-
1
-
-
67650337802
-
Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: A Phase II study from the European Organisation for Research and Treatment of Cancer - Soft Tissue and Bone Sarcoma Group (EORTC Study 62043)
-
Sleijfer S, Ray-Coquard I, Papai Z et al. Pazopanib, a multikinase angiogenesis inhibitor, in patients with relapsed or refractory advanced soft tissue sarcoma: a Phase II study from the European Organisation for Research and Treatment of Cancer - Soft Tissue and Bone Sarcoma Group (EORTC Study 62043). J. Clin. Oncol. 27(19), 3126-3132 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.19
, pp. 3126-3132
-
-
Sleijfer, S.1
Ray-Coquard, I.2
Papai, Z.3
-
2
-
-
33847290787
-
Novel treatment strategies for soft tissue sarcoma
-
Kasper B, Thierry G, D'Hondt V, Gebhart M, Awada A. Novel treatment strategies for soft tissue sarcoma. Crit. Rev. Oncol. Hematol. 62(1), 9-15 (2007).
-
(2007)
Crit. Rev. Oncol. Hematol.
, vol.62
, Issue.1
, pp. 9-15
-
-
Kasper, B.1
Thierry, G.2
D'Hondt, V.3
Gebhart, M.4
Awada, A.5
-
3
-
-
70350635631
-
New medical treatment options and strategies to assess clinical outcome in soft tissue sarcoma
-
Schmitt T, Kasper B. New medical treatment options and strategies to assess clinical outcome in soft tissue sarcoma. Expert. Rev. Anticancer Ther. 9(8), 1159-1167 (2009).
-
(2009)
Expert. Rev. Anticancer Ther.
, vol.9
, Issue.8
, pp. 1159-1167
-
-
Schmitt, T.1
Kasper, B.2
-
4
-
-
1242297774
-
Serum vascular endothelial growth factor as a tumour marker in soft tissue sarcoma
-
Hayes AJ, Mostyn-Jones A, Koban MU et al. Serum vascular endothelial growth factor as a tumour marker in soft tissue sarcoma. Br. J. Surg. 91(2), 242-247 (2004).
-
(2004)
Br. J. Surg.
, vol.91
, Issue.2
, pp. 242-247
-
-
Hayes, A.J.1
Mostyn-Jones, A.2
Koban, M.U.3
-
5
-
-
0028012103
-
Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor-B chain expression: An immunohistochemical and in situ hybridization assay
-
Wang J, Coltrera MD, Gown AM. Cell proliferation in human soft tissue tumors correlates with platelet-derived growth factor-B chain expression: an immunohistochemical and in situ hybridization assay. Cancer Res. 54(2), 560-564 (1994).
-
(1994)
Cancer Res.
, vol.54
, Issue.2
, pp. 560-564
-
-
Wang, J.1
Coltrera, M.D.2
Gown, A.M.3
-
6
-
-
20044372153
-
Phase II study of ET-743 in advanced soft tissue sarcomas: A European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial
-
Le Cesne A, Blay JY, Judson I et al. Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial. J. Clin. Oncol. 23(3), 576-584 (2005).
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.3
, pp. 576-584
-
-
Le Cesne, A.1
Blay, J.Y.2
Judson, I.3
-
7
-
-
24944460785
-
Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: Multicenter Phase II and pharmacokinetic study
-
Garcia-Carbonero R, Supko JG, Maki RG et al. Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: multicenter Phase II and pharmacokinetic study. J. Clin. Oncol. 23(24), 5484-5492 (2005).
-
(2005)
J. Clin. Oncol.
, vol.23
, Issue.24
, pp. 5484-5492
-
-
Garcia-Carbonero, R.1
Supko, J.G.2
Maki, R.G.3
-
8
-
-
34447572873
-
Randomized Phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: Results of sarcoma alliance for research through collaboration study 002 [corrected]
-
Maki RG, Wathen JK, Patel SR et al. Randomized Phase II study of gemcitabine and docetaxel compared with gemcitabine alone in patients with metastatic soft tissue sarcomas: results of sarcoma alliance for research through collaboration study 002 [corrected]. J. Clin. Oncol. 25(19), 2755-2763 (2007).
