Para-Phenylenediamine-induced autophagy in human uroepithelial cell line mediated mutant p53 and activation of ERK signaling pathway

Toxicology in Vitro

Volumn 25, Issue 8, 2011, Pages 1630-1637

  Huang, Ya Chun ^a   Hung, Wen Chun ^b   Chye, Soi Moi ^c   Chen, Wan Tzu ^d   Chai, Chee Yin ^a,b,d  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^c INTERNATIONAL MEDICAL UNIVERSITY   (Malaysia)

^d KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Autophagy; Beclin 1; Mutant p53; Para Phenylenediamine; SV HUC 1 cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; BECLIN 1; MICROTUBULE ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN LIGHT CHAIN 3B; MITOGEN ACTIVATED PROTEIN KINASE 1; MUTANT PROTEIN; PHENYLENEDIAMINE; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL LINE; CONTROLLED STUDY; ELECTRON MICROSCOPY; EPITHELIUM CELL; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UROEPITHELIUM CELL;

APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE; COLORING AGENTS; EPITHELIAL CELLS; HAIR DYES; HUMANS; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; MUTATION; PHENYLENEDIAMINES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53; UROTHELIUM;

EID: 82655173965     PISSN: 08872333     EISSN: 18793177     Source Type: Journal    
DOI: 10.1016/j.tiv.2011.06.013     Document Type: Article

References (57)

