Sustained expression of the RON receptor tyrosine kinase by pancreatic cancer stem cells as a potential targeting moiety for antibody-directed chemotherapeutics

Molecular Pharmaceutics

Volumn 8, Issue 6, 2011, Pages 2310-2319

  Padhye, Snehal S ^a   Guin, Sunny ^a   Yao, Hang Ping ^b   Zhou, Yong Qing ^b   Zhang, Ruiwen ^a   Wang, Ming Hai ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^b ZHEJIANG UNIVERSITY   (China)

Author keywords

drug delivery; immunoliposome; pancreatic cancer stem cell; receptor tyrosine kinase; targeted therapy

Indexed keywords

ACTIN; ALDEHYDE DEHYDROGENASE; ANTIBODY; ANTINEOPLASTIC AGENT; BMI1 PROTEIN; CD24 ANTIGEN; DASATINIB; DOXORUBICIN; GEMCITABINE; HERMES ANTIGEN; IMMUNOLIPOSOME; LAPATINIB; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; PROTEIN RON; PROTEIN RON BETA; PROTEIN TYROSINE KINASE; SUNITINIB; TRANSCRIPTION FACTOR SLUG; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER MODEL; CANCER RESISTANCE; CANCER STEM CELL; CELL DIFFERENTIATION; CELL RENEWAL; CELL SELECTION; CELL VIABILITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG UPTAKE; EPITHELIUM CELL; HUMAN; HUMAN CELL; IC 50; INTERNALIZATION; MESENCHYME CELL; METASTASIS; MOUSE; NONHUMAN; PANCREAS CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CELL DIFFERENTIATION; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASTIC STEM CELLS; PANCREATIC NEOPLASMS; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 82955173078     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp200193u     Document Type: Article

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