Preliminary study of antidiabetic activity of the methanolic leaf extract of Axonopus compressus (P. Beauv) in alloxan-induced diabetic rats

Journal of Ethnopharmacology

Volumn 138, Issue 3, 2011, Pages 713-716

  Ibeh, Bartholomew O ^a   Ezeaja, Maxwell I ^a  

^a MICHAEL OKPARA UNIVERSITY OF AGRICULTURE   (Nigeria)

Author keywords

Alloxan monohydrate; Axonopus compressus; Blood glucose; Diabetes mellitus

Indexed keywords

ALLOXAN; ANTIDIABETIC AGENT; AXONOPUS COMPRESSUS EXTRACT; GLIBENCLAMIDE; GLUCOSE; METHANOL; PLANT EXTRACT; POLYSORBATE 20; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; AUTOANALYZER; AXONOPUS COMPRESSUS; BLOOD ANALYSIS; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG ISOLATION; FEMALE; GLUCOSE BLOOD LEVEL; MALE; MEDICINAL PLANT; NONHUMAN; PLANT LEAF; RAT;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; HYPOGLYCEMIC AGENTS; MALE; MEDICINE, AFRICAN TRADITIONAL; METHANOL; MICE; NIGERIA; PHYTOTHERAPY; PLANT EXTRACTS; PLANT LEAVES; POACEAE; RATS; RATS, WISTAR; SOLVENTS; TOXICITY TESTS, ACUTE;

AXONOPUS COMPRESSUS; RATTUS;

EID: 82455164213     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.10.009     Document Type: Article

References (35)

