Preliminary report: Vitamin D deficiency in advanced cancer patients with symptoms of fatigue or anorexia

Oncologist

Volumn 16, Issue 11, 2011, Pages 1637-1641

  Dev, Rony ^a   del Fabbro, Egidio ^a   Schwartz, Gary G ^b   Hui, David ^a   Palla, Shana L ^a   Gutierrez, Noah ^a   Bruera, Eduardo ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b WAKE FOREST UNIVERSITY HEALTH SCIENCES   (United States)

Author keywords

Cancer; Symptoms; Testosterone; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; ANