Regulation of microglia effector functions by tumor necrosis factor signaling

GLIA

Volumn 60, Issue 2, 2012, Pages 189-202

  Harms, Ashley S ^a   Lee, Jae Kyung ^b   Nguyen, Thi A ^b   Chang, Jianjun ^b   Ruhn, Kelly M ^a   Treviño, Isaac ^a   Tansey, Malú G ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokines; Cytotoxicity; Dopaminergic; Microglia; TNF

Indexed keywords

CASPASE 3; CXCL1 CHEMOKINE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; CELL STRUCTURE; CELL VACUOLE; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; FLOW CYTOMETRY; MICROGLIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; CELL LINE, TUMOR; COCULTURE TECHNIQUES; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; NERVE DEGENERATION; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 83055172675     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.21254     Document Type: Article

References (28)

1. Aggarwal BB, Samanta A, Feldmann M. 2000a. TNFa. In: Oppenheim JJ, Feldmann M, editors. Cytokine reference. London: Academic Press. pp. 414-434.
2. Carson MJ, Thrash JC, Walter B. 2006. The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival. Clin Neurosci Res 6: 237-245.
3. Choi HK, Won LA, Kontur PJ, Hammond DN, Fox AP, Wainer BH, Hoffmann PC, Heller A. 1991. Immortalization of embryonic mesencephalic dopaminergic neurons by somatic cell fusion. Brain Res 552: 67-76.
4. Douni E, Akassoglou K, Alexopoulou L, Georgopoulos S, Haralambous S, Hill S, Kassiotis G, Kontoyiannis D, Pasparakis M, Plows D, Probert L, Kollias G. 1995. Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. J Inflamm 47: 27-38.
5. Duke DC, Moran LB, Pearce RK, Graeber MB. 2007. The medial and lateral substantia nigra in Parkinson's disease: mRNA profiles associated with higher brain tissue vulnerability. Neurogenetics 8: 83-94.
6. Ferger B, Leng A, Mura A, Hengerer B, Feldon J. 2004. Genetic ablation of tumor necrosis factor-alpha (TNF-alpha) and pharmacological inhibition of TNF-synthesis attenuates MPTP toxicity in mouse striatum. J Neurochem 89: 822-33.
7. Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG. 2009. Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 4: 47.
8. Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, Samokhvalov IM, Merad M. 2010. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330: 841-845.
9. Godoy MC, Tarelli R, Ferrari CC, Sarchi MI, Pitossi FJ. 2008. Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain 131(Pt 7): 1880-1894.
10. Harms AS, Barnum CJ, Ruhn KA, Varghese S, Trevino I, Blesch A, Tansey MG. 2011. Delayed dominant-negative TNF gene therapy halts progressive loss of nigral dopaminergic neurons in a rat model of Parkinson's disease. Mol Ther 19: 46-52.
11. Holness CL, da Silva RP, Fawcett J, Gordon S, Simmons DL. 1993. Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family. J Biol Chem 268: 9661-6.
12. Koprich JB, Reske-Nielsen C, Mithal P, Isacson O. 2008. Neuroinflammation mediated by IL-1 beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J Neuroinflammation 5: 8.
13. Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG. 2008. Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory response. J Neurosci 28: 8517-8528.
14. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Blurton-Jones M, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. 2009. Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis 34: 163-177.
15. McCoy MK, Martinez TN, Ruhn KA, Szymkowski DE, Smith CG, Botterman BR, Tansey KE, Tansey MG. 2006. Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson's disease. J Neurosci 26: 9365-9375.
16. McCoy MK, Ruhn KA, Martinez TN, McAlpine FE, Blesch A, Tansey MG. 2008. Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats. Mol Ther 16: 1572-1579.
17. McCoy MK, Tansey MG. 2008. TNF signaling inhibition in the CNS: Implications for normal brain function and neurodegenerative disease. J Neuroinflammation 5: 45.
18. Moussaud S, Draheim HJ. 2010. A new method to isolate microglia from adult mice and culture them for an extended period of time. J Neurosci Methods 187: 243-253.
19. Pasparakis M, Alexopoulou L, Episkopou V, Kollias G. 1996. Immune and inflammatory responses in TNF alpha-deficient mice: A critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J Exp Med 184: 1397-1411.
20. Ransohoff RM, Perry VH. 2009. Microglial physiology: Unique stimuli, specialized responses. Annu Rev Immunol 27: 119-145.
21. Rousselet E, Callebert J, Parain K, Joubert C, Hunot S, Hartmann A, Jacque C, Perez-Diaz F, Cohen-Salmon C, Launay JM, Hirsch EC. 2002. Role of TNF-alpha receptors in mice intoxicated with the parkinsonian toxin MPTP. Exp Neurol 177: 183-192.
22. Sriram K, Matheson JM, Benkovic SA, Miller DB, Luster MI, O'Callaghan JP. 2002. Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's disease. FASEB J 16: 1474-1476.
23. Sriram K, Matheson JM, Benkovic SA, Miller DB, Luster MI, O'Callaghan JP. 2006a. Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: Role of TNF-alpha. Faseb J 20: 670-682.
24. Sriram K, Miller DB, O'Callaghan JP. 2006b. Minocycline attenuates microglial activation but fails to mitigate striatal dopaminergic neurotoxicity: Role of tumor necrosis factor-alpha. J Neurochem 96: 706-718.
25. Stellwagen D, Malenka RC. 2006. Synaptic scaling mediated by glial TNF-alpha. Nature 440: 1054-1059.
26. Tansey MG, Szymkowski DE. 2009. The TNF superfamily in 2009: New pathways, new indications, and new drugs. Drug Discov Today 14: 1082-1088.
27. Tran TA, McCoy MK, Sporn MB, Tansey MG. 2008. The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection. J Neuroinflammation 5: 14.
28. Whitton PS. 2007. Inflammation as a causative factor in the aetiology of Parkinson's disease. Br J Pharmacol 150: 963-976.