GMP-compliant radiosynthesis of [18F]altanserin and human plasma metabolite studies

Applied Radiation and Isotopes

Volumn 67, Issue 4, 2009, Pages 598-601

  Hasler, F ^a   Kuznetsova, O F ^b   Krasikova, R N ^b   Cservenyak, T ^c   Quednow, B B ^a   Vollenweider, F X ^a   Ametamey, S M ^c   Westera, G ^c  

^a UNIVERSITY HOSPITAL OF PSYCHIATRY   (Switzerland)

^b RUSSIAN ACADEMY OF SCIENCES   (Russian Federation)

^c SWISS FEDERAL INSTITUTE OF TECHNOLOGY   (Switzerland)

Author keywords

18F altanserin; GMP; Human study; Metabolite analysis; Positron emission tomography (PET); Radiosynthesis

Indexed keywords

[18F]ALTANSERIN; GMP; HUMAN STUDY; METABOLITE ANALYSIS; POSITRON EMISSION TOMOGRAPHY (PET); RADIOSYNTHESIS;

ANIMAL CELL CULTURE; BIOCHEMISTRY; BIOMOLECULES; DIAGNOSTIC RADIOGRAPHY; EXTRACTION; HEATING; MEDICAL IMAGING; METABOLISM; METABOLITES; PLASMA (HUMAN); PLASMAS; POSITRON ANNIHILATION SPECTROSCOPY; POSITRONS; TOMOGRAPHY;

POSITRON EMISSION TOMOGRAPHY;

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALTANSERIN F 18; DEXFENFLURAMINE; DRUG METABOLITE; PLACEBO; PSILOCYBINE; SEROTONIN 2A RECEPTOR; TRACER; UNCLASSIFIED DRUG;

ARTERY; ARTICLE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG METABOLISM; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; GOOD MANUFACTURING PRACTICE; HEATING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MICROWAVE COOKING; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RECEPTOR OCCUPANCY; SOLID PHASE EXTRACTION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUORINE RADIOISOTOPES; HUMANS; KETANSERIN; POSITRON-EMISSION TOMOGRAPHY; QUALITY CONTROL;

EID: 59949098677     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2008.12.007     Document Type: Article

References (7)

1. Biver F., Goldman S., Luxen A., Monclus M., Forestini M., Mendlewicz J., and Lotstra F. Multicompartmental study of fluorine-18 altanserin binding to brain 5HT2 receptors in humans using positron emission tomography. Eur. J. Nucl. Med. 21 (1994) 937-946
2. 18F]-altanserin. Appl. Radiat. Isot. 64 (2006) 989-994
3. Lemaire C., Cantineau R., Guillaume M., Plenevaux A., and Christiaens L. Fluorine-18-altanserin: a radioligand for the study of serotonin receptors with PET: radiolabeling and in vivo biologic behavior in rats. J. Nucl. Med. 32 (1991) 2266-2272
4. Monclus M., Van Naemen J., Mulleneers E., Damhaut P., Luxen A., and Goldman S. Automatic synthesis of [(18)F]altanserin, a radiopharmaceutical for positron emission tomographic studies of the serotonergic type-2 receptor. Clin. Positron Imaging 1 (1998) 111-116
5. Price J.C., Lopresti B.J., Mason N.S., Holt D.P., Huang Y., and Mathis C.A. Analyses of [(18)F] altanserin bolus injection PET data. I: consideration of radiolabeled metabolites in baboons. Synapse 41 (2001) 1-10
6. Price J.C., Lopresti B.J., Mason N.S., Holt D.P., Huang Y., and Mathis C.A. Analyses of [(18)F] altanserin bolus injection PET data. II: consideration of radiolabeled metabolites in humans. Synapse 41 (2001) 11-21
7. Tan P.Z., Baldwin R.M., Van Dyck C.H., Al-Tikriti M., Roth B., Khan N., Charney D.S., and Innis R.B. Characterization of radioactive metabolites of 5-HT2A receptor PET ligand [18F]altanserin in human and rodent. Nucl. Med. Biol. 26 (1999) 601-608