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Volumn 440, Issue 3, 2011, Pages 309-318

Salmonella enterica serotype Typhimurium usurps the scaffold protein IQGAP1 to manipulate Rac1 and MAPK signalling

Author keywords

IQ motif containing GTPase activating protein 1 (IQGAP1); Microbial pathogenesis; Protein scaffold; Salmonella

Indexed keywords

IQ MOTIF CONTAINING GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; RAC1 PROTEIN;

EID: 82455220362     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110419     Document Type: Article
Times cited : (23)

References (50)
  • 1
    • 77955878047 scopus 로고    scopus 로고
    • Foodborne illness: Is it on the rise?
    • Nyachuba, D. G. (2010) Foodborne illness: is it on the rise? Nutr. Rev. 68, 257-269
    • (2010) Nutr. Rev. , vol.68 , pp. 257-269
    • Nyachuba, D.G.1
  • 2
    • 73649135423 scopus 로고    scopus 로고
    • Global trends in typhoid and paratyphoid fever
    • Crump, J. A. and Mintz, E. D. (2010) Global trends in typhoid and paratyphoid fever. Clin. Infect. Dis. 50, 241-246
    • (2010) Clin. Infect. Dis. , vol.50 , pp. 241-246
    • Crump, J.A.1    Mintz, E.D.2
  • 3
    • 0037452070 scopus 로고    scopus 로고
    • Microbial pathogenesis and cytoskeletal function
    • DOI 10.1038/nature01603
    • Gruenheid, S. and Finlay, B. B. (2003) Microbial pathogenesis and cytoskeletal function. Nature 422, 775-781 (Pubitemid 36514121)
    • (2003) Nature , vol.422 , Issue.6933 , pp. 775-781
    • Gruenheid, S.1    Finlay, B.B.2
  • 4
    • 0035432063 scopus 로고    scopus 로고
    • Pathogenic trickery: Deception of host cell processes
    • DOI 10.1038/35085062
    • Knodler, L. A., Celli, J. and Finlay, B. B. (2001) Pathogenic trickery: deception of host cell processes. Nat. Rev. Mol. Cell Biol. 2, 578-588 (Pubitemid 33674009)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.8 , pp. 578-588
    • Knodler, L.A.1    Celli, J.2    Brett, F.B.3
  • 5
    • 35448975718 scopus 로고    scopus 로고
    • Type III secretion systems and disease
    • DOI 10.1128/CMR.00013-07
    • Coburn, B., Sekirov, I. and Finlay, B. B. (2007) Type III secretion systems and disease. Clin. Microbiol. Rev. 20, 535-549 (Pubitemid 47623767)
    • (2007) Clinical Microbiology Reviews , vol.20 , Issue.4 , pp. 535-549
    • Coburn, B.1    Sekirov, I.2    Finlay, B.B.3
  • 6
    • 0032577563 scopus 로고    scopus 로고
    • S. typhimurium Encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells
    • DOI 10.1016/S0092-8674(00)81442-7
    • Hardt, W. D., Chen, L. M., Schuebel, K. E., Bustelo, X. R. and Galan, J. E. (1998) S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells. Cell 93, 815-826 (Pubitemid 28257587)
    • (1998) Cell , vol.93 , Issue.5 , pp. 815-826
    • Hardt, W.-D.1    Chen, L.-M.2    Schuebel, K.E.3    Bustelo, X.R.4    Galan, J.E.5
  • 7
    • 0035823591 scopus 로고    scopus 로고
    • SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell
    • Friebel, A., Ilchmann, H., Aepfelbacher, M., Ehrbar, K., Machleidt, W. and Hardt, W. D. (2001) SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell. J. Biol. Chem. 276, 34035-34040
    • (2001) J. Biol. Chem. , vol.276 , pp. 34035-34040
