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Volumn 36, Issue 1, 2012, Pages 22-28

The anti-oxidant and anti-apoptotic effects of nebivolol and zofenopril in a model of cerebral ischemia/reperfusion in rats

Author keywords

Apoptosis; Nebivolol; Oxidative stress; Prolidase; Zofenopril

Indexed keywords

ARYLDIALKYLPHOSPHATASE; CASPASE 3; MALONALDEHYDE; NEBIVOLOL; NITRIC OXIDE; PROLINE DIPEPTIDASE; ZOFENOPRIL;

EID: 82555172350     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2011.08.011     Document Type: Article
Times cited : (40)

References (53)
  • 2
    • 33748258361 scopus 로고    scopus 로고
    • An angiotensin-converting enzyme inhibitor, zofenopril, prevents renal ischemia/reperfusion injury in rats
    • Altunoluk B., Soylemez H., Oguz F., Turkmen E., Fadillioglu E. An angiotensin-converting enzyme inhibitor, zofenopril, prevents renal ischemia/reperfusion injury in rats. Ann Clin Lab Sci 2006, 36:326-332.
    • (2006) Ann Clin Lab Sci , vol.36 , pp. 326-332
    • Altunoluk, B.1    Soylemez, H.2    Oguz, F.3    Turkmen, E.4    Fadillioglu, E.5
  • 3
    • 57649186797 scopus 로고    scopus 로고
    • Post-ischemic brain damage: pathophysiology and role of inflammatory mediators
    • Amantea D., Nappi G., Bernardi G., Bagetta G., Corasaniti M.T. Post-ischemic brain damage: pathophysiology and role of inflammatory mediators. FEBS J 2009, 276:13-26.
    • (2009) FEBS J , vol.276 , pp. 13-26
    • Amantea, D.1    Nappi, G.2    Bernardi, G.3    Bagetta, G.4    Corasaniti, M.T.5
  • 4
    • 34247869032 scopus 로고    scopus 로고
    • Defining the role of zofenopril in the management of hypertension and ischemic heart disorders
    • Ambrosioni E. Defining the role of zofenopril in the management of hypertension and ischemic heart disorders. Am J Cardiovasc Drugs 2007, 7:17-24.
    • (2007) Am J Cardiovasc Drugs , vol.7 , pp. 17-24
    • Ambrosioni, E.1
  • 5
    • 33847301442 scopus 로고    scopus 로고
    • Effects of zofenopril on myocardial ischemia in post-myocardial infarction patients with preserved left ventricular function: the Survival of Myocardial Infarction Long-term Evaluation (SMILE)-ISCHEMIA study
    • Survival of Myocardial Infarction Long-term Evaluation Study Group
    • Borghi C., Ambrosioni E. Effects of zofenopril on myocardial ischemia in post-myocardial infarction patients with preserved left ventricular function: the Survival of Myocardial Infarction Long-term Evaluation (SMILE)-ISCHEMIA study. Am Heart J 2007, 153:7-14. Survival of Myocardial Infarction Long-term Evaluation Study Group.
    • (2007) Am Heart J , vol.153 , pp. 7-14
    • Borghi, C.1    Ambrosioni, E.2
  • 6
    • 80054776666 scopus 로고    scopus 로고
    • Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients
    • Cacciatore F., Bruzzese G., Vitale D.F., Liguori A., de Nigris F., Fiorito C., et al. Effects of ACE inhibition on circulating endothelial progenitor cells, vascular damage, and oxidative stress in hypertensive patients. Eur J Clin Pharmacol 2011, 10.1007/s00228-011-1029-0.
    • (2011) Eur J Clin Pharmacol
    • Cacciatore, F.1    Bruzzese, G.2    Vitale, D.F.3    Liguori, A.4    de Nigris, F.5    Fiorito, C.6
  • 7
    • 0036794826 scopus 로고    scopus 로고
    • Zofenopril inhibits the expression of adhesion molecules on endothelial cells by reducing reactive oxygen species
    • Cominacini L., Pasini A., Garbin U., Evangelista S., Crea A.E., Tagliacozzi D., et al. Zofenopril inhibits the expression of adhesion molecules on endothelial cells by reducing reactive oxygen species. Am J Hypertens 2002, 15:891-895.
