Combination of ketamine and propofol versus either agent alone for procedural sedation in the emergency department

American Journal of Health-System Pharmacy

Volumn 68, Issue 23, 2011, Pages 2248-2256

  Thomas, Michael C ^a   Jennett Reznek, Alison M ^b   Patanwala, Asad E ^c  

^a SOUTHERN UNIVERSITY   (United States)

^b MASSACHUSETTS COLLEGE OF PHARMACY AND HEALTH SCIENCES   (United States)

^c UNIVERSITY OF ARIZONA   (United States)

Author keywords

Anesthetics; Combined therapy; Conscious sedation; Dosage; Hospitals; Ketamine; Propofol; Toxicity

Indexed keywords

4 AMINOBUTYRIC ACID; FENTANYL; KETAMINE; MIDAZOLAM; PROPOFOL; SUFENTANIL;

ABSENCE OF SIDE EFFECTS; ANESTHESIA INDUCTION; ANESTHESIA LEVEL; APNEA; ARTICLE; BRADYCARDIA; BREAST BIOPSY; CARBON DIOXIDE TENSION; CATARACT EXTRACTION; CLINICAL EVALUATION; CONTINUOUS INFUSION; CRITICALLY ILL PATIENT; DREAM; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; EMERGENCY WARD; GASTROINTESTINAL SYMPTOM; HALLUCINATION; HEART RATE; HUMAN; HYPOTENSION; INJECTION SITE PAIN; LOW DRUG DOSE; MEAN ARTERIAL PRESSURE; META ANALYSIS (TOPIC); MONOTHERAPY; NAUSEA; OXYGEN SATURATION; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); RESPIRATION DEPRESSION; RISK ASSESSMENT; SEDATION; SIDE EFFECT; SINGLE DRUG DOSE; TREATMENT DURATION; VISUAL DISORDER; VOMITING;

EID: 82655171614     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp110136     Document Type: Article

References (40)