    • Friebel, A.1    Ilchmann, H.2    Aepfelbacher, M.3    Ehrbar, K.4    Machleidt, W.5    Hardt, W.D.6
  • 8
    • 23844535784 scopus 로고    scopus 로고
    • WAVE2 signaling mediates invasion of polarized epithelial cells by Salmonella typhimurium
    • DOI 10.1074/jbc.M500617200
    • Shi, J., Scita, G. and Casanova, J. E. (2005) WAVE2 signalling mediates invasion of polarized epithelial cells by Salmonella typhimurium. J. Biol. Chem. 280, 29849-29855 (Pubitemid 41177062)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.33 , pp. 29849-29855
    • Shi, J.1    Scita, G.2    Casanova, J.E.3
  • 9
    • 33845729059 scopus 로고    scopus 로고
    • The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton
    • DOI 10.1038/nrm2069, PII NRM2069
    • Takenawa, T. and Suetsugu, S. (2007) The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat. Rev. Mol. Cell Biol. 8, 37-48 (Pubitemid 46012013)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.1 , pp. 37-48
    • Takenawa, T.1    Suetsugu, S.2
  • 10
    • 0037406727 scopus 로고    scopus 로고
    • Coordinate regulation of Salmonella enterica serovar typhimurium invasion of epithelial cells by the Arp2/3 complex and Rho GTPases
    • DOI 10.1128/IAI.71.5.2885-2891.2003
    • Criss, A. K. and Casanova, J. E. (2003) Co-ordinate regulation of Salmonella enterica serovar typhimurium invasion of epithelial cells by the Arp2/3 complex and Rho GTPases. Infect. Immun. 71, 2885-2891 (Pubitemid 36519903)
    • (2003) Infection and Immunity , vol.71 , Issue.5 , pp. 2885-2891
    • Criss, A.K.1    Casanova, J.E.2
  • 11
    • 0030448437 scopus 로고    scopus 로고
    • Requirement of CDC42 for Salmonella-induced cytoskeletal and nuclear responses
    • DOI 10.1126/science.274.5295.2115
    • Chen, L. M., Hobbie, S. and Galan, J. E. (1996) Requirement of Cdc42 for Salmonella -induced cytoskeletal and nuclear responses. Science 274, 2115-2118 (Pubitemid 27020711)
    • (1996) Science , vol.274 , Issue.5295 , pp. 2115-2118
    • Chen, L.-M.1    Hobbie, S.2    Galan, J.E.3
  • 12
    • 33750724697 scopus 로고    scopus 로고
    • Differential activation and function of Rho GTPases during Salmonella -host cell interactions
    • Patel, J. C. and Galan, J. E. (2006) Differential activation and function of Rho GTPases during Salmonella -host cell interactions. J. Cell Biol. 175, 453-463
    • (2006) J. Cell Biol. , vol.175 , pp. 453-463
    • Patel, J.C.1    Galan, J.E.2
  • 13
    • 77952725343 scopus 로고    scopus 로고
    • Salmonella enterica serovar Typhimurium invades fibroblasts by multiple routes differing from the entry into epithelial cells
    • Aiastui, A., Pucciarelli, M. G. and Garcia-del Portillo, F. (2010) Salmonella enterica serovar Typhimurium invades fibroblasts by multiple routes differing from the entry into epithelial cells. Infect. Immun. 78, 2700-2713
    • (2010) Infect. Immun. , vol.78 , pp. 2700-2713
    • Aiastui, A.1    Pucciarelli, M.G.2    Garcia-del Portillo, F.3
  • 14
    • 34250671989 scopus 로고    scopus 로고
    • Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: A perspective
    • DOI 10.1016/j.cellsig.2007.04.012, PII S0898656807001222
