Mechanisms of cramp contractions: Peripheral or central generation?

Journal of Physiology

Volumn 589, Issue 23, 2011, Pages 5759-5773

  Minetto, Marco Alessandro ^a,b   Holobar, Aleš ^c   Botter, Alberto ^b   Ravenni, Roberta ^d   Farina, Dario ^e  

^a UNIVERSITY OF TURIN   (Italy)

^b POLITECNICO DI TORINO   (Italy)

^c UNIVERSITY OF MARIBOR   (Slovenia)

^d Division of Neurology   (Italy)

^e UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; ADULT; ARTICLE; CONTROLLED STUDY; DISEASE DURATION; ELECTROMYOGRAPHY; ELECTROSTIMULATION; HUMAN; HUMAN EXPERIMENT; MALE; MOTONEURON; MOTOR UNIT; MUSCLE CONTRACTION; MUSCLE CRAMP; NERVE BLOCK; NERVE CELL MEMBRANE POTENTIAL; NERVE CONDUCTION; NORMAL HUMAN; PAIN THRESHOLD; PERIPHERAL NERVE; PRIORITY JOURNAL;

ADULT; ANESTHETICS; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; HUMANS; MALE; MOTOR NEURONS; MUSCLE CONTRACTION; MUSCLE CRAMP; MUSCLE, SKELETAL; NERVE BLOCK; PERIPHERAL NERVOUS SYSTEM; SPINAL CORD; TIBIAL NERVE;

EID: 82455186105     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.212332     Document Type: Article

References (50)

