A blinded, randomized controlled trial to evaluate ketamine/propofol versus ketamine alone for procedural sedation in children

Annals of Emergency Medicine

Volumn 57, Issue 5, 2011, Pages 425-433

  Shah, Amit ^a,b   Mosdossy, Gregory ^a,b   McLeod, Shelley ^a,b   Lehnhardt, Kris ^a,b   Peddle, Michael ^a,b   Rieder, Michael ^a  

^a WESTERN UNIVERSITY   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE; PROPOFOL; SODIUM CHLORIDE;

AGITATION; ANESTHETIC RECOVERY; ARTICLE; CHILD; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP SEDATION; DELIRIUM; DIPLOPIA; DRUG EFFICACY; FATTY ACID DESATURATION; FEMALE; HALLUCINATION; HUMAN; HYPERSALIVATION; INJECTION SITE PAIN; MAJOR CLINICAL STUDY; MALE; MUSCLE RIGIDITY; NAUSEA; NURSE; PHYSICIAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RASH; SCORING SYSTEM; SIDE EFFECT; UPPER RESPIRATORY TRACT OBSTRUCTION; VOMITING;

ADOLESCENT; ANALGESIA; ANALGESICS; ANESTHETICS, COMBINED; CHILD; CHILD, PRESCHOOL; DEEP SEDATION; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; EMERGENCY SERVICE, HOSPITAL; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INJECTIONS, INTRAVENOUS; KETAMINE; MALE; ORTHOPEDIC PROCEDURES; PROPOFOL; TIME FACTORS;

EID: 79955470762     PISSN: 01960644     EISSN: 10976760     Source Type: Journal    
DOI: 10.1016/j.annemergmed.2010.08.032     Document Type: Article

References (43)

