Human serum levels of fetal antigen 1 (FA1/Dlk1) increase with obesity, are negatively associated with insulin sensitivity and modulate inflammation in vitro

International Journal of Obesity

Volumn 32, Issue 7, 2008, Pages 1122-1129

  Chacon M R ^a   Miranda, M ^a   Jensen, C H ^b   Fernandez Real J M ^c   Vilarrasa, N ^d   Gutierrez C ^a   Naf S ^a   Gomez, J M ^d   Vendrell, J ^a  

^a HOSPITAL UNIVERSITARI JOAN XXIII   (Spain)

^b UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^c Instituto de Salud Carlos III   (Spain)

^d HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Dlk1; FA1; Inflammation; Insulin sensitivity

Indexed keywords

ADIPONECTIN; FETAL ANTIGEN; FETAL ANTIGEN 1; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; RNA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ADIPOCYTE; ADULT; ANTHROPOMETRY; ARTICLE; BLOOD LEVEL; BODY MASS; CELL LINE; CHOLESTEROL BLOOD LEVEL; CONFIDENCE INTERVAL; FAT CONTENT; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INFLAMMATION; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; PROPORTIONAL HAZARDS MODEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADIPOCYTES; ADIPOKINES; ADULT; BARIATRIC SURGERY; CELL LINE; CROSS-SECTIONAL STUDIES; CYTOKINES; FEMALE; HUMANS; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LINEAR MODELS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MONOCYTES; OBESITY; OBESITY, MORBID; OVERWEIGHT; POSTOPERATIVE PERIOD;

EID: 47249134617     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2008.40     Document Type: Article

References (28)

