Dioxin exposure and cancer risk in the seveso women's health study

Environmental Health Perspectives

Volumn 119, Issue 12, 2011, Pages 1700-1705

  Warner, Marcella ^a   Mocarelli, Paolo ^b   Samuels, Steven ^c   Needham, Larry ^d   Brambilla, Paolo ^b   Eskenazi, Brenda ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b DESIO HOSPITAL   (Italy)

^c STATE UNIVERSITY OF NEW YORK   (United States)

^d NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

Cancer; Cohort studies; Dioxins; Environmental carcinogens; Female; Neoplasms; Tetra chlorodibenzodioxin

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ADOLESCENT; ADULT; ARTICLE; BLOOD LEVEL; BONE CANCER; BREAST CANCER; CANCER INCIDENCE; CANCER RISK; CHILD; COHORT ANALYSIS; CONCENTRATION (PARAMETERS); CONTAMINATION; DIGESTIVE SYSTEM CANCER; ENVIRONMENTAL EXPOSURE; EXPLOSION; FEMALE; FOLLOW UP; HEMATOLOGIC MALIGNANCY; HUMAN; INFANT; ITALY; MAJOR CLINICAL STUDY; MASS SPECTROMETRY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; REPRODUCTIVE HEALTH; RESPIRATORY TRACT CANCER; RETROSPECTIVE STUDY; SCHOOL CHILD; SKIN CANCER; THYROID CANCER; UROGENITAL TRACT CANCER; WOMEN'S HEALTH;

EID: 82755162822     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1103720     Document Type: Article

References (37)

1. Akins JR, Waldrep K, Bernert JT Jr. 1989. The estimation of total serum lipids by a completely enzymatic 'summation' method. Clin Chim Acta 184:219-226.
2. American Cancer Society. 2010. Cancer Facts & Figures 2010. Atlanta, GA:American Cancer Society.
3. Baan R, Grosse Y, Straif K, Secretan B, El Ghissassi F, Bouvard V, et al. 2009. A review of human carcinogens-Part F: chemical agents and related occupations. Lancet Oncol 10:1143-1144.
4. Birnbaum L. 1994. The mechanism of dioxin toxicity: relation- ship to risk assessment. Environ Health Perspect 102(suppl 9):157-167.
5. Birnbaum L. 1995. Developmental effects of dioxins and related endocrine disrupting chemicals. Toxicol Lett 82-83:743-750.
6. Birnbaum LS, Fenton SE. 2003. Cancer and developmental exposure to endocrine disruptors. Environ Health Perspect 111:389-394.
7. Brody JG, Rudel RA. 2003. Environmental pollutants and breast cancer. Environ Health Perspect 111:1007-1019.
8. Caldarella A, Crocetti E, Bianchi S, Vezzosi V, Urso C, Biancalini M, et al. 2011. Female breast cancer status according to ER, PR, and HER2 expression: a population based analysis. Pathol Oncol Res 17(3):753-758.
9. Consonni D, Pesatori AC, Zocchetti C, Sindaco R, D'Oro LC, Rubagotti M, et al. 2008. Mortality in a population exposed to dioxin after the Seveso, Italy, accident in 1976: 25 years of follow-up. Am J Epidemiol 167:847-858.
10. Di Domenico A, Silano V, Viviano G, Zapponi G. 1980. Accidental release of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) at Seveso, Italy. II. TCDD distribution in the soil surface layer. Ecotoxicol Environ Saf 4:298-320.
11. Eskenazi B, Mocarelli P, Warner M, Needham L, Patterson D, Samuels S, et al. 2004. Relationship of serum TCDD concentrations and age at exposure of female residents of Seveso, Italy. Environ Health Perspect 112:22-27.
12. Eskenazi B, Mocarelli P, Warner M, Samuels S, Vercellini P, Olive D, et al. 2000. Seveso Women's Health Study: a study of the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on reproductive health. Chemosphere 40:1247-1253.
13. Flesch-Janys D, Becher H, Manz A, Morgenstern I, Nagel S, Steindorf K. 1999. Epidemiologic investigation of breast can- cer incidence in a cohort of female workers with high expo- sure to PCDD/F and HCH. Organohalogen Compd 44:379-382.
14. Hornung R, Reed L. 1990. Estimation of average concentration in the presence of non-detectable values. Appl Occup Environ Hyg 5:48-51.
15. Hulka BS, Moorman PG. 2001. Breast cancer: hormones and other risk factors. Maturitas 38:103-113.
16. IARC (International Agency for Research on Cancer). 1997. Polychlorinated dibenzo-para-dioxins and polychlorinated dibenzofurans. IARC Monogr Eval Carcinog Risks Hum 33-342.
17. Italian Association of Cancer Registries. 2010. I Tumori in Italia. Available: http://www.tumori.net/it/ [accessed 26 August 2010].
18. Key TJ, Verkasalo PK, Banks E. 2001. Epidemiology of breast cancer. Lancet Oncol 2:133-140.
19. Kociba RJ, Keyes DG, Beyer JE, Carreon RM, Wade CE, Dittenber DA, et al. 1978. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo- p-dioxin in rats. Toxicol Appl Pharmacol 46:279-303.
20. Kogevinas M, Becher H, Benn T, Bertazzi PA, Boffetta P, Bueno-de-Mesquita HB, et al. 1997. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study. Am J Epidemiol 145:1061-1075.
21. Kogevinas M, Saracci R, Winkelmann R, Johnson ES, Bertazzi PA, Bueno de Mesquita BH, et al. 1993. Cancer incidence and mortality in women occupationally exposed to chlorophenoxy herbicides, chlorophenols, and dioxins. Cancer Causes Control 4:547-553.
22. Kreuzer PE, Csanády GA, Baur C, Kessler W, Päpke O, Greim H, et al. 1997. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and congeners in infants. A toxicokinetic model of human lifetime body burden by TCDD with special emphasis on its uptake by nutrition. Arch Toxicol 71:383-400.
23. Manz A, Berger J, Dwyer JH, Flesch-Janys D, Nagel S, Waltsgott H. 1991. Cancer mortality among workers in chemical plant contaminated with dioxin. Lancet 338:959-964.
24. Mocarelli P, Pocchiari F, Nelson N. 1988. Preliminary report: 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure to humans- Seveso, Italy. Morb Mortal Wkly Rep 37:733-736.
25. Nishimura N, Miyabara Y, Sato M, Yonemoto J, Tohyama C. 2002. Immunohistochemical localization of thyroid stimu- lating hormone induced by a low oral dose of 2,3,7,8-tetra chlorodibenzo-p-dioxin in female Sprague-Dawley rats. Toxicology 171:73-82.
26. Nishimura N, Yonemoto J, Miyabara Y, Sato M, Tohyama C. 2003. Rat thyroid hyperplasia induced by gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-di- oxin. Endocrinology 144:2075-2083.
27. Patterson DG Jr., Hampton L, Lapeza CR Jr., Belser WT, Green V, Alexander L, et al. 1987. High-resolution gas chromatographic/high-resolution mass spectrometric analysis of human serum on a whole-weight and lipid basis for 2,3,7,8- tetrachlorodibenzo-p-dioxin. Anal Chem 59:2000-2005.
28. Pesatori AC, Consonni D, Rubagotti M, Grillo P, Bertazzi PA. 2009. Cancer incidence in the population exposed to dioxin after the "Seveso accident": twenty years of follow-up. Environ Health 8:39-49.
29. Pirkle J, Wolfe W, Patterson D, Needham L, Michalek J, Miner J, et al. 1989. Estimates of the half-life of 2,3,7,8-tet-rachlorodibenzo-p-dioxin in Vietnam veterans of Operation Ranch Hand. J Toxicol Environ Health 27:165-171.
30. Pisani P, Faggiano F, Krogh V, Palli D, Vineis P, Berrino F. 1997. Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC Centres. Int J Epidemiol 26:152-160.
31. Salehi F, Turner MC, Phillips KP, Wigle DT, Krewski D, Aronson KJ. 2008. Review of the etiology of breast cancer with special attention to organochlorines as potential endocrine disruptors. J Toxicol Environ Health B Crit Rev 11:276-300.
32. Steenland K, Bertazzi P, Baccarelli A, Kogevinas M. 2004. Dioxin revisited: developments since the 1997 IARC classification of dioxin as a human carcinogen. Environ Health Perspect 112:1265-1268.
33. Travis RC, Key TJ. 2003. Oestrogen exposure and breast cancer risk. Breast Cancer Res 5:239-247.
34. Warner M, Eskenazi B, Mocarelli P, Gerthoux PM, Samuels S, Needham L, et al. 2002. Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health Study. Environ Health Perspect 110:625-628.
35. World Health Organization. 1980. International Classification of Diseases, 9th Revision. Geneva:World Health Organization.
36. Yoshizawa K, Walker NJ, Nyska A, Kissling GE, Jokinen MP, Brix AE, et al. 2010. Thyroid follicular lesions induced by oral treatment for 2 years with 2,3,7,8-tetrachlorodiben- zo-p-dioxin and dioxin-like compounds in female Harlan Sprague-Dawley rats. Toxicol Pathol 38:1037-1050.
37. Zook D, Rappe C. 1994. Environmental sources, distribution, and fate. In: Dioxins and Health (Schecter A, ed). New York:Plenum Press, 79-113.