    • (2002) Am J Hypertens , vol.15 , pp. 891-895
    • Cominacini, L.1    Pasini, A.2    Garbin, U.3    Evangelista, S.4    Crea, A.E.5    Tagliacozzi, D.6
  • 8
    • 0242552054 scopus 로고    scopus 로고
    • Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation
    • Cominacini L., Fratta, Pasini A., Garbin U., Nava C., Davoli A., et al. Nebivolol and its 4-keto derivative increase nitric oxide in endothelial cells by reducing its oxidative inactivation. J Am Coll Cardiol 2003, 42:1838-1844.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1838-1844
    • Cominacini, L.1    Fratta2    Pasini, A.3    Garbin, U.4    Nava, C.5    Davoli, A.6
  • 9
    • 0025125066 scopus 로고
    • Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method
    • Cortas N.K., Wakid N.W. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 1990, 36:1440-1443.
    • (1990) Clin Chem , vol.36 , pp. 1440-1443
    • Cortas, N.K.1    Wakid, N.W.2
  • 10
    • 24144473653 scopus 로고    scopus 로고
    • Oxidative and antioxidative potential of brain microglial cells
    • Dringen R. Oxidative and antioxidative potential of brain microglial cells. Antioxid Redox Signal 2007, 7:1223-1233.
    • (2007) Antioxid Redox Signal , vol.7 , pp. 1223-1233
    • Dringen, R.1
  • 11
    • 0020534463 scopus 로고
    • The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts
    • Eckerson H.W., Romson J., Wyte C., La Du B.N. The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts. Am J Hum Genet 1983, 35:214-227.
    • (1983) Am J Hum Genet , vol.35 , pp. 214-227
    • Eckerson, H.W.1    Romson, J.2    Wyte, C.3    La Du, B.N.4
  • 12
    • 1542316295 scopus 로고    scopus 로고
    • A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation
    • Erel O. A novel automated direct measurement method for total antioxidant capacity using a new generation, more stable ABTS radical cation. Clin Biochem 2004, 37:277-285.
    • (2004) Clin Biochem , vol.37 , pp. 277-285
    • Erel, O.1
  • 13
    • 29144527533 scopus 로고    scopus 로고
    • A new automated colorimetric method for measuring total oxidant status
    • Erel O. A new automated colorimetric method for measuring total oxidant status. Clin Biochem 2005, 38:1103-1111.
    • (2005) Clin Biochem , vol.38 , pp. 1103-1111
    • Erel, O.1
  • 14
    • 34047229326 scopus 로고    scopus 로고
    • Effect of dl-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells
    • Evangelista S., Garbin U., Pasini A.F., Stranieri C., Boccioletti V., Cominacini L. Effect of dl-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells. Pharmacol Res 2007, 55:303-309.
    • (2007) Pharmacol Res , vol.55 , pp. 303-309
    • Evangelista, S.1    Garbin, U.2    Pasini, A.F.3    Stranieri, C.4    Boccioletti, V.5    Cominacini, L.6
  • 16
    • 1642581441 scopus 로고    scopus 로고
    • Cardioprotective effect of zofenopril in perfused rat heart subjected to ischemia and reperfusion
    • Frascarelli S., Ghelardoni S., Ronca-Testoni S., Zucchi R. Cardioprotective effect of zofenopril in perfused rat heart subjected to ischemia and reperfusion. J Cardiovasc Pharmacol 2004, 43:294-299.
    • (2004) J Cardiovasc Pharmacol , vol.43 , pp. 294-299
    • Frascarelli, S.1    Ghelardoni, S.2    Ronca-Testoni, S.3    Zucchi, R.4
  • 17
    • 0016335917 scopus 로고
    • Superoxide dismutase
    • Fridovich I. Superoxide dismutase. Adv Enzymol 1974, 41:35-97.
    • (1974) Adv Enzymol , vol.41 , pp. 35-97
    • Fridovich, I.1
  • 18
    • 54249115381 scopus 로고    scopus 로고
    • Nebivolol reduces experimentally induced warm renal ischemia reperfusion injury in rats
    • Gandhi C., Zalawadia R., Balaraman R. Nebivolol reduces experimentally induced warm renal ischemia reperfusion injury in rats. Ren Fail 2008, 30:921-930.
    • (2008) Ren Fail , vol.30 , pp. 921-930
    • Gandhi, C.1    Zalawadia, R.2    Balaraman, R.3
  • 19
    • 62949101948 scopus 로고    scopus 로고
    • NADPH oxidases and angiotensin II receptor signaling
    • Garrido A.M., Griendling K.K. NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol 2009, 302:148-158.