1. Abdallah BM, Jensen CH, Gutierrez G, Leslie GQ, Jensen TG, Kassem M. Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1. J Bone Miner Res 2004; 19: 841-852.
2. Wang Y, Sul HS. Ectodomain shedding of preadipocyte factor 1 (Pref-1) by tumor necrosis factor alpha converting enzyme (TACE) and inhibition of adipocyte differentiation. Mol Cell Biol 2006; 26: 5421-5435.
3. Baladron V, Ruiz-Hidalgo MJ, Nueda ML, Diaz-Guerra MJ, Garcia-Ramirez JJ, Bonvini E et al. dlk acts as a negative regulator of Notch1 activation through interactions with specific EGF-like repeats. Exp Cell Res 2005; 303: 343-359.
4. Moore KA, Pytowski B, Witte L, Hicklin D, Lemischka IR. Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs. Proc Natl Acad Sci USA 1997; 94: 4011-4016.
5. Carlsson C, Tornehave D, Lindberg K, Galante P, Billestrup N, Michelsen B et al. Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas. Endocrinology 1997; 138: 3940-3948.
6. Crameri RM, Langberg H, Magnusson P, Jensen CH, Schroder HD, Olesen JL et al. Changes in satellite cells in human skeletal muscle after a single bout of high intensity exercise. J Physiol 2004; 558: 333-340.
7. Tanimizu N, Nishikawa M, Saito H, Tsujimura T, Miyajima A. Isolation of hepatoblasts based on the expression of Dlk/Pref-1. J Cell Sci 2003; 116: 1775-1786.
8. Jensen P, Bauer M, Jensen CH, Widmer HR, Gramsbergen JB, Blaabjerg M et al. Expansion and characterization of ventral mesencephalic precursor cells: Effect of mitogens and investigation of FA1 as a potential dopaminergic marker. J Neurosci Res 2007; 85: 1884-1893.
9. Floridon C, Jensen CH, Thorsen P, Nielsen O, Sunde L, Westergaard JG et al. Does fetal antigen 1 (FA1) identify cells with regenerative, endocrine and neuroendocrine potentials? A study of FA1 in embryonic, fetal, and placental tissue and in maternal circulation. Differentiation 2000; 66: 49-59.
10. Jensen CH, Teisner B, Hojrup P, Rasmussen HB, Madsen OD, Nielsen B et al. Studies on the isolation, structural analysis and tissue localization of fetal antigen 1 and its relation to a human adrenal-specific cDNA, pG2. Hum Reprod 1993; 8: 635-641.
11. Jensen CH, Krogh TN, Hojrup P, Clausen PP, Skjodt K, Larsson LI et al. Fetal antigen 1 (FA1), a circulating member of the epidermal growth factor (EGF) superfamily: ELISA development, physiology and metabolism in relation to renal function. Clin Chim Acta 1997; 268: 1-20.
12. Abdallah BM, Boissy P, Tan Q, Dahlgaard J, Traustadottir GA, Kupisiewicz K et al. dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors. J Biol Chem 2007; 282: 7339-7351.
13. Abdallah BM, Ding M, Jensen CH, Ditzel N, Flyvbjerg A, Jensen TG et al. Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology 2007; 148: 3111-3121.
14. Ansell PJ, Zhou Y, Schjeide BM, Kerner A, Zhao J, Zhang X et al. Regulation of growth hormone expression by Delta-like protein 1 (Dlk1). Mol Cell Endocrinol 2007; 271: 55-63.
15. Moon YS, Smas CM, Lee K, Villena JA, Kim KH, Yun EJ et al. Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity. Mol Cell Biol 2002; 22: 5585-5592.
16. Lee K, Villena JA, Moon YS, Kim KH, Lee S, Kang C et al. Inhibition of adipogenesis and development of glucose intolerance by soluble preadipocyte factor-1 (Pref-1). J Clin Invest 2003; 111: 453-461.
17. . Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997; 20: 1183-1197.
18. World Health Organization. Obesity: preventing and managing the global epidemic. In: WHO (eds.). WHO Technical Report Series 894. WHO: Geneva, 2000, pp 8-9.
19. Fernandez-Real JM, Broch M, Richart C, Vendrell J, Lopez-Bermejo A, Ricart W. CD14 monocyte receptor, involved in the inflammatory cascade, and insulin sensitivity. J Clin Endocrinol Metab 2003; 88: 1780-1784.
20. Vendrell J, Broch M, Vilarrasa N, Molina A, Gomez JM, Gutierrez C et al. Resistin, adiponectin, ghrelin, leptin, and pro-inflammatory cytokines: relationships in obesity. Obes Res 2004; 12: 962-971.
21. Chacon MR, Fernandez-Real JM, Richart C, Megia A, Gomez JM, Miranda M et al. Monocyte chemoattractant protein-1 in obesity and type 2 diabetes. Insulin sensitivity study. Obesity 2007; 15: 664-672.
22. Jensen CH, Schroder HD, Teisner B, Laursen I, Brandrup F, Rasmussen HB. Fetal antigen 1, a member of the epidermal growth factor superfamily, in neurofibromas and serum from patients with neurofibromatosis type 1. Br J Dermatol 1999; 140: 1054-1059.
23. Andersen M, Jensen CH, Stoving RK, Larsen JB, Schroder HD, Teisner B et al. Fetal antigen 1 in healthy adults and patients with pituitary disease: relation to physiological, pathological, and pharmacological GH levels. J Clin Endocrinol Metab 2001; 86: 5465-5470.
24. Vilarrasa N, Vendrell J, Maravall J, Broch M, Estepa A, Megia A et al. Distribution and determinants of adiponectin, resistin and ghrelin in a randomly selected healthy population. Clin Endocrinol 2005; 63: 329-335.
25. Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444: 860-867.
26. Blanco-Colio LM, Martin-Ventura JL, de Teresa E, Farsang C, Gaw A, Gensini G et al. Elevated ICAM-1 and MCP-1 plasma levels in subjects at high cardiovascular risk are diminished by atorvastatin treatment. Atorvastatin on Inflammatory Markers study: a substudy of Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration. Am Heart J 2007; 153: 881-888.
27. Wu X, Mahadev K, Fuchsel L, Ouedraogo R, Xu SQ, Goldstein BJ. Adiponectin suppresses I{kappa}B kinase activation induced by tumor necrosis factor-{alpha} or high glucose in endothelial cells: role of cAMP and AMP kinase signaling. Am J Physiol Endocrinol Metab 2007; 293: E1836-E1844.
28. Friedrichsen BN, Carlsson C, Moldrup A, Michelsen B, Jensen CH, Teisner B et al. Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications. J Endocrinol 2003; 176: 257-266.