Effect of sildenafil citrate (Viagra ®) on trace element concentration in serum and brain of rats

Journal of Trace Elements in Medicine and Biology

Volumn 25, Issue 4, 2011, Pages 236-238

  Fayed, Abdel Hasseb A ^a   Gad, Shereen B ^a  

^a Alexandria University   (Egypt)

Author keywords

Brain; Rats; Serum; Sildenafil; Trace element

Indexed keywords

CHROMIUM; COBALT; COPPER; IRON; SELENIUM; SILDENAFIL; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BRAIN LEVEL; CHROMIUM BLOOD LEVEL; COBALT BLOOD LEVEL; CONTROLLED STUDY; COPPER BLOOD LEVEL; FLAME EMISSION ATOMIC ABSORPTION SPECTROMETRY; IRON BLOOD LEVEL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SELENIUM BLOOD LEVEL; TRACE METAL BLOOD LEVEL; ZINC BLOOD LEVEL;

ANIMALS; BRAIN; MALE; PIPERAZINES; PURINES; RATS; SULFONES; TRACE ELEMENTS;

RATTUS;

EID: 82855172055     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2011.09.003     Document Type: Article

References (28)

1. Karatza A.A., Bush A., Magee A.G. Saftey and efficacy of sildenafil therapy in children with pulmonary hypertension. Int J Cardiol 2005, 100(2):267-273.
2. Gopal V.K., Francis S.H., Corbin J.D. Allosteric sites of phosphodiestrase-5 (PDE-5). Eur J Biochem 2001, 268(11):3304-3312.
3. Zhang L., Zhang R.L., Wang Y., Zhang C., Zhang Zg, Meng H., Chopp M. Functional recovery in aged and young rats after embolic stroke. Treatment with phosphodiestrase type 5 inhibitor. Stroke 2005, 36:847-852.
4. Elrod J.W., Duranski M.R., Langston W., Greer J.J., Tao L., Dugas T.R., Kevil C.G., Champion H.C., Lefer D.J. eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circ Res 2006, 99:78-85.
5. Zhang R.L., Zhang Z., Zhang L., Wang Y., Zhang C., Chopp M. Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia. J Neurosci Res 2006, 83:1213-1219.
6. Kotera J., Fujishige K., Omori K. Immunohistochemical localization of cGMP-binding c-GMP-specific phosphodiestrase (PDE-5) in rat tissues. J Histochem Cytochem 2000, 48(5):685-693.
7. Lin C.S., Lin G., Xin Z.C., Lue T.F. Expression, distribution and regulation of phosphodiestrase 5. Curr Pharm Des 2006, 12:3439-3457.
8. Feng G., Masao S., Hideaki N. Phosphodiestrase 5 inhibitor, zaprinast, selectively increases cerebral blood flow in the ischemic penumbra in the rat brain. Neurol Res 2005, 27(6):638-643.
9. Madsen E., Gitlin J.D. Copper and iron disorders of the brain. Annu Rev Neurosci 2007, 30:317-337.
10. Takeda A. Essential trace metals and brain function. Yakugaku Zasshi 2004, 124(9):577-585.
11. Takeda A. Zinc homeostasis and functions of zinc in the brain. Biometals 2001, 14(3-4):343-351.
12. Pinero D.J., Connor J.R. Iron in the brain: an important contribution in normal and diseased states. Neuroscientist 2000, 6(6):435-453.
13. Shlomo Y., Youdim M.B.H. Brain iron: a lesson from animal models. Am J Clin Nutr 1989, 50(3):618-629.
14. Hartter De, Bamea A. Evidence for release of copper in the brain: depolarization-induced release of newly taken-up copper. Synapse 1988, 2(4):412-415.
15. Bou-Resli M.N., Mathew T.C., Dashti H.M., Al-Zaid N.S. Brain selenium accumulation in rat pups of selenium supplemented mothers. Anat Histol Embryol 2002, 31(4):228-231.
16. Savaskan N.E., Brauer A.U., Kuhbacher M., Eyupolu I.Y., Kyriakopoulos A., Ninnemann O., Bchne D., Nitsch R. Selenium deficiency increases susceptibility to glutamate-induced excitotoxicity. The FASEB J 2003, 17:112-114.
17. Schweizer U., Brauer A.U., Kohrle J., Nitsch R., Savaskan N.E. Selenium and brain function: a poorly recognized liaison. Brain Res Rev 2004, 45(3):164-178.
18. Nudler S.L., Quinteros F.A., Miler E.A., Cabilla J.P., Ronchetti S.A., Duvilanski B.H., Chromium V.I. administration induces oxidative stress in hypothalamus and anterior pituitary gland for male rats. Toxicol Lett 2009, 185(3):187-192.
19. Shafiei M., Mahmoudian M., Rostami P., Nemati F. Effect of sildenafil (Viagra) on memory retention of a passive avoidance response in rats. Acta Physiologica Hungarica 2006, 93(1):53-59.
20. Fayed A.H. Brain trace element concentration of rats treated with the plant alkaloid, vincamine. Biol Trace Elem Res 2010, 136:314-319.
21. Snedecor G.W., Cochran W.G. Statistical methods 1980, Iowa State University Press, Ames. 7th ed.
22. De la Torre F.R., Ferrari L., Salibian A. Freshwater pollution biomarker: response of brain acetylcholinestrase activity in two fish species. Comp Biochem Physiol C: Toxicol Pharmacol 2002, 131(3):271-280.
23. Hall C.N., Attwell D. Assesing the physiological concentrations and targets of nitric oxide in brain tissue. J Physiol 2008, 586(15):3597-3615.
24. Klevay L.M. Hypertension in rats due to copper deficiency. Nutr Rep Int 1987, 35:999-1005.
25. Allan C.B., Lacourciere G.M., Stadtman T.C. Responsiveness of selenoproteins to dietary selenium. Annu Rev Nutr 1999, 19:1-16.
26. Shinde U.A., Mehta A.A., Goyal R.K. Nitric oxide: a molecule of the millennium. Indian J Exp Biol 2000, 38:201-210.
27. Banan A., Fields J.Z., Decker H., Zhang Y., Keshavarzian A. Nitric oxide and its metabolites mediate ethanol-induced microtubule disruption and intestinal barrier dysfunction. J Pharmacol Exp Ther 2000, 294:997-1008.
28. Watanabe C., Satoh H. Brain selenium status and behavioral development in selenium-deficient pre weanling mice. Physiol Behavior 1994, 56(5):927-932.