ATP synthase ecto-α-subunit: A novel therapeutic target for breast cancer

Journal of Translational Medicine

Volumn 9, Issue 1, 2011, Pages

  Pan, Jian ^a,b   Sun, Li Chao ^b   Tao, Yan Fang ^a   Zhou, Zhuan ^b,c   Du, Xiao Li ^b,d   Peng, Liang ^b,e   Feng, Xing ^a   Wang, Jian ^a   Li, Yi Ping ^a   Liu, Ling ^a   Wu, Shui Yan ^a   Zhang, Yan Lan ^a   Hu, Shao Yan ^a   Zhao, Wen Li ^a   Zhu, Xue Ming ^a   Lou, Guo Liang ^a,f   Ni, Jian ^g  

^a CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b CANCER HOSPITAL   (China)

^c UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e CHINA JAPAN FRIENDSHIP HOSPITAL   (China)

^f SECOND MILITARY MEDICAL UNIVERSITY   (China)

^g NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Atp synthase subunit; Breast cancer; Monoclonal antibody; Tissue microarray; Two dimensional liquid phase chromatographic fractionation

Indexed keywords

ATP SYNTHASE ALPHA SUBUNIT; PROTEIN ANTIBODY; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; UNCLASSIFIED DRUG; ANTIBODY;

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST HYPERPLASIA; CANCER CELL; CANCER CELL CULTURE; CANCER STAGING; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METASTASIS; PROTEIN EXPRESSION; TUMOR DIFFERENTIATION; TUMOR VOLUME; UPREGULATION; APOPTOSIS; BREAST TUMOR; CANCER INVASION; CELL MEMBRANE; CELL MOTION; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION; GENETICS; HYPERPLASIA; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; MIDDLE AGED; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROTEIN SUBUNIT; TISSUE MICROARRAY; TUMOR CELL LINE;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CELL PROLIFERATION; CHROMATOGRAPHY, LIQUID; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; MIDDLE AGED; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MOLECULAR TARGETED THERAPY; NEOPLASM INVASIVENESS; PROTEIN SUBUNITS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TISSUE ARRAY ANALYSIS;

EID: 82955207195     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-211     Document Type: Article

References (38)

