Bryostatin 1 down-regulates mdr1 and potentiates vincristine cytotoxicity in diffuse large cell lymphoma xenografts

Clinical Cancer Research

Volumn 4, Issue 5, 1998, Pages 1305-1314

  Al Katib, Ayad M ^a   Smith, Mitchell R ^b   Kamanda, William S ^c   Pettit, George R ^d   Hamdan, Mohammed ^a   Mohamed, Anwar N ^a   Chelladurai, Bhadrani ^a   Mohammad, Ramzi M ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Wayne State Univ School of Medicine ^*  (United States)

^c MICHIGAN STATE UNIVERSITY   (United States)

^d ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; BRYOSTATIN 1; COMPLEMENTARY DNA; CYCLOPHOSPHAMIDE; CYTARABINE; CYTOTOXIC AGENT; DOXORUBICIN; ETOPOSIDE; FOLINIC ACID; MESSENGER RNA; METHOTREXATE; PREDNISONE; VINCRISTINE;

ADULT; ANIMAL MODEL; ARTICLE; CANCER CHEMOTHERAPY; CASE REPORT; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LARGE CELL LYMPHOMA; LYMPHOMA CELL; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHODGKIN LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; XENOGRAFT;

ADULT; ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CELL COUNT; DOWN-REGULATION; DRUG SYNERGISM; FEMALE; HUMANS; KARYOTYPING; LACTONES; LYMPHOMA, LARGE-CELL, DIFFUSE; MACROLIDES; MALE; MICE; MICE, SCID; NEOPLASM PROTEINS; P-GLYCOPROTEIN; SUBRENAL CAPSULE ASSAY; TUMOR CELLS, CULTURED; VINCRISTINE;

