Unsuppressed parathyroid hormone in patients with autoimmune/inflammatory rheumatic diseases: Implications for vitamin D supplementation

Rheumatology

Volumn 50, Issue 12, 2011, Pages 2290-2296

  Sainaghi, Pier Paolo ^a,b   Bellan, Mattia ^a   Antonini, Giuseppina ^b   Bellomo, Giorgio ^b   Pirisi, Mario ^a,b  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^b MAGGIORE DELLA CARITÀ HOSPITAL   (Italy)

Author keywords

25(OH) vitamin D; Autoimmune inflammatory rheumatic disease; Parathyroid hormone

Indexed keywords

CALCIUM; IMMUNOSUPPRESSIVE AGENT; PARATHYROID HORMONE; PHOSPHATE; VITAMIN D;

ADULT; AGED; ANKYLOSING SPONDYLITIS; ARTICLE; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; FEMALE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; VITAMIN BLOOD LEVEL; VITAMIN D METABOLISM; VITAMIN SUPPLEMENTATION;

AGED; AUTOIMMUNE DISEASES; BONE DENSITY CONSERVATION AGENTS; CALCIUM; DIETARY SUPPLEMENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; PARATHYROID HORMONE; PHOSPHORIC ACID ESTERS; RETROSPECTIVE STUDIES; RHEUMATIC DISEASES; RISK FACTORS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 82355195079     PISSN: 14620324     EISSN: 14620332     Source Type: Journal    
DOI: 10.1093/rheumatology/ker314     Document Type: Article

References (25)

1. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001; 22:47-501.
2. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int 2005;16:713-6.
3. Chapuy MC, Preziosi P, Maamerx M et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 1997;7:439-43.
4. Lemire JM. Immunomodulatory role of 1,25-dihydroxyvitamin D3. J Cell Biochem 1992;49:26-31.
5. Griffin MD, Lutz WH, Phan VA, Bachman LA, McKean DJ, Kumar R. Potent inhibition of dendritic cell differentiation and maturation by vitamin D analogs. Biochem Biophys Res Commun 2000;270:701-8.
6. Helming L, Böse J, Ehrchen J et al. 1alpha,25-Dihydroxyvitamin D3 is a potent suppressor of interferon gamma-mediated macrophage activation. Blood 2005;106:4351-8.
7. van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol 2005;97:93-101.
8. Mahon BD, Gordon SA, Cruz J et al. Cytokine profile in patients with multiple sclerosis following vitamin D supplementation. J Neuroimmunol 2003;134:128-32.
9. Als OS, Riis B, Christiansen C. Serum concentration of vitamin D metabolites in rheumatoid arthritis. Clin Rheumatol 1987;6:238-43.
10. Hyppönen E, Läärä E, Reunanen A, Järvelin MR, Virtanen SM. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 2001;358: 1500-3.
11. Merlino LA, Curtis J, Mikuls TR et al. Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum 2004;50:72-7.
12. Patel S, Farragher T, Berry J, Bunn D, Silman A, Symmons D. Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis. Arthritis Rheum 2007;56:2143-9.
13. Sainaghi PP, Bellan M, Carda S et al. Response to vitamin D supplementation in inflammatory autoimmune diseases; a retrospective study [abstract]. Ann Rheum Dis 2010; 69(Suppl. 3):652.
14. Cutolo M, Otsa K, Laas K et al. Circannual vitamin D serum levels and disease activity in rheumatoid arthritis: northern versus southern Europe. Clin Exp Rheumatol 2006;24:702-4.
15. McKenna MJ, Freaney R. Secondary hyperparathyroidism in the elderly: means to defining hypovitaminosis D. Osteoporos Int 1998;8(Suppl. 2):S3-6.
16. Kochupillai N. The physiology of vitamin D: current concepts. Indian J Med Res 2008;127:256-62.
17. Cantley LK, Russell J, Lettieri D, Sherwood LM. 1,25-Dihydroxyvitamin D3 suppresses parathyroid hormone secretion from bovine parathyroid cells in tissue culture. Endocrinology 1985;117:2114-9.
18. Demay MB, Kiernan MS, DeLuca HF, Kronenberg HM. Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci USA 1992;89:8097-101.
19. Souberbielle JC, Cormier C, Kindermans C et al. Vitamin D status and redefining serum parathyroid hormone reference range in the elderly. J Clin Endocrinol Metab 2001;86:3086-90.
20. Vieth R, Ladak Y, Walfish PG. Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 2003;88:185-91.
21. Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009;19:73-8.
22. Cantorna MT, Mahon BD. Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Exp Biol Med 2004;229:1136-42.
23. Holick MF. The vitamin D deficiency pandemic and consequences for nonskeletal health: mechanisms of action. Mol Aspects Med 2008;29:361-8.
24. Zerwekh JE. Blood biomarkers of vitamin D status. Am J Clin Nutr 2008;87:1087S-91S.
25. Bonadonna S, Burattin A, Nuzzo M et al. Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects. Eur J Endocrinol 2005;152:199-205.