1. Carey LA. Through a glass darkly: advances in understanding breast cancer biology, 2000-2010. Clin Breast Cancer 10:188-195.
2. Jensen JD, Knoop A, Ewertz M, Laenkholm AV. ER, HER2, and TOP2A expression in primary tumor, synchronous axillary nodes, and asynchronous metastases in breast cancer. Breast Cancer Res Treat
3. Coradini D, Daidone MG. Biomolecular prognostic factors in breast cancer. Curr Opin Obstet Gynecol 2004, 16:49-55. 10.1097/00001703-200402000-00010, 15128008.
4. Hayashi N, Nakamura S, Tokuda Y, Shimoda Y, Yagata H, Yoshida A, Ota H, Hortobagyi GN, Cristofanilli M, Ueno NT. Prognostic value of HER2-positive circulating tumor cells in patients with metastatic breast cancer. Int J Clin Oncol
5. Hynes NE, Lane HA. ERBB receptors and cancer: the complexity of targeted inhibitors. Nat Rev Cancer 2005, 5:341-354. 10.1038/nrc1609, 15864276.
6. Goldhirsch A, Wood WC, Gelber RD, Coates AS, Thurlimann B, Senn HJ. Meeting highlights: updated international expert consensus on the primary therapy of early breast cancer. J Clin Oncol 2003, 21:3357-3365. 10.1200/JCO.2003.04.576, 12847142.
7. Vichapat V, Gillett C, Fentiman IS, Tutt A, Holmberg L, Luchtenborg M. Risk factors for metachronous contralateral breast cancer suggest two aetiological pathways. Eur J Cancer
8. Tot T, Gere M, Pekar G, Tarjan M, Hofmeyer S, Hellberg D, Lindquist D, Chen TH, Yen AM, Chiu SY, Tabar L. Breast cancer multifocality, disease extent, and survival. Hum Pathol
9. Maric P, Ozretic P, Levanat S, Oreskovic S, Antunac K, Beketic-Oreskovic L. Tumor markers in breast cancer--evaluation of their clinical usefulness. Coll Antropol 35:241-247.
10. Wellman G. Breast cancer awareness and survivorship. S D Med 64:157.
11. Jauhiainen M, Monkkonen H, Raikkonen J, Monkkonen J, Auriola S. Analysis of endogenous ATP analogs and mevalonate pathway metabolites in cancer cell cultures using liquid chromatography-electrospray ionization mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2009, 877:2967-2975. 10.1016/j.jchromb.2009.07.010, 19665949.
12. Ran Y, Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, Sun L, Liu J, Yang Z. A novel role for tissue factor pathway inhibitor-2 in the therapy of human esophageal carcinoma. Hum Gene Ther 2009, 20:41-49. 10.1089/hum.2008.129, 20377370.
13. von Ballmoos C, Wiedenmann A, Dimroth P. Essentials for ATP synthesis by F1F0 ATP synthases. Annu Rev Biochem 2009, 78:649-672. 10.1146/annurev.biochem.78.081307.104803, 19489730.
14. Rees DM, Leslie AG, Walker JE. The structure of the membrane extrinsic region of bovine ATP synthase. Proc Natl Acad Sci USA 2009, 106:21597-21601. 10.1073/pnas.0910365106, 2789756, 19995987.
15. Champagne E, Martinez LO, Collet X, Barbaras R. Ecto-F1Fo ATP synthase/F1 ATPase: metabolic and immunological functions. Curr Opin Lipidol 2006, 17:279-284. 10.1097/01.mol.0000226120.27931.76, 16680033.
16. Chi SL, Wahl ML, Mowery YM, Shan S, Mukhopadhyay S, Hilderbrand SC, Kenan DJ, Lipes BD, Johnson CE, Marusich MF, et al. Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. Cancer Res 2007, 67:4716-4724. 10.1158/0008-5472.CAN-06-1094, 17510399.
17. Moser TL, Stack MS, Asplin I, Enghild JJ, Hojrup P, Everitt L, Hubchak S, Schnaper HW, Pizzo SV. Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci USA 1999, 96:2811-2816. 10.1073/pnas.96.6.2811, 15851, 10077593.
18. Malaval C, Laffargue M, Barbaras R, Rolland C, Peres C, Champagne E, Perret B, Terce F, Collet X, Martinez LO. RhoA/ROCK I signalling downstream of the P2Y13 ADP-receptor controls HDL endocytosis in human hepatocytes. Cell Signal 2009, 21:120-127. 10.1016/j.cellsig.2008.09.016, 18948190.
19. Vantourout P, Martinez LO, Fabre A, Collet X, Champagne E. Ecto-F1-ATPase and MHC-class I close association on cell membranes. Mol Immunol 2008, 45:485-492. 10.1016/j.molimm.2007.05.026, 17643490.
