HGF/C-MET system pathways in benign and malignant histotypes of thyroid nodules: An immunohistochemical characterization

Histology and Histopathology

Volumn 27, Issue 1, 2012, Pages 113-121

  Ruggeri, Rosaria Maddalena ^a   Vitarelli, Enrica ^b   Barresi, Gaetano ^b   Trimarchi, Francesco ^a   Benvenga, Salvatore ^a   Trovato, Maria ^b  

^a Dipartimento Clinico Sperimentale di Medicina e Farmacologia   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Akt; HGF c met signaling; PI3K; pSTAT3; Rho; STAT3; Thyroid nodules

Indexed keywords

HGF PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; STAT3 PROTEIN; STAT3 PROTEIN, HUMAN;

ADENOMA; ARTICLE; CANCER STAGING; CHEMISTRY; EPITHELIUM CELL; HUMAN; IMMUNOHISTOCHEMISTRY; PATHOLOGY; PHOSPHORYLATION; STROMA CELL; THYROID NODULE; THYROID TUMOR;

ADENOMA; EPITHELIAL CELLS; HEPATOCYTE GROWTH FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; NEOPLASM STAGING; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-MET; RHO GTP-BINDING PROTEINS; STAT3 TRANSCRIPTION FACTOR; STROMAL CELLS; THYROID NEOPLASMS; THYROID NODULE;

EID: 82855169404     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Abubaker J., Jehan Z., Bavi P., Sultana M., Al-Harbi S., Ibrahim M., Al-Nuaim A., Ahmed M., Amin T., Al-Fehaily M., Al-Sanea O., Al-Dayel F., Uddin S. and Al-Kuraya K.S. (2008). Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population. J. Clin. Endocrinol. Metab. 93, 611-618.
2. Barone M.V., Sepe L., Melillo R.M., Mineo A., Santelli G., Monaco C., Castellone M.D., Tramontano D., Fusco A. and Santoro M. (2001). RET/PTC1 oncogene signaling in PC Cl 3 thyroid cells requires the small GTP-binding protein Rho. Oncogene 20, 6973-6982.
3. Boccaccio C., Ando M., Tamagnone L., Bardelli A., Michieli P., Battistini C. and Comoglio P.M. (1998). Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 391, 285-288.
4. Bottaro D.P., Rubin J.S., Faletto D.L., Chan A.M., Kmiecik T.E., Vande Woude G.F. and Aaronson S.A. (1991). Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 251, 802-804.
5. Coleman M.L., Marshall C.J. and Olson M.F. (2004). RAS and RHO GTPases in G1-phase cell-cycle regulation. Nat. Rev. Mol. Cell. Biol. 5, 355-366.
6. Coulonval K., Vandeput F., Stein R.C., Kozma S.C., Lamy F. and Dumont J.E. (2000). Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin. Biochem. J. 348, 351-358.
7. Di Renzo M.F., Olivero M., Serini G., Orlandi F., Pilotti S., Belfiore A., Costantino A., Vigneri R., Angeli A. and Pierotti M.A. (1995). Overexpression of the c-MET/HGF receptor in human thyroid carcinomas derived from the follicular epithelium J. Endocrinol. Invest. 18, 134-139.
8. Gentile A., Trusolino L. and Comoglio P.M. (2008). The Met tyrosine kinase receptor in development and cancer. Cancer. Metastasis. Rev. 27,85-94.
9. Giordano S., Zhen Z., Medico E., Gaudino G., Salimi F. and Comoglio P.M. (1993). Transfer of the motogenic and invasive response to scatter factor/hepatocyte growth factor by transfection of the human c-MET proto-oncogene. Proc. Natl. Acad. Sci. USA 90, 649-653.
10. Graziani A., Gramaglia D., Cantley L.C. and Comoglio P.M. (1991). The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase. J. Biol. Chem. 266, 22087-22090.
11. Hermanek P. and Sobin L.H. (2002). Thyroid gland (ICD-OC73). In: TNM Classification of Malignant Tumors. 6th ed. Hermanek P. and Sobin L.H. (eds). International Union Against Cancer/Springer-Verlag, New York. pp 89-98.
12. Hou P., Liu D., Shan Y., Hu S., Studeman K., Condouris S., Wang Y., Trink A., El-Naggar A.K., Tallini G., Vasko V. and Xing M. (2007). Genetic alterations and their relationship in the phosphatidylinositol 3-kinase/AKT pathway in thyroid cancer. Clin. Cancer. Res. 13, 1161-1170.
13. Hou P., Ji M. and Xing M. (2008). Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors. Cancer. 113, 2440-2447
14. Kitajo H., Shibata T., Nagayasu H., Kawano T., Hamada J., Yamashita T. and Arisue M. (2003). Rho regulates the hepatocyte growth factor/scatter factor-stimulated cell motility of human oral squamous cell carcinoma cells. Oncol. Rep. 10, 1351-1356.
15. Kodama A., Matozaki T., Fukuhara A., Kikyo M., Ichihashi M. and Takai Y. (2000). Involvement of an SHP-2-Rho small G protein pathway in hepatocyte growth factor/scatter factor-induced cell scattering. Mol. Biol. Cell. 11, 2565-2575.
16. Kondo T., Ezzat S. and Asa S.L. (2006). Pathogenetic mechanisms in thyroid follicular-cell neoplasia. Nat. Rev. Cancer. 6, 292-306.
17. Li Volsi V.A., Albores-SaAvedra J., Asa S.L., Baloch Z.W., Sobrinho-Simoes M. and Wenig B. (2004). Tumours of thyroid and parathyroid. In: WHO Classification of Tumours: Pathology and Genetics of Tumours of Endocrine Organs. DeLellis R.A. Lloyd R.V. Heitz P.U. and Eng C. (eds). World Health Organization (WHO). Geneva/IARC, Lyon. pp 49-100.
18. Liu Z., Hou P., Ji M., Guan H., Studeman K., Jensen K., Vasko V., El-Naggar A.K. and Xing M. (2008). Highly Prevalent Genetic Alterations in Receptor Tyrosine Kinases and Phosphatidylinositol 3-Kinase/Akt and Mitogen-Activated Protein Kinase Pathways in Anaplastic and Follicular Thyroid Cancers. J. Clin. Endocrinol. Metab. 93, 3106-3116.
19. Miao H., Nickel C.H., Cantley L.G., Bruggeman L.A., Bennardo L.N. and Wang B. (2003). EphA kinase activation regulates HGF-induced epithelial branching morphogenesis. J. Cell Biol. 162, 1281-1292.
20. Miyakawa M., Tsushima T., Murakami H., Wakai K., Isozaki O. and Takano K. (2003). Increased expression of phosphorylated p70S6 kinase and Akt in papillary thyroid cancer tissues. Endocr. J. 50, 77-83.
