-
1
-
-
20344370764
-
Allosteric mechanisms of signal transduction
-
DOI 10.1126/science.1108595
-
Changeux, J. P., and Edelstein, S. J. (2005) Allosteric mechanisms of signal transduction, Science 308, 1424-1428. (Pubitemid 40791288)
-
(2005)
Science
, vol.308
, Issue.5727
, pp. 1424-1428
-
-
Changeux, J.-P.1
Edelstein, S.J.2
-
2
-
-
50449109973
-
Allostery: An illustrated definition for the 'second secret of life'
-
Fenton, A. W. (2008) Allostery: an illustrated definition for the 'second secret of life', Trends Biochem Sci 33, 420-425.
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 420-425
-
-
Fenton, A.W.1
-
3
-
-
0032199006
-
Binding, gating, affinity and efficacy: The interpretation of structureactivity relationships for agonists and of the effects of mutating receptors
-
Colquhoun, D. (1998) Binding, gating, affinity and efficacy: the interpretation of structureactivity relationships for agonists and of the effects of mutating receptors, Br J Pharmacol 125, 924-947.
-
(1998)
Br J Pharmacol
, vol.125
, pp. 924-947
-
-
Colquhoun, D.1
-
4
-
-
0021504608
-
The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus)
-
Carter, P. J., Winter, G., Wilkinson, A. J., and Fersht, A. R. (1984) The use of double mutants to detect structural changes in the active site of the tyrosyl-tRNA synthetase (Bacillus stearothermophilus), Cell 38, 835-840.
-
(1984)
Cell
, vol.38
, pp. 835-840
-
-
Carter, P.J.1
Winter, G.2
Wilkinson, A.J.3
Fersht, A.R.4
-
5
-
-
0037448581
-
A receptor
-
DOI 10.1038/nature01280
-
Kash, T. L., Jenkins, A., Kelley, J. C., Trudell, J. R., and Harrison, N. L. (2003) Coupling of agonist binding to channel gating in the GABA(A) receptor, Nature 421, 272-275. (Pubitemid 36139131)
-
(2003)
Nature
, vol.421
, Issue.6920
, pp. 272-275
-
-
Kash, T.L.1
Jenkins, A.2
Kelley, J.C.3
Trudell, J.R.4
Harrison, N.L.5
-
6
-
-
58149093958
-
An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating
-
Gleitsman, K. R., Kedrowski, S. M., Lester, H. A., and Dougherty, D. A. (2008) An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating, J Biol Chem 283, 35638-35643.
-
(2008)
J Biol Chem
, vol.283
, pp. 35638-35643
-
-
Gleitsman, K.R.1
Kedrowski, S.M.2
Lester, H.A.3
Dougherty, D.A.4
-
7
-
-
34548485996
-
C receptors
-
DOI 10.1074/jbc.M702524200
-
Price, K. L., Millen, K. S., and Lummis, S. C. (2007) Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors, J Biol Chem 282, 25623-25630. (Pubitemid 47372843)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.35
, pp. 25623-25630
-
-
Price, K.L.1
Millen, K.S.2
Lummis, S.C.R.3
-
8
-
-
51649117317
-
A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics
-
Venkatachalan, S. P., and Czajkowski, C. (2008) A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics, Proc Natl Acad Sci U S A 105, 13604-13609.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13604-13609
-
-
Venkatachalan, S.P.1
Czajkowski, C.2
-
9
-
-
0034607683
-
Evidence for long range allosteric interactions between the extracellular and cytoplasmic parts of bacteriorhodopsin from the mutant R82A and its second site revertant R82A/G231C
-
DOI 10.1074/jbc.275.18.13431
-
Alexiev, U., Mollaaghababa, R., Khorana, H. G., and Heyn, M. P. (2000) Evidence for long range allosteric interactions between the extracellular and cytoplasmic parts of bacteriorhodopsin from the mutant R82A and its second site revertant R82A/G231C, J Biol Chem 275, 13431-13440. (Pubitemid 30257406)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.18
, pp. 13431-13440
-
-
Alexiev, U.1
Mollaaghababa, R.2
Gobind Khorana, H.3
Heyn, M.P.4
-
10
-
-
67649400916
-
Long-range coupling in an allosteric receptor revealed by mutant cycle analysis
-
Gleitsman, K. R., Shanata, J. A., Frazier, S. J., Lester, H. A., and Dougherty, D. A. (2009) Long-range coupling in an allosteric receptor revealed by mutant cycle analysis, Biophys J 96, 3168-3178.