20. Das B, Mondragon MO, Sadeghian M, Hatcher VB, Norin AJ. A novel ligand in lymphocyte-mediated cytotoxicity: expression of the beta subunit of H+ transporting ATP synthase on the surface of tumor cell lines. J Exp Med 1994, 180:273-281. 10.1084/jem.180.1.273, 2191542, 8006588.
21. Sergeant N, Wattez A, Galvan-valencia M, Ghestem A, David JP, Lemoine J, Sautiere PE, Dachary J, Mazat JP, Michalski JC, et al. Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease. Neuroscience 2003, 117:293-303. 10.1016/S0306-4522(02)00747-9, 12614671.
22. Jian P, Li ZW, Fang TY, Jian W, Zhuan Z, Mei LX, Yan WS, Jian N. Retinoic acid induces HL-60 cell differentiation via the upregulation of miR-663. J Hematol Oncol 4:20.
23. Jian P, Yanfang T, Zhuan Z, Jian W, Xueming Z, Jian N. MMP28 (epilysin) as a novel promoter of invasion and metastasis in gastric cancer. BMC Cancer 11:200.
24. Papathanassiu AE, MacDonald NJ, Bencsura A, Vu HA. F1F0-ATP synthase functions as a co-chaperone of Hsp90-substrate protein complexes. Biochem Biophys Res Commun 2006, 345:419-429. 10.1016/j.bbrc.2006.04.104, 16682002.
25. Pan J, Hu H, Zhou Z, Sun L, Peng L, Yu L, Sun L, Liu J, Yang Z, Ran Y. Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cells. Oncol Rep 24:105-112.
26. Zhang X, Gao F, Yu LL, Peng Y, Liu HH, Liu JY, Yin M, Ni J. Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells. Acta Pharmacol Sin 2008, 29:942-950. 10.1111/j.1745-7254.2008.00830.x, 18664327.
27. Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A, Chinnaiyan AM. ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia 2004, 6:1-6. 1635162, 15068665.
28. Montel V, Huang TY, Mose E, Pestonjamasp K, Tarin D. Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model. Am J Pathol 2005, 166:1565-1579. 10.1016/S0002-9440(10)62372-3, 1606408, 15855655.
29. Talbot JC, Dautant A, Polidori A, Pucci B, Cohen-Bouhacina T, Maali A, Salin B, Brethes D, Velours J, Giraud MF. Hydrogenated and fluorinated surfactants derived from Tris(hydroxymethyl)-acrylamidomethane allow the purification of a highly active yeast F1-F0 ATP-synthase with an enhanced stability. J Bioenerg Biomembr 2009, 41:349-360. 10.1007/s10863-009-9235-5, 19821035.
30. Saum R, Schlegel K, Meyer B, Muller V. The F1FO ATP synthase genes in Methanosarcina acetivorans are dispensable for growth and ATP synthesis. FEMS Microbiol Lett 2009, 300:230-236. 10.1111/j.1574-6968.2009.01785.x, 19796137.
31. Mitrofan LM, Pelkonen J, Monkkonen J. The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro. Bone 2009, 45:1153-1160. 10.1016/j.bone.2009.08.010, 19699819.
32. Smallbone K, Gavaghan DJ, Gatenby RA, Maini PK. The role of acidity in solid tumour growth and invasion. J Theor Biol 2005, 235:476-484. 10.1016/j.jtbi.2005.02.001, 15935166.
33. Lu ZJ, Song QF, Jiang SS, Song Q, Wang W, Zhang GH, Kan B, Chen LJ, Yang JL, Luo F, et al. Identification of ATP synthase beta subunit (ATPB) on the cell surface as a non-small cell lung cancer (NSCLC) associated antigen. BMC Cancer 2009, 9:16. 10.1186/1471-2407-9-16, 2654462, 19144153.
34. Martin B, Aragues R, Sanz R, Oliva B, Boluda S, Martinez A, Sierra A. Biological pathways contributing to organ-specific phenotype of brain metastatic cells. J Proteome Res 2008, 7:908-920. 10.1021/pr070426d, 18257520.
35. Radojkovic C, Genoux A, Pons V, Combes G, de Jonge H, Champagne E, Rolland C, Perret B, Collet X, Terce F, Martinez LO. Stimulation of cell surface F1-ATPase activity by apolipoprotein A-I inhibits endothelial cell apoptosis and promotes proliferation. Arterioscler Thromb Vasc Biol 2009, 29:1125-1130. 10.1161/ATVBAHA.109.187997, 19372457.
36. Chi SL, Pizzo SV. Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. Cancer Res 2006, 66:875-882. 10.1158/0008-5472.CAN-05-2806, 16424020.
37. Wang J, Han Y, Liang J, Cheng X, Yan L, Wang Y, Liu J, Luo G, Chen X, Zhao L, et al. Effect of a novel inhibitory mAb against beta-subunit of F1F0 ATPase on HCC. Cancer Biol Ther 2008, 7:1829-1835. 10.4161/cbt.7.11.6861, 18836304.
38. Abstracts. Pacing Clin Electrophysiol 34:1307-1451.