21. Naldini L., Vigna E., Narsimhan R., Gaudino G., Zarnegar R., Michalopoulos G.K. and Comoglio P.M. (1991). Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the protooncogene c-MET. Oncogene 6, 501-504.
22. Noguchi Y,. Nakamura S., Yasuda T., Kitagawa M., Kohn L.D., Saito Y. and Hirai A. (1998). Newly synthesized Rho A, not Ras, is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth-stimulated rat FRTL-5 cells. J. Biol. Chem. 273, 3649-3653.
23. Okano J., Shiota G., Matsumoto K., Yasui S., Kurimasa A., Hisatome I., Steinberg P. and Murawaki Y. (2003). Hepatocyte growth factor exerts a proliferative effect on oval cells through the PI3K/AKT signaling pathway. Biochem. Biophys. Commun. 309, 298-304.
24. Oyama T., Ichimura E., Sano T., Kashiwabara K., Fukuda T. and Nakajima T. (1998). C-Met expression of thyroid tissue with special reference to papillary carcinoma. Pathol. Int. 48, 763-768.
25. Paes J.E. and Ringel M.D. (2008). Dysregulation of the phosphatidylinositol 3-kinase pathway in thyroid neoplasia. Endocrinol. Metab. Clin. North. Am. 37,375-387.
26. Pelicci G., Giordano S., Zhen Z., Salcini A.E., Lanfrancone L., Bardelli A., Panayotou G., Waterfield M.D., Ponzetto C., Pelicci P.G. and Comoglio P.M. (1995). The motogenic and mitogenic responses to HGF are amplified by the Shc adaptor protein. Oncogene 10, 1631-1638.
27. Ponzetto C., Bardelli A., Zhen Z., Maina F., dalla Zonca P., Giordano S., Graziani A., Panayotou G. and Comoglio P.M. (1994). A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 77, 261-271.
28. Ponzetto C., Zhen Z. and Audero E. (1996). Specific uncoupling of GRB2 from the met receptor. J. Biol. Chem. 14, 14119-14123.
29. Potempa S. and Ridley A.J. (1998). Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol. Cell. Biol. 9, 2185-2200.
30. Ridley A.J., Comoglio P.M. and Hall A. (1995). Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol. Cell. Biol. 15,1110-1122.
31. Royal I., Lamarche-Vane N., Lamorte L., Kaibuchi K. and Park M. (2000). Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Mol. Biol. Cell. 11,1709-1725.
32. Ruggeri R.M., Vitarelli E., Barresi G., Trimarchi F., Benvenga S. and Trovato M. (2010). The tyrosine kinase receptor c-met, its cognate ligand HGF and the tyrosine kinase receptor trasducers STAT3, PI3K and RHO in thyroid nodules associated with Hashimoto's thyroiditis: an immunohistochemical characterization. Eur. J. Histochem. 3, 54(2):e24.
33. Santarpia L., El-Naggar A.K., Cote G.J., Myers J.N. and Sherman S.I. (2008). Phosphatidylinositol 3-kinase/akt and ras/raf-mitogenactivated protein kinase pathway mutations in anaplastic thyroid cancer. J. Clin. Endocrinol. Metab. 93, 278-284.
34. Shinohara M., Chung Y.J., Saji M. and Ringel M.D. (2007). AKT in thyroid tumorigenesis and progression. Endocrinology. 148, 942-947.
35. Trovato M., Villari D., Bartolone L., Spinella S., Simone A., Violi M.A., Trimarchi F., Batolo D. and Benvenga S. (1998). Expression of the hepatocyte growth factor and c-met in normal thyroid, nonneoplastic, and neoplastic nodules. Thyroid. 8,125-131.
36. Trovato M., Grosso M., Vitarelli E., Ruggeri R.M., Alesci S., Trimarchi F., Barresi G. and Benvenga S. (2003). Distinctive expression of STAT3 in papillary thyroid carcinomas and a subset of follicular adenomas Histol. Histopathol. 18, 393-399.
37. Vandeput F., Perpete S., Coulonval K., Lamy F. and Dumont J.E. (2003). Role of the different mitogen-activated protein kinase subfamilies in the stimulation of dog and human thyroid epithelial cell proliferation by cyclic adenosine 5'-monophosphate and growth factors. Endocrinology 144, 1341-1349.
38. Wang Y., Hou P., Yu H., Wang W., Ji M., Zhao S., Yan S., Sun X., Liu D., Shi B., Zhu G., Condouris S. and Xing M. (2007). High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinositol-3-kinase/AKT pathway in thyroid tumors. J. Clin. Endocrinol. Metab. 92, 2387-2390.
39. Weidner K.M., Weidner K.M., Sachs M., Riethmacher D. and Birchmeier W. (1993). The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J. Cell Biol. 121, 145-154.
40. Weng L.P., Gimm O., Kum J.B., Smith W.M., Zhou X.P., Wynford-Thomas D., Leone G. and Eng C. (2001). Transient ectopic expression of PTEN in thyroid cancer cell lines induces cell cycle arrest and cell type-dependent cell death. Hum. Mol. Genet. 10, 251-258.