    • (2009) Mol Cell Endocrinol , vol.302 , pp. 148-158
    • Garrido, A.M.1    Griendling, K.K.2
  • 20
    • 69549129282 scopus 로고    scopus 로고
    • Short-term treatment with a beta-blocker with vasodilative capacities improves intrarenal endothelial function in experimental renal failure
    • Gschwend S., Haug M.B., Nierhaus M., Schulz A., Vetter R., Kossmehl P., et al. Short-term treatment with a beta-blocker with vasodilative capacities improves intrarenal endothelial function in experimental renal failure. Life Sci 2009, 85:431-437.
    • (2009) Life Sci , vol.85 , pp. 431-437
    • Gschwend, S.1    Haug, M.B.2    Nierhaus, M.3    Schulz, A.4    Vetter, R.5    Kossmehl, P.6
  • 23
    • 77954201785 scopus 로고    scopus 로고
    • Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection
    • Jung J.E., Kim G.S., Chen H., Maier C.M., Narasimhan P., Song Y.S., et al. Reperfusion and neurovascular dysfunction in stroke: from basic mechanisms to potential strategies for neuroprotection. Mol Neurobiol 2010, 41:172-179.
    • (2010) Mol Neurobiol , vol.41 , pp. 172-179
    • Jung, J.E.1    Kim, G.S.2    Chen, H.3    Maier, C.M.4    Narasimhan, P.5    Song, Y.S.6
  • 24
    • 73349124791 scopus 로고    scopus 로고
    • Nebivolol: haemodynamic effects and clinical significance of combined beta-blockade and nitric oxide release
    • Kamp O., Metra M., Bugatti S., Bettari L., Dei Cas A., Petrini N., et al. Nebivolol: haemodynamic effects and clinical significance of combined beta-blockade and nitric oxide release. Drugs 2010, 70:41-56.
    • (2010) Drugs , vol.70 , pp. 41-56
    • Kamp, O.1    Metra, M.2    Bugatti, S.3    Bettari, L.4    Dei Cas, A.5    Petrini, N.6
  • 25
    • 34347266215 scopus 로고    scopus 로고
    • Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia
    • Khan M., Elango C., Ansari M.A., Singh I., Singh A.K. Caffeic acid phenethyl ester reduces neurovascular inflammation and protects rat brain following transient focal cerebral ischemia. J Neurochem 2007, 102:365-377.
    • (2007) J Neurochem , vol.102 , pp. 365-377
    • Khan, M.1    Elango, C.2    Ansari, M.A.3    Singh, I.4    Singh, A.K.5
  • 26
    • 77955845955 scopus 로고    scopus 로고
    • Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia
    • Kilinc M., Gürsoy-Ozdemir Y., Gürer G., Erdener S.E., Erdemli E., Can A., et al. Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia. Neurobiol Dis 2010, 40:293-302.
    • (2010) Neurobiol Dis , vol.40 , pp. 293-302
    • Kilinc, M.1    Gürsoy-Ozdemir, Y.2    Gürer, G.3    Erdener, S.E.4    Erdemli, E.5    Can, A.6
  • 27
    • 49449117172 scopus 로고    scopus 로고
    • Melatonin regulates nitric oxide synthase expression in ischemic brain injury
    • Koh P.O. Melatonin regulates nitric oxide synthase expression in ischemic brain injury. J Vet Med Sci 2008, 70:747-750.
    • (2008) J Vet Med Sci , vol.70 , pp. 747-750
    • Koh, P.O.1
  • 28
    • 33746387005 scopus 로고    scopus 로고
    • Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice
    • Kuang X., Yao Y., Du J.R., Liu Y.X., Wang C.Y., Qian Z.M. Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice. Brain Res 2006, 1102:145-153.
    • (2006) Brain Res , vol.1102 , pp. 145-153
    • Kuang, X.1    Yao, Y.2    Du, J.R.3    Liu, Y.X.4    Wang, C.Y.5    Qian, Z.M.6
  • 29
    • 70249144995 scopus 로고    scopus 로고
    • Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model
    • Lapchak P.A. Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model. Brain Res 2009, 1294:211-217.
    • (2009) Brain Res , vol.1294 , pp. 211-217
    • Lapchak, P.A.1
  • 31
    • 79954568978 scopus 로고    scopus 로고
    • A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness
    • Maes M., Galecki P., Chang Y.S., Berk M. A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35:676-692.
    • (2011) Prog Neuropsychopharmacol Biol Psychiatry , vol.35 , pp. 676-692
    • Maes, M.1    Galecki, P.2    Chang, Y.S.3    Berk, M.4
  • 32
    • 0025110014 scopus 로고
    • Protective effects of sulfhydryl-containing angiotensin converting enzyme inhibitors against free radical injury in endothelial cells
    • Mak I.T., Freedman A.M., Dickens B.F., Weglicki W.B. Protective effects of sulfhydryl-containing angiotensin converting enzyme inhibitors against free radical injury in endothelial cells. Biochem Pharmacol 1990, 40:2169-2175.
