999, 157:172-177.
123. Melendez P., McHale J., Bartolome J., Archbald L., Donovan G. Uterine involution and fertility of Holstein cows subsequent to early postpartum PGF2alfa treatment for acute puerperal metritis. J Dairy Sci 2004, 87:3238-3246.
124. Chenault J., Hanson B., Gilette G., Lasvergeres F. Reduction in the days from weaning to oestrus and fertile service in sows following a single post-partum injection of Lutalyse®/Dinolytic™ sterile solution. Proc 14th IPVS Congress 1996, 628.
125. Vanderhaeghe C., Dewulf J., Daems A., Van Soom A., de Kruif A., Maes D. Influence of postpartum cloprostenol treatment in sows on subsequent reproductive performance under field conditions. Reprod Dom Anim 2008, 43:484-489.
126. Ainsworth L., Tsang B.K., Downey B.R., Marcus G.J. The synthesis and action of stroids and prostaglandins during follicular maturation in the pig. J Reprod Fertil 1990, 40(suppl):137-150.
127. Claus R. Physiological role of seminal components in the reproductive tract of the female pig. J Reprod Fertil 1990, 40(Suppl):117-131.
128. Srikandakumar A.D., Downey B.R. Induction of ovulation in gilts with cloprostenol. Theriogenology 1989, 32:445-449.
129. Ainsworth L., Baker R.D., Armstrong D.T. Pre-ovulatory changes in follicular fluid prostaglandin F levels in swine. Prostaglandins 1975, 9:915-925.
130. Pena F., Dominguez J.C., Alegre B., Pelaez J. Effect of vulvomucosal injection of PGF2α at insemination on subsequent fertility and litter size in pigs under field conditions. Anim Reprod Sci 1998, 52:63-69.
131. Pena F.J., Gil M.C., Pena F. Effect of vulvomucosal injection of D-cloprostenol at weaning and at insemination on reproductive performances of sow during the low fertility summer season under field condition. Anim Reprod Sci 2001, 68:77-83.
132. Pena F.J., Dominguez J.C., Pelaez J., Alegre B. Intrauterine infusion of PGF2a at insemination enhances reproductive performance of sows during the low fertility season. Vet J 2000, 159:259-261.
133. Horvat G., Bilkei G. Exogenous prostaglandin F2α at the time of ovulation improves reproductive efficiency in repeat breeder sows. Theriogenology 2003, 59:1479-1484.
134. Kos M., Bilkei G. Prostaglandin F2a supplemented semen improves reproductive performance in artificially inseminated sows. Anim Reprod Sci 2004, 80:113-120.
135. Langendijk P., Bouwman E.G., Kidson A., Kirkwood R.N., Soede N.M., Kemp B. Functions of myometrial activity in sperm transport through the genital tract and fertilisation in sows. Reproduction 2002, 123:683-690.