-
(2009)
Biophys J
, vol.96
, pp. 3168-3178
-
-
Gleitsman, K.R.1
Shanata, J.A.2
Frazier, S.J.3
Lester, H.A.4
Dougherty, D.A.5
-
11
-
-
3342967463
-
Ligand-binding residues integrate affinity and efficacy in the NMDA receptor
-
DOI 10.1124/mol.66.2.209
-
Kalbaugh, T. L., VanDongen, H. M., and Van-Dongen, A. M. (2004) Ligand-binding residues integrate affinity and efficacy in the NMDA receptor, Mol Pharmacol 66, 209-219. (Pubitemid 38989477)
-
(2004)
Molecular Pharmacology
, vol.66
, Issue.2
, pp. 209-219
-
-
Kalbaugh, T.L.1
VanDongen, H.M.A.2
VanDongen, A.M.J.3
-
12
-
-
0029123899
-
The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating
-
Filatov, G. N., and White, M. M. (1995) The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating, Mol Pharmacol 48, 379-384.
-
(1995)
Mol Pharmacol
, vol.48
, pp. 379-384
-
-
Filatov, G.N.1
White, M.M.2
-
13
-
-
0030480913
-
Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position
-
DOI 10.1016/S0896-6273(00)80252-4
-
Kearney, P. C., Zhang, H., Zhong, W., Dougherty, D. A., and Lester, H. A. (1996) Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 90 position, Neuron 17, 1221-1229. (Pubitemid 27021106)
-
(1996)
Neuron
, vol.17
, Issue.6
, pp. 1221-1229
-
-
Kearney, P.C.1
Zhang, H.2
Zhong, W.3
Dougherty, D.A.4
Lester, H.A.5
-
14
-
-
0029163027
-
Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors
-
Labarca, C., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P., and Lester, H. A. (1995) Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors, Nature 376, 514-516.
-
(1995)
Nature
, vol.376
, pp. 514-516
-
-
Labarca, C.1
Nowak, M.W.2
Zhang, H.3
Tang, L.4
Deshpande, P.5
Lester, H.A.6
-
15
-
-
3042607961
-
The Cys-loop superfamily of ligand-gated ion channels: The impact of receptor structure on function
-
DOI 10.1042/BST0320529
-
Connolly, C. N., and Wafford, K. A. (2004) The Cys-loop superfamily of ligand-gated ion channels: the impact of receptor structure on function, Biochemical Society Transactions 32, 529-534. (Pubitemid 38813555)
-
(2004)
Biochemical Society Transactions
, vol.32
, Issue.3
, pp. 529-534
-
-
Connolly, C.N.1
Wafford, K.A.2
-
16
-
-
44849128243
-
Cys-loop neuroreceptors: Structure to the rescue?
-
DOI 10.1021/cr078207z
-
Dougherty, D. A. (2008) Cys-loop neuroreceptors: structure to the rescue?, Chem Rev 108, 1642-1653. (Pubitemid 351796402)
-
(2008)
Chemical Reviews
, vol.108
, Issue.5
, pp. 1642-1653
-
-
Dougherty, D.A.1
-
17
-
-
33645302360
-
Recent advances in Cys-loop receptor structure and function
-
Sine, S. M., and Engel, A. G. (2006) Recent advances in Cys-loop receptor structure and function, Nature 440, 448-455.
