Long-term outcome in children with nutritional vitamin B12 deficiency;Nutrisyonel vitamin B12 eksikliǧi olan çocuklarda uzun dönem sonuçlar

Turkish Journal of Hematology

Volumn 28, Issue 4, 2011, Pages 286-293

  Evim, Melike Sezgin ^a   Erdöl, Şahin ^a   Özdemir, Özlem ^a   Baytan, Birol ^a   Güneş, Adalet Meral ^a  

^a ULUDAG UNIVERSITY   (Turkey)

Author keywords

Children; Neurologic outcome; Vitamin B12 deficiency

Indexed keywords

CLONAZEPAM; CYANOCOBALAMIN; FERRITIN; FOLIC ACID; HOMOCYSTEINE; IRON; PIRACETAM;

ADD ON THERAPY; ADOLESCENT; ARTICLE; BLOOD CELL COUNT; BODY HEIGHT; BODY WEIGHT; CHILD; CHILD NUTRITION; CLINICAL ARTICLE; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DENVER DEVELOPMENTAL SCREENING TEST; ECCHYMOSIS; EDUCATIONAL STATUS; EVOKED BRAIN STEM AUDITORY RESPONSE; EVOKED VISUAL RESPONSE; FAILURE TO THRIVE; FEMALE; FOLIC ACID BLOOD LEVEL; HEAD CIRCUMFERENCE; HEARING; HUMAN; INCOME; INFANT; IRON BINDING CAPACITY; MALE; MUSCLE HYPOTONIA; MYOCLONUS; PALLOR; PETECHIA; PRESCHOOL CHILD; PSYCHOMOTOR RETARDATION; SCHOOL CHILD; TREMOR; VISION; VITAMIN BLOOD LEVEL; WEAKNESS;

EID: 82955217773     PISSN: 13007777     EISSN: 13085263     Source Type: Journal    
DOI: 10.5152/tjh.2011.82     Document Type: Article

References (41)

