Diversity of genotypes in CTX-M-producing Klebsiella pneumoniae isolated in different hospitals in Brazil

Brazilian Journal of Infectious Diseases

Volumn 15, Issue 5, 2011, Pages 420-425

  Gomes Chagas, Thiago Pavoni ^a   Alves, Ronaldo Mendes ^b   Vallim, Deyse Christina ^c   Seki, Liliane Miyuki ^d   Campos, Leila Carvalho ^b   Asensi, Marise Dutra ^b  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d FEDERAL RURAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

lactamases; Genotype; Klebsiella pneumoniae

Indexed keywords

AMIKACIN; AZTREONAM; BETA LACTAMASE CTX M; CEFEPIME; CEFOTAXIME; CEFTAZIDIME; CIPROFLOXACIN; COTRIMOXAZOLE; GENTAMICIN; IMIPENEM; NORFLOXACIN;

AGAR DIFFUSION; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLACTX M GENE; BLASHV GENE; BLATEM GENE; BRAZIL; ENZYME SYNTHESIS; GENETIC VARIABILITY; GENOTYPE; HOSPITAL PATIENT; INTEGRON; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; POLYMERASE CHAIN REACTION;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BRAZIL; CROSS INFECTION; DISK DIFFUSION ANTIMICROBIAL TESTS; DNA, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENETIC VARIATION; GENOTYPE; HOSPITALS; HUMANS; KLEBSIELLA PNEUMONIAE;

EID: 82855181533     PISSN: 14138670     EISSN: 16784391     Source Type: Journal    
DOI: 10.1016/S1413-8670(11)70222-7     Document Type: Article

References (32)

