Revisiting the canonical tumour progression model

Pathologie Biologie

Volumn 59, Issue 6, 2011, Pages 294-297

  Ansieau, S ^a   Hinkal, G ^a,b   Morel, A P ^a,b   Puisieux, A ^a,b,c  

^a INSERM   (France)

^b CENTRE LÉON BÉRARD   (France)

^c UNIVERSITÉ LYON 1   (France)

Author keywords

Epithelial mesenchymal transition; Failsafe programs; Metastasis; TWIST

Indexed keywords

TRANSCRIPTION FACTOR TWIST; TRANSCRIPTION FACTOR TWIST1; TRANSCRIPTION FACTOR TWIST2; UNCLASSIFIED DRUG;

APOPTOSIS; BREAST CANCER; CANCER CELL CULTURE; CELL MIGRATION; DOWN REGULATION; EDITORIAL; EPITHELIAL MESENCHYMAL TRANSITION; GENE; GENE EXPRESSION; HUMAN; NEUROBLASTOMA; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TWIST1 GENE; TWIST2 GENE;

CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; DISEASE PROGRESSION; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; NEOPLASMS; ONCOGENES; TUMOR ESCAPE; TWIST TRANSCRIPTION FACTOR;

EID: 82955188100     PISSN: 03698114     EISSN: 17683114     Source Type: Journal    
DOI: 10.1016/j.patbio.2009.11.005     Document Type: Editorial

References (39)