    • (1990) Biochem Pharmacol , vol.40 , pp. 2169-2175
    • Mak, I.T.1    Freedman, A.M.2    Dickens, B.F.3    Weglicki, W.B.4
  • 33
    • 1542542220 scopus 로고    scopus 로고
    • An AT1-receptor antagonist and an angiotensin-converting enzyme inhibitor protect against hypoxia-induced apoptosis in human aortic endothelial cells through upregulation of endothelial cell nitric oxide synthase activity
    • Matsumoto N., Manabe H., Ochiai J., Fujita N., Takagi T., Uemura M., et al. An AT1-receptor antagonist and an angiotensin-converting enzyme inhibitor protect against hypoxia-induced apoptosis in human aortic endothelial cells through upregulation of endothelial cell nitric oxide synthase activity. Shock 2003, 19:547-552.
    • (2003) Shock , vol.19 , pp. 547-552
    • Matsumoto, N.1    Manabe, H.2    Ochiai, J.3    Fujita, N.4    Takagi, T.5    Uemura, M.6
  • 35
    • 17944397753 scopus 로고    scopus 로고
    • Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension
    • Napoli C., Sica V., de Nigris F., Pignalosa O., Condorelli M., Ignarro L.J., et al. Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension. Am Heart J 2004, 148:1-5.
    • (2004) Am Heart J , vol.148 , pp. 1-5
    • Napoli, C.1    Sica, V.2    de Nigris, F.3    Pignalosa, O.4    Condorelli, M.5    Ignarro, L.J.6
  • 36
    • 33750600184 scopus 로고    scopus 로고
    • Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats
    • Oelze M., Daiber A., Brandes R.P., Hortmann M., Wenzel P., Hink U., et al. Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats. Hypertens 2006, 48:677-684.
    • (2006) Hypertens , vol.48 , pp. 677-684
    • Oelze, M.1    Daiber, A.2    Brandes, R.P.3    Hortmann, M.4    Wenzel, P.5    Hink, U.6
  • 37
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H., Ohishi N., Tagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979, 95:351-358.
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Tagi, K.3
  • 39
    • 79956093736 scopus 로고    scopus 로고
    • Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method
    • Ozturk E, Balat O, Acilmis YG, Ozcan C, Pence S, Erel O. Measurement of the placental total antioxidant status in preeclamptic women using a novel automated method. J Obstet Gynaecol Res 2011;37:337-42.
    • (2011) J Obstet Gynaecol Res , vol.37 , pp. 337-342
    • Ozturk, E.1    Balat, O.2    Acilmis, Y.G.3    Ozcan, C.4    Pence, S.5    Erel, O.6
  • 40
  • 41
    • 15744379732 scopus 로고    scopus 로고
    • Significance of elevated blood pressure and its management on the short-term outcome of patients with acute ischemic stroke
    • Rodriguez-Garcia J.L., Botia E., de La Sierra A., Villanueva M.A., Gonzalez-Spinola J. Significance of elevated blood pressure and its management on the short-term outcome of patients with acute ischemic stroke. Am J Hypertens 2005, 18:379-384.
    • (2005) Am J Hypertens , vol.18 , pp. 379-384
    • Rodriguez-Garcia, J.L.1    Botia, E.2    de La Sierra, A.3    Villanueva, M.A.4    Gonzalez-Spinola, J.5
  • 42
    • 0345167921 scopus 로고    scopus 로고
    • The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress
    • Scribner A.W., Loscalzo J., Napoli C. The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress. Eur J Pharmacol 2003, 482:95-99.
    • (2003) Eur J Pharmacol , vol.482 , pp. 95-99
    • Scribner, A.W.1    Loscalzo, J.2    Napoli, C.3
  • 43
    • 79952376741 scopus 로고    scopus 로고
    • The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats
    • Shi L.L., Chen B.N., Gao M., Zhang H.A., Li Y.J., Wang L., et al. The characteristics of therapeutic effect of pinocembrin in transient global brain ischemia/reperfusion rats. Life Sci 2011, 88:521-528.
    • (2011) Life Sci , vol.88 , pp. 521-528
    • Shi, L.L.1    Chen, B.N.2    Gao, M.3    Zhang, H.A.4    Li, Y.J.5    Wang, L.6
  • 44
    • 0021244677 scopus 로고
    • Models for studying long-term recovery following forebrain ischemia in the rat, II: a 2-vessel occlusion model
    • Smith M.L., Bendek G., Dahlgren N., Rosen I., Wieloch T., Siesjo B.K. Models for studying long-term recovery following forebrain ischemia in the rat, II: a 2-vessel occlusion model. Acta Neurol Scand 1984, 69:385-401.