EID: 0031924260     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Cordon Cardo, C., O'Brien, J. P., Boccia, J., Casals, D., Bertino, J. R., and Melamed, M. R. Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor issues. J. Histochem. Cytochem., 38: 1277-1287, 1990.
2. Cornwell, M. M. Molecular biology of P-glycoprotein. In: Robert F. Ozols (ed.). Molecular and Clinical Advances in Anticancer Drug Resistance, pp. 37-56. Boston: Kluwer Academic Publishers, 1991.
3. Cordon, C. C., O'Brien, J. P., Casals, D., Rittman, G. L., Biedler, J. L., Melamed, M. R., and Bertino, J. R. Multidrug resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc. Natl. Acad. Sci. USA, 86: 695-698, 1989.
4. Chaudhary, P. M., and Roninson, I. B. Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells. Cell, 66: 85-92, 1991.
5. Drach, D., Zhao, S., Drach, J., Mahadevia, R., Gattringer, C., Huber, H., and Andreeff, M. Subpopulations of normal peripheral blood and bone marrow cells express a functional multidrug resistant phenotype. Blood, 80: 2729-2734, 1992.
6. Veda, K., Cornwell, M. M., Gottesman, M. M., Pastan, I., Roninson, I. B., Ling, V., and Riordan, J. R. The mdr1 gene, responsible for multidrug resistance, codes for P-glycoprotein. Biochem. Biophys. Res. Commun., 141: 956-962, 1986.
7. Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M. M., Pastan, I., and Willingham, M. C. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein p. 170: evidence for localization in brain capillaries and cross reactivity of one antibody with a muscle protein. J. Histochem. Cytochem., 37: 159-164, 1989.
8. Fojo, A. T., Veda, K., Salmon, D. J., Poplack, D. G., Gottesman, M. M., and Pastan, I. Expression of a multidrug resistance gene in human tumors and tissues. Proc. Natl. Acad. Sci. USA, 84: 265-269, 1987.
9. Miller, T. P., Grogan, T. M., Dalton, W. S., Spier, C. M., Scheper, R. J., and Salmon, S. E. P-glycoprotein expression in malignant lymphoma and reversal of clinical drug resistance with chemotherapy plus high dose verapamil. J. Clin. Oncol., 9: 17-24, 1991.
10. Cheng, A. L., Su, I. J., Chen, Y. C., Lee, T. C., and Wang, C. H. Expression of P-glycoprotein and glutathione S-transferase in recurrent lymphomas: the possible role of Epstein-Barr virus, immunophenotypes, and other predisposing factors. J. Clin. Oncol., 11: 109-115, 1993.
11. Salmon, S. E., Grogan, T. M., Miller, T., Scheper, R., and Dalton, W. S. Prediction of doxorubicin resistance in vitro in myeloma, lymphoma, and breast cancer by P-glycoprotein staining. J. Natl. Cancer Inst., 81: 696-701, 1989.
12. Pastan, I., and Gottesman, M. Multiple-drug resistance in human cancer. N. Engl. J. Med., 316: 1388-1393, 1987.
13. Ford, J. M., and Hait, W. N. Pharmacology of drugs that alter multidrug resistance in cancer. Pharmacol Rev., 42: 155-199, 1990.
14. Ozols, R., Cunnion, R., Klecker, R., Hamilton, T., Ostchega, Y., Parrillo, J., and Young, R. Verapamil and Adriamycin in the treatment of drug resistant ovarian cancer patients. J. Clin. Oncol., 5: 641-647, 1987.
15. Stone, R. M., Sariban, E., Pettit, G. R., and Kufe, D. W. Bryostatin 1 activates protein kinase C and induces monocytic differentiation of HL-60 cells. Blood, 72: 208-213, 1988.
16. Jones, R. J., Sharkis, S. J., Miller, C. B., Rowinsky, E. K., Burke, P. J., and May, W. S. Bryostatin 1, a unique biologic response modifier: anti-leukemic activity in vitro. Blood, 75: 1319-1323, 1990.
17. Mohammad, R. M., Al-Katib, A., Pettit, G. R., and Sensebrenner, L. L. Differential effects of bryostatin 1 on human non-Hodgkin's B-Lymphoma cell lines. Leuk. Res., 17: 1-8, 1993.
18. Mohammad, R. M., Diwakaran, H., Maki, A., Emara, M. A., Pettit, G. R., Redman, B., and Al-Katib, A. Bryostatin 1 induces apoptosis and augments inhibitory effects of vincristine in human diffuse large cell lymphoma. Leuk. Res., 19: 667-673, 1995.
19. Elias, L., Portlock, C. S., and Rosenberg, S. A. Combination chemotherapy of diffuse histiocytic lymphoma with cyclophosphamide, Adriamycin, vincristine, and prednisone (CHOP). Cancer (Phila.), 42: 1705-1710, 1978.
20. Fisher, R. I., Gaynor, E. R., Dahlberg, S., Oken, M. M., Grogan, T. M., Mize, E. M., Click, J. H., Coltman, C. A., Jr., and Miller, T. P. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N. Engl. J. Med., 328: 1002-1006, 1993.