1. Podschun R., Ullmann U. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 1998, 11(4):589-603.
2. Paterson D.L., Bonomo R.A. Extended-spectrum β-lactamases: a clinical update. Clin Microbiol Rev 2005, 18(4):657-686.
3. Bradford P.A. Extended-spectrum β-lactamases in the 21st century: characterization, epidemiology, and detection of this important resistance threat. Clin Microbiol Rev 2001, 14(4):933-951.
4. Cantón R., Coque T.M. The CTX-M β-lactamase pandemic. Curr Opinion in Microbiol 2006, 9(5):466-475.
5. Bonnet R. Growing group of extended-spectrum β-lactamase: the CTX-M enzymes. Antimicrob Agents Chemother 2004, 48(1):1-14.
6. Quinteros M., Radice M., Gardella N., et al. Extended-Spectrum β-Lactamases in Enterobacteriaceae in Buenos Aires, Argentina. Public Hospitals. Antimicrob Agents Chemother 2003, 47(9):2864-2867.
7. Yan J.J., Hsueh P.R., Lu J.J., et al. Extended-Spectrum β-Lactamases and Plasmid-Mediated AmpC Enzymes among Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from Seven Medical Centers in Taiwan. Antimicrob Agents Chemother 2006, 50(5):1861-1864.
8. Livermore D.M., Hawkey P.M. CTX-M: changing the face of ESBLs in the UK. J Antimicrob Chemother 2005, 56(3):451-454.
9. Villegas M.V., Kattan J.N., Quinteros M.G., et al. Prevalence of extended-spectrum β-lactamases in South America. Clin Microbiol Infect 2008, 14:154-158.
10. Rossolini G.M., D'Andrea M.M., Mugnaioli C. The spread of CTX-M-type extended-spectrum β-lactamases. Clin Microbiol Infect 2008, 14:33-41.
11. Performance standards for antimicrobial susceptibility testing. CLSI/NCCLS M100-S19 2009, CLSI. Clinical and Laboratory Standards Institute, CLSI, Wayne, PA.
12. Hasman H., Mevius D., Veldman K., et al. β-lactamases among extended-spectrum β-lactamase (ESBL)-resistant Salmonella from poultry, poultry products and human patients in The Netherlands. J Antimicrob Chemother 2005, 56(1):115-121.
13. Mulvey M.R., Soule G., Boyd D., et al. Characterization of the first extended-spectrum β-lactamase-producing Salmonella isolate identified in Canada. J Clin Microbiol 2003, 41(1):460-462. The Multi-Provincial Salmonella Typhimurium Case Control Study Group.
14. Sandvang D., Aarestrup F.M., Jensen L.B. Characterization of integrons and antibiotic resistance genes in Danish multiresistant Salmonella enterica Typhmurium DT104. FEMS Microbiol Lett 1997, 157:177-181.
15. Seifert H., Gerner-Smidt P. Comparison of ribotyping and pulsed-field gel electrophoresis for molecular typing of Acinetobacter isolates. J Clin Microbiol 1995, 33(5):1402-1407.
16. Tenover F.C., Arbeit R.D., Goering R.V., et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995, 33(9):2233-2239.
17. Hyle E.P., Lipworth A.D., Zaoutis T.E., et al. Risk Factors for Increasing Multidrug Resistance among Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella Species. Clin Infect Dis 2005, 40(9):1317-1324.
18. Mendes C., Kiffer C., Segura A., et al. Klebsiella pneumoniae with multiple antimicrobial resistance. Braz J Infect Dis 2004, 8(1):109-111.
19. Lincopan N., Mcculloch J.A., Reinert C., et al. First isolation of metallo-β-lactamase-producing multiresistant Klebsiella pneumoniae from a patient in Brazil. J Clin Microbiol 2005, 43(1):516-519.
20. Valverde A., Coque T.M., Sanchez-Moreno M.P., et al. Dramatic increase in prevalence of fecal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae during nonoutbreak situations in Spain. J Clin Microbiol 2004, 42(10):4769-4775.
21. Bonnet R., Sampaio J.L.M., Labia R., et al. A novel CTX-M β-lactamase (CTX-M-8) in cefotaxime-resistant Enterobacteriaceae isolated in Brazil. Antimicrob Agents Chemother 2000, 44(7):1936-1942.
22. Partridge S.R., Hall R.M. In34, a complex In5 family class 1 integron containing orf513 and dfrA10. Antimicrob Agents Chemother 2003, 47(1):342-349.
23. Bauernfeind A., Casellas J.M., Goldberg M., et al. A new plasmidic cefotaximase from patients infected with Salmonella typhimurium. Infection 1992, 20(3):158-163.
24. Do Carmo F.J.R., Silva R.M., Castanheira M., et al. Prevalence and genetic characterization of blaCTX-M among Klebsiella pneumoniae isolates collected in an intesive care unit in Brazil. J Chemother 2008, 20(5):600-603.
25. Garcia D.O., Doi Y., Szabo D., et al. Multiclonal outbreak of Klebsiella pneumoniae producing extended-spectrum β-lactamase CTX-M-2 and novel variant CTX-M-59 in a neonatal intensive care unit in Brazil. Antimicrob Agents Chemother 2008, 52(5):1790-1793.
26. Clímaco E.C., Minarini L.A., Da Costa Darini A.L. CTX-M-producing Klebsiella spp. in a Brazilian hospital: what has changed in 6 years?. Diagn Microbiol Infect Dis 2010, 68(2):186-189.
27. Minarini L.A., Poirel L., Trevisani N.A., et al. Predominance of CTX-M-type extended-spectrum β-lactamase genes among enterobacterial isolates from outpatients in Brazil. Diagn Microbiol Infect Dis 2009, 65(2):202-206.
28. Kiratisin P., Apisarnthanarak A., Laesripa C., et al. Molecular characterization and epidemiology of extended spectrum-β-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates causing health care-associated infection in Thailand, where the CTX-M family is endemic. Antimicrob Agents Chemother 2008, 52(8):2818-2824.
29. Tullus K., Berglund B., Fryklund B., et al. Epidemiology of fecal strains of the family Enterobacteriaceae in 22 neonatal wards and influence of antibiotic policy. J Clin Microbiol 1998, 26(6):1166-1170.
30. Weller T.M., MacKenzie F.M., Forbes K.J. Molecular epidemiology of a large outbreak of multiresistant Klebsiella pneumoniae. J Med Microbiol 1997, 46(11):921-926.
31. Cuzon G., Naas T., Truong H., et al. Worldwide diversity of Klebsiella pneumoniae that produce β-lactamase blaKPC-2 gene. Emerg Infect Dis 2010, 16(9):1349-1356.
32. Pereira P.S., Seki L.M., Figueira, et al. Epidemiologia molecular de cepas de K. pneumoniae produtoras de KPC-2 do Rio de Janeiro: disseminação do ST 437 (abstract MH-003). Abstracts: II Simpósio Internacional de Microbiologia Clínica (Florianópolis) Florianópolis 2010, SBM.