1. H.P. Ammon, and M. Merck Thiols and pancreatic beta-cell function - a review Cell Biochemistry and Function 3 1985 157 171
2. F.M. Ashcroft, P. Proks, P.A. Smith, C. Ammala, K. Bokvist, and P. Rorsman Stimulus-secretion coupling in pancreatic cells Journal of Cellular Biochemistry 55S 1994 54 65
3. R.H. Burnell, and G.M. Maxwell General and coronary haemolytic effects of tween 20 Australian Journal of Experimental Biology and Medical Science 52 1974 151 156
4. R.R. Chattopadhyay Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats Indian Journal of Experimental Biology 31 1993 891 893
5. I.E. Cork Problems of reproducibility and of bioassay using crude extracts with reference to Aloe Vera Pharmacognosy Communications 1 2011 52 62
6. Delagan-Bunch, C. Common weeds in West African Soil. www.eHow.com. Retrieved online 3rd November 2010.
7. S.P. Dhanabal, M.K. Raja, M. Ramanathan, and B. Suresh Hypoglycemic activity of Nymphaea stellata leaves ethanolic extract in alloxan-induced diabetic rats Fitoterapia 78 2007 288 291
8. D.O. Edem Hypoglycemic effects of ethanolic extract of Aligator pear seed (Persea Americana Mill) in rats European Journal of Scientific Research 33 2009 669 678
9. E. Edwin, E. Sheeja, S.P. Dhanabal, and B. Suresh Antihyperglycemic activity of Passiflora mollissima Bailey Indian Journal of Pharmaceutical Sciences 64 2007 570 571
10. T.M. Funom Etiology and pathophysiology of diabetes mellitus 2010 www.ezinearticles.com
11. M. Haeg-Weber, and W.H. Hori Effect of calcium blockers on intracellular calcium Nephrology Dialysis Transplantation 9 Suppl. 3 1994 24 27
12. V. Herbert The antioxidant supplement myth American Journal of Clinical Nutrition 60 1994 157 158
13. V. Herbert Vitamin C supplement and disease - counterpoint Journal of the American College of Nutrition 14 1995 112 113
14. M.D. Ivorra, M. Paya, and A. Villarm Hypoglycemic and insulin release effects of tormentic acid: a new hypoglycemic natural product Planta Medica 54 1988 282 285
15. G. Jelodar, M. Mohsen, and S. Shahram Effect of Walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan-induced diabetic rats African Journal of Traditional, Complementary and Alternative Medicines 3 2003 299 305
16. B. Kameswararao, M.M. Kesavulu, and C. Apparao Evaluation of antidiabetic effect of Momordica cymbalaria fruit in alloxan-diabetic rats Fitoterapia 74 2003 7 13
17. Kartesz, J. Axonopus. Retrieved online http://plants. USDA. Gov 3rd November 2010.
18. Kelly, C. Understanding the fasting blood plasma glucose test, http://www.about.fbpgt.com.2008. Retrieved online on 5th November 2010.
19. G. Klein, J. Kim, K. Himmeldirk, Y. Cao, and X. Chen Antidiabetes and anti-obesity activity of Lagerstroemia speciosa Evidence-Based Complementary and Alternative Medicine 4 2007 401 407
20. S. Lenzen, and U. Panten Alloxan: history and mechanism of action Diabetologia 31 1988 337 342
21. D. Lorke A new approach to practical acute toxicity Archives of Toxicology 53 1983 275 289
22. C. Manidool Axonopus compressus (P. Beauv) N. Manneje, R.M. Jones, Plant Resources of South-East Asia 1992 Pudox Scientifica Publishers Wageningen, Netherlands 53 54
23. M. Neelesh, J. Sanjay, and M. Sappa Antidiabetic potentials of medicinal plants Acta Poloniae Pharmaceutica-Drug Research 67 2010 113 118
24. L.W. Oberly Free radicals and diabetes Free Radical Biology and Medicine 5 1988 113 124
25. E.A. Ogie-Odia, D. Esiegbe, M.N. Elechie, J. Erhabor, and E. Ogbebor Foliar epidermal and phytochemical studies of the grasses Cymbopogon citratus (Stapf.), Axonopus compressus (S. W. Beauv) and Eragrostis tremula (S. W. Beauv) in Ekpoma. Edo State, Nigeria Science World Journal 6 2010 21 26
26. M.T. Pepato, D.M. Mori, A.M. Baviera, J.B. Harami, R.C. Vendramini, and I.L. Brunetti Fruit of the Jambolan tree and experimental diabetes Journal of Ethnopharmacology 96 2005 43 48
27. S. Sharma, M. Chaturved, E. Edwin, S. Shukla, and H. Sagrawat Evaluation of the phytochemicals and antidiabetic activity of Ficus bengalensis International Journal of Diabetes in Developing Countries 27 2007 57 59
28. V. Suba, T. Murugesan, R. Bhaskara-Rao, L. Ghosh, M. Pal, and S.C. Mandal Antidiabetic potential of Barleria lupulina extract in rats Fitoterapia 75 2004 1 4
29. T. Szkudelski The mechanism of alloxan and streptozotocin action on β-cells of the rat pancreas Physiological Research 50 2001 537 546
30. S. Venkatesh, R.G. Dayanand, R.B. Madhava, M. Ramesh, and A.V.N. Apparao Antihyperglycemic activity of Caralluma attenuta Fitoterapia 74 2003 274 279
31. P.M. Venogopal, P.S.M. Prince, and L. Pari Hypoglycemic activity of Syzigium cumini seeds: effects on lipid peroxidation in auxon diabetic rats Journal of Ethnopharmacology 61 1998 1 7
32. K.S. Vivek, K. Suresh, J.P. Hitesh, and H. Schivakumar Hypoglycemic acitivity of Ficus glomerate in Alloxan induced diabetic rats International Journal of Pharmaceutical Sciences Review and Research 1 2010 18 22
33. J.W. Ward, and J.R. Elsea Animal case and use in drug fate and metabolism R.G. Edward, L.H. Jean, Methods and Techniques vol. 11 1997 Marcel Deker New York 372 390
34. S. Wild, G. Roglic, A. Green, and H. Sicree-King Global prevalence of diabetes: estimates for 2000 and projections for 2030 Diabetes Care 5 2004 1047 1053
35. H. Yamamoto, Y. Uchigata, and H. Okamoto Streptozotocin and alloxan induce DNA strand breaks and poly (ADP-ribose) synthetase in pancreatic islets Nature 294 1981 284 286