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.19
, pp. 2755-2763
-
-
Maki, R.G.1
Wathen, J.K.2
Patel, S.R.3
-
9
-
-
54449099288
-
Paclitaxel in patients with advanced angiosarcomas of soft tissue: A retrospective study of the EORTC soft tissue and bone sarcoma group
-
Schlemmer M, Reichardt P, Verweij J et al. Paclitaxel in patients with advanced angiosarcomas of soft tissue: a retrospective study of the EORTC soft tissue and bone sarcoma group. Eur. J. Cancer 44(16), 2433-2436 (2008).
-
(2008)
Eur. J. Cancer
, vol.44
, Issue.16
, pp. 2433-2436
-
-
Schlemmer, M.1
Reichardt, P.2
Verweij, J.3
-
10
-
-
84860887517
-
Activity of eribulin mesylate (E7389) in patients with soft tissue sarcoma (STS): Phase II studies of the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC 62052)
-
Presented at: Chicago, IL, USA, 4-8 June
-
Schöffski I, Ray-Coquard L, Cioffi A et al. Activity of eribulin mesylate (E7389) in patients with soft tissue sarcoma (STS): Phase II studies of the European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group (EORTC 62052). Presented at: 2010 ASCO Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
-
(2010)
2010 ASCO Annual Meeting
-
-
Schöffski, I.1
Ray-Coquard, L.2
Cioffi, A.3
-
11
-
-
79957793286
-
Testing new regimens in patients with advanced soft tissue sarcoma: Analysis of publications from the last 10 years
-
Penel N, Van Glabbeke M, Marreaud S, Ouali M, Blay JY, Hohenberger P. Testing new regimens in patients with advanced soft tissue sarcoma: analysis of publications from the last 10 years. Ann. Oncol. 22(6), 1266-1272 (2011).
-
(2011)
Ann. Oncol.
, vol.22
, Issue.6
, pp. 1266-1272
-
-
Penel, N.1
Van Glabbeke, M.2
Marreaud, S.3
Ouali, M.4
Blay, J.Y.5
Hohenberger, P.6
-
12
-
-
80054055727
-
Results of the Phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT)
-
Presented at: Chicago, IL, USA, 3-7 June
-
Chawla P, Blay J, Ray-Coquard IL et al. Results of the Phase III, placebo-controlled trial (SUCCEED) evaluating the mTOR inhibitor ridaforolimus (R) as maintenance therapy in advanced sarcoma patients (pts) following clinical benefit from prior standard cytotoxic chemotherapy (CT). Presented at: 2011 ASCO Annual Meeting. Chicago, IL, USA, 3-7 June 2011.
-
(2011)
2011 ASCO Annual Meeting
-
-
Chawla, P.1
Blay, J.2
Ray-Coquard, I.L.3
-
13
-
-
49449117755
-
Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2- pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor
-
Harris PA, Boloor A, Cheung M et al. Discovery of 5-[[4-[(2,3-dimethyl- 2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J. Med. Chem. 51(15), 4632-4640 (2008).
-
(2008)
J. Med. Chem.
, vol.51
, Issue.15
, pp. 4632-4640
-
-
Harris, P.A.1
Boloor, A.2
Cheung, M.3
-
14
-
-
77952483702
-
Pazopanib: A multikinase inhibitor with activity in advanced renal cell carcinoma
-
Bukowski RM. Pazopanib: a multikinase inhibitor with activity in advanced renal cell carcinoma. Expert. Rev. Anticancer Ther. 10(5), 635-645 (2010).
-
(2010)
Expert. Rev. Anticancer Ther.
, vol.10
, Issue.5
, pp. 635-645
-
-
Bukowski, R.M.1
-
15
-
-
34447322566
-
Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity
-
Kumar R, Knick VB, Rudolph SK et al. Pharmacokinetic-pharmacodynamic correlation from mouse to human with pazopanib, a multikinase angiogenesis inhibitor with potent antitumor and antiangiogenic activity. Mol. Cancer Ther. 6(7), 2012-2021 (2007).
-
(2007)
Mol. Cancer Ther.
, vol.6
, Issue.7
, pp. 2012-2021
-
-
Kumar, R.1
Knick, V.B.2
Rudolph, S.K.3
-
16
-
-
79952543555
-
Pazopanib - The newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma
-
Keisner SV, Shah SR. Pazopanib - the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs 71(4), 443-454 (2011).
