Molecular imaging of cancer: Prediction and early detection of response by NMR spectroscopy and imaging

International Drug Discovery

Volumn 2011, Issue 5, 2011, Pages 20-23

  Lee, Seung Cheol ^a   Poptani, Harish ^a   James Delikatny, E ^a   Wasik, Mariusz ^a   Marcek, Michal ^a   Schuster, Stephen J ^a   Nasta, Sunita D ^a   Svoboda, Jakub ^a   Goldstein, Steven C ^a   Arias Mendozal, Fernando ^a,b   Glickson, Jerry D ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b The University of Pennsylvania School of Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 PHOSPHOFRUCTOKINASE; BRYOSTATIN; CHOLINE; CYCLOPHOSPHAMIDE; DOXORUBICIN; ENOLASE; ENOLASE 1; HEXOKINASE; HEXOKINASE 2; LACTIC ACID; LENALIDOMIDE; PHOSPHOETHANOLAMINE; PHOSPHOMONOESTER; PHOSPHORUS 31; PHOSPHORUS DERIVATIVE; PHOSPHORYLCHOLINE; PREDNISONE; PYRUVATE KINASE; RAPAMYCIN; RITUXIMAB; THALIDOMIDE; UNCLASSIFIED DRUG; VINCRISTINE;

ARTICLE; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER RESISTANCE; DIFFUSION WEIGHTED IMAGING; DRUG RESPONSE; DRUG TREATMENT FAILURE; HEAD AND NECK CARCINOMA; HUMAN; LARGE CELL LYMPHOMA; MOLECULAR IMAGING; MULTIPLE CYCLE TREATMENT; NONHODGKIN LYMPHOMA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PREDICTIVE VALUE; SENSITIVITY AND SPECIFICITY; SQUAMOUS CELL CARCINOMA; TUMOR REGRESSION;