-
(2006)
Nature
, vol.440
, pp. 448-455
-
-
Sine, S.M.1
Engel, A.G.2
-
18
-
-
0000677660
-
Expression of exogenous ion channels and neurotransmitter receptors in RNA-injected Xenopus oocytes
-
(Longstaff, A., and Revest, P., Eds.), Humana Press, Totowa, NJ
-
Dascal, N., and Lotan, I. (1992) Expression of exogenous ion channels and neurotransmitter receptors in RNA-injected Xenopus oocytes, In Methods in Molecular Biology (Longstaff, A., and Revest, P., Eds.), pp 205-225, Humana Press, Totowa, NJ.
-
(1992)
Methods in Molecular Biology
, pp. 205-225
-
-
Dascal, N.1
Lotan, I.2
-
19
-
-
34548831934
-
Establishing an ion pair interaction in the homomeric ρ1 γ-aminobutyric acid type A receptor that contributes to the gating pathway
-
DOI 10.1074/jbc.M702314200
-
Wang, J., Lester, H. A., and Dougherty, D. A. (2007) Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway, J Biol Chem 282, 26210-26216. (Pubitemid 47443808)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.36
, pp. 26210-26216
-
-
Wang, J.1
Lester, H.A.2
Dougherty, D.A.3
-
20
-
-
0032311418
-
In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system
-
DOI 10.1016/S0076-6879(98)93031-2
-
Nowak, M.W., Gallivan, J. P., Silverman, S. K., Labarca, C. G., Dougherty, D. A., and Lester, H. A. (1998) In vivo incorporation of unnatural amino acids into ion channels in Xenopus oocyte expression system, Methods in Enzymology 293, 504-529. (Pubitemid 29342505)
-
(1998)
Methods in Enzymology
, vol.293
, pp. 504-529
-
-
Nowak, M.W.1
Gallivan, J.P.2
Silverman, S.K.3
Labarca, C.G.4
Dougherty, D.A.5
Lester, H.A.6
-
21
-
-
43449120151
-
Physical organic chemistry on the brain
-
DOI 10.1021/jo8001722
-
Dougherty, D. A. (2008) Physical organic chemistry on the brain, J Org Chem 73, 3667-3673. (Pubitemid 351671429)
-
(2008)
Journal of Organic Chemistry
, vol.73
, Issue.10
, pp. 3667-3673
-
-
Dougherty, D.A.1
-
22
-
-
39149121526
-
Singlechannel recording of ligand-gated ion channels
-
Mortensen,M., andSmart,T. G. (2007) Singlechannel recording of ligand-gated ion channels, Nat Protoc 2, 2826-2841.
-
(2007)
Nat Protoc
, vol.2
, pp. 2826-2841
-
-
Mortensen, M.1
Smart, T.G.2
-
23
-
-
1842686239
-
Gating Dynamics of the Acetylcholine Receptor Extracellular Domain
-
DOI 10.1085/jgp.200309004
-
Chakrapani, S., Bailey, T. D., and Auerbach, A. (2004) Gating dynamics of the acetylcholine receptor extracellular domain, J Gen Physiol 123, 341-356. (Pubitemid 38469279)
-
(2004)
Journal of General Physiology
, vol.123
, Issue.4
, pp. 341-356
-
-
Chakrapani, S.1
Bailey, T.D.2
Auerbach, A.3
-
24
-
-
0034677524
-
Mapping the conformational wave of acetylcholine receptor channel gating
-
DOI 10.1038/35001586
-
Grosman, C., Zhou, M., and Auerbach, A. (2000) Mapping the conformational wave of acetylcholine receptor channel gating, Nature 403, 773-776. (Pubitemid 30111838)
-
(2000)
Nature
, vol.403
, Issue.6771
, pp. 773-776
-
-
Grosman, C.1
Zhou, M.2
Auerbach, A.3
|