-
(2011)
Drugs
, vol.71
, Issue.4
, pp. 443-454
-
-
Keisner, S.V.1
Shah, S.R.2
-
17
-
-
77950688983
-
Anti-angiogenic tyrosine kinase inhibitors: What is their mechanism of action?
-
Gotink KJ, Verheul HM. Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action? Angiogenesis 13(1), 1-14 (2010).
-
(2010)
Angiogenesis
, vol.13
, Issue.1
, pp. 1-14
-
-
Gotink, K.J.1
Verheul, H.M.2
-
19
-
-
67449164582
-
Phase i trial of pazopanib (GW786034), an oral multikinase angiogenesis inhibitor, in patients with advanced cancer: Results of safety, pharmacokinetics, and clinical activity
-
Hurwitz HI, Dowlati A, Saini S et al. Phase I trial of pazopanib (GW786034), an oral multikinase angiogenesis inhibitor, in patients with advanced cancer: results of safety, pharmacokinetics, and clinical activity. Clin. Cancer Res. 15(12), 4220-4227 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.12
, pp. 4220-4227
-
-
Hurwitz, H.I.1
Dowlati, A.2
Saini, S.3
-
23
-
-
82455161643
-
A Phase i and pharmacokinetic single agent study of pazopanib (P) in patients (Pts) with advanced malignancies and varying degrees of liver dysfunction (LD)
-
Presented at: Chicago, IL, USA, 4-8 June
-
Shibata SLJ, Chung VM, Lenz H et al. A Phase I and pharmacokinetic single agent study of pazopanib (P) in patients (Pts) with advanced malignancies and varying degrees of liver dysfunction (LD). Presented at: 2010 ASCO Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
-
(2010)
2010 ASCO Annual Meeting
-
-
Shibata, S.L.J.1
Chung, V.M.2
Lenz, H.3
-
24
-
-
79953864160
-
Pazopanib for the treatment of renal cancer
-
Rini B, Al-Marrawi MY. Pazopanib for the treatment of renal cancer. Expert Opin. Pharmacother. 12(7), 1171-1189 (2011).
-
(2011)
Expert Opin. Pharmacother.
, vol.12
, Issue.7
, pp. 1171-1189
-
-
Rini, B.1
Al-Marrawi, M.Y.2
-
25
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
Escudier B, Eisen T, Stadler WM et al. Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356(2), 125-134 (2007).
-
(2007)
N. Engl. J. Med.
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
-
26
-
-
0036189675
-
Progression-free rate as the principal end point for Phase II trials in soft tissue sarcomas
-
Van Glabbeke M, Verweij J, Judson J, Nielsen OS. Progression-free rate as the principal end point for Phase II trials in soft tissue sarcomas. Eur. J. Cancer 38(4), 543-549 (2002).
-
(2002)
Eur. J. Cancer
, vol.38
, Issue.4
, pp. 543-549
-
-
Van Glabbeke, M.1
Verweij, J.2
Judson, J.3
Nielsen, O.S.4
-
27
-
-
82455161641
-
PALETTE: A randomized, double-blind, Phase III trial of pazopanib versus placebo in patients (pts) with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy - An EORTC STBSG Global Network Study (EORTC 62072)
-
Presented at: Chicago, IL, USA, 3-7 June
-
Van der Graaf WT, Blay J, Chawla SP et al. PALETTE: a randomized, double-blind, Phase III trial of pazopanib versus placebo in patients (pts) with soft-tissue sarcoma (STS) whose disease has progressed during or following prior chemotherapy - an EORTC STBSG Global Network Study (EORTC 62072). Presented at: 2011 ASCO Annual Meeting. Chicago, IL, USA, 3-7 June 2011.
-
(2011)
2011 ASCO Annual Meeting
-
-
Van Der Graaf, W.T.1
Blay, J.2
Chawla, S.P.3
-
28
-
-
33751212451
-
Hair depigmentation during chemotherapy with a class III/V receptor tyrosine kinase inhibitor
-
Routhouska S, Gilliam AC, Mirmirani P. Hair depigmentation during chemotherapy with a class III/V receptor tyrosine kinase inhibitor. Arch. Dermatol. 142(11), 1477-1479 (2006).
-
(2006)
Arch. Dermatol.
