The future role of rectal and vaginal microbicides to prevent HIV infection in heterosexual populations: Implications for product development and prevention

Sexually Transmitted Infections

Volumn 87, Issue 7, 2011, Pages 646-653

  Boily, Marie Claude ^a   Dimitrov, Dobromir ^b   Abdool Karim, Salim S ^c   Mâsse, Benoît ^b,d  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

^d UNIVERSITY OF MONTREAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MICROBICIDE;

ADULT; ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; FEMALE; HETEROSEXUALITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEXUAL INTERCOURSE; SEXUAL TRANSMISSION; SEXUALLY TRANSMITTED DISEASE; VIRUS TRANSMISSION;

ADMINISTRATION, INTRAVAGINAL; ADMINISTRATION, RECTAL; ANTI-INFECTIVE AGENTS; FEMALE; HETEROSEXUALITY; HIV INFECTIONS; HUMANS; MALE; MODELS, THEORETICAL; SEXUAL BEHAVIOR;

EID: 82555193798     PISSN: 13684973     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/sextrans-2011-050184     Document Type: Article

References (58)

1. McCoy S, Watts C, Padian N. Preventing HIV infection: turning the tide for young women. Lancet 2010;376:1281-2.
2. Padian NS, Buvé A, Balkus J, et al. Biomedical interventions to prevent HIV infection: evidence, challenges, and way forward. Lancet 2008;372:585-99.
3. Mc Cormack S, Hayes R, Lacey C, et al. Microbicide and HIV prevention. BMJ 2001;322:410-13.
4. Minces LR, McGowan I. Advances in the development of microbicides for the prevention of HIV infection. Curr Infect Dis Rep 2010;12:56-62.
5. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and Safety of Tenofovir Gel, an antiretroviral microbcide, for the prevention of HIV infection in women. Science 2010;329:1168-74.
6. Baleta A. Antiretroviral gel shows promise against HIV. Lancet 2010;376:304.
7. Alliance for Microbicide Development. Pipeline update of microbicide and PrEP candidates [Internet]. http://www.microbicide.org/uploads/3/1/2/1/3121935/ microbicide-pipeline-update-1-oct-2009.pdf (accessed 31 Jul 2010).
8. McGowan I. Rectal microbicides: a new focus for HIV prevention. Sex Transm Infect 2008;84:413-17.
9. Hendrix CW, Cao YJ, Fuchs EJ. Topical microbicides to prevent HIV: clinical drug development challenges. Annu Rev Pharmacol Toxicol 2009;49:349-75.
10. Baggaley RF, White RG, Boily M. HIV transmission risk through anal intercourse: systematic review, meta-analysis and implications for HIV prevention. Int J Epidemiol 2010;39:1048-63.
11. Baggaley RM, White RG, Boily M. Infectiousness of HIV-infected homosexual men in the era of HAART. AIDS 2010;24:2418-20.
12. Boily MC, Baggaley R, Masse B. The role of heterosexual anal intercourse for HIV transmission in developing countries: are we ready to draw conclusions? Sex Transm Infect 2009;85:408-10.
13. Boily MC, Baggaley RF, Wang L, et al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies. Lancet Infect Dis 2009;9:118-29.
14. Jin F, Jansson J, Law M, et al. Per-contact probability of HIV transmission in homosexual men in Sydney in the era of HAART. AIDS 2010;24:907-13.
15. Abdool Karim SS, Ramjee G. Anal sex and HIV transmission in women. Am J Public Health 1998;88:1265-6. (Pubitemid 28361383)
16. Matasha E, Ntembelea T, Mayaud P, et al. Sexual and reproductive health among primary and secondary school pupils in Mwanza, Tanzania: need for intervention. AIDS Care 1998;10:571-82. (Pubitemid 28461401)
17. Kalichman S, Cain D, Simbayi L. Heterosexual anal intercourse among community and clinical settings in Cape Town, South Africa. Sex Transm Iinfect 2009;5:411-15.
18. Minani I, Alary M, Lowndes CM, et al. Higher levels of HIV-related risky behaviour reported in Polling Booth Surveys (PBS) compared to Face-to-Face Interviews in a General Population Survey (GPS) in Cotonou-Benin (West Africa). In: Abstract OS1.8.03. London: ISSTDR, 2009.
