A fast and robust method for automated analysis of axonal transport

European Biophysics Journal

Volumn 40, Issue 9, 2011, Pages 1061-1069

  Welzel, Oliver ^a   Knörr, Jutta ^b   Stroebel, Armin M ^a   Kornhuber, Johannes ^a   Groemer, Teja W ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b Sozialstiftung Bamberg ^*  (Germany)

Author keywords

Axonal transport; Fluorescence microscopy; Hippocampal neurons; Hough transform; Kymograph; Vesicle sharing

Indexed keywords

SYNAPTOPHYSIN; TETANUS TOXIN;

ALGORITHM; ANIMAL; ARTICLE; AUTOMATION; ELECTROKYMOGRAPHY; IMAGE PROCESSING; METABOLISM; METHODOLOGY; MOVEMENT (PHYSIOLOGY); NERVE FIBER; QUALITY CONTROL; RAT; REPRODUCIBILITY; SYNAPSE; TIME; WISTAR RAT;

ALGORITHMS; ANIMALS; AUTOMATION; AXONS; BENCHMARKING; IMAGE PROCESSING, COMPUTER-ASSISTED; KYMOGRAPHY; MOVEMENT; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SYNAPSES; SYNAPTOPHYSIN; TETANUS TOXIN; TIME FACTORS;

EID: 82755182959     PISSN: 01757571     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00249-011-0722-3     Document Type: Article

References (38)

