Use of a plackett-burman statistical design to determine the effect of selected amino acids on monoclonal antibody production in CHO cells

Biotechnology Progress

Volumn 27, Issue 6, 2011, Pages 1709-1717

  Gonzalez Leal I J ^a   Carrillo Cocom, L M ^a   Ramirez Medrano A ^a   Lopez Pacheco F ^a   Bulnes Abundis, D ^a   Webb Vargas, Y ^a   Alvarez, M M ^a  

^a SCHOOL OF ENGINEERING AND SCIENCES   (Mexico)

Author keywords

amino acids; CHO cells; culture media optimization; fed batch culture; monoclonal antibody production

Indexed keywords

ACID MIXTURES; AMINO ACID SUPPLEMENTATION; CELL LINES; CELL VIABILITY; CHINESE HAMSTER OVARY; CHO CELL; CONSUMPTION RATES; CULTURE MEDIA; CULTURE MEDIA OPTIMIZATION; FED-BATCH CULTURES; HIGH DENSITY; LITERATURE REVIEWS; MATERIAL BALANCE; MONOCLONAL ANTIBODIES (MAB); MONOCLONAL ANTIBODY PRODUCTION; OUTPUT VARIABLES; PLACKETT-BURMAN; POSITIVE EFFECTS; RELATIVE MASS; SPECIFIC GROWTH RATE; SPECIFIC PRODUCTIVITY; STATISTICAL DESIGN; TWO STAGE; VIABLE CELLS;

BATCH CELL CULTURE; CELLS; DESIGN; EXPERIMENTS; GROWTH RATE; MONOCLONAL ANTIBODIES; OPTIMIZATION;

AMINO ACIDS;

AMINO ACID; MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; BIOREACTOR; BIOSYNTHESIS; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; CHO CELL; CULTURE MEDIUM; CYTOLOGY; HAMSTER; HYBRIDOMA; KINETICS; METABOLISM; STATISTICAL MODEL;

AMINO ACIDS; ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; BIOREACTORS; CELL PROLIFERATION; CELL SURVIVAL; CHO CELLS; CRICETINAE; CULTURE MEDIA, SERUM-FREE; HYBRIDOMAS; KINETICS; MODELS, STATISTICAL;

CRICETULUS GRISEUS;

EID: 82955235242     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.674     Document Type: Article

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