19. McGowan I, Taylor DJ. Heterosexual anal intercourse has the potential to cause a significant loss of power in vaginal microbicide effectiveness studies. Sex Transm Dis 2010;37:10-13.
20. Masse BR, Boily MC, Dimitrov D, et al. Efficacy dilution in randomized placebo-controlled vaginal microbicide trials. ETE 2009;6:5.
21. McGowan I, Anton P. Rectal microbicides. Current Opin HIV AIDS 2008;3:593-8.
22. Parikh U, Dobard C, Sharma S, et al. Complete protection from repeated vaginal SHIV exposures in macaques by a topical gel containing Tenofovir alone or with emtricitabine. J Virol 2009;83:10358-65.
23. Cranage M, Sharpe S, Herrera C, et al. Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of Tenofovir gel. PLoS Med 2008;5:e157.
24. McNeil DGJ. Advance on AIDS raises questions as well as joy. The New York Time 2010. http://www.nytimes.com/2010/07/27/health/27AIDS.html
25. Breban R, McGowan I, Topaz EJ, et al. Modeling the potential impact of rectal microbicides to reduce HIV transmission in bathhouses. Math Biosci Eng 2008;3:459-66.
26. Dimitrov D, Masse M, Boily MC. Who Will Benefit from a Wide-Scale Introduction of Vaginal Microbicides in Developing Countries? Stat Comm Infect Dis 2010;2:Article 4.
27. Foss AM, Vickerman PT, Alary M, et al. How much could a microbicide's sexually transmitted infection efficacy contribute to reducing HIV risk and the level of condom use needed to lower risk? Model estimates. Sex Transm Inf 2009;85:276-82.
28. Foss AM, Vickerman PT, Heise L, et al. Shifts in condom use following microbicide introduction: should we be concerned? AIDS 2003;44:1227-37. (Pubitemid 36675364)
29. Wilson DP, Coplan P. Mathematical models and health economic aspects of microbicides. Curr Opin HIV AIDS 2008;3:587-92.
30. Weber J, Desai K, Darbyshire J; on The Behalf Of The Microbicides Development. The development of vaginal microbicides for the prevention of HIV transmission. PLoS Medicine 2005;2:392-5.
31. Boily MC. Population-level impact of microbicides to prevent HIV: the efficacy that matters. 2010 International Microbicides Conference; 22-25 May 2010. Pittsburgh, Pennsylvania: Pittsburgh Symposium presentation, 2010:176.
32. Boily MC, Desai K, Masse B, et al. The incremental role of male circumcision on HIV infection through its protective effect against other sexually transmitted infections: from efficacy to effectiveness to population-level impact. Sex Transm Inf 2008;84(Suppl 2):ii28-34.
33. Collaborative Group on AIDS Incubation and HIV Survival. Time from HIV-1 seroconversion to AIDS and death before widespread use of highly active antiretroviral therapy: a collaborative re-analysis. Collaborative Group on AIDS Incubation and HIV Survival including the CASCADE EU Concerted Action. Lancet 2000;355:1131-7.
34. San Andres Rebollo FJ, Rubio Garcia R, Castilla Catalan JP, et al. Mortality and survival in a cohort of 1, 115 HIV-infected patients (1989-97). An Med Interna 2004;21:523-32. (Pubitemid 40018753)
35. Ferry B, Carael M, Buvé A, et al. Comparison of key parameters of sexual behaviour in four African urban populations with different levels of HIV infection. AIDS 2001;15(Suppl 4):S41-50. (Pubitemid 32913003)
36. Van Damme L, Ramjee G, Alary M, et al. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. Lancet 2002;360:971-7. (Pubitemid 35284107)
37. Skoler-Karpoff S, Ramjee G, Ahmed K, et al. Efficacy of carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial. Lancet 2008;372:1977-87.
38. Langhaug L, Cheung Y, Pascoe S, et al. How you ask really matters: randomised comparison of four sexual behaviour questionnaire delivery modes in Zimbabwean youth. Sex Transm Inf 2010;87:165-73.