    • Pullikuth, A. K. and Catling, A. D. (2007) Scaffold mediated regulation of MAPK signalling and cytoskeletal dynamics: a perspective. Cell. Signalling 19, 1621-1632 (Pubitemid 46935436)
    • (2007) Cellular Signalling , vol.19 , Issue.8 , pp. 1621-1632
    • Pullikuth, A.K.1    Catling, A.D.2
  • 15
    • 0034997845 scopus 로고    scopus 로고
    • Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions
    • DOI 10.1210/er.22.2.153
    • Pearson, G., Robinson, F., Beers Gibson, T., Xu, B. E., Karandikar, M., Berman, K. and Cobb, M. H. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr. Rev. 22, 153-183 (Pubitemid 32458157)
    • (2001) Endocrine Reviews , vol.22 , Issue.2 , pp. 153-183
    • Pearson, G.1    Robinson, F.2    Gibson, T.B.3    Xu, B.-E.4    Karandikar, M.5    Berman, K.6    Cobb, M.H.7
  • 16
    • 2942530310 scopus 로고    scopus 로고
    • ERK and p38 MAPK-activated protein kinases: A family of protein kinases with diverse biological functions
    • DOI 10.1128/MMBR.68.2.320-344.2004
    • Roux, P. P. and Blenis, J. (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol. Mol. Biol. Rev. 68, 320-344 (Pubitemid 38756868)
    • (2004) Microbiology and Molecular Biology Reviews , vol.68 , Issue.2 , pp. 320-344
    • Roux, P.P.1    Blenis, J.2
  • 17
    • 0036137133 scopus 로고    scopus 로고
    • Proteolytic inhibition of Salmonella enterica serovar Typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells
    • DOI 10.1128/IAI.70.1.86-95.2002
    • Mynott, T. L., Crossett, B. and Prathalingam, S. R. (2002) Proteolytic inhibition of Salmonella enterica serovar Typhimurium-induced activation of the mitogen-activated protein kinases ERK and JNK in cultured human intestinal cells. Infect. Immun. 70, 86-95 (Pubitemid 34028602)
    • (2002) Infection and Immunity , vol.70 , Issue.1 , pp. 86-95
    • Mynott, T.L.1    Crossett, B.2    Prathalingam, S.R.3
  • 18
    • 0031306875 scopus 로고    scopus 로고
    • Involvement of Mitogen-Activated Protein Kinase Pathways in the Nuclear Responses and Cytokine Production Induced by Salmonella typhimurium in Cultured Intestinal Epithelial Cells
    • Hobbie, S., Chen, L. M., Davis, R. J. and Galan, J. E. (1997) Involvement of mitogen-activated protein kinase pathways in the nuclear responses and cytokine production induced by Salmonella typhimurium in cultured intestinal epithelial cells. J. Immunol. 159, 5550-5559 (Pubitemid 127470084)
    • (1997) Journal of Immunology , vol.159 , Issue.11 , pp. 5550-5559
    • Hobbie, S.1    Chen, L.M.2    Davis, R.J.3    Galan, J.E.4
  • 19
    • 0032975712 scopus 로고    scopus 로고
    • Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates
    • Procyk, K. J., Kovarik, P., von Gabain, A. and Baccarini, M. (1999) Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. Infect. Immun. 67, 1011-1017 (Pubitemid 29108471)
    • (1999) Infection and Immunity , vol.67 , Issue.3 , pp. 1011-1017
    • Procyk, K.J.1    Kovarik, P.2    Von Gabain, A.3    Baccarini, M.4
  • 20
    • 0043093686 scopus 로고    scopus 로고
    • IQGAP proteins are integral components of cytoskeletal regulation
    • DOI 10.1038/sj.embor.embor867
