Focal adhesion kinase regulation of endothelial barrier function, apoptosis, and neovascularization

Microvascular Research

Volumn 83, Issue 1, 2012, Pages 1-2

  Mehta, Dolly ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; PAXILLIN; PROTEIN KINASE C DELTA; PROTEIN P53; PROTEINASE ACTIVATED RECEPTOR 1; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SPHINGOSINE 1 PHOSPHATE; TALIN; VASCULAR ENDOTHELIAL CADHERIN; VASCULOTROPIN RECEPTOR; VINCULIN;

ACUTE LUNG INJURY; ANGIOGENESIS; APOPTOSIS; CELL JUNCTION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; EDITORIAL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; INFLAMMATION; LIGAND BINDING; LIPID PEROXIDATION; LUNG ENDOTHELIUM; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CAPILLARY PERMEABILITY; ENDOTHELIAL CELLS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; FOCAL ADHESIONS; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; SIGNAL TRANSDUCTION;

EID: 82955198469     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2011.10.001     Document Type: Editorial

References (19)

1. Belvitch P., Dudek S.M. Role of FAK in S1P-regulated endothelial permeability. Microvasc. Res. 2011.
2. Diaz J.V., et al. Therapeutic strategies for severe acute lung injury. Crit. Care Med. 2010, 38:1644-1650.
3. Grinnell K.L., Harrington E.O. Interplay between FAK, PKCdelta, and p190RhoGAP in the regulation of endothelial barrier function. Microvasc. Res. 2011.
4. Guan J.L., et al. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regul. 1991, 2:951-964.
5. Infusino G.A., Jacobson J.R. Endothelial FAK as a therapeutic target in disease. Microvasc Res 2012, 83:89-96.
6. Johnson E.R., Matthay M.A. Acute lung injury: epidemiology, pathogenesis, and treatment. J. Aerosol Med. Pulm. Drug Deliv. 2010, 23:243-252.
7. Lu Q., Rounds S. Focal adhesion kinase and endothelial cell apoptosis. Microvasc. Res. 2011.
8. McVerry B.J., Garcia J.G. In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell Signal. 2005, 17(2):131-139.
9. Mehta D., Malik A.B. Signaling mechanisms regulating endothelial permeability. Physiol. Rev. 2006, 86:279-367.
10. Parsons J.T. Focal adhesion kinase: the first ten years. J. Cell Sci. 2003, 116:1409-1416.
11. Romer L.H., Birukov K.G., Garcia J.G. Focal adhesions: paradigm for a signaling nexus. Circ. Res. 17 2011, 98(5):606-616.
12. Quadri S.K. Cross talk between focal adhesion kinase and cadherins: role in regulating endothelial barrier function. Microvasc. Res. 2011.
13. Shen T.L., et al. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J. Cell Biol. 2005, 169:941-952.
14. Thennes T., Mehta D. Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function. Microvasc. Res. 2011.
15. Usatyuk P.V., Natarajan V. Hydroxyalkenals and oxidized phospholipids modulation of endothelial cytoskeleton, focal adhesion and adherens junction proteins in regulating endothelial barrier function. Microvasc. Res. 2011.
16. Wary K.K., et al. Focal adhesion kinase regulation of neovascularization. Microvasc. Res. 2011.
17. Yuan S.Y., et al. Neutrophil transmigration, focal adhesion kinase and endothelial barrier function. Microvasc. Res. 2011.
18. Zebda N., et al. Focal adhesion kinase regulation of mechanotransduction and its impact on endothelial cell functions. Microvasc. Res. 2011.
19. Zhao Y.Y., et al. Endothelial cell-restricted disruption of FoxM1 impairs endothelial repair following LPS-induced vascular injury. J. Clin. Invest. 2006, 116:2333-2343.