Plasma PTX3 protein levels inversely correlate with insulin secretion and obesity, whereas visceral adipose tissue PTX3 gene expression is increased in obesity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 301, Issue 6, 2011, Pages

  Osorio Conles, O ^a   Guitart, M ^a,b   Chacon M R ^b,c   Maymo Masip, E ^b,c   Moreno Navarrete, J M ^d   Montori Grau, M ^a,b   Naf S ^b,c   Fernandez Real, J M ^d   Vendrell, J ^b,c   Gomez Foix A M ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^c HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^d HOSPITAL JOSEP TRUETA   (Spain)

Author keywords

Insulin sensitivity; Pentraxins; Proinflammatory cytokines; Protein pentraxin 3

Indexed keywords

GLUCOSE; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; PENTRAXIN 3; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADIPOCYTE; ADULT; ARTICLE; BODY MASS; BODY WEIGHT; COHORT ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; INSULIN RELEASE; INTRAABDOMINAL FAT; MALE; OBESITY; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIMPSON GOLABI BEHMEL SYNDROME; SUBCUTANEOUS FAT; UPREGULATION; WAIST HIP RATIO;

ADIPOCYTES; ADULT; AGED; C-REACTIVE PROTEIN; CELLS, CULTURED; COHORT STUDIES; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFANT; INFLAMMATION MEDIATORS; INSULIN; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; OBESITY; SERUM AMYLOID P-COMPONENT; UP-REGULATION;

EID: 82355187955     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00163.2011     Document Type: Article

References (45)

