Earlier age of onset in BRCA carriers-anticipation or cohort effect?

Current Oncology

Volumn 18, Issue 6, 2011, Pages 257-258

  Narod, Steven A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

AGE DISTRIBUTION; ANTICIPATION; BREAST CANCER; CANCER DIAGNOSIS; COHORT ANALYSIS; EDITORIAL; GENE MUTATION; GENETIC SCREENING; HETEROZYGOTE DETECTION; HUMAN; ONSET AGE; PEDIGREE ANALYSIS; PENETRANCE; PREVALENCE; RISK FACTOR;

EID: 82955194553     PISSN: None     EISSN: 17187729     Source Type: Journal    
DOI: 10.3747/co.v18i6.973     Document Type: Editorial

References (15)

1. Martinez-Delgado B, Yanowsky K, Inglada-Perez L, et al. Genetic anticipation is associated with telomere shortening in hereditary breast cancer. PLoS Genet 2011;7:e1002182.
2. Litton JK, Ready K, Chen H, et al. Earlier age of onset of BRCA mutation-related cancers in subsequent generations. Cancer 2011;:[Epub ahead of print].
3. Narod S, Lynch H, Conway T, Watson P, Feunteun J, Lenoir G. Increasing incidence of breast cancer in family with BRCA1 mutation. Lancet 1993;341:1101-2.
4. Foulkes WD, Brunet JS, Wong N, Goffin J, Chappuis PO. Change in the penetrance of founder BRCA1/2 mutations? A retrospective cohort study. J Med Genet 2002;39:407-9.
5. Dagan E, Gershoni-Baruch R. Anticipation in hereditary breast cancer. Clin Genet 2002;62:147-50.
6. Antoniou A, Pharoah PD, Narod S, et al. Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies. Am J Hum Genet 2003;72:1117-30.
7. King MC, Marks JH, Mandell JB on behalf of the New York Breast Cancer Study Group. Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2. Science 2003;302:643-6.
8. Gronwald J, Huzarski T, Byrski B, et al. Cancer risks in first degree relatives of BRCA1 mutation carriers: effects of mutation and proband disease status. J Med Genet 2006;43:424-8.
9. Peixoto A, Salgueiro N, Santos C, et al. BRCA1 and BRCA2 germline mutational spectrum and evidence for genetic anticipation in Portuguese breast/ovarian cancer families. Fam Cancer 2006;5:379-87.
10. Paltiel O, Friedlander Y, Deutsch L, et al. The interval between cancer diagnosis among mothers and offspring in a populationbased cohort. Fam Cancer 2007;6:121-9.
11. Matsunaga E. Hereditary retinoblastoma: delayed mutation or host resistance? Am J Hum Genet 1978;30:406-24.
12. Ranen NG, Stine OC, Abbott MH, et al. Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease. Am J Hum Genet 1995;57:593-602.
13. Tsilfidis C, MacKenzie AE, Mettler G, Barceló J, Korneluk RG. Correlation between CTG trinucleotide repeat length and frequency of severe congenital myotonic dystrophy. Nat Genet 1992;1:192-5.
14. Hamel N, Feng BJ, Foretova L, et al. On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations. Eur J Hum Genet 2011;19:300-6.
15. Lubinski J, Huzarski T, Byrski T, et al. The risk of breast cancer in women with a BRCA1 mutation from North America and Poland. Int J Cancer 2011;:[Epub ahead of print].