Characterization of propofol in human breath of patients undergoing anesthesia

International Journal for Ion Mobility Spectrometry

Volumn 14, Issue 4, 2011, Pages 167-175

  Kreuder, A E ^a,c   Buchinger, H ^b   Kreuer, S ^b   Volk, Th ^b   Maddula, S ^c   Baumbach, J I ^c  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c KIST Europe ^*  (Germany)

Author keywords

Breath; Intensive care; Medical application; Propofol; Propofol CAS 2078 54 8 ; VOC; Volatile organic compounds

Indexed keywords

BREATH; DETECTION LIMITS; HUMAN BREATH; INTENSIVE CARE; ION MOBILITY SPECTROMETRY; KINETIC MODELS; MULTI-CAPILLARY COLUMNS; PROPOFOL;

MEDICAL APPLICATIONS; VOLATILE ORGANIC COMPOUNDS;

ANESTHESIOLOGY;

EID: 82455187902     PISSN: 14356163     EISSN: 18654584     Source Type: Journal    
DOI: 10.1007/s12127-011-0080-y     Document Type: Article

References (30)

1. Eiceman GA, Karpas Z (2005) Ion mobility spectrometry, 2nd edn. CRC Press, Taylor & Francis, Boca Raton, p 350.
2. Vautz W, Baumbach JI (2008) Analysis of bio-processes using ion mobility spectrometry. Eng Life Sci 8(1): 19-25.
3. O'Donnell RM, Harrington PdB, Sun X (2007) Applications of ion mobility spectrometry and differential mobility spectrometry in drug screening and quality control of pharmaceuticals.
4. Baumbach JI, et al. (2010) Breath discovery based on ion mobility spectrometry and classification and differentiation models for lung diseases. Biomedizinische Technik 55(Suppl. 1).
5. Karpas Z et al (2002) Novel application for ion mobility spectrometry: diagnosing vaginal infections through measurement of biogenic amines. Anal Chim Acta 474(1-2): 115-123.
6. Vautz W, Baumbach JI (2008) Exemplar application of multi-capillary column ion mobility spectrometry for biological medical purpose. Int J Ion Mobility Spectrom 11(1): 35-42.
7. Smedsgaard J, Nielsen J (2005) Metabolite profiling of fungi and yeast: from phenotype to metabolome by MS and informatics. J Exp Bot 56(410): 273-286.
8. Maddula S (2005) Volatile metabolite fingerprints of Escherichia coli. In: Dept. of Biochemical and Chemical Engineering. University Dortmund, Dortmund. p. 52.
9. Griffin JL, Kauppinen RA (2007) Tumour metabolomics in animal models of human cancer. J Proteome Res 6(2): 498-505.
10. Mieth M et al (2010) Automated needle trap heart-Cut GC/MS and needle trap comprehensive two-dimensional GC/TOF-MS for breath gas analysis in the clinical environment. Anal Chem 82(6): 2541-2551.
11. Buszewski B et al (2009) Analysis of exhaled breath from smokers, passive smokers and non-smokers by solid-phase microextraction gas chromatography/mass spectrometry. Biomed Chromatogr 23(5): 551-556.
12. Beauchamp J, Kirsch F, Buettner A (2010) Real-time breath gas analysis for pharmacokinetics: monitoring exhaled breath by on-line proton-transfer-reaction mass spectrometry after ingestion of eucalyptol-containing capsules. J Breath Res 4(Copyright (C) 2010 American Chemical Society (ACS). All Rights Reserved.): p. No pp. given.
13. Herbig J et al (2009) On-line breath analysis with PTR-TOF. J Breath Res 3(2): 027004/1-027004/10.
14. Smith D et al (2010) Isoprene levels in the exhaled breath of 200 healthy pupils within the age range 7-18 years studied using SIFT-MS. J Breath Res 4(1): 017101/1-017101/7.
15. Seeley MJ et al (2009) In vitro SIFT-MS validation of a breath fractionating device using a model VOC and ventilation system. J Breath Res 3(016001): 7. doi: 10. 1088/1752-7155/3/1/016001.
16. Horvath I et al (2009) Exhaled biomarkers in lung cancer. Eur Respir J 34(1): 261-275.
17. Dragonieri S et al (2009) An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer 64(2): 166-170.
18. Silkoff P (2008) History, technical and regulatory aspects of exhaled nitric oxide. J Breath Res 2(3): 037001/1-037001/8.
19. De Lacy Costello B et al (2008) An analysis of volatiles in the headspace of the faeces of neonates. J Breath Res 2(3): 037023/1-037023/8.
20. Davies AN, Baumbach JI (2008) Early lung cancer diagnostics by ion mobility spectrometry data handling. Spectrosc Eur 20(5): 18-21.
21. Bader S (2005) Atemluftüberwachung mittels mikrostrukturierter Ionenbeweglichkeitsspektrometrie: statistische Analyse zum Auffinden von Biomarkern für Lungenkrebs, In: Fachbereich Statistik. Universität Dortmund, Dortmund. p. 113.
22. Westhoff M et al (2010) Differentiation of chronic obstructive pulmonary disease (COPD) including lung cancer from healthy control group by breath analysis using ion mobility spectrometry. Int J Ion Mobility Spectrom 13(3-4): 131-139.
23. Baumbach JI, Westhoff M (2006) Ion mobility spectrometry to detect lung cancer and airway infections. Spectrosc Eur 18(6): 22-27.
24. Baumbach JI, et al. (2010) Metabolites in human breath during indursulfase therapy of a patient with hunter disease-first results of time series using MCC/IMS. Biomedizinische Technik 55(Suppl. 1).
25. Perl T et al (2009) Determination of serum propofol concentrations by breath analysis using ion mobility spectrometry. Br J Anaesth 103(6): 822-827.
26. Perl T, et al. (2010) Propofol in der Atemluft-MCC-Ionen mobilitäts spektrometrie propofol in expired air using MCC-ion mobility spectrometry. Biomedizinische Technik 55(Suppl. 1).
27. Dawidowicz AL et al (2000) The role of human lungs in the biotransformation of propofol. Anesthesiology 93(4): 992-997.
28. Borsdorf H, Mayer T, Zaresjousheghani M, Eiceman GA (2011) Recent developments in ion mobility spectrometry. Appl Spectrosc Rev 46: 472-521.
29. Marquez-Sillero I, Aguilera-Herrador E, Cardenas S, Valcarcel M (2011) Ion-mobility spectrometry for environmental analysis. Trac-Trends Anal Chem 30: 677-690.
30. Armenta S, Alcala M, Blanco M (2011) A review of recent, unconventional applications of ion mobility spectrometry (IMS). Anal Chim Acta 703: 114-123.