1. Godwin SA, Caro DA, Wolf SJ et al. Clinical policy: procedural sedation and analgesia in the emergency department. Ann Emerg Med. 2005; 45:177-96.
2. Mace SE, Barata IA, Cravero JP et al. Clinical policy: evidence-based approach to pharmacologic agents used in pediatric sedation and analgesia in the emergency department. Ann Emerg Med. 2004; 44:342-77. (Pubitemid 39242671)
3. Miner JR, Krauss B. Procedural sedation and analgesia research: state of the art. Acad Emerg Med. 2007; 14:170-8. (Pubitemid 46157193)
4. Sheta SA. Procedural sedation analgesia. Saudi J Anaesth. 2010; 4:11-6.
5. Frazee BW, Park RS, Lowery D et al. Propofol for deep procedural sedation in the ED. Am J Emerg Med. 2005; 23:190-5. (Pubitemid 40349224)
6. Dunn T, Mossop D, Newton A et al. Propofol for procedural sedation in the emergency department. Emerg Med J. 2007; 24:459-61. (Pubitemid 47034085)
7. Miner JR, Gray RO, Bahr J et al. Randomized clinical trial of propofol versus ketamine for procedural sedation in the emergency department. Acad Emerg Med. 2010; 17:604-11.
8. Miner JR, Martel ML, Meyer M et al. Procedural sedation of critically ill patients in the emergency department. Acad Emerg Med. 2005; 12:124-8. (Pubitemid 40169932)
9. Newton A, Fitton L. Intravenous ketamine for adult procedural sedation in the emergency department: a prospective cohort study. Emerg Med J. 2008; 25:498-501.
10. Sacchetti A, Senula G, Strickland J et al. Procedural sedation in the community emergency department: initial results of the ProSCED registry. Acad Emerg Med. 2007; 14:41-6. (Pubitemid 46016989)
11. Willman EV, Andolfatto G. A prospective evaluation of "ketofol" (ketamine/ propofol combination) for procedural sedation and analgesia in the emergency department. Ann Emerg Med. 2007; 49:23-30. (Pubitemid 46013962)
12. Zed PJ, Abu-Laban RB, Chan WW et al. Efficacy, safety and patient satisfaction of propofol for procedural sedation and analgesia in the emergency department: a prospective study. CJEM. 2007; 9:421- 7.
13. Miner JR, Burton JH. Clinical practice advisory: emergency department procedural sedation with propofol. Ann Emerg Med. 2007; 50:182-7.
14. Miner JR, Danahy M, Moch A et al. Randomized clinical trial of etomidate versus propofol for procedural sedation in the emergency department. Ann Emerg Med. 2007; 49:15-22. (Pubitemid 46013960)
15. Ketamine package insert. Lake Forest, IL: Hospira, Inc.; 2006 Aug.
16. Green SM, Roback MG, Kennedy RM et al. Clinical practice guideline for emergency department ketamine dissociative sedation: 2011 update. Ann Emerg Med. 2011; 57:449-61.
17. Strayer RJ, Nelson LS. Adverse events associated with ketamine for procedural sedation in adults. Am J Emerg Med. 2008; 26:985-1028.
18. Andolfatto G, Willman E. A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketaminepropofol combination (ketofol). Acad Emerg Med. 2010; 17:194-201.
19. David H, Shipp J. A randomized controlled trial of ketamine/propofol versus propofol alone for emergency department procedural sedation. Ann Emerg Med. 2011; 57:435-41.
20. Rapeport DA, Martyr JW, Wang LP. The use of "ketofol" (ketamine-propofol admixture) infusion in conjunction with regional anaesthesia. Anaesth Intensive Care. 2009; 37:121-3.
21. Shah A, Mosdossy G, McLeod S et al. A blinded, randomized controlled trial to evaluate ketamine-propofol versus ketamine alone for procedural sedation in children. Ann Emerg Med. 2010; 57:425- 33.
22. Propofol package insert. Wilmington, DE: AstraZeneca Pharmaceuticals, LP; 2007 Aug.
23. Burton JH, Miner JR, Shipley ER et al. Propofol for emergency department procedural sedation and analgesia: a tale of three centers. Acad Emerg Med. 2006; 13:24-30. (Pubitemid 41827290)
24. Dundee JW, Knox JW, Black GW et al. Ketamine as an induction agent in anaesthetics. Lancet. 1970; 1:1370-1.
25. Green SM, Roback MG, Krauss B et al. Predictors of emesis and recovery agitation with emergency department ketamine sedation: an individual-patient data meta-analysis of 8,282 children. Ann Emerg Med. 2009; 54:171-80.
26. Loh L, Singer L, Morgan M et al. Influence of diazepam on the emergence reactions following ketamine anaesthesia. Can Anaesth Soc J. 1972; 19:421-5.
27. Mattila MA, Larni HM, Nummi SE et al. Effect of diazepam on emergence from ketamine anaesthesia. A double-blind study. Anaesthesist. 1979; 28:20-3. (Pubitemid 9196515)
28. Tomatir E, Atalay H, Gurses E et al. Effects of low dose ketamine before induction on propofol anesthesia for pediatric magnetic resonance imaging. Paediatr Anaesth. 2004; 14:845-50. (Pubitemid 39331506)
29. McCollum JS, Milligan KR, Dundee JW. The antiemetic action of propofol. Anaesthesia. 1988; 43:239-40.
30. Vasileiou I, Xanthos T, Koudouna E et al. Propofol: a review of its non-anaesthetic effects. Eur J Pharmacol. 2009; 605:1-8.
31. Frey K, Sukhani R, Pawlowski J et al. Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedation quality, intraocular pressure changes, and recovery profiles. Anesth Analg. 1999; 89:317-21. (Pubitemid 29367709)
32. Badrinath S, Avramov MN, Shadrick M et al. The use of a ketamine-propofol combination during monitored anesthesia care. Anesth Analg. 2000; 90:858-62. (Pubitemid 30190791)
33. Mortero RF, Clark LD, Tolan MM et al. The effects of small-dose ketamine on propofol sedation: respiration, postoperative mood, perception, cognition, and pain. Anesth Analg. 2001; 92:1465-9. (Pubitemid 32493163)
34. Frizelle HP, Duranteau J, Samii K. A comparison of propofol with a propofolketamine combination for sedation during spinal anesthesia. Anesth Analg. 1997; 84:1318-22. (Pubitemid 27250478)
35. Singh R, Batra YK, Bharti N et al. Comparison of propofol versus propofolketamine combination for sedation during spinal anesthesia in children: randomized clinical trial of efficacy and safety. Paediatr Anaesth. 2010; 20:439-44.
36. Akin A, Esmaoglu A, Guler G et al. Propofol and propofol-ketamine in pediatric patients undergoing cardiac catheterization. Pediatr Cardiol. 2005; 26:553-7. (Pubitemid 43015785)
37. Akin A, Esmaoglu A, Tosun Z et al. Comparison of propofol with propofolketamine combination in pediatric patients undergoing auditory brainstem response testing. Int J Pediatr Otorhinolaryngol. 2005; 69:1541-5. (Pubitemid 41463615)
38. Messenger DW, Murray HE, Dungey PE et al. Subdissociative-dose ketamine versus fentanyl for analgesia during propofol procedural sedation: a randomized clinical trial. Acad Emerg Med. 2008; 15:877- 86.
39. Slavik VC, Zed PJ. Combination ketamine and propofol for procedural sedation and analgesia. Pharmacotherapy. 2007; 27:1588-98. (Pubitemid 350060212)
40. Donnelly R, Willman E, Andolfatto G. Stability of ketamine-propofol mixtures for procedural sedation and analgesia in the emergency department. Can J Hosp Pharm. 2008; 61:426-30.