-
1
-
-
34547108600
-
Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat a of low density lipoprotein receptor decreases receptor recycling and increases degradation
-
Zhang D.W., Lagace D.A., Garuti R., et al. Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat a of low density lipoprotein receptor decreases receptor recycling and increases degradation. J. Biol. Chem. 2007, 282:18602-18612.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 18602-18612
-
-
Zhang, D.W.1
Lagace, D.A.2
Garuti, R.3
-
2
-
-
34548175537
-
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis
-
Qian Y.W., Schmidt R.J., Zhang Y., et al. Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. J. Lipid Res. 2007, 48:1488-1498.
-
(2007)
J. Lipid Res.
, vol.48
, pp. 1488-1498
-
-
Qian, Y.W.1
Schmidt, R.J.2
Zhang, Y.3
-
3
-
-
13844310887
-
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
-
Maxwell K.N., Fisher E.A., Breslow J.L. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc. Natl. Acad. Sci. USA 2005, 102:2069-2074.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 2069-2074
-
-
Maxwell, K.N.1
Fisher, E.A.2
Breslow, J.L.3
-
4
-
-
36849085368
-
The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men
-
Scartezini M., Hubbart C., Whittall R.A., et al. The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men. Clin. Sci. 2007, 113:435-441.
-
(2007)
Clin. Sci.
, vol.113
, pp. 435-441
-
-
Scartezini, M.1
Hubbart, C.2
Whittall, R.A.3
-
5
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel M., Varret M., Rabes J.P., et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat. Genet. 2003, 34:154-156.
-
(2003)
Nat. Genet.
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.P.3
-
6
-
-
33645103550
-
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
-
Cohen J.C., Boerwinkle E., Mosley T.H., Hobbs H.H. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N. Engl. J. Med. 2006, 354:1264-1272.
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley, T.H.3
Hobbs, H.H.4
-
7
-
-
66349126280
-
PCSK9: a convertase that coordinates LDL catabolism
-
Horton J.D., Cohen J.C., Hobbs H.H. PCSK9: a convertase that coordinates LDL catabolism. J. Lipid Res. 2009, 50:S172-S177.
-
(2009)
J. Lipid Res.
, vol.50
-
-
Horton, J.D.1
Cohen, J.C.2
Hobbs, H.H.3
-
8
-
-
79251473377
-
Will the ubiquitin system furnish as many drug targets as protein kinases?
-
Cohen P., Tcherpakov M. Will the ubiquitin system furnish as many drug targets as protein kinases?. Cell 2010, 143:686-693.
-
(2010)
Cell
, vol.143
, pp. 686-693
-
-
Cohen, P.1
Tcherpakov, M.2
-
10
-
-
0346096508
-
Quality control in the endoplasmic reticulum protein factory
-
Sitia R., Braakman I. Quality control in the endoplasmic reticulum protein factory. Nature 2003, 426:891-894.
-
(2003)
Nature
, vol.426
, pp. 891-894
-
-
Sitia, R.1
Braakman, I.2
-
11
-
-
34347401218
-
Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms
-
Miranda M., Sorkin A. Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms. Mol. Interv. 2007, 7:157-167.
-
(2007)
Mol. Interv.
, vol.7
, pp. 157-167
-
-
Miranda, M.1
Sorkin, A.2
-
12
-
-
33846471122
-
Proteasome-independent functions of ubiquitin in endocytosis and signaling
-
Mukhopadhyay D., Riezman H. Proteasome-independent functions of ubiquitin in endocytosis and signaling. Science 2007, 315:201-205.
-
(2007)
Science
, vol.315
, pp. 201-205
-
-
Mukhopadhyay, D.1
Riezman, H.2
-
13
-
-
70350746156
-
Dissection of the endogenous cellular pathways of pcsk9-induced low density lipoprotein receptor degradation
-
Poirier S., Mayer G., Poupon V., et al. Dissection of the endogenous cellular pathways of pcsk9-induced low density lipoprotein receptor degradation. J. Biol. Chem. 2009, 284:28856-28864.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 28856-28864
-
-
Poirier, S.1
Mayer, G.2
Poupon, V.3
-
14
-
-
67650092919
-
LXR regulates cholesterol uptake through idol-dependent ubiquitination of the LDL receptor
-
Zelcer N., Hong C., Boyadjian R., Tontonoz P. LXR regulates cholesterol uptake through idol-dependent ubiquitination of the LDL receptor. Science 2009, 325:100-104.
-
(2009)
Science
, vol.325
, pp. 100-104
-
-
Zelcer, N.1
Hong, C.2
Boyadjian, R.3
Tontonoz, P.4
-
15
-
-
77953767546
-
The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2
-
Hong C., Duit S., Jalonen P., et al. The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. J. Biol. Chem. 2010, 285:19720-19726.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 19720-19726
-
-
Hong, C.1
Duit, S.2
Jalonen, P.3
-
16
-
-
0242412524
-
Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination
-
Martin N.P., Lefkowitz R.J., Shenoy S.K. Regulation of V2 vasopressin receptor degradation by agonist-promoted ubiquitination. J. Biol. Chem. 2003, 278:45954-45959.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 45954-45959
-
-
Martin, N.P.1
Lefkowitz, R.J.2
Shenoy, S.K.3
-
17
-
-
79955378862
-
Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists
-
Scotti E., Hong C., Yoshinaga Y., et al. Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. Mol. Cell Biol. 2011, 31:1885-1893.
-
(2011)
Mol. Cell Biol.
, vol.31
, pp. 1885-1893
-
-
Scotti, E.1
Hong, C.2
Yoshinaga, Y.3
|