1. Baldissera F, Cavallari P & Dworzak F (1991). Cramps: a sign of motoneurone 'bistability' in a human patient. Neurosci Lett 133, 303-306.
2. Baldissera F, Cavallari P & Dworzak F (1994). Motor neuron 'bistability'. A pathogenetic mechanism for cramps and myokymia. Brain 117, 929-939.
3. Berg RW, Alaburda A & Hounsgaard J (2007). Balanced inhibition and excitation drive spike activity in spinal half-centers. Science 315, 390-393.
4. Bergenheim M, Ribot-Ciscar E, Roll JP & Thunberg J (2004). Spontaneous bursting neuronal discharges recorded from peripheral nerve in human: injury discharges or not? Neurosci Lett 359, 1-4.
5. Bergmans J (1968). Post-tetanic repetitive activity in single human motor axons. Arch Int Physiol Biochim 76, 560-562.
6. Bertolasi L, De Grandis D, Bongiovanni LG, Zanette GP & Gasperini M (1993). The influence of muscular lengthening on cramps. Ann Neurol 33, 176-180.
7. Bertolasi L, Priori A, Tomelleri G, Bongiovanni LG, Fincati E, Simonati A, De Grandis D & Rizzuto N (1997). Botulinum toxin treatment of muscle cramps: a clinical and neurophysiological study. Ann Neurol 41, 181-186.
8. Bigland-Ritchie BR, Dawson NJ, Johansson RS & Lippold OC (1986). Reflex origin for the slowing of motoneurone firing rates in fatigue of human voluntary contractions. J Physiol 379, 451-459.
9. Bostock H, Baker M & Reid G (1991). Changes in excitability of human motor axons underlying post-ischaemic fasciculations: evidence for two stable states. J Physiol 441, 537-557.
10. Bostock H & Bergmans J (1994). Post-tetanic excitability changes and ectopic discharges in a human motor axon. Brain 117, 913-928.
11. Caress JB & Walker FO (2002). The spectrum of ectopic motor nerve behavior: from fasciculations to neuromyotonia. Neurologist 8, 41-46.
12. Crone C, Hultborn H, Kiehn O, Mazieres L & Wigström H (1988). Maintained changes in motoneuronal excitability by short-lasting synaptic inputs in the decerebrate cat. J Physiol 405, 321-343.
13. Enoka RM, Robinson GA & Kossev AR (1989). Task and fatigue effects on low-threshold motor units in human hand muscle. J Neurophysiol 62, 1344-1359.
14. Farina D, Gazzoni M & Merletti R (2003). Assessment of low back muscle fatigue by surface EMG signal analysis: methodological aspects. J Electromyogr Kinesiol 13, 319-332.
15. Gorassini MA, Bennett DJ & Yang JF (1998). Self-sustained firing of human motor units. Neurosci Lett 247, 13-16.
16. Heckman CJ, Johnson M, Mottram C & Schuster J (2008). Persistent inward currents in spinal motoneurons and their influence on human motoneuron firing patterns. Neuroscientist 14, 264-275.
17. Hounsgaard J, Hultborn H, Jespersen B & Kiehn O (1988). Bistability of alpha-motoneurones in the decerebrate cat and in the acute spinal cat after intravenous 5-hydroxytryptophan. J Physiol 405, 345-367.
18. Hultborn H, Brownstone RB, Toth TI & Gossard JP (2004). Key mechanisms for setting the input-output gain across the motoneuron pool. Prog Brain Res 143, 77-95.
19. Khan SI & Burne JA (2007). Reflex inhibition of normal cramp following electrical stimulation of the muscle tendon. J Neurophysiol 98, 1102-1107.
20. Kugelberg E & Cobb W (1951). Repetitive discharges in human motor nerve fibers during the post-ischaemic state. J Neurol Neurosurg Psychiatry 14, 88-94.
21. Lambert E (1968). Electromyography in amyotrophic lateral sclerosis. In Motor Neuron Disease; Research on Amyotrophic Lateral Sclerosis and Related Disorders, ed. Norris FH & Kurland LT, pp. 135-153. Grune & Stratton, New York .
22. Layzer RB (1994). The origin of muscle fasciculations and cramps. Muscle Nerve 17, 1243-1249.
23. Layzer RB & Rowland LP (1971). Cramps. N Engl J Med 285, 31-40.
24. Lee RH & Heckman CJ (1998). Bistability in spinal motoneuronsin vivo: systematic variations in persistent inward currents. J Neurophysiol 80, 583-593.
25. Macefield VG (1998). Spontaneous and evoked ectopic discharges recorded from single human axons. Muscle Nerve 21, 461-468.
26. Macefield VG, Fuglevand AJ, Howell JN & Bigland-Ritchie B (2000). Discharge behaviour of single motor units during maximal voluntary contractions of a human toe extensor. J Physiol 528, 227-234.
27. McGill KC, Lateva ZC & Marateb HR (2005). EMGLAB: an interactive EMG decomposition program. J Neurosci Methods 149, 121-133.
28. Mandrile F, Farina D, Pozzo M & Merletti R (2003). Stimulation artifact in surface EMG signal: effect of the stimulation waveform, detection system, and current amplitude using hybrid stimulation technique. IEEE Trans Neural Syst Rehabil Eng 11, 407-415.
29. Merlo A, Farina D & Merletti R (2003). A fast and reliable technique for muscle activity detection from surface EMG signals. IEEE Trans Biomed Eng 50, 316-323.
30. Miller KC & Knight KL (2007). Pain and soreness associated with a percutaneous electrical stimulation muscle cramping protocol. Muscle Nerve 36, 711-714.
31. Miller KC & Knight KL (2009). Electrical stimulation cramp threshold frequency correlates well with the occurrence of skeletal muscle cramps. Muscle Nerve 39, 364-368.
32. Miller TM & Layzer RB (2005). Muscle cramps. Muscle Nerve 32, 431-442.
33. Minetto MA & Botter A (2009). Elicitability of muscle cramps in different leg and foot muscles. Muscle Nerve 40, 535-544.
34. Minetto MA, Botter A, De Grandis D & Merletti R (2009a). Time and frequency domain analysis of surface myoelectric signals during electrically-elicited cramps. Neurophysiol Clin 39, 15-25.
35. Minetto MA, Botter A, Ravenni R, Merletti R & De Grandis D (2008). Reliability of a novel neurostimulation method to study involuntary muscle phenomena. Muscle Nerve 37, 90-100.
36. Minetto MA, Holobar A, Botter A & Farina D (2009b). Discharge properties of motor units of the abductor hallucis muscle during cramp contractions. J Neurophysiol 102, 1890-1901.
37. Mogyoros I, Bostock H & Burke D (2000). Mechanisms of paresthesias arising from healthy axons. Muscle Nerve 23, 310-320.
38. Moritz CT, Barry BK, Pascoe MA & Enoka RM (2005). Discharge rate variability influences the variation in force fluctuations across the working range of a hand muscle. J Neurophysiol 93, 2449-2459.
39. Nordin M, Nyström B, Wallin U & Hagbarth KE (1984). Ectopic sensory discharges and paresthesiae in patients with disorders of peripheral nerves, dorsal roots and dorsal columns. Pain 20, 231-245.
40. Nordstrom MA, Gorman RB, Laouris Y, Spielmann JM & Stuart DG (2007). Does motoneuron adaptation contribute to muscle fatigue? Muscle Nerve 35, 135-158.
41. Norris FH Jr, Gasteiger EL & Chatfield PO (1957). An electromyographic study of induced and spontaneous muscle cramps. Electroencephalogr Clin Neurophysiol 9, 139-147.
42. Obi T, Mizoguchi K, Matsuoka H, Takatsu M & Nishimura Y (1993). Muscle cramp as the result of impaired GABA function-an electrophysiological and pharmacological observation. Muscle Nerve 16, 1228-1231.
43. Ochoa JL & Torebjörk HE (1980). Paraesthesiae from ectopic impulse generation in human sensory nerves. Brain 103, 835-853.
44. Roeleveld K, van Engelen BG & Stegeman DF (2000). Possible mechanisms of muscle cramp from temporal and spatial surface EMG characteristics. J Appl Physiol 88, 1698-1706.
45. -1th World Congress in Sports Medicine Handbook, pp. 67-70. Melbourne .
46. Ross BH & Thomas CK (1995). Human motor unit activity during induced muscle cramp. Brain 118, 983-993.
47. Roth G (1984). Fasciculations and their F-response. Localisation of their axonal origin. J Neurol Sci 63, 299-306.
48. Serrao M, Arendt-Nielsen L, Ge HY, Pierelli F, Sandrini G & Farina D (2007). Experimental muscle pain decreases the frequency threshold of electrically elicited muscle cramps. Exp Brain Res 182, 301-308.
49. Schwellnus MP (2007). Muscle cramping in the marathon: aetiology and risk factors. Sports Med 37, 364-367.
50. Schwellnus MP (2009). Cause of exercise associated muscle cramps (EAMC) - altered neuromuscular control, dehydration or electrolyte depletion? Br J Sports Med 43, 401-408.