1. Abderrahim-Ferkoune A, Bezy O, Chiellini C, Maffei M, Grimaldi P, Bonino F, Moustaid-Moussa N, Pasqualini F, Mantovani A, Ailhaud G, Amri E. Characterization of the long pentraxin PTX3 as a TNFalphainduced secreted protein of adipose cells. J Lipid Res 44: 994-1000, 2003.
2. Alberti L, Gilardini L, Zulian A, Micheletto G, Peri G, Doni A, Mantovani A, Invitti C. Expression of long pentraxin PTX3 in human adipose tissue and its relation with cardiovascular risk factors. Atherosclerosis 202: 455-460, 2009.
3. Alles V, Bottazzi B, Peri G, Golay J, Introna M, Mantovani A. Inducible expression of PTX3, a new member of the pentraxin family, in human mononuclear phagocytes. Blood 84: 3483-3493, 1994.
4. Basile A, Sica A, d'Aniello E, Breviario F, Garrido G, Castellano M, Mantovani A, Introna M. Characterization of the promoter for the human long pentraxin PTX3. Role of NF-kappaB in tumor necrosis factor-alpha and interleukin-1beta regulation. J Biol Chem 272: 8172-8178, 1997.
5. Bastard J, Maachi M, Lagathu C, Kim M, Caron M, Vidal H, Capeau J, Feve B. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17: 4-12, 2006.
6. Bergman R, Prager R, Volund A, Olefsky J. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp. J Clin Invest 79: 790-800, 1987.
7. Bosutti A, Malaponte G, Zanetti M, Castellino P, Heer M, Guarnieri G, Biolo G. Calorie restriction modulates inactivity-induced changes in the inflammatory markers C-reactive protein and pentraxin-3. J Clin Endocrinol Metab 93: 3226-3229, 2008.
8. Bottazzi B, Doni A, Garlanda C, Mantovani A. An integrated view of humoral innate immunity: pentraxins as a paradigm. Annu Rev Immunol 28: 157-183, 2010.
9. Breviario F, d'Aniello E, Golay J, Peri G, Bottazzi B, Bairoch A, Saccone S, Marzella R, Predazzi V, Rocchi M. Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component. J Biol Chem 267: 22190-22197, 1992.
10. Chacón M, Miranda M, Jensen C, Fernández-Real J, Vilarrasa N, Gutiérrez C, Näf S, Gomez J, Vendrell J. Human serum levels of fetal antigen 1 (FA1/Dlk1) increase with obesity, are negatively associated with insulin sensitivity and modulate inflammation in vitro. Int J Obes (Lond) 32: 1122-1129, 2008.
11. Chevillard G, Derjuga A, Devost D, Zingg H, Blank V. Identification of interleukin-1beta regulated genes in uterine smooth muscle cells. Reproduction 134: 811-822, 2007.
12. Doni A, Michela M, Bottazzi B, Peri G, Valentino S, Polentarutti N, Garlanda C, Mantovani A. Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-gamma. J Leukoc Biol 79: 797-802, 2006.
13. Duvnjak L, Duvnjak M. The metabolic syndrome-an ongoing story. J Physiol Pharmacol 60, Suppl 7: 19-24, 2009.
14. Fain J. Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74: 443-477, 2006.
15. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752-1761, 2004.
16. Garlanda C, Bottazzi B, Bastone A, Mantovani A. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Annu Rev Immunol 23: 337-366, 2005.
17. Han B, Mura M, Andrade C, Okutani D, Lodyga M, dos Santos C, Keshavjee S, Matthay M, Liu M. TNFalpha-induced long pentraxin PTX3 expression in human lung epithelial cells via JNK. J Immunol 175: 8303-8311, 2005.
18. Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, Shimomura I. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 56: 901-911, 2007.
19. Hotamisligil G, Arner P, Caro J, Atkinson R, Spiegelman B. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J Clin Invest 95: 2409-2415, 1995.
20. Introna M, Alles V, Castellano M, Picardi G, De Gioia L, Bottazzai B, Peri G, Breviario F, Salmona M, De Gregorio L, Dragani T, Srinivasan N, Blundell T, Hamilton T, Mantovani A. Cloning of mouse ptx3, a new member of the pentraxin gene family expressed at extrahepatic sites. Blood 87: 1862-1872, 1996.
21. Jensen MD, Haymond MW. Protein metabolism in obesity: effects of body fat distribution and hyperinsulinemia on leucine turnover. Am J Clin Nutr 53: 172-176, 1991.
22. Juge-Aubry C, Somm E, Chicheportiche R, Burger D, Pernin A, Cuénod-Pittet B, Quinodoz P, Giusti V, Dayer J, Meier C. Regulatory effects of interleukin (IL)-1, interferon-beta, and IL-4 on the production of IL-1 receptor antagonist by human adipose tissue. J Clin Endocrinol Metab 89: 2652-2658, 2004.
