Liquid chromatography-tandem mass spectrometry screening method for the simultaneous detection of stimulants and diuretics in urine

Journal of Analytical Toxicology

Volumn 35, Issue 9, 2011, Pages 665-674

  Hsu, Ku Fu ^a   Chien, Kuei Yu ^b   Chang Chien, Guo Ping ^c   Lin, Su Fan ^c   Hsu, Pei Hsuan ^c   Hsu, Mei Chich ^a  

^a NATIONAL TAIWAN SPORT UNIVERSITY   (Taiwan)

^b KAINAN UNIVERSITY   (Taiwan)

^c CHENG SHIU UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; ACETAZOLAMIDE; ADRAFINIL; AMILORIDE; AMPHETAMINE; BENDROFLUMETHIAZIDE; BENZOYLECGONINE; BENZTHIAZIDE; BENZYLHYDROCHLOROTHIAZIDE; CENTRAL STIMULANT AGENT; DIURETIC AGENT; EPHEDRINE; ETILEFRINE; FENFLURAMINE; HEPTAMINOL; HYDROXYAMPHETAMINE; MEPHENTERMINE; METHAMPHETAMINE; METHYLEPHEDRINE; N ETHYL 3,4 METHYLENEDIOXYAMPHETAMINE; NIKETHAMIDE; NOREPHEDRINE; NORPSEUDOEPHEDRINE; NORSELEGILINE; PHENTERMINE; PSEUDOEPHEDRINE; SIBUTRAMINE; STRYCHNINE; UNINDEXED DRUG;

ARTICLE; ATHLETE; DOPING; DRUG DETERMINATION; ELECTROSPRAY; HUMAN; LABORATORY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; REPRODUCIBILITY; SCREENING; SOLID PHASE EXTRACTION; TAIWAN; TANDEM MASS SPECTROMETRY; URINALYSIS; URINE;

ATHLETIC PERFORMANCE; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIURETICS; DOPING IN SPORTS; HUMANS; LIMIT OF DETECTION; PERFORMANCE-ENHANCING SUBSTANCES; REPRODUCIBILITY OF RESULTS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTANCE ABUSE DETECTION; TAIWAN; TANDEM MASS SPECTROMETRY;

EID: 82855171006     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/anatox/35.9.665     Document Type: Article

References (27)