1. Ballard DH (1981) Generalizing the Hough transform to detect arbitrary shapes. Pattern Recogn 13:111-122
2. Betz WJ, Bewick GS, Ridge RM (1992) Intracellular movements of fluorescently labeled synaptic vesicles in frog motor nerve terminals during nerve stimulation. Neuron 9:805-813
3. Bilsland LG, Sahai E, Kelly G, Golding M, Greensmith L, Schiavo G (2010) Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci US A 107:20523-20528
4. Bohnert S, Schiavo G (2005) Tetanus toxin is transported in a novel neuronal compartment characterized by a specialized p H regu- lation. J Biol Chem 280:42336-42344 (Pubitemid 43023205)
5. Bonanomi D, Rusconi L, Colombo CA, Benfenati F, Valtorta F (2007) Synaptophysin I selectively specifies the exocytic path- way of synaptobrevin 2/VAMP2. Biochem J 404:525-534 (Pubitemid 46953927)
6. Canny J (1986) A computational approach to edge-detection. IEEE Trans Pattern Anal Mach Intell 8:679-698
7. Cheezum MK, Walker WF, Guilford WH (2001) Quantitative comparison of algorithms for tracking single fluorescent particles. Biophys J 81:2378-2388 (Pubitemid 32917184)
8. Darcy KJ, Staras K, Collinson LM, Goda Y (2006) Constitutive sharing of recycling synaptic vesicles between presynaptic boutons. Nat Neurosci 9:315-321 (Pubitemid 43290960)
9. De Bolt S, Gutierrez R, Ehrhardt DW, Melo CV, Ross L, Cutler SR, Somerville C, Bonetta D (2007) Morlin, an inhibitor of cortical microtubule dynamics and cellulose synthase movement. Proc Natl Acad Sci USA 104:5854-5859 (Pubitemid 47175623)
10. Deinhardt K, Berninghausen O, Willison HJ, Hopkins CR, Schiavo G (2006) Tetanus toxin is internalized by a sequential clathrin- dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol 174:459-471 (Pubitemid 44156775)
11. Ekstrom P, Kanje M (1984) Inhibition of fast axonal transport by erythro-9-[3-(2-hydroxynonyl)]adenine. J Neurochem 43:1342-1345 (Pubitemid 15206980)
12. Groemer TW, Klingauf J (2007) Synaptic vesicles recycling sponta- neously and during activity belong to the same vesicle pool. Nat Neurosci 10:145-147 (Pubitemid 46174836)
13. Hough PVC (1962) Method and means for recognizing complex patterns. Hough P. V. C., United States
14. Kamat V, Ganesan S (1995) An efficient implementation of the Hough transform for detecting vehicle license plates using DSP'S real-time technology and applications symposium, 1995. In: Proceedings, pp 58-59
15. Lalli G, Bohnert S, Deinhardt K, Verastegui C, Schiavo G (2003) The journey of tetanus and botulinum neurotoxins in neurons. Trends Microbiol 11:431-437 (Pubitemid 37101483)
16. Miller KE, Sheetz MP (2004) Axonal mitochondrial transport and potential are correlated. J Cell Sci 117:2791-2804 (Pubitemid 38997261)
17. Miller KE, Sheetz MP (2006) Direct evidence for coherent low velocity axonal transport of mitochondria. J Cell Biol 173:373-381
18. Morfini GA, Burns M, Binder LI, Kanaan NM, La Pointe N, Bosco DA, Brown RH Jr, Brown H, Tiwari A, Hayward L, Edgar J, Nave KA, Garberrn J, Atagi Y, Song Y, Pigino G, Brady ST (2009) Axonal transport defects in neurodegenerative diseases. J Neurosci 29:12776-12786
19. Pereira AJ, Maiato H (2010) Improved kymography tools and its applications to mitosis. Methods 51:214-219
20. Roy S, Zhang B, Lee VM, Trojanowski JQ (2005) Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol 109:5-13 (Pubitemid 40287785)
21. Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM (2007) Rapid and intermittent cotransport of slow component-b pro- teins. J Neurosci 27:3131-3138 (Pubitemid 46474114)
22. Roze E, Bonnet C, Betuing S, Caboche J (2010) Huntington's disease. Adv Exp Med Biol 685:45-63
23. Ryan TA, Smith SJ (1995) Vesicle pool mobilization during action potential firing at hippocampal synapses. Neuron 14:983-989
24. Ryan TA, Li L, Chin LS, Greengard P, Smith SJ (1996) Synaptic vesicle recycling in synapsin I knock-out mice. J Cell Biol 134:1219-1227 (Pubitemid 26300167)
25. Salinas S, Bilsland LG, Schiavo G (2008) Molecular landmarks along the axonal route: axonal transport in health and disease. Curr Opin Cell Biol 20:445-453
26. Salinas S, Schiavo G, Kremer EJ (2010) A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins. Nat Rev Microbiol 8:645-655
27. Sbalzarini IF, Koumoutsakos P (2005) Feature point tracking and trajectory analysis for video imaging in cell biology. J Struct Biol 151:182-195 (Pubitemid 41074826)
28. Shakiryanova D, Tully A, Levitan ES (2006) Activity-dependent synaptic capture of transiting peptidergic vesicles. Nat Neurosci 9:896-900 (Pubitemid 43980503)
29. Smal I, Draegestein K, Galjart N, Niessen W, Meijering E (2008) Particle filtering for multiple object tracking in dynamic fluorescence microscopy images: application to microtubule growth analysis. IEEE Trans Med Imaging 27:789-804 (Pubitemid 351760851)
30. Staras K, Branco T, Burden JJ, Pozo K, Darcy K, Marra V, Ratnayaka A, Goda Y (2010) A vesicle superpool spans multiple presyn-aptic terminals in hippocampal neurons. Neuron 66:37-44
31. Stroebel A, Welzel O, Kornhuber J, Groemer TW (2010) Background determination-based detection of scattered peaks. Microsc Res Tech 73:1115-1122
32. Threadgill R, Bobb K, Ghosh A (1997) Regulation of dendritic growth and remodeling by Rho, Rac, and Cdc42. Neuron 19:625-634
33. Welzel O, Boening D, Stroebel A, Reulbach U, Klingauf J, Kornhuber J, Groemer TW (2009) Determination of axonal transport velocities via image cross- and autocorrelation. Eur Biophys J 38:883-889
34. Welzel O, Tischbirek CH, Jung J, Kohler EM, Svetlitchny A, Henkel AW, Kornhuber J, Groemer TW (2010) Synapse clusters are preferentially formed by synapses with large recycling pool sizes. PLo S ONE 5:e13514
35. Yanamura Y, Goto M, Nishiyama D, Soga M, Nakatani H, Saji H (2003) Extraction and tracking of the license plate using Hough transform and voted block matching Intelligent Vehicles Sym-posium, 2003. In: Proceedings. IEEE, pp 243-246
36. Yu B, Jain AK (1997) Lane boundary detection using a multireso-lution Hough transform image processing, 1997. In: Proceedings, international conference on, vol 2, pp 748-751
37. Zhang K, Osakada Y, Xie W, Cui B (2011) Automated image analysis for tracking cargo transport in axons. Microsc Res Tech 74:n/a. doi:10.1002/jemt. 20934
38. Zhou HM, Brust-Mascher I, Scholey JM (2001) Direct visualization of the movement of the monomeric axonal transport motor UNC-104 along neuronal processes in living Caenorhabditis elegans. J Neurosci 21:3749-3755 (Pubitemid 32466466)