23. Lee G, Goodman A, Lee T, Vilcek J. Relationship of TSG-14 protein to the pentraxin family of major acute phase proteins. J Immunol 153: 3700-3707, 1994.
24. Lee G, Lee T, Vilcek J. TSG-14, a tumor necrosis factor-and IL-1- inducible protein, is a novel member of the pentaxin family of acute phase proteins. J Immunol 150: 1804-1812, 1993.
25. Lee MJ, Kim J, Kim MY, Bae YS, Ryu SH, Lee TG, Kim JH. Proteomic analysis of tumor necrosis factor-alpha-induced secretome of human adipose tissue-derived mesenchymal stem cells. J Proteome Res 9: 1754-1762, 2010.
26. Luchetti M, Piccinini G, Mantovani A, Peri G, Matteucci C, Pomponio G, Fratini M, Fraticelli P, Sambo P, Di Loreto C, Doni A, Introna M, Gabrielli A. Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA). Clin Exp Immunol 119: 196-202, 2000.
27. Mantovani A, Garlanda C, Doni A, Bottazzi B. Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3. J Clin Immunol 28: 1-13, 2008.
28. Matthews D, Hosker J, Rudenski A, Naylor B, Treacher D, Turner R. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
29. Melemedjian OK, Asiedu MN, Tillu DV, Peebles KA, Yan J, Ertz N, Dussor GO, Price TJ. IL-6-and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex. J Neurosci 30: 15113-15123, 2010.
30. Miyaki A, Maeda S, Yoshizawa M, Misono M, Sasai H, Shimojo N, Tanaka K, Ajisaka R. Is pentraxin 3 involved in obesity-induced decrease in arterial distensibility? J Atheroscler Thromb 17: 278-284, 2010.
31. Moreno-Navarrete JM, Martínez-Barricarte R, Catalán V, Sabater M, Gómez-Ambrosi J, Ortega FJ, Ricart W, Blüher M, Frühbeck G, Rodríguez de Cordoba S, Fernández-Real JM. Complement factor H is expressed in adipose tissue in association with insulin resistance. Diabetes 59: 200-209, 2010.
32. Nauta A, de Haij S, Bottazzi B, Mantovani A, Borrias M, Aten J, Rastaldi M, Daha M, van Kooten C, Roos A. Human renal epithelial cells produce the long pentraxin PTX3. Kidney Int 67: 543-553, 2005.
33. Norata G, Garlanda C, Catapano A. The long pentraxin PTX3: a modulator of the immunoinflammatory response in atherosclerosis and cardiovascular diseases. Trends Cardiovasc Med 20: 35-40, 2010.
34. Ogawa T, Kawano Y, Imamura T, Kawakita K, Sagara M, Matsuo T, Kakitsubata Y, Ishikawa T, Kitamura K, Hatakeyama K, Asada Y, Kodama T. Reciprocal contribution of pentraxin 3 and C-reactive protein to obesity and metabolic syndrome. Obesity (Silver Spring) 18: 1871- 1874, 2010.
35. Pepys M, Hirschfield G. C-reactive protein: a critical update. J Clin Invest 111: 1805-1812, 2003.
36. Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 30: e36, 2002.
37. Raymond F, Métairon S, Kussmann M, Colomer J, Nascimento A, Mormeneo E, García-Martínez C, Gómez-Foix AM. Comparative gene expression profiling between human cultured myotubes and skeletal muscle tissue. BMC Genomics 11: 125, 2010.
38. Shah A, Mehta N, Reilly M. Adipose inflammation, insulin resistance, and cardiovascular disease. JPEN J Parenter Enteral Nutr 32: 638-644, 2008.
39. Shim BJ, Jeon HK, Lee SJ, Kim SS, Park MY, Lee DH, Shin WS, Lee JM, Youn HJ, Chung WS, Seung KB. The Relationship Between Serum Pentraxin 3 and Central Obesity in ST-Segment Elevation Myocardial Infarction Patients. Korean Circ J 40: 308-313, 2010.
40. Tischler ME, Ost AH, Spina B, Cook PH, Coffman J. Regulation of protein turnover by glucose, insulin, and amino acids in adipose tissue. Am J Physiol Cell Physiol 247: C228-C233, 1984.
41. Wabitsch M, Brenner R, Melzner I, Braun M, Möller P, Heinze E, Debatin K, Hauner H. Characterization of a human preadipocyte cell strain with high capacity for adipose differentiation. Int J Obes Relat Metab Disord 25: 8-15, 2001.
42. (a)World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 894: i-xii, 1-253, 2000.
43. Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss JW 3rd, Su AI. BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol 10: R130, 2009.
44. Yamasaki K, Kurimura M, Kasai T, Sagara M, Kodama T, Inoue K. Determination of physiological plasma pentraxin 3 (PTX3) levels in healthy populations. Clin Chem Lab Med 47: 471-477, 2009.
45. Zanetti M, Bosutti A, Ferreira C, Vinci P, Biolo G, Fonda M, Valente M, Cattin L, Guarnieri G, Barazzoni R. Circulating pentraxin 3 levels are higher in metabolic syndrome with subclinical atherosclerosis: evidence for association with atherogenic lipid profile. Clin Exp Med 9: 243-248, 2009.