1. Aita V.M., Liang X.H., Murty V.V., Pincus D.L., Yu W., Cayanis E., Kalachikov S., Gilliam T.C., Levine B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999, 59:59-65.
2. Albino A.P., Lloyd K.O., Houghton A.N., Oettgen H.F., Old L.J. Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens. J. Exp. Med. 1981, 154:1764-1778.
3. Bush C., Price P., Norton J., Parkins C.S., Bailey M.J., Boyd J., Jones C.R., A'Hern R.P., Horwich A. Proliferation in human bladder carcinoma measured by Ki-67 antibody labelling: its potential clinical importance. Br. J. Cancer 1991, 64:357-360.
4. Chang C., Simmons D.T., Martin M.A., Mora P.T. Identification and partial characterization of new antigens from simian virus 40-transformed mouse cells. J. Virol. 1979, 31:463-471.
5. Chen S.C., Chen C.H., Chern C.L., Hsu L.S., Huang Y.C., Chung K.T., Chye S.M. p-Phenylenediamine induces p53-mediated apoptosis in Mardin-Darby canine kidney cells. Toxicol. In Vitro 2006, 20:801-807.
6. Cheng Y., Qiu F., Tashiro S., Onodera S., Ikejima T. ERK and JNK mediate TNFalpha-induced p53 activation in apoptotic and autophagic L929 cell death. Biochem. Biophys. Res. Commun. 2008, 376:483-488.
7. Chung K.T., Cerniglia C.E. Mutagenicity of azo dyes: structure-activity relationships. Mutat. Res. 1992, 277:201-220.
8. Corcelle E., Nebout M., Bekri S., Gauthier N., Hofman P., Poujeol P., Fenichel P., Mograbi B. Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity. Cancer Res. 2006, 66:6861-6870.
9. Crighton D., Wilkinson S., Ryan K.M. DRAM links autophagy to p53 and programmed cell death. Autophagy 2007, 3:72-74.
10. Cuervo A.M., Dice J.F. Lysosomes, a meeting point of proteins, chaperones, and proteases. J. Mol. Med. 1998, 76:6-12.
11. Dunn W.A. Autophagy and related mechanisms of lysosome-mediated protein degradation. Trends Cell Biol. 1994, 4:139-143.
12. Ellington A.A., Berhow M.A., Singletary K.W. Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells. Carcinogenesis 2006, 27:298-306.
13. Eskelinen E.L., Cuervo A.M., Taylor M.R., Nishino I., Blum J.S., Dice J.F., Sandoval I.V., Lippincott-Schwartz J., August J.T., Saftig P. Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2. Traffic 2005, 6:1058-1061.
14. Fang L., Li G., Liu G., Lee S.W., Aaronson S.A. P53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K/Akt signaling cascades. EMBO J. 2001, 20:1931-1939.
15. Gulati A.P., Yang Y.M., Harter D., Mukhopadhyay A., Aggarwal B.B., Benzil D.L., Whysner J., Albino A.P., Murali R., Jhanwar-Uniyal M. Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1. Mol. Carcinog. 2006, 45:26-37.
16. Hollstein M., Rice K., Greenblatt M.S., Soussi T., Fuchs R., Sorlie T., Hovig E., Smith-Sorensen B., Montesano R., Harris C.C. Database of p53 gene somatic mutations in human tumors and cell lines. Nucleic Acids Res. 1994, 22:3551-3555.
17. Huang Y.C., Hung W.C., Chen W.T., Yu H.S., Chai C.Y. Sodium arsenite-induced DAPK promoter hypermethylation and autophagy via ERK1/2 phosphorylation in human uroepithelial cells. Chem. Biol. Interact. 2009, 181:254-262.
18. Huang Y.C., Hung W.C., Kang W.Y., Chen W.T., Chai C.Y. p-Phenylenediamine induced DNA damage in SV-40 immortalized human uroepithelial cells and expression of mutant p53 and COX-2 proteins. Toxicol. Lett. 2007, 170:116-123.
19. Hussain S.P., Harris C.C. Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes. Cancer Res. 1998, 58:4023-4037.
20. Kabeya Y., Mizushima N., Ueno T., Yamamoto A., Kirisako T., Noda T., Kominami E., Ohsumi Y., Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19:5720-5728.
21. Kabeya Y., Mizushima N., Yamamoto A., Oshitani-Okamoto S., Ohsumi Y., Yoshimori T. LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation. J. Cell Sci. 2004, 117:2805-2812.
22. Kadlubar F.F. A transversion mutation hypothesis for chemical carcinogenesis by N2-substitution of guanine in DNA. Chem. Biol. Interact. 1980, 31:255-263.
23. Kihara A., Kabeya Y., Ohsumi Y., Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep. 2001, 2:330-335.
24. Kim J., Klionsky D.J. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem. 2000, 69:303-342.
25. Kress M., May E., Cassingena R., May P. Simian virus 40-transformed cells express new species of proteins precipitable by anti-simian virus 40 tumor serum. J. Virol. 1979, 31:472-483.
26. Lawrence N.S., Beckett E.L., Davis J., Compton R.G. Voltammetric investigation of hair dye constituents: application to the quantification of p-phenylenediamine. Analyst 2001, 126:1897-1900.
27. Lee S.W., Fang L., Igarashi M., Ouchi T., Lu K.P., Aaronson S.A. Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53. Proc. Natl. Acad. Sci. USA 2000, 97:8302-8305.
28. Levine A.J. p53, the cellular gatekeeper for growth and division. Cell. 1997, 88:323-331.