    • Briggs, M. W. and Sacks, D. B. (2003) IQGAP proteins are integral components of cytoskeletal regulation. EMBO Rep. 4, 571-574 (Pubitemid 36939947)
    • (2003) EMBO Reports , vol.4 , Issue.6 , pp. 571-574
    • Briggs, M.W.1    Sacks, D.B.2
  • 21
    • 21044443326 scopus 로고    scopus 로고
    • IQGAP1: A key regulator of adhesion and migration
    • DOI 10.1242/jcs.02379
    • Noritake, J., Watanabe, T., Sato, K., Wang, S. and Kaibuchi, K. (2005) IQGAP1: a key regulator of adhesion and migration. J. Cell Sci. 118, 2085-2092 (Pubitemid 40872832)
    • (2005) Journal of Cell Science , vol.118 , Issue.10 , pp. 2085-2092
    • Noritake, J.1    Watanabe, T.2    Sato, K.3    Wang, S.4    Kaibuchi, K.5
  • 25
    • 0037025333 scopus 로고    scopus 로고
    • IQGAP1 is a component of Cdc42 signaling to the cytoskeleton
    • DOI 10.1074/jbc.M111165200
    • Swart-Mataraza, J. M., Li, Z. and Sacks, D. B. (2002) IQGAP1 is a component of Cdc42 signalling to the cytoskeleton. J. Biol. Chem. 277, 24753-24763 (Pubitemid 34952007)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.27 , pp. 24753-24763
    • Swart-Mataraza, J.M.1    Li, Z.2    Sacks, D.B.3
  • 27
    • 0029891491 scopus 로고    scopus 로고
    • IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs
    • Hart, M. J., Callow, M. G., Souza, B. and Polakis, P. (1996) IQGAP1, a calmodulin-binding protein with a RasGAP-related domain, is a potential effector for Cdc42Hs. EMBO J. 15, 2997-3005 (Pubitemid 26187748)
    • (1996) EMBO Journal , vol.15 , Issue.12 , pp. 2997-3005
    • Hart, M.J.1    Callow, M.G.2    Souza, B.3    Polakis, P.4
  • 28
    • 33646726750 scopus 로고    scopus 로고
    • IQGAP1 in cellular signaling: bridging the GAP
    • DOI 10.1016/j.tcb.2006.03.002, PII S0962892406000821
    • Brown, M. D. and Sacks, D. B. (2006) IQGAP1 in cellular signalling: bridging the GAP. Trends Cell Biol. 16, 242-249 (Pubitemid 43744436)
    • (2006) Trends in Cell Biology , vol.16 , Issue.5 , pp. 242-249
    • Brown, M.D.1    Sacks, D.B.2
  • 30
    • 24344491858 scopus 로고    scopus 로고
    • IQGAP1 is a scaffold for mitogen-activated protein kinase signaling
    • DOI 10.1128/MCB.25.18.7940-7952.2005
    • Roy, M., Li, Z. and Sacks, D. B. (2005) IQGAP1 is a scaffold for mitogen-activated protein kinase signalling. Mol. Cell Biol. 25, 7940-7952 (Pubitemid 41262989)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.18 , pp. 7940-7952
    • Roy, M.1    Li, Z.2    Sacks, D.B.3
  • 31
    • 2342424547 scopus 로고    scopus 로고
    • IQGAP1 Binds ERK2 and Modulates Its Activity
    • DOI 10.1074/jbc.M308405200
    • Roy, M., Li, Z. and Sacks, D. B. (2004) IQGAP1 binds ERK2 and modulates its activity. J. Biol. Chem. 279, 17329-17337 (Pubitemid 38560493)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.17 , pp. 17329-17337
    • Roy, M.1    Li, Z.2    Sacks, D.B.3
  • 32
    • 79952317707 scopus 로고    scopus 로고
    • IQGAP1 in microbial pathogenesis: Targeting the actin cytoskeleton
    • Kim, H., White, C. D. and Sacks, D. B. (2011) IQGAP1 in microbial pathogenesis: targeting the actin cytoskeleton. FEBS Lett. 585, 723-729
    • (2011) FEBS Lett. , vol.585 , pp. 723-729
    • Kim, H.1    White, C.D.2    Sacks, D.B.3
  • 33
    • 35648942810 scopus 로고    scopus 로고
    • IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42
    • DOI 10.1074/jbc.M702537200
    • Brown, M. D., Bry, L., Li, Z. and Sacks, D. B. (2007) IQGAP1 regulates Salmonella invasion through interactions with actin, Rac1, and Cdc42. J. Biol. Chem. 282, 30265-30272 (Pubitemid 350035299)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.41 , pp. 30265-30272
    • Brown, M.D.1    Bry, L.2    Li, Z.3    Sacks, D.B.4
  • 34
    • 58049216318 scopus 로고    scopus 로고
    • Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin
    • Brown, M. D., Bry, L., Li, Z. and Sacks, D. B. (2008) Actin pedestal formation by enteropathogenic Escherichia coli is regulated by IQGAP1, calcium, and calmodulin. J. Biol. Chem. 283, 35212-35222
    • (2008) J. Biol. Chem. , vol.283 , pp. 35212-35222
    • Brown, M.D.1    Bry, L.2    Li, Z.3    Sacks, D.B.4
  • 38
    • 34447565907 scopus 로고    scopus 로고
    • Multiple proteins mediate IQGAP1-stimulated cell migration
    • DOI 10.1016/j.cellsig.2007.04.011, PII S0898656807001209
    • Mataraza, J. M., Li, Z., Jeong, H. W., Brown, M. D. and Sacks, D. B. (2007) Multiple proteins mediate IQGAP1-stimulated cell migration. Cell. Signalling 19, 1857-1865 (Pubitemid 47081378)
    • (2007) Cellular Signalling , vol.19 , Issue.9 , pp. 1857-1865
    • Mataraza, J.M.1    Li, Z.2    Jeong, H.-W.3    Brown, M.D.4    Sacks, D.B.5
  • 39
    • 0035930580 scopus 로고    scopus 로고
    • The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42
    • Sokol, S. Y., Li, Z. and Sacks, D. B. (2001) The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42. J. Biol. Chem. 276, 48425-48430
    • (2001) J. Biol. Chem. , vol.276 , pp. 48425-48430
    • Sokol, S.Y.1    Li, Z.2    Sacks, D.B.3
  • 40
    • 3242782491 scopus 로고    scopus 로고
    • Secretion and function of Salmonella SPI-2 effector SseF require its chaperone, SscB
    • DOI 10.1128/JB.186.15.5078-5086.2004
    • Dai, S. and Zhou, D. (2004) Secretion and function of Salmonella SPI-2 effector SseF require its chaperone, SscB. J. Bacteriol. 186, 5078-5086 (Pubitemid 38970834)
    • (2004) Journal of Bacteriology , vol.186 , Issue.15 , pp. 5078-5086
    • Dai, S.1    Zhou, D.2
  • 41
    • 0025890969 scopus 로고
    • Mechanism of collagen phagocytosis by human gingival fibroblasts: Importance of collagen structure in cell recognition and internalization
    • Knowles, G. C., McKeown, M., Sodek, J. and McCulloch, C. A. (1991) Mechanism of collagen phagocytosis by human gingival fibroblasts: importance of collagen structure in cell recognition and internalization. J. Cell Sci. 98, 551-558 (Pubitemid 21925005)
    • (1991) Journal of Cell Science , vol.98 , Issue.4 , pp. 551-558
    • Knowles, G.C.1    Mckeown, M.2    Sodek, J.3    Mcculloch, C.A.G.4
  • 42
    • 0035154467 scopus 로고    scopus 로고
    • Involvement of actin filaments and integrins in the binding step in collagen phagocytosis by human fibroblasts
    • Segal, G., Lee, W., Arora, P. D., McKee, M., Downey, G. and McCulloch, C. A. (2001) Involvement of actin filaments and integrins in the binding step in collagen phagocytosis by human fibroblasts. J. Cell Sci. 114, 119-129 (Pubitemid 32118062)