EID: 82555184008     PISSN: 21504792     EISSN: 21504806     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Negendank, W. STUDIES OF HUMAN TUMORS BY MRS - A REVIEW. Nmr in Biomedicine 5, 303-324 (1992).
2. Arias-Mendoza, F., Payne, G. S., Zakian, K., Stubbs, M., Cruz-Lobo, J. G., Schwarz, A. J., Shukla-Dave, A., Howe, F., Maisey, N. R., Cunningham, D., Poptani, H., Smith, M. R., O'Connor, O. A., Pettengell, R., Leach, M. O., Koutcher, J. A., Griffiths, J. R., Heerschap, A., Glickson, J. D. & Brown, T. R. Treatment response predictor using 31P MRS for chop and R-chop therapy in diffuse large B-cell lymphoma. Annals of Oncology 19, 147-147 (2008).
3. Arias-Mendoza, F., Payne, G. S., Zakian, K. L., Schwarz, A. J., Stubbs, M., Stoyanova, R., Ballon, D., Howe, F. A., Koutcher, J. A., Leach, M. O., Griffiths, J. R., Heerschap, A., Glickson, J. D., Nelson, S. J., Evelhoch, J. L., Charles, H. C., Brown, T. R. & Cooperative Grp, M. R. S. In vivo P-31 MR spectral patterns and reproducibility in cancer patients studied in a multi-institutional trial. Nmr in Biomedicine 19, 504-512 (2006).
4. Arias-Mendoza, F., Smith, M. R. & Brown, T. R. Predicting treatment response in non-Hodgkin's lymphoma from the pretreatment tumor content of phosphoethanolamine plus phosphocholine. Academic Radiology 11, 368-376 (2004).
5. Arias-Mendoza, F., Zakian, K., Schwartz, A., Howe, F. A., Koutcher, J. A., Leach, M. O., Griffiths, J. R., Heerschap, A., Glickson, J. D., Nelson, S. J., Evelhoch, J. L., Charles, H. C., Brown, T. R. & Cooperative Grp, M. R. S. A. C. Methodological standardization for a multi-institutional in vivo trial of localized P-31 MR spectroscopy in human cancer research. In vitro and normal volunteer studies. Nmr in Biomedicine 17, 382-391 (2004).
6. Arias-Mendoza, F., Smith, M. R., Berardocco, F., Stoyanova, R., Li, C. Brown, T. R. Correlation of analysis of 31P MR spectroscopy in vivo with malignancy and treatment response in nonHodgkin's lymphoma. Radiology 213P, 276 (1999).
7. Shukla-Dave, A., Poptani, H., Loevner, L. A., Mancuso, A., Serrai, H., Rosenthal, D. I., Kilger, A. M., Nelson, D. S., Zakian, K. L., Arias-Mendoza, F., Rijpkema, M., Koutcher, J. A., Brown, T. R., Heerschap, A. & Glickson, J. D. Prediction of treatment response of head and neck cancers with P-31 MR spectroscopy from pretreatment relative phosphomonoester levels. Academic Radiology 9, 688-694 (2002).
8. Mohammad, R. M., Wall, N. R., Dutcher, J. A. & Al-Katib, A. M. The addition of bryostatin 1 to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy improves response in a CHOP-resistant human diffuse large cell lymphoma xenograft model. Clinical Cancer Research 6, 4950-4956 (2000).
9. Al-Katib, A. M., Smith, M. R., Kamanda, W. S., Pettit, G. R., Hamdan, M., Mohamed, A. N., Chelladurai, B. & Mohammad, R. M. Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse large cell lymphoma xenografts. Clinical Cancer Research 4, 1305-1314 (1998).
10. Lee, S. C., Delikatny, E. J., Poptani, H., Pickup, S. & Glickson, J. D. In vivo H-1 MRS of WSU-DLCL2 human non-Hodgkin's lymphoma xenografts: response to rituximab and rituximab plus CHOP. Nmr in Biomedicine 22, 259-265 (2009).
11. Lee, S. C., Huang, M. Q., Nelson, D. S., Pickup, S., Wehrli, S., Adegbola, O., Poptani, H., Delikatny, E. J. & Glickson, J. D. In vivo MRS markers of response to CHOP chemotherapy in the WSU-DLCL2 human diffuse large B-cell lymphoma xenograft. Nmr in Biomedicine 21, 723-733 (2008).
12. Huang, M. Q., Nelson, D. S., Pickup, S., Qiao, H., Delikatny, E. J., Poptani, H. & Glickson, J. D. In vivo monitoring response to chemotherapy of human diffuse large B-Cell lymphoma xenografts in SCID mice by H-1 and P-31 MRS. Academic Radiology 14, 1531-1539 (2007).
13. Lee, S. C., Poptani, H., Jenkins, W. T., Kim, S., Koch, C. J., Delikatny, E. J. & Glickson, J. D. Early detection of radiation therapy response in non-Hodgkin's lymphoma xenografts by in vivo 1H magnetic resonance spectroscopy and imaging. Nmr in Biomedicine EPUB Ahead of Print, March 28, 2010 (2010).
14. Huang, M. Q., Pickup, S., Nelson, D. S., Qiao, H., Xu, H. N., Li, L. Z., Zhou, R., Delikatny, E. J., Poptani, H. & Glickson, J. D. Monitoring response to chemotherapy of non-Hodgkin's lymphoma xenografts by T-2-weighted and diffusion-weighted MRI. Nmr in Biomedicine 21, 1021-1029 (2008).
15. Mellon, E. A., Lee, S. C., Pickup, S., Kim, S., Goldstein, S. C., Floyd, T. F., Poptani, H., Delikatny, E. J., Reddy, R. & Glickson, J. D. Detection of Lactate With a Hadamard Slice Selected, Selective Multiple Quantum Coherence, Chemical Shift Imaging Sequence (HDMD-SelMQC-CSI) on a Clinical MRI Scanner: Application to Tumors and Muscle Ischemia. Magnetic Resonance in Medicine 62, 1404-1413 (2009).
16. Pickup, S., Lee, S. C., Mancuso, A. & Glickson, J. D. Lactate imaging with Hadamard-encoded slice-selective multiple quantum coherence chemicalshift imaging. Magnetic Resonance in Medicine 60, 299-305 (2008).
17. Serrai, H., Nadal-Desbarats, L., Poptani, H., Glickson, J. D. & Senhadji, L. Lactate editing and lipid suppression by continuous wavelet transform analysis: Application to simulated and H-1 MRS brain tumor time-domain data. Magnetic Resonance in Medicine 43, 649-656 (2000).