1. Stabler SP, Allen RH. Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr 2004;24:299-326.[[CrossRef]
2. Rasmussen SA, Fernhoff PM, Scanlon KS. Vitamin B12 deficieny children and adolecents. J Pediatr 2001;138:10-7.[[CrossRef]
3. Goraya JS. Vitamin B12 deficiency in childhood and adolescence. J Pediatr 2002;140:636.[[CrossRef]
4. Graham SM, Arvela OM, Wise GA. Long-term neurological consequences of nutritional VB12 deficiency in infants. J Pediatr 1992;121:710-4.[[CrossRef]
5. Baysal A. Beslenme. Folik asit ve B12. 4.baski{dotless}. Ankara: Hacettepe yayi{dotless}nlari{dotless};1983. 199-205.
6. Ensari S. Türkiye İstatistik Kurumunun Yoksulluk Analizleri Üzerine. Maliye Finans Yazi{dotless}lari{dotless} 2010;87:9-15.
7. Altay C, Cetin M, Gümrük F, Irken G, Yetgin S, Laleli Y. Familial selective vitamin B12 malabsorption (Imerslund-Gräsbeck syndrome) in a pool of Turkish patients. Pediatr Hematol Oncol 1995;12:19-28.[[CrossRef]
8. Schilling RF. Intrinsic factor studies II. The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B12. J Lab Clin Med 1953;42:860-6.
9. Bor MV, Nexø E, Hvas AM. Holo-transcobalamin concentration and transcobalamin saturation reflect recent vitamin B12 absorption better than does serum vitamin B12. Clin Chem 2004;50:1043-9.[[CrossRef]
10. Bor MV, Cetin M, Aytaç S, Altay C, Nexo E. Nonradioactive vitamin B12 absorption test evaluated in controls and in patients with inherited malabsorption of vitamin B12. Clin Chem 2005;51:2151-5.[[CrossRef]
11. Sarigedik U. Turkey livestock and products annual. USDA Foreign Agricultural Service GAIN Report. 2006;5:55-7.
12. Koc A, Uzunlu V, Bayaner A. Turkish agricultural projection 2000-2010. Agricultural Eco res Inst, Ministry Agriculture Rural Affairs. 2001;1:34.
13. Ackurt F, Wetherilt H, Loker M, Hacibekiroglu M. Biochemical assessment of nutritional status in preand post-natal Turkish women and outcome of pregnancy. Eur J Clin Nutr 1995;49:613-22.
14. Harma M, Yurtseven Ş, Koç A Demir N. Şanli{dotless}urfa ilinde gebe kadi{dotless}nlari{dotless}n B12 ve folik asit serum düzeyleri. Jinekoloji ve Obstetrik Dergisi. 2003;17:212-7.
15. Koc A, Kocyigit A, Soran M, Demir N, Sevinc E, Erel O, Mil Z. High frequency of maternal vitamin B12 deficiency as an important cause of infantile vitamin B12 deficiency in Sanliurfa Province of Turkey. Eur J Nutr 2006;45:291-7.[[CrossRef]
16. Andrès E, Affenberger S, Zimmer J, Vinzio S, Grosu D, Pistol G, Maloisel F, Weitten T, Kaltenbach G, Blicklé JF. Current hematological findings in cobalamin deficiency. A study of 201 consecutive patients with documented cobalamin deficiency. Clin Lab Haematol 2006;28:50-6.[[CrossRef]
17. Bay A, Öner AF, Nalbantoǧlu Ö, Demirtaş M, Açikgöz M. Megaloblastik anemili 45 olgunun klinik ve hematolojik yönden deǧerlendirilmesi. Van Ti{dotless}p Dergisi 2006;13:46-8.
18. Sayli TR, Başak AN, Gümrük F, Gürgey A, Altay C. Imerslund-Gräsbeck syndrome coexisting with betathalassemia trait. Pediatr Hematol Oncol 1994;11:223-5.[[CrossRef]
19. Wickramasinghe N. Diagnosis of megaloblastic anaemias. Blood Reviews 2006;20:299-318.[[CrossRef]
20. Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol 1990;34:99-107.[[CrossRef]
21. Savage DG, Lindenbaum J, Stabler SP, Allen RH. Sensitivity of serum methylmalonic acid and total homocysteine derterminations for diagnosing cobalamin and folate deficiencies. Am J Med 1994;96:239-46.[[CrossRef]
22. Healton EB, Savage DG, Brust JC, Garrett TJ, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine (Baltimore) 1991;70:229-45.[[CrossRef]
23. Lindenbaum J, Healton EB, Savage DG, Brust JC, Garrett TJ, Podell ER, Marcell PD, Stabler SP, Allen RH. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med 1988;318:1720-8.[[CrossRef]
24. Metz J, Bell AH, Flicker L, Bottiglieri T, Ibrahim J, Seal E, Schultz D, Savoia H, McGrath KM. The significance of subnormal serum vitamin B12 concentration in older people: a case control study. J Am Geriatr Soc 1996;44:1355-61.
25. Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990;76:871-81.
26. Chalouhi C, Faesch S, Anthonie-Milhomme MC, Fulla Y, Dulac O, Cheron G. Neurological concequences of vitamin B12 deficiency and its treatment. Pediatr Emerg Care 2008;24:538-41.[[CrossRef]
27. Weis R, Fogelman Y, Bennett M. Severe B12 deficiency in an infant associated with a maternal deficiency and a strict vegetarian diet. J Padiatr Hematol Oncol 2004;26:270-1.[[CrossRef]
28. Casella EB, Valente M, de Navarro JM, Kok F. Vitamin B12 deficiency in infancy as a cause of developmental regression. Brain Dev 2005;27:592-4.[[CrossRef]
29. Garewal G, Narang A, Das KC. Infantile tremor syndrome: a vitamin B12 deficiency syndrome in infants. J Trop Pediatr 1988;34:174-8.
30. Kalayci O, Cetin M, Kirel B, Ozdirim E, Yetgin S, Aysun S, Gurgey A. Neurologic findings of vitamin B12 deficiency: presentation of 7 cases. Turk J Pediatr 1996;38:67-72.
31. Zengin E, Sarper N, Caki Kiliç S. Clinical manifestations of infants with nutritional vitamin B deficiency due to maternal dietary deficiency. Acta Paediatr 2009;98: 98-102.[[CrossRef]
32. Incecik F, Hergüner MO, Altunbaşak S, Leblebisatan G. Neurologic findings of nutritional vitamin B12 deficiency in children. Turk J Pediatr 2010;52:17-21.
33. Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008;66:250-5.[[CrossRef]
34. Biancheri R, Cerone R, Rossi A, Schiaffino MC, Caruso U, Minniti G, Perrone MV, Tortori-Donati P, Veneselli E. Early-onset cobalamin C/D deficiency: epilepsy and electroencephalographic features. Epilepsia 2002;43:616-22.[[CrossRef]
35. Biancheri R, Cerone R, Schiaffino MC, Caruso U, Veneselli E, Perone MV, Rossi A, Gatti R. Cobalamin (Cbl) C/D deficiency: clinical, neurophysiological and neuroradiologic findings in 14 cases. Neuropediatrics 2001;32:14-22.[[CrossRef]
36. Rossi A, Cerone R, Biancheri R, Gatti R, Schiaffino MC, Fonda C, Zammarchi E, Tortori-Donati P. Early-onset combined methylmalonic aciduria and homocystinuria: neuroradiologic findings. AJNR Am J Neuroradiol 2001;22:554-63.
37. Benbir G, Uysal S, Saltik S, Zeybek CA, Aydin A, Dervent A, Yalcinkaya C. Seizures during treatment of Vitamin B 12 deficiency. Seizure 2007;16:69-73.[[CrossRef]
38. Ozdemir O, Baytan B, Gunes AM, Okan M. Involuntary movements during vitamin B12 treatment. J Child Neurol 2010;25:227-30.[[CrossRef]
39. Krumholz A, Weiss HD, Goldstein PJ, Harris KC. Evoked responses in vitamin B12 deficiency. Ann Neurol 1981;9:407-9.[[CrossRef]
40. von Schenck U, Bender-Götze C, Koletzko B. Persistence of neurological damage induced by dietary vitamin B-12 deficiency in infancy. Arch Dis Child 1997;77:137-9.[[CrossRef]
41. Pearson AG, Turner AJ. Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase. Nature 1975;258:173-4.[[CrossRef]