1. L. Avois, N. Robinson, C. Saudan, N. Baume, P. Mangin, and M. Saugy. Central nervous system stimulants and sport practice. Br. J. Sports Med. 40: i16-i20 (2006).
2. D.G. Bell, I. Jacobs, and K. Ellerington. Effect of caffeine and ephedrine ingestion on anaerobic exercise performance. Med. Sci. Sports Exerc. 33: 1399-1403 (2001).
3. V. Morra, P. Davit, P. Capra, M.Vincenti, A. Di Stilo, and F. Botrè. Fast gas chromatographic/mass spectrometric determination of diuretics and masking agents in human urine development and validation of a productive screening protocol for antidoping analysis. J. Chromatogr. A 1135: 219-229 (2006).
4. World Anti-Doping Code: The 2010 Prohibited list, international standard. http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/WADA_Prohibited_List_2010_EN.pdf (accessed 2010).
5. 2008 adverse analytical findings reported by accredited laboratories. http://www.wada-ama.org/Documents/Science_Medicine/Laboratories/WADA_LaboStatistics_2008.pdf (accessed 2010).
6. S.J. Park, H.S. Pyo,Y.J. Kim, M.S. Kim, and J. Park. Systematic analysis of diuretic doping agents by HPLC screening and GC/MS confirmation. J. Anal. Toxicol. 14: 84-90 (1990).
7. M.E. Soares, M. Carvalho, H. Carmo, F. Remiao, F. Carvalho, and M.L. Bastos. Simultaneous determination of amphetamine derivatives in human urine after SPE extraction and HPLC-UV analysis. Biomed. Chromatogr. 18: 125-131 (2004).
8. A.M. Lisi, G.J. Trout, and R. Kazlauskas. Screening for diuretics in human urine by gas chromatography-mass spectrometry with derivatisation by direct extractive alkylation. J. Chromatogr. A 563: 257-270 (1991).
9. A.A. Marais and J.B. Laurens. Rapid GC-MS confirmation of amphetamines in urine by extractive acylation. Forensic Sci. Int. 183: 78-86 (2009).
10. C. Brunelli, C. Bicchi, A. Di Stilo, A. Salomone, and M.Vincenti. High-speed gas chromatography in doping control: fast-GC and fast-GC/MS determination of beta-adrenoceptor ligands and diuretics. J. Sep. Sci. 29: 2765-2771 (2006).
11. K. Deventer, F.T. Delbeke, K. Roels, and P.Van Eenoo. Screening for 18 diuretics and probenecid in doping analysis by liquid chromatography-tandem mass spectrometry. Biomed. Chromatogr. 16: 529-535 (2002).
12. T.Y.Wu and M.R. Fuh. Determination of amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxyethylamphetamine, and 3,4-methylenedioxymethamphetamine in urine by online solid-phase extraction and ion-pairing liquid chromatography with detection by electrospray tandem mass spectrometry. Rapid. Commun.Mass Spectrom. 19: 775-780 (2005).
13. K. Deventer, O. Pozo, P.Van Eenoo, and F.T. Delbeke. Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis. J. Chromatogr. A 1216: 2446-2473 (2009).
14. L. Perrenoud, M. Saugy, and C. Saudan. Detection in urine of 4-methyl-2-hexaneamine, a doping agent. J. Chromatogr. B 877: 3767-3770 (2009).
15. M. Kolmonen, A. Leinonen, A. Pelander, and I. Ojanperä. A general screening method for doping agents in human urine by solid phase extraction and liquid chromatography/time-of-flight mass spectrometry. Anal. Chim. Acta 585: 94-102 (2007).
16. M. Mazzarino and F. Botrè. A fast liquid chromatographic/mass spectrometric screening method for the simultaneous detection of synthetic glucocorticoids, some stimulants, anti-oestrogen drugs and synthetic anabolic steroids. Rapid Commun.Mass Spectrom. 20: 3465-3476 (2006).
17. K. Deventer, P. Van Eenoo, and F.T. Delbeke. Simultaneous determination of beta-blocking agents and diuretics in doping analysis by liquid chromatography/mass spectrometry with scan-toscan polarity switching. Rapid Commun. Mass Spectrom. 19: 90-98 (2005).
18. 2003 adverse analytical findings reported by accredited laboratories. http://www.wada-ama.org/Documents/Science_Medicine/Laboratories/WADA_LaboStatistics_2003.pdf (accessed 2010).
19. 2004 adverse analytical findings reported by accredited laboratories. http://www.wada-ama.org/Documents/Science_Medicine/Laboratories/WADA_LaboStatistics_2004.pdf (accessed 2010).
20. 2005 adverse analytical findings reported by accredited laboratories. http://www.wada-ama.org/Documents/Science_Medicine/Laboratories/WADA_LaboStatistics_2005.pdf (accessed 2010).
21. 2006 adverse analytical findings reported by accredited laboratories. http://www.wada-ama.org/Documents/Science_Medicine/Laboratories/WADA_LaboStatistics_2006.pdf (accessed 2010).
22. 2007 adverse analytical findings reported by accredited laboratories. http://www.wada-ama.org/Documents/Science_Medicine/Laboratories/WADA_LaboStatistics_2007.pdf (accessed 2010).
23. M. Mazzarino, X. de la Torre, and F. Botrè. A screening method for the simultaneous detection of glucocorticoids, diuretics, stimulants, anti-oestrogens, beta-adrenergic drugs and anabolic steroids in human urine by LC-ESI-MS/MS. Anal. Bioanal. Chem. 392: 681-698 (2008).
24. The World Anti-Doping Agency WADA Technical Document-TD2009MRPL. http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-IS-Laboratories/WADA_TD2009MRPL_EN.pdf (accessed 2010).
25. The World Anti-Doping Agency WADA Technical Document-TD2003IDCR. http://www.wada-ama.org/rtecontent/document/criteria_1_2.pdf (accessed 2010).
26. M.C. Hsu, S.F. Lin, C.P. Kuan, W.L. Chu, K.H. Chan, and G.P. Chang-Chien. Oxethazaine as the source of mephentermine and phentermine in athlete's urine. Forensic Sci. Int. 185: e1-e5 (2009).
27. G.R.Wilkinson and A.H. Beckett. Absorption, metabolism and excretion of the ephedrines in man. I. The influence of urinary pH and urine volume output. J. Pharmacol. Exp. Ther. 162: 139-147 (1968).