, vol.142
, Issue.11
, pp. 1477-1479
-
-
Routhouska, S.1
Gilliam, A.C.2
Mirmirani, P.3
-
29
-
-
82455205368
-
Effect of pazopanib on hair and skin hypopigmentation: A series of three patients
-
Presented at: Chicago, IL, USA, 4-8 June
-
Sideras K, Menefee ME, Burton JK et al. Effect of pazopanib on hair and skin hypopigmentation: a series of three patients. Presented at: 2010 ASCO Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
-
(2010)
2010 ASCO Annual Meeting
-
-
Sideras, K.1
Menefee, M.E.2
Burton, J.K.3
-
30
-
-
77949890945
-
Pazopanib in locally advanced or metastatic renal cell carcinoma: Results of a randomized Phase III trial
-
Sternberg CN, Davis ID, Mardiak J et al. Pazopanib in locally advanced or metastatic renal cell carcinoma: results of a randomized Phase III trial. J. Clin. Oncol. 28(6), 1061-1068 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.6
, pp. 1061-1068
-
-
Sternberg, C.N.1
Davis, I.D.2
Mardiak, J.3
-
31
-
-
77951666852
-
Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism
-
Xu CF, Reck BH, Xue Z et al. Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. Br. J. Cancer 102(9), 1371-1377 (2010).
-
(2010)
Br. J. Cancer
, vol.102
, Issue.9
, pp. 1371-1377
-
-
Xu, C.F.1
Reck, B.H.2
Xue, Z.3
-
32
-
-
79956146844
-
Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma
-
Xu C, Reck BH, Goodman VL et al. Association of the hemochromatosis gene with pazopanib-induced transaminase elevation in renal cell carcinoma. J. Hepatol. 54(6), 1237-1243 (2011).
-
(2011)
J. Hepatol.
, vol.54
, Issue.6
, pp. 1237-1243
-
-
Xu, C.1
Reck, B.H.2
Goodman, V.L.3
-
33
-
-
77952318310
-
Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J. Clin. Oncol. 28(13), 2137-2143 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.13
, pp. 2137-2143
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
34
-
-
82455205369
-
Soluble factors (SF) associated with efficacy and toxicity of pazopanib (PZB) in advanced soft tissue sarcoma (STS) patients (pts): An EORTC-STBSG study
-
Presented at: Chicago, IL, USA, 4-8 June
-
Sleijfer A, Van Glabbeke M, Lamers C et al. Soluble factors (SF) associated with efficacy and toxicity of pazopanib (PZB) in advanced soft tissue sarcoma (STS) patients (pts): an EORTC-STBSG study. Presented at: 2010 ASCO Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
-
(2010)
2010 ASCO Annual Meeting
-
-
Sleijfer, A.1
Van Glabbeke, M.2
Lamers, C.3
-
35
-
-
69849083217
-
Absence of progression as assessed by response evaluation criteria in solid tumors predicts survival in advanced GI stromal tumors treated with imatinib mesylate: The intergroup EORTC-ISG-AGITG Phase III trial
-
Le Cesne A, Van Glabbeke M, Verweij J et al. Absence of progression as assessed by response evaluation criteria in solid tumors predicts survival in advanced GI stromal tumors treated with imatinib mesylate: the intergroup EORTC-ISG-AGITG Phase III trial. J. Clin. Oncol. 27(24), 3969-3974 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.24
, pp. 3969-3974
-
-
Le Cesne, A.1
Van Glabbeke, M.2
Verweij, J.3
-
36
-
-
77949898532
-
Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: A meta-analysis of 1640 patients
-
Gastrointestinal Stromal Tumor Meta-Analysis Group (MetaGIST)
-
Gastrointestinal Stromal Tumor Meta-Analysis Group (MetaGIST). Comparison of two doses of imatinib for the treatment of unresectable or metastatic gastrointestinal stromal tumors: a meta-analysis of 1640 patients. J. Clin. Oncol. 28(7), 1247-1253 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.7
, pp. 1247-1253
-
-
-
37
-
-
77954987954
-
(Pre-)Clinical pharmacology and activity of pazopanib, a novel multikinase angiogenesis inhibitor
-
Hamberg P, Verweij J, Sleijfer S. (Pre-)Clinical pharmacology and activity of pazopanib, a novel multikinase angiogenesis inhibitor. Oncologist 15(6), 539-547 (2010).
-
(2010)
Oncologist
, vol.15
, Issue.6
, pp. 539-547
-
-
Hamberg, P.1
Verweij, J.2
Sleijfer, S.3
|