1. Junttila M.R., Evan G.I. p53-a Jack of all trades but master of none. Nat Rev Cancer 2009, 53.
2. Brosh R., Rotter V. When mutants gain new powers: News from the mutant p53 field. Nat Rev Cancer 2009, 9:701-713.
3. Yang J., Mani S.A., Donaher J.L., Ramaswamy S., Itzykson R.A., Come C., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004, 117:927-939.
4. Thiery J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 2003, 15:740-746.
5. Yang J., Weinberg R.A. Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell 2008, 14:818-829.
6. Nieto M.A. Epithelial-Mesenchymal transitions in development and disease: Old views and new perspectives. Int J Dev Biol 2008.
7. Ansieau S., Bastid J., Doreau A., Morel A.P., Bouchet B.P., Thomas C., et al. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 2008, 14:79-89.
8. Evan G.I., Wyllie A.H., Gilbert C.S., Littlewood T.D., Land H., Brooks M., et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992, 69:119-128.
9. Hermeking H., Eick D. Mediation of c-Myc-induced apoptosis by p53. Science 1994, 265:2091-2093.
10. Brodeur G.M., Seeger R.C., Schwab M., Varmus H.E., Bishop J.M. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 1984, 224:1121-1124.
11. Maestro R., Dei Tos A.P., Hamamori Y., Krasnokutsky S., Sartorelli V., Kedes L., et al. Twist is a potential oncogene that inhibits apoptosis. Genes Dev 1999, 13:2207-2217.
12. Valsesia-Wittmann S., Magdeleine M., Dupasquier S., Garin E., Jallas A.C., Combaret V., et al. Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells. Cancer Cell 2004, 6:625-630.
13. Puisieux A., Valsesia-Wittmann S., Ansieau S. A twist for survival and cancer progression. Br J Cancer 2006, 94:13-17.
14. Stasinopoulos I.A., Mironchik Y., Raman A., Wildes F., Winnard P., Raman V. HOXA5-twist interaction alters p53 homeostasis in breast cancer cells. J Biol Chem 2005, 280:2294-2299.
15. Hamamori Y., Sartorelli V., Ogryzko V., Puri P.L., Wu H.Y., Wang J.Y., et al. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell 1999, 96:405-413.
16. Shiota M., Izumi H., Onitsuka T., Miyamoto N., Kashiwagi E., Kidani A., et al. Twist and p53 reciprocally regulate target genes via direct interaction. Oncogene 2008.
17. Kwok W.K., Ling M.T., Lee T.W., Lau T.C., Zhou C., Zhang X., et al. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Can Res Suppl 2005, 65:5153-5162.
18. Zhang Z., Xie D., Li X., Wong Y.C., Xin D., Guan X.Y., et al. Significance of TWIST expression and its association with E-cadherin in bladder cancer. Hum Pathol 2007, 38:598-606.
19. Ohuchida K., Mizumoto K., Ohhashi S., Yamaguchi H., Konomi H., Nagai E., et al. Twist, a novel oncogene, is upregulated in pancreatic cancer: Clinical implication of Twist expression in pancreatic juice. Int J Cancer 2007, 120:1634-1640.
20. Husemann Y., Geigl J.B., Schubert F., Musiani P., Meyer M., Burghart E., et al. Systemic spread is an early step in breast cancer. Cancer Cell 2008, 13:58-68.
21. Schardt J.A., Meyer M., Hartmann C.H., Schubert F., Schmidt-Kittler O., Fuhrmann C., et al. Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancer. Cancer Cell 2005, 8:227-239.
22. Stoecklein N.H., Hosch S.B., Bezler M., Stern F., Hartmann C.H., Vay C., et al. Direct genetic analysis of single disseminated cancer cells for prediction of outcome and therapy selection in esophageal cancer. Cancer Cell 2008, 13:441-453.
23. Morel A.P., Lievre M., Thomas C., Hinkal G., Ansieau S., Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS ONE 2008, 3:e2888.
24. Mani S.A., Guo W., Liao M.J., Eaton E.N., Ayyanan A., Zhou A.Y., et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704-715.
25. Brabletz T., Jung A., Spaderna S., Hlubek F., Kirchner T. Opinion: Migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat Rev Cancer 2005, 5:744-749.
26. Gupta P.B., Chaffer C.L., Weinberg R.A. Cancer stem cells: Mirage or reality?. Nat Med 2009, 15:1010-1012.
27. Wu W.S., Heinrichs S., Xu D., Garrison S.P., Zambetti G.P., Adams J.M., et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 2005, 123:641-653.
28. Lee S.H., Lee S.J., Jung Y.S., Xu Y., Kang H.S., Ha N.C., et al. Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function. Neoplasia 2009, 11:22-31. 6p.
29. Kurrey N.K., Jalgaonkar S.P., Joglekar A.V., Ghanate A.D., Chaskar P.D., Doiphode R.Y., et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 2009, 27:2059-2068.
30. Arima Y., Inoue Y., Shibata T., Hayashi H., Nagano O., Saya H., et al. Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition. Cancer Res 2008, 68:5104-5112.
31. Debies M.T., Gestl S.A., Mathers J.L., Mikse O.R., Leonard T.L., Moody S.E., et al. Tumor escape in a Wnt1-dependent mouse breast cancer model is enabled by p19Arf/p53 pathway lesions but not p16 Ink4a loss. J Clin Invest 2008, 118:51-63.
32. Marion R.M., Strati K., Li H., Murga M., Blanco R., Ortega S., et al. A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity. Nature 2009, 460:1149-1153.
33. Krizhanovsky V., Lowe S.W. Stem cells: The promises and perils of p53. Nature 2009, 460:1085-1086.
34. Hong H., Takahashi K., Ichisaka T., Aoi T., Kanagawa O., Nakagawa M., et al. Suppression of induced pluripotent stem cell generation by the p53-p21 pathway. Nature 2009, 460:1132-1135.
35. Li H., Collado M., Villasante A., Strati K., Ortega S., Canamero M., et al. The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature 2009, 460:1136-1139.
36. Utikal J., Polo J.M., Stadtfeld M., Maherali N., Kulalert W., Walsh R.M., et al. Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 2009, 460:1145-1148.
37. Creighton C.J., Li X., Landis M., Dixon J.M., Neumeister V.M., Sjolund A., et al. Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc Natl Acad Sci U S A 2009, 106:13820-13825.
38. Gupta P.B., Onder T.T., Jiang G., Tao K., Kuperwasser C., Weinberg R.A., et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009, 138:645-659.
39. Harney A.S., Lee J., Manus L.M., Wang P., Ballweg D.M., LaBonne C., et al. Targeted inhibition of Snail family zinc finger transcription factors by oligonucleotide-Co(III) Schiff base conjugate. Proc Natl Acad Sci U S A 2009, 106:13667-13672.