Combined preconditioning and in vivo chemoselection with 6-thioguanine alone achieves highly efficient reconstitution of normal hematopoiesis with HPRT-deficient bone marrow

Experimental Hematology

Volumn 40, Issue 1, 2012, Pages

  Hacke, Katrin ^a   Szakmary, Akos ^a   Cuddihy, Andrew R ^a   Rozengurt, Nora ^a   Lemp, Nathan A ^a   Aubrecht, Jiri ^b   Lawson, Gregory W ^c   Rao, Nagesh P ^c   Crooks, Gay M ^a   Schiestl, Robert H ^a   Kasahara, Noriyuki ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; TIOGUANINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW TOXICITY; BONE MARROW TRANSPLANTATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; ENZYME ACTIVITY; FEMALE; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; LESCH NYHAN SYNDROME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; TRANSGENE; VASCULAR ENDOTHELIUM; ANIMAL; BONE MARROW; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECT; ENZYMOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; MOUSE MUTANT; TIME; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

ANIMALS; BONE MARROW; BONE MARROW TRANSPLANTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; THIOGUANINE; TIME FACTORS; TRANSPLANTATION CONDITIONING;

EID: 83055184275     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2011.09.009     Document Type: Article

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