Saffron (Crocus sativus) ethanolic extract and its constituent, safranal, inhibits morphine-induced place preference in mice

Pakistan Journal of Biological Sciences

Volumn 14, Issue 20, 2011, Pages 939-944

  Ghoshooni, H ^a   Daryaafzoon, M ^b   Sadeghi Gharjehdagi, S ^a   Zardooz, H ^c   Sahraei, H ^a   Tehrani, S P ^b   Noroozzadeh, A ^a   Bahrami Shenasfandi, F ^a   Kaka, G H ^a   Sadraei, S H ^a  

^a BAQIYATALLAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF TEHRAN   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Conditioned place preference; Mice; Morphine; afranai; Saffron

Indexed keywords

ALCOHOL; CYCLOHEXENE DERIVATIVE; MORPHINE; PLANT EXTRACT; SAFRANAL; TERPENE;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; CHEMISTRY; CROCUS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; INSTRUMENTAL CONDITIONING; MALE; MOUSE; PILOT STUDY; REWARD;

ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; CROCUS; CYCLOHEXENES; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; MALE; MICE; MORPHINE; PILOT PROJECTS; PLANT EXTRACTS; REWARD; TERPENES;

EID: 82855160978     PISSN: 10288880     EISSN: 18125735     Source Type: Journal    
DOI: 10.3923/pjbs.2011.939.944     Document Type: Article

References (23)

1. Abe, K. and H. Saito, 2000. Effects of saffron extract and its costituent crocin on learning behavior and long-term potentiation. Phytother. Res., 14: 149-152
2. Ahmad, A.S., M.A. Ansari, M. Ahmad, S. Saleem, S. Yousuf, M.N. Hoda and F. Islam, 2005. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacol. Biochem. Behav., 81: 805-813.
3. Akhondzadeh, S., H. Fallah-Pour, K. Afkham, A.H. Jamshidi and F. Khalighi-Cigaroudi, 2004. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern. Med., 4: 12-16.
4. Cami, J. and M. Farre, 2003. Drug addiction. New Engl. J. Med., 4: 975-986.
5. Di Chiara, G., 2002. Nucleus accumbens shell and core dopamine: Differential role in behavior and addiction. Behav. Brain Res., 137: 75-114.
6. Hosseinzadeh, H, and H.M. Younesi, 2002. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol., 1: 7-15.
7. Hosseinzadeh, H. and Z. Jahanian, 2010. Effect of Crocus sativus L. (saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother. Res., 24: 726-730.
8. Imenshahidi, M., H. Zafari and H. Hosseinzadeh, 2011. Effects of crocin on the acquisition and reinstatement of morphine-induced conditioned place preference in mice. Pharmacologyonnline, 1: 1007-1013.
9. Johnson, S.W. and R.A. North, 1992. Opioids excite dopamine neurons by hyperpolarization o local interneurons. Neuroscience, 12: 483-488.
10. Karami, M., M.R. Zarrindast, H. Sepehri and H. Sahraei, 2002. Role of nitric oxide in the rat hippocampal CA1 area on morphine-induced conditioned place preference. Eur. J. Pharmacol., 449: 113-119.
11. Khakpour, B., M. Rostampour, H. Sahraei, M. Kamalinejad and J. Shams, 2008. Effects of the aqueous extract of Crocus sativus flower stigmata on the acquisition and expression of morphine induced motor sensitivity in male mice. Kowsar Med. J., 12: 313-321.
12. Mobasher, M., H. Sahraei, B. Sadeghi-Rad, M. Kamalinejad and J. Shams, 2006. The effects of the Crocus sativus extract on the acquisition and expression of morphine-induced conditioned place preference in mice. J. Rafsanjan Univ. Med. Sci. Health Serv., 5: 143-150.
13. Mojabi, N., A. Eidi, H. Sahraee, M. Kamalnejad, F. Khamseh and A. Khoshbaten, 2008. Study of the effects of alcoholic extract of Crocus sativus on the acquisition and expression of morphine-induced conditioned place preference in rats. Kowsar Med. J., 13: 197-210.
14. Mojabi, N., A. Eidi, M. Kamalinejad, A. Khoshbaten and A. Noroozzadeh et al., 2008. Study of the effects of intra-nucleus accumbens shell injections of alcoholic extract of Crocus sativus on the acquisition and expression of morphine-induced conditioned place preference in rats. Physiol. Pharmacol., 12: 121-128.
15. Pontieri, F.E., G. Tanda, and G. Di Chiara, 1995. Intravenous cocaine, morphine and amphetamine preferentially increase extracellular dopamine in the shell as compared with the core of the rat nucleus accumbens. Proc. Natl. Acad. Sci. USA., 92: 12304-12308.
16. Pourmotabbed, A., B. Rostamian, G. Manouchehri, G. Pirzadeh-Jahromi and H. Sahraei et al., 2004. Effects of papaver rhoeas extract on the expression and development of morphine-dependence in mice. J. Ethnopharmacol., 95: 431-435.
17. Sahraei, H., J. Shams, S. Marjani, S. Molavi and M. Kamalinejad, 2007. Effects of the Crocus sativus L. extract on the acquisition and expression of morphine-induced behavioral sensitization in female mice. J. Med. Plants, 6: 26-35.
18. Sahraei, H., M. Mohammadi, M. Kamalinejad, J. Shams, H. Ghoshooni and A. Noroozzadeh, 2008. Effects of the Crocus sativus L. extract on the acquisition and expression of morphine-induced conditioned place preference in female mice. J. Med. Plants., 7: 39-48.
19. Sahraei, H., S.M. Fatemi, S. Pashei-Rad, Z. Faghih-Monzavi, S.H. Salimi and M. Kamalinegad, 2006. Effects of Papaver rhoeas extract on the acquisition and expression of morphine induced conditioned place preference in mice. J. Ethnopharmacol., 103: 420-424.
20. Sarris, J., 2007. Herbal medicines in the treatment of psychiatric disorders: A systemic review. Phytother. Res., 21: 703-716.
21. Schmidt, M., G. Betti and A. Hensel, 2007. Saffron in phytotherapy: Pharmacology and clinical uses. Wien. Med. Wochenschr., 157: 315-319.
22. Shams, J., M. Hedayati, F. Asefi and H. Sahraei, 2010. Water extract of saffron (Crocus sativus) increases brain dopamine and glutamate concentration in the rat. Eur. Neuropsychopharmacol., 20: S353-S353.
23. Tzschentke, T.M., 2007. Measuring reward with the conditioned place preference (CPP) paradigm: Update of the last decade. Addiction Biol., 12: 227-462.