NIRF, a novel ubiquitin ligase, interacts with hepatitis B virus core protein and promotes its degradation

Biotechnology Letters

Volumn 34, Issue 1, 2012, Pages 29-36

  Qian, Guanhua ^a   Jin, Fangmin ^a   Chang, Lei ^b   Yang, Yan ^a   Peng, Huimin ^a,b   Duan, Changzhu ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Beijing Proteome Research Center   (China)

Author keywords

Core protein; Degradation; Hepatitis B virus; NIRF; Ubiquitin ligase

Indexed keywords

ACCEPTOR SITES; CORE PROTEINS; HEPATITIS B VIRUS; IN-VIVO; LOW LEVEL; LYSINE RESIDUES; MULTIFUNCTIONAL PROTEIN; NIRF; NUCLEOCAPSIDS; PROTEIN LEVEL; RING FINGER; UBIQUITIN; UBIQUITIN LIGASE; UBIQUITIN LIGASES; VIRAL MATURATION;

AMINO ACIDS; DEGRADATION; VIRUSES;

PROTEINS;

HEPATITIS B CORE ANTIGEN; UBIQUITIN PROTEIN LIGASE; UHRF2 PROTEIN, HUMAN;

ARTICLE; CELL STRAIN HEPG2; HEPATITIS B VIRUS; HOST PATHOGEN INTERACTION; HUMAN; IMMUNOLOGY; LIVER CELL; METABOLISM; PROTEIN ANALYSIS; VIROLOGY;

HEP G2 CELLS; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATOCYTES; HOST-PATHOGEN INTERACTIONS; HUMANS; PROTEIN INTERACTION MAPPING; UBIQUITIN-PROTEIN LIGASES;

HEPATITIS B VIRUS;

EID: 83055176348     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-011-0751-0     Document Type: Article

References (27)

1. Arbuthnot P, Kew M (2001) Hepatitis B virus and hepatocellular carcinoma. Int J Exp Pathol 82(2): 77-100.
2. Blot V, Perugi F, Gay B, Prevost MC, Briant L, Tangy F, Abriel H, Staub O, Dokelar MC, Pique C (2004) Nedd4. 1-mediated ubiquitination and subsequent recruitment of Tsg101 ensure HTLV-1 Gag trafficking towards the multivesicular body pathway prior to virus budding. J Cell Sci 117(Pt 11): 2357-2367.
3. Bronner C, Achour M, Arima Y, Chataigneau T, Saya H, Schini-Kerth VB (2007) The UHRF family: oncogenes that are druggable targets for cancer therapy in the near future? Pharmacol Ther 115(3): 419-434.
4. Dawson SP (2008) Hepatocellular carcinoma and the ubiquitin-proteasome system. Biochim Biophys Acta 1782(12): 775-784.
5. Duan CZ, Pu SP, Mori T, Kochi H, Qiu ZY (2006)) Studies on the interactions between NIRF and P53. Prog Biochem Biophys 33(2): 163-168.
6. Funk A, Mhamdi M, Will H, Sirma H (2007) Avian hepatitis B viruses: molecular and cellular biology, phylogenesis, and host tropism. World J Gastroenterol 13(1): 91-103.
7. Gao G, Luo HL (2006) The ubiquitin-proteasome pathway in viral infections. Can J Physiol Pharmacol 84(1): 5-14.
8. He XY, Duan CZ, Chen JX, Ouyang X, Zhang Z, Li CL, Peng HM (2009) Let-7a elevates p21WAF1 levels by targeting of NIRF and suppresses the growth of A549 lung cancer cells. FEBS Lett 583: 3501-3507.
9. Ingham RJ, Gish G, Pawson T (2004) The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture. Oncogene 23(11): 1972-1984.
10. Iwata A, Nagashima Y, Matsumoto L, Suzuki T, Yamanaka T, Date H, Deoka K, Nukina N, Tsuji S (2009) Intranuclear degradation of polyglutamine aggregates by the ubiquitin-proteasome system. J Biol Chem 284(15): 9796-9803.
11. Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD (2000) The lore of the RINGs-substrate recognition and catalysis by ubiquitin ligases. Trends Cell Biol 10(10): 429-439.
12. Kee Y, Huibregtse JM (2007) Regulation of catalytic activities of HECT ubiquitin ligases. Biochem Biophys Res Commun 354(2): 329-333.
13. Kim JH, Kang S, Kim J, Ahn BY (2003) Hepatitis B virus core protein stimulates the proteasome-mediated degradation of viral X protein. J Virol 77(13): 7166-7173.
14. Lambert C, Doring T, Prange R (2007) Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and 2-adaptin. J Virol 81(17): 9050-9060.
15. Li Y, Mori T, Hata H, Homma Y, Kochi H (2004) NIRF induces G1 arrest and associates with Cdk2. Biochem Biophys Res Commun 319(2): 464-468.
16. Li HC, Huang EY, Su PY, Wu SY, Yang CC, Lin YS, Chang WC, Shih C (2010) Nuclear export and import of human HBV capsid protein and particles. PLoS Pathog 6(10): e1001162.
17. Madden CR, Finegold MJ, Slagle BL (2002) Altered DNA mutation spectrum in aflatoxin B1-treated transgenic mice that express the hepatitis B virus X protein. J Virol 76(22): 11770-11774.
18. Mori T, Li Y, Hata H, Ono K, Kochi H (2002) NIRF, a novel RING finger protein, is involved in cell-cycle regulation. Biochem Biophys Res Commun 296(3): 530-536.
19. Mori T, Li Y, Hata H, Kochi H (2004) NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein. FEBS Lett 557(1-3): 209-214.
20. Pickart CM, Eddins MJ (2004) Ubiquitin: structures, functions, mechanisms. Biochim Biophys Acta 1695(1-3): 55-72.
21. Ponsel D, Bruss V (2003) Mapping of amino acid side chains on the surface of hepatitis B virus capsids required for envelopment and virion formation. J Virol 77(1): 416-422.
22. Rost M, Mann S, Lambert C, Doring T, Thome N, Prange R (2006) γ2-Adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation. J Biol Chem 281(39): 29297-29308.
23. Seeger C, Mason WS (2000) Hepatitis B virus biology. Microbiol Mol Biol Rev 64(1): 51-68.
24. Shearwin-Whyatt L, Dalton HE, Foot N, Kumar S (2006) Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins. Bioessays 28(6): 617-628.
25. Vana ML, Tang Y, Chen AP, Medina G, Carter C, Leis J (2004) Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells. J Virol 78(24): 13943-13953.
26. Xu WS, Zhao KK, Miao XH, Wu N, Cai X, Zhang RQ, Wan J (2010) Effect of oxymatrine on the replication cycle of hepatitis B virus in vitro. World J Gastroenterol 16(16): 2028-2037.
27. Yeh CT, Wong SW, Fung YK, Ou JH (1993) Cell cycle regulation of nuclear localization of hepatitis B virus core protein. Proc Natl Acad Sci USA 90: 6459-6463.