39. Todd J, Cremin I, McGrath N, et al. Reported number of sexual partners: comparison of data from four African longitudinal studies. Sex Transm Inf 2009;85(Suppl 1):i72-80.
40. Allen S, Meinzen-derr J, Kautzman M, et al. Sexual behavior of HIV discordant couples after HIV counseling and testing. AIDS 2003;17:733-40. (Pubitemid 36521080)
41. Foss AM, Hossain M, Vickerman PT, et al. A systematic review of published evidence on intervention impact on condom use in sub-Saharan Africa and Asia. Sex Transm Inf 2007;83:510-16. (Pubitemid 350290969)
42. Buvé A, Caraël M, Hayes RJ, et al. Multicentre study on factors determining differences in rate of spread of HIV in sub-Saharan Africa: methods and prevalence of HIV infection. AIDS 2001;15(Suppl 4):S5-14.
43. Hargreaves JR, Bonell CP, Morison LA, et al. Explaining continued high HIV prevalence in South Africa: socioeconomic factors, HIV incidence and sexual behaviour change among a rural cohort, 2001-2004. AIDS 2007;21(Suppl 7):S39-48. (Pubitemid 350174558)
44. Laumann E, Gagnon J, Michael T, et al. The Social Organization of Sexuality: Sexual Practices in the United States. Chicago: University of Chicago Press, 1994.
45. Messiah A, Pelletier A. Partner-specific sexual practices among heterosexual men and women with multiple partners: results from the French National survey, ACSF. Analyse des comportements sexuels en France. Arch Sex Behav 1996;25:233-47. (Pubitemid 26152196)
46. Silveira M, Beria J, Horta B, et al. Factors associated with risk behaviors for sexually transmitted disease/AIDS among urban Brazilian women: a population-based study. Sex Transm Dis 2002;9:536-41. (Pubitemid 35001344)
47. Leonard L, Ross M. The last sexual encounter: the contextualization of sexual risk behaviour. Int J STD AIDS 1997;8:643-5. (Pubitemid 27389430)
48. O'Connor C, Wen L, Rissel C, et al. Sexual behaviour and risk in Vietnamese men living in metropolitan Sydney. Sex Transm Inf 2007;83:147-50. (Pubitemid 46729158)
49. Celum C. The interaction between herpes simplex virus and human immunodeficiency virus. Herpes 2004;11(Suppl 1):36A-45.
50. Lissouba P, Taljaard D, Rech D, et al. A model for the roll-out of comprehensive adult male circumcision services in African low-Income settings of high HIV incidence: the ANRS 12126 Bophelo Pele project. PLoS Med 2010;7:e1000309.
51. Cleary S. Equity and efficiency in scaling up access to HIV-related interventions in resource-limited settings. Curr Opin HIV AIDS 2010;5:210-14.
52. Verma R, Shekhar A, Khobragade S, et al. Scale-up and coverage of Avahan: a large-scale HIV-prevention programme among female sex workers and men who have sex with men in four Indian states. Sex Trans Infec 2010;86(Suppl 1):I76-82.
53. Geonnotti A, Katz D. Compartmental transport model of microbicide delivery by an intravaginal ring. J Pharm Sci 2010;99:3514-21.
54. Coly A, Gorbach P. Microbicide acceptability research: recent findings and evolution across phases of product development. Curr Opin HIV AIDS 2008;3:581-6.
55. Greene E, Batona G, Hallad J, et al. Acceptability and adherence of a candidate microbicide gel among high-risk women in Africa and India. Cult Heatlh Sex 2010;12:739-54.
56. Karmon E, Potts M, Getz WM. Microbicides and HIV: help or hindrance? J Acquir Immune Defic Syndr 2003;34:71-5. (Pubitemid 37100115)
57. Halperin D. Heterosexual anal intercourse: prevalence, cultural factors, and HIV infection and other health risks, Part I. AIDS Patient Care STDs 1999;13:717-30. (Pubitemid 30016740)
58. Leichliter J, Chandra A, Liddon N, et al. Prevalence and correlates of heterosexual anal and oral sex in adolescents and adults in the United States. J Infect Dis 2007;196:1852-9. (Pubitemid 351411947)