    • (2001) Journal of Cell Science , vol.114 , Issue.1 , pp. 119-129
    • Segal, G.1    Lee, W.2    Arora, P.D.3    McKee, M.4    Downey, G.5    McCulloch, C.A.G.6
  • 43
    • 0034711219 scopus 로고    scopus 로고
    • E-cadherin-mediated cell-cell attachment activates Cdc42
    • DOI 10.1074/jbc.M003430200
    • Kim, S. H., Li, Z. and Sacks, D. B. (2000) E-cadherin-mediated cell-cell attachment activates Cdc42. J. Biol. Chem. 275, 36999-37005 (Pubitemid 32002115)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.47 , pp. 36999-37005
    • Kim, S.H.1    Li, Z.2    Sacks, D.B.3
  • 44
    • 0033157323 scopus 로고    scopus 로고
    • Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway
    • Steele-Mortimer, O., Meresse, S., Gorvel, J. P., Toh, B. H. and Finlay, B. B. (1999) Biogenesis of Salmonella typhimurium-containing vacuoles in epithelial cells involves interactions with the early endocytic pathway. Cell. Microbiol. 1, 33-49 (Pubitemid 129667951)
    • (1999) Cellular Microbiology , vol.1 , Issue.1 , pp. 33-49
    • Steele-Mortimer, O.1    Meresse, S.2    Gorvel, J.-P.3    Toh, B.-H.4    Finlay, B.B.5
  • 45
    • 34250729896 scopus 로고    scopus 로고
    • Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation
    • DOI 10.1083/jcb.200612071
    • Brandt, D. T., Marion, S., Griffiths, G., Watanabe, T., Kaibuchi, K. and Grosse, R. (2007) Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation. J. Cell Biol. 178, 193-200 (Pubitemid 47076456)
    • (2007) Journal of Cell Biology , vol.178 , Issue.2 , pp. 193-200
    • Brandt, D.T.1    Marion, S.2    Griffiths, G.3    Watanabe, T.4    Kaibuchi, K.5    Grosse, R.6
  • 46
    • 0029763527 scopus 로고    scopus 로고
    • Role of integrins in regulation of collagen phagocytosis by human fibroblasts
    • DOI 10.1002/(SICI)1097-4652(199609)168:3<695::AID-JCP22>3.0.CO;2-X
    • Lee, W., Sodek, J. and McCulloch, C. A. (1996) Role of integrins in regulation of collagen phagocytosis by human fibroblasts. J. Cell. Physiol. 168, 695-704 (Pubitemid 26302876)
    • (1996) Journal of Cellular Physiology , vol.168 , Issue.3 , pp. 695-704
    • Lee, W.1    Sodek, J.2    McCulloch, C.A.G.3
  • 47
    • 59749095198 scopus 로고    scopus 로고
    • Protein scaffolds in MAP kinase signalling
    • Brown, M. D. and Sacks, D. B. (2009) Protein scaffolds in MAP kinase signalling. Cell. Signalling 21, 462-469
    • (2009) Cell. Signalling , vol.21 , pp. 462-469
    • Brown, M.D.1    Sacks, D.B.2
  • 48
    • 33751294581 scopus 로고    scopus 로고
    • The role of scaffold proteins in MEK/ERK signalling
    • Sacks, D. B. (2006) The role of scaffold proteins in MEK/ERK signalling. Biochem. Soc. Trans. 34, 833-836
    • (2006) Biochem. Soc. Trans. , vol.34 , pp. 833-836
    • Sacks, D.B.1
  • 49
    • 70849112486 scopus 로고    scopus 로고
    • Cell signalling in space and time: Where proteins come together and when they're apart
    • Scott, J. D. and Pawson, T. (2009) Cell signalling in space and time: where proteins come together and when they're apart. Science 326, 1220-1224
    • (2009) Science , vol.326 , pp. 1220-1224
    • Scott, J.D.1    Pawson, T.2


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