1. G. Andolfatto, and E.V. Willman A prospective case series of pediatric procedural sedation and analgesia in the emergency department using single-syringe ketamine-propofol combination (ketofol) Acad Emerg Med 17 2010 194 201
2. E.V. Willman, and G. Andolfatto A prospective evaluation of "ketofol" (ketamine/propofol combination) for procedural sedation and analgesia in the emergency department Ann Emerg Med 49 2007 23 30 (Pubitemid 46013962)
3. D.W. Messenger, H.E. Murray, and P.E. Dungey Subdissociative-dose ketamine versus fentanyl for analgesia during propofol procedural sedation: a randomized clinical trial Acad Emerg Med 15 2008 877 886
4. G.Q. Sharieff, D.R. Trocinski, and J.T. Kanegaye Ketamine-propofol combination sedation for fracture reduction in the pediatric emergency department Pediatr Emerg Care 23 2007 881 884 (Pubitemid 350307360)
5. H.P. Frizelle, J. Duranteau, and K. Samii A comparison of propofol with a propofol-ketamine combination for sedation during spinal anesthesia Anesth Analg 84 1997 1318 1322 (Pubitemid 27250478)
6. K. Frey, R. Sukhani, and J. Pawlowski Propofol versus propofol-ketamine sedation for retrobulbar nerve block: comparison of sedation quality, intraocular pressure changes, and recovery profiles Anesth Analg 89 1999 317 321 (Pubitemid 29367709)
7. R.F. Mortero, L.D. Clarketamine, and M.M. Tolan The effects of small-dose ketamine on propofol sedation: respiration, postoperative mood, perception, cognition, and pain Anesth Analg 92 2001 1465 1469 (Pubitemid 32493163)
8. B. Krauss, and S. Green Sedation and analgesia for procedures in children N Engl J Med 342 2000 938 945 (Pubitemid 30177055)
9. B. Krauss, and S. Green Procedural sedation and analgesia in children Lancet 367 2006 766 780 (Pubitemid 43326295)
10. G. Dolansky, A. Shah, and G. Mosdossy What is the evidence for the safety and efficacy of using ketamine in children? Paediatr Child Health 13 2008 307 308 (Pubitemid 351754211)
11. A. Sacchetti, E. Stander, and N. Ferguson Pediatric procedural sedation in the community emergency department: results from the ProSCED registry Pediatr Emerg Care 23 2007 218 222 (Pubitemid 46626039)
12. J.P. Cravero, M.L. Beach, and G.T. Blike The incidence and nature of adverse events during pediatric sedation/anesthesia with propofol for procedures outside the operating room: a report from the Pediatric Sedation Research Consortium Anesth Analg 108 2009 795 804
13. J.R. Miner The surgical stress response, preemptive analgesia, and procedural sedation in the emergency department Acad Emerg Med 15 2008 955 958
14. A. Borgeat, O.H. Wilder-Smith, and M. Saiah Subhypnotic doses of propofol possess direct antiemetic properties Anesth Analg 74 1992 539 541
15. I. Smith, T.G. Monk, and P.F. White Propofol infusion during regional anesthesia: sedative, amnestic, and anxiolytic properties Anesth Analg 79 1994 313 319 (Pubitemid 24240871)
16. B.L. Friedberg Propofol-ketamine technique: dissociative anesthesia for office surgery (a 5-year review of 1264 cases) Aesthetic Plast Surg 23 1999 70 75 (Pubitemid 29098196)
17. P. Picard, and M.R. Tramr Prevention of pain on injection with propofol: a quantitative systematic review Anesth Analg 90 2000 963 969 (Pubitemid 30190810)
18. S.W. Koo, S.J. Cho, and Y.K. Kim Small-dose ketamine reduces the pain of propofol injection Anesth Analg 103 2006 1444 1447
19. E. Barbi, F. Marchetti, and T. Gerarduzzi Pretreatment with intravenous ketamine reduces propofol injection pain Paediatr Anaesth 13 2003 764 768 (Pubitemid 37475875)
20. I.A. Erden, A.G. Pamuk, and S.B. Akinci Comparison of propofol-fentanyl with propofol-fentanyl-ketamine combination in pediatric patients undergoing interventional radiology procedures Paediatr Anaesth 19 2009 500 506
21. B. Mankikian, J.P. Cantineau, and R. Sartene Ventilatory pattern and chest wall mechanics during ketamine anesthesia in humans Anesthesiology 65 1986 492 499 (Pubitemid 17200389)
22. P.F. White, W.L. Way, and A.J. Trevor Ketamine-its pharmacology and therapeutic uses Anesthesiology 56 1982 119 136
23. S.M. Green, and B. Krauss Clinical practice guideline for emergency department ketamine dissociative sedation in children Ann Emerg Med 44 2004 460 471 (Pubitemid 39425047)
24. G.M. Hoffman, R. Nowakowski, and T.J. Troshynski Risk reduction in pediatric procedural sedation by application of an American Academy of Pediatrics/American Society of Anesthesiologists process model Pediatrics 109 2002 236 243 (Pubitemid 34126863)
25. J. Aldrete, and D. Kroulik A postanesthetic recovery score Anesth Analg 49 1970 924 933
26. M. Bhatt, R.M. Kennedy, and M.H. Osmond Consensus-based recommendations for standardizing terminology and reporting adverse events for emergency department procedural sedation and analgesia in children Ann Emerg Med 53 2009 426 435
27. V. Tolia, C. Han, and J.D. North Taste comparisons for lansoprazole strawberry-flavoured delayed-release orally disintegrating tablet and ranitidine peppermint-flavoured syrup in children Clin Drug Invest 25 2005 285 292 (Pubitemid 40806942)
28. E. Bahn, and K. Holt Procedural sedation and analgesia: a review and new concepts Emerg Med Clin North Am 23 2005 503 517
29. S.A. Godwin, D.A. Caro, and S.J. Wolf Clinical policy: procedural sedation and analgesia in the emergency department Ann Emerg Med 45 2005 177 196
30. M.A. Miller, P. Levy, and M.M. Patel Procedural sedation and analgesia in the emergency department: what are the risks? Emerg Med Clin North Am 23 2005 551 572
31. M.G. Roback, J.E. Wathen, and T. MacKenzie A randomized, controlled trial of i.v. versus i.m. ketamine for sedation of pediatric patients receiving emergency department orthopedic procedures Ann Emerg Med 48 2006 605 612 (Pubitemid 44556892)
32. A.H. Bleiberg, C.A. Salvaggio, and L.C. Roy Low-dose ketamine: efficacy in pediatric sedation Pediatr Emerg Care 23 2007 158 162 (Pubitemid 46596628)
33. R.J. Dachs, and G.M. Innes Intravenous ketamine sedation of pediatric patients in the emergency department Ann Emerg Med 29 1997 146 150 (Pubitemid 27030031)
34. J.E. Wathen, M.G. Robacketamine, and T. Mackenzie Does midazolam alter the clinical effects of intravenous ketamine sedation in children? a double-blind, randomized, controlled, emergency department trial Ann Emerg Med 36 2000 579 588
35. S.M. Green, S.G. Rothrocketamine, and T. Harris Intravenous ketamine for pediatric sedation in the emergency department: safety profile with 156 cases Acad Emerg Med 5 1998 971 976 (Pubitemid 28463186)
36. A. Vardi, Y. Salem, and S. Padeh Is propofol safe for procedural sedation in children? a prospective evaluation of propofol versus ketamine in pediatric critical care Crit Care Med 30 2002 1231 1236 (Pubitemid 34620963)
37. S.A. Godambe, V. Elliot, and D. Matheny Comparison of propofol/ fentanyl versus ketamine/midazolam for brief orthopedic procedural sedation in a pediatric emergency department Pediatrics 112 2003 116 123 (Pubitemid 36792938)
38. J.R. Miner, M.H. Biros, and S. Krieg Randomized clinical trial of propofol versus methohexital for procedural sedation during fracture and dislocation reduction in the emergency department Acad Emerg Med 10 2003 931 937 (Pubitemid 37093194)
39. W.T. Langston, J.E. Wathen, and M.G. Roback Effect of ondansetron on the incidence of vomiting associated with ketamine sedation in children: a double-blind, randomized, placebo-controlled trial Ann Emerg Med 52 2008 30 34
40. T.S. Sherwin, S.M. Green, and A. Khan Does adjunctive midazolam reduce recovery agitation after ketamine sedation for pediatric procedures? a randomized, double-blind, placebo-controlled trial Ann Emerg Med 35 2000 229 238 (Pubitemid 30643569)
41. J.H. Burton, J.R. Miner, and E.R. Shipley Propofol for emergency department procedural sedation and analgesia: a tale of three centres Acad Emerg Med 13 2006 24 30 (Pubitemid 41827290)
42. T. Dunn, D. Mossop, and A. Newton Propofol for procedural sedation in the emergency department Emerg Med J 24 2007 459 461 (Pubitemid 47034085)
43. J.R. Miner, M. Danahy, and A. Moch Randomized clinical trial of etomidate versus propofol for procedural sedation in the emergency department Ann Emerg medication 49 2007 15 22 (Pubitemid 46013960)