Obesity and recurrent vascular risk after a recent ischemic stroke

Stroke

Volumn 42, Issue 12, 2011, Pages 3397-3402

  Ovbiagele, Bruce ^a   Bath, Philip M ^b   Cotton, Daniel ^c   Vinisko, Richard ^c   Diener, Hans Christoph ^d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

Body mass index; Myocardial infarction; Obesity; Outcomes; Overweight; Paradox; Prognosis; Recurrent stroke; Vascular death

Indexed keywords

ADULT; AGED; ARTICLE; BODY MASS; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; HAZARD RATIO; HEART INFARCTION; HUMAN; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY (TOPIC); OBESITY; PRIORITY JOURNAL; RECURRENCE RISK; RECURRENT VASCULAR RISK;

AGED; BRAIN ISCHEMIA; CARDIOVASCULAR DISEASES; DATABASES, FACTUAL; FEMALE; HUMANS; MALE; MIDDLE AGED; OBESITY; RECURRENCE; RISK; RISK FACTORS; STROKE;

EID: 83055187197     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.111.624957     Document Type: Article

References (26)

1. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors:2001. JAMA. 2003;289:76-79. (Pubitemid 36026281)
2. Ziccardi P, Nappo F, Giugliano G, Esposito K, Marfella R, Cioffi M, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation. 2002;19:105:804-809. (Pubitemid 34174919)
3. De Pergola G, De Mitrio V, Giorgino F, Sciaraffia M, Minenna A, Di Bari L, et al. Increase in both pro-thrombotic and anti-thrombotic factors in obese premenopausal women: relationship with body fat distribution. Int J Obes Relat Metab Disord. 1997;21:527-535. (Pubitemid 27273497)
4. Towfighi A, Ovbiagele B. Metabolic syndrome and stroke. Curr Diab Rep. 2008;8:37-41. (Pubitemid 351384874)
5. Kurth T, Gaziano JM, Berger K, Kase CS, Rexrode KM, Cook NR, Buring JE, Manson JE. Body mass index and the risk of stroke in men. Arch Intern Med. 2002;162:2557-2562. (Pubitemid 35453494)
6. Abbott RD, Behrens GR, Sharp DS, Rodriguez BL, Burchfiel CM, Ross GW, et al. Body mass index and thromboembolic stroke in nonsmoking men in older middle age. The Honolulu Heart Program. Stroke. 1994;25:2370-2376. (Pubitemid 24359304)
7. Rexrode KM, Hennekens CH, Willett WC, Colditz GA, Stampfer MJ, Rich-Edwards JW, et al. A prospective study of body mass index, weight change, and risk of stroke in women. JAMA. 1997;277:1539-1545. (Pubitemid 27213303)
8. Strazzullo P, D'Elia L, Cairella G, Garbagnati F, Cappuccio FP, Scalfi L. Excess body weight and incidence of stroke: meta-analysis of prospective studies with 2 million participants. Stroke. 2010;41:e418-426.
9. Uretsky S, Messerli FH, Bangalore S, Champion A, Cooper-Dehoff RM, Zhou Q, et al. Obesity paradox in patients with hypertension and coronary artery disease. Am J Med. 2007;120:863-870. (Pubitemid 47451305)
10. Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol. 2009;53:1925-1932.
11. Olsen TS, Dehlendorff C, Petersen HG, Andersen KK. Body mass index and poststroke mortality. Neuroepidemiology. 2008;30:93-100. (Pubitemid 351501623)
12. Vemmos K, Ntaios G, Spengos K, Savvari P, Vemmou A, Pappa T, et al. Association between obesity and mortality after acute first-ever stroke: the obesity-stroke paradox. Stroke. 2011;42:30-36.
13. Ruland S, Hung E, Richardson D, Misra S, Gorelick PB. Impact of obesity and the metabolic syndrome on risk factors in African American stroke survivors: a report from the AAASPS. Arch Neurol. 2005;62:386-390. (Pubitemid 40349473)
14. Diener HC, Sacco R, Yusuf S. Rationale, design and baseline data of a randomized, double-blind, controlled trial comparing two antithrombotic regimens (a fixed-dose combination of extended-release dipyridamole plus ASA with clopidogrel) and telmisartan versus placebo in patients with strokes: the Prevention Regimen for Effectively Avoiding Second Strokes Trial (PRoFESS). Cerebrovasc Dis. 2007;23:368-380. (Pubitemid 46742325)
15. Yusuf S, Diener HC, Sacco RL, Cotton D, Ounpuu S, Lawton WA, et al. Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med. 2008;359:1225-1237.
16. Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008;359:1238-1251.
17. McTigue K, Harris R, Hemphill B, Lux L, Sutton S, Bunton AJ, et al. Screening and interventions for obesity in adults: summary of the evidence for the US Preventive Services Task Force. Ann Intern Med. 2003;139:933-949.
18. Sacco RL, Adams R, Albers G, Alberts MJ, Benavente O, Furie K, et al. Guidelines for prevention of stroke in patients with ischemic stroke or transient ischemic attack: a statement for healthcare professionals from the American Heart Association/American Stroke Association Council on Stroke: co-sponsored by the Council on Cardiovascular Radiology and Intervention: the American Academy of Neurology affirms the value of this guideline. Stroke. 2006;37:577-617. (Pubitemid 43732031)
19. WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363:157-163.
20. Dahabreh IJ, Kent DM. Index event bias as an explanation for the paradoxes of recurrence risk research. JAMA. 2011;305:822-823.
21. Goldstein LB, Adams R, Alberts MJ, Appel LJ, Brass LM, Bushnell CD, et al. Primary prevention of ischemic stroke: a guideline from the American Heart Association/American Stroke Association Stroke Council: cosponsored by the Atherosclerotic Peripheral Vascular Disease Interdisciplinary Working Group; Cardiovascular Nursing Council; Clinical Cardiology Council; Nutrition, Physical Activity, and Metabolism Council; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: the American Academy of Neurology affirms the value of this guideline. Stroke. 2006;37:1583-1633. (Pubitemid 44313592)
22. Fonarow GC. Clinical implications of the obesity paradox in patients with coronary artery disease. Am J Med. 2009;122:1069.
23. Suk SH, Sacco RL, Boden-Albala B, Cheun JF, Pittman JG, Elkind MS, et al. Abdominal obesity and risk of ischemic stroke: the Northern Manhattan Stroke Study. Stroke. 2003;34:1586-1592. (Pubitemid 36842606)
24. Kragelund C, Hassager C, Hildebrandt P, Torp-Pedersen C, Kober L. Impact of obesity on long-term prognosis following acute myocardial infarction. Int J Cardiol. 2005;98:123-131. (Pubitemid 40169862)
25. Dallongeville J, Bhatt DL, Steg PG, Ravaud P, Wilson PW, Eagle KA, et al. Relation between body mass index, waist circumference, and cardiovascular outcomes in 19 579 diabetic patients with established vascular disease: the REACH Registry. Eur J Cardiovasc Prev Rehabil. Epub ahead of print February 25, 2011. DOI:10.1177/1741826710394305.
26. Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373:1083-1096.