    • (1984) Acta Neurol Scand , vol.69 , pp. 385-401
    • Smith, M.L.1    Bendek, G.2    Dahlgren, N.3    Rosen, I.4    Wieloch, T.5    Siesjo, B.K.6
  • 45
    • 79951677752 scopus 로고    scopus 로고
    • Nebivolol has protective effect against endothelial and ileal dysfunction due to I/R
    • Soydan G., Cekiç E.G., Tuncer M. Nebivolol has protective effect against endothelial and ileal dysfunction due to I/R. J Surg Res 2011, 166:156-161.
    • (2011) J Surg Res , vol.166 , pp. 156-161
    • Soydan, G.1    Cekiç, E.G.2    Tuncer, M.3
  • 46
    • 28144453502 scopus 로고    scopus 로고
    • Nitric oxide regulates prolidase activity by serine/threonine phosphorylation
    • Surazynski A., Liu Y., Miltyk W., Phang J.M. Nitric oxide regulates prolidase activity by serine/threonine phosphorylation. J Cell Biochem 2005, 96:1086-1094.
    • (2005) J Cell Biochem , vol.96 , pp. 1086-1094
    • Surazynski, A.1    Liu, Y.2    Miltyk, W.3    Phang, J.M.4
  • 48
    • 77951287071 scopus 로고    scopus 로고
    • Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats
    • Toblli J., Cao G., Rivas C., Munoz M., Giani J., Dominici F., et al. Cardiovascular protective effects of nebivolol in Zucker diabetic fatty rats. J Hypertens 2010, 28:1007-1019.
    • (2010) J Hypertens , vol.28 , pp. 1007-1019
    • Toblli, J.1    Cao, G.2    Rivas, C.3    Munoz, M.4    Giani, J.5    Dominici, F.6
  • 49
    • 0036035522 scopus 로고    scopus 로고
    • Medroxyprogesterone acetate, enoxaparin and pentoxyfylline cause alterations in lipid peroxidation, paraoxonase (PON1) activities and homocysteine levels in the acute oxidative stress in an experimental model of spinal cord injury
    • Topsakal C., Kilic N., Erol F.S., Kaplan M., Akdemir I., Tiftikci M., et al. Medroxyprogesterone acetate, enoxaparin and pentoxyfylline cause alterations in lipid peroxidation, paraoxonase (PON1) activities and homocysteine levels in the acute oxidative stress in an experimental model of spinal cord injury. Acta Neurochir (Wien) 2002, 144:1021-1031.
    • (2002) Acta Neurochir (Wien) , vol.144 , pp. 1021-1031
    • Topsakal, C.1    Kilic, N.2    Erol, F.S.3    Kaplan, M.4    Akdemir, I.5    Tiftikci, M.6
  • 50
    • 33744517635 scopus 로고    scopus 로고
    • Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
    • Wang Z.F., Tang L.L., Yan H., Wang Y.J., Tang X.C. Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice. Pharmacol Biochem Behav 2006, 83:603-611.
    • (2006) Pharmacol Biochem Behav , vol.83 , pp. 603-611
    • Wang, Z.F.1    Tang, L.L.2    Yan, H.3    Wang, Y.J.4    Tang, X.C.5
  • 51
    • 67650457594 scopus 로고    scopus 로고
    • Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat
    • Whaley-Connell A., Habibi J., Johnson M., Tilmon R., Rehmer N., Rehmer J., et al. Nebivolol reduces proteinuria and renal NADPH oxidase-generated reactive oxygen species in the transgenic Ren2 rat. Am J Nephrol 2009, 30:354-360.
    • (2009) Am J Nephrol , vol.30 , pp. 354-360
    • Whaley-Connell, A.1    Habibi, J.2    Johnson, M.3    Tilmon, R.4    Rehmer, N.5    Rehmer, J.6
  • 52
    • 40849084883 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase involved in NGF/VEGF-induced neuroprotective effect
    • Yang J.P., Liu X.F., Liu H.J., Xu G.L., Ma Y.P. Extracellular signal-regulated kinase involved in NGF/VEGF-induced neuroprotective effect. Neurosci Lett 2008, 434:212-217.
    • (2008) Neurosci Lett , vol.434 , pp. 212-217
    • Yang, J.P.1    Liu, X.F.2    Liu, H.J.3    Xu, G.L.4    Ma, Y.P.5


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