21. Bardales, R. H., Al-Katib, A. M., Carrato, A., and Koziner, B. Detection of intracytoplasmic immunoglobulin by flow cytometry in B cell malignancies. J. Histochem. Cytochein., 37: 83-89, 1989.
22. Mohammad, R. M., Al-Katib, A., Pettit, G. R., and Sensebrenner, L. L. Successful treatment of human Waldenstrom's macroglobulinemia with combination biological chemotherapy agents. Cancer Res., 54: 165-168, 1994.
23. Corbett, T. H., Valeriote, F. A., Polin, L., Panchapor, C., Pugh, S., White, K., Lowinchik, N., Knight, J., Bissery, M. C., Wozniak, A., LoRusso, P., Biernat, L., Polin, D., Knight, L., Biggar, S., Looney, D., Demchik, L., Jones, J., Jones, L., Blair, S., Palmer, K., Essenmacher, S., Lisow, L., Mattes, K. C., Cavanaught, P. F., Rake, J. B., and Baker, L. Discovery of solid tumor active agents using a soft-agar-colony-formation disk-diffusion assay. In: F. A. Valeriote, T. H. Corbett, and L. H. Baker (eds.), Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development, pp. 35-87. Boston: Kluwer Academic Publishers, 1992.
24. Mohamed, A. N., and Wolman, S. R. Chromosome analysis in cell culture. In: G. Studzinski (ed.), Cell Growth and Apoptosis; A Practical Approach, Ed. 2, Vol. 2., pp. 79-96. New York: Oxford University Press, 1995.
25. Mohammad, R. M., Mohamed, A. N., KuKuruga, M., Smith, R. M., and Al-Katib, A. A human B-cell lymphoma line with a de novo multidrug phenotype. Cancer (Phila.), 69: 1468-1474, 1992.
26. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
27. DeVita, V., Jr., Canellos, G., Chabner, B., Shein, P., Hubbard, S., and Young, R. Advanced diffuse histiocytic lymphoma, a potentially curable disease: results with combination chemotherapy. Lancet, 1: 248-250, 1975.
28. Gordon, L. I., Harrington, D., Andersen, J., Colgan, J., Glick, J., Neiman, R., Mann, R., Resnick, G., Barcos, M., Gottlieb, A., and O'Connell, M. Comparison of a second-generation combination chemotherapeutic regimen (m-BACOD) with standard regimen (CHOP) for advanced diffuse non-Hodgkin's lymphoma. N. Engl. J. Med., 327: 1342-1349, 1992.
29. Niehans, G. A., Jaszcz, W., Brunette, V., Perri, R. T., Gajl-Peczalska, K., Wick, M. R., Tsuruo, T., and Bloomfield, C. D. Immunohistochemical identification of P-glycoprotein in previously untreated, diffuse large cell and immunoblastic lymphomas. Cancer Res., 52: 3768-3775, 1992.
30. Pettit, G. R., Herald, C. L., Doubek, D. L., Herald, D. L., Arnold, E., and Clardy, J. Isolation and structure of Bryostatin 1. J. Am. Chem. Soc., 104: 6846-6848, 1982.
31. Schuchter, L. M., Esa, A. H., May, S., Laulis, M. K., Pettit, G. R., and Hess, A. D. Successful treatment of murine melanoma with bryostatin 1. Cancer Res., 51: 682-687, 1991.
32. Hornung, R. L., Pearson, J. W., Beckwith, M., and Longo, D. L. Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity. Cancer Res., 52: 101-107, 1992.
33. Li, B., Sehajpal, P. K., Khanna, A., Vlassara, H., Cerami, A., Stenzel, K. H., and Suthanthiran, M. Differential regulation of transforming growth factor βand interleukin 2 genes in human T cells: demonstration by usage of novel competitor DNA constructs in the quantitative polymerase chain reaction. J. Exp. Med., 174: 1259-1262, 1991.
34. Siebert, P. D., and Larrick, J. W. PCR mimics: competitive DNA fragments for use as internal standards in quantitative PCR. Biotechniques, 14: 244-249, 1993.
35. Yang, J. M., Chin, K. V., and Hait, W. N. Interaction of P-glycoprotein with protein kinase C in human multidrug resistant carcinoma cells, Cancer Res., 56: 3490-3494, 1996.
36. Lee, W. P. P-glycoprotein is hyperphosphorylated in multidrug resistant HOB1 lymphoma cells treated with overdose of vincristine. Biochim. Biophys. Acta, 1245: 57-61, 1995.
37. Goodfellow, H. R., Sardini, A., Ruetz, S., Callaghan, R., Gros, P., McNaughton, P. A., and Higgins, C. F. Protein kinase C-mediated phosphorylation does not regulate drug transport by the human multidrug resistance P-glycoprotein. J. Biol. Chem., 271: 13668-13674, 1996.
38. Germann, V. A., Chambers, T. C., Ambudkar, S. V., Licht, T., Cardarelli, C. O., Pastan, I., and Gottesman, M. M. Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells. J. Biol. Chem., 271: 1708-1716, 1996.
39. Smith, C. D., and Ziffier, J. T. Circumvention of P-glycoprotein-mediated multiple drug resistance by phosphorylation mediators is independent of protein kinases. J. Biol. Chem., 270: 28145-28152, 1995.