29. Liang X.H., Jackson S., Seaman M., Brown K., Kempkes B., Hibshoosh H., Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676.
30. Liang X.H., Yu J., Brown K., Levine B. Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res. 2001, 61:3443-3449.
31. Maiuri M.C., Malik S.A., Morselli E., Kepp O., Criollo A., Mouchel P.L., Carnuccio R., Kroemer G. Stimulation of autophagy by the p53 target gene Sestrin2. Cell Cycle 2009, 8:1571-1576.
32. Maltzman W., Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol. Cell. Biol. 1984, 4:1689-1694.
33. Milne D.M., Palmer R.H., Meek D.W. Mutation of the casein kinase II phosphorylation site abolishes the anti-proliferative activity of p53. Nucleic Acids Res. 1992, 20:5565-5570.
34. Murata M., Nishimura T., Chen F., Kawanishi S. Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase. Mutat. Res. 2006, 607:184-191.
35. Nakopoulou L., Vourlakou C., Zervas A., Tzonou A., Gakiopoulou H., Dimopoulos M.A. The prevalence of bcl-2, p53, and Ki-67 immunoreactivity in transitional cell bladder carcinomas and their clinicopathologic correlates. Hum. Pathol. 1998, 29:146-154.
36. NTP Bioassay of p-phenylenediamine dihydrochloride for possible carcinogenicity. Natl. Cancer Inst. Carcinog. Tech. Rep. Ser. 1979, 174:1-107.
37. Ogier-Denis E., Codogno P. Autophagy: a barrier or an adaptive response to cancer. Biochim. Biophys. Acta 2003, 1603:113-128.
38. Ogier-Denis E., Pattingre S., El Benna J., Codogno P. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J. Biol. Chem. 2000, 275:39090-39095.
39. Oh S.H., Lim S.C. Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. J. Pharmacol. Exp. Ther. 2009, 329:112-122.
40. Pattingre S., Bauvy C., Codogno P. Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J. Biol. Chem. 2003, 278:16667-16674.
41. Picardo M., Cannistraci C., Cristaudo A., De Luca C., Santucci B. Study on cross-reactivity to the para group. Dermatologica 1990, 181:104-108.
42. Rez G., Toth S., Palfia Z. Cellular autophagic capacity is highly increased in azaserine-induced premalignant atypical acinar nodule cells. Carcinogenesis 1999, 20:1893-1898.
43. Scarlatti F., Bauvy C., Ventruti A., Sala G., Cluzeaud F., Vandewalle A., Ghidoni R., Codogno P. Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1. J. Biol. Chem. 2004, 279:18384-18391.
44. Schwartz D., Rotter V. P53-dependent cell cycle control: response to genotoxic stress. Semin. Cancer Biol. 1998, 8:325-336.
45. Shinojima N., Yokoyama T., Kondo Y., Kondo S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy 2007, 3:635-637.
46. Sionov R.V., Haupt Y. The cellular response to p53: the decision between life and death. Oncogene 1999, 18:6145-6157.
47. Sipeki S., Bander E., Ways D.K., Farago A. Activation of Erk1/Erk2 and transiently increased p53 levels together may account for p21 expression associated with phorbol ester-induced transient growth inhibition in HepG2 cells. Cell. Signal. 2002, 14:115-121.
48. Sivaprasad U., Basu A. Inhibition of ERK attenuates autophagy and potentiates tumour necrosis factor-alpha-induced cell death in MCF-7 cells. J. Cell. Mol. Med. 2008, 12:1265-1271.
49. Smith Pease C.K. From xenobiotic chemistry and metabolism to better prediction and risk assessment of skin allergy. Toxicology 2003, 192:1-22.
50. Sontag J.M. Carcinogenicity of substituted-benzenediamines (phenylenediamines) in rats and mice. J. Natl Cancer Inst. 1981, 66:591-602.
51. Tang D., Wu D., Hirao A., Lahti J.M., Liu L., Mazza B., Kidd V.J., Mak T.W., Ingram A.J. ERK activation mediates cell cycle arrest and apoptosis after DNA damage independently of p53. J. Biol. Chem. 2002, 277:12710-12717.
52. Tasdemir E., Chiara Maiuri M., Morselli E., Criollo A., D'Amelio M., Djavaheri-Mergny M., Cecconi F., Tavernarakis N., Kroemer G. A dual role of p53 in the control of autophagy. Autophagy 2008, 4:810-814.
53. Thyssen J.P., Johansen J.D., Menne T. Contact allergy epidemics and their controls. Contact Dermatitis 2007, 56:185-195.
54. Toth S., Nagy K., Palfia Z., Rez G. Changes in cellular autophagic capacity during azaserine-initiated pancreatic carcinogenesis. Acta Biol. Hung. 2001, 52:393-401.
55. Toth S., Nagy K., Palfia Z., Rez G. Cellular autophagic capacity changes during azaserine-induced tumour progression in the rat pancreas. Up-regulation in all premalignant stages and down-regulation with loss of cycloheximide sensitivity of segregation along with malignant transformation. Cell Tissue Res. 2002, 309:409-416.
56. Wu G.S. The functional interactions between the p53 and MAPK signaling pathways. Cancer Biol. Ther. 2004, 3:156-161.
57. Zhu J.H., Horbinski C., Guo F., Watkins S., Uchiyama Y., Chu C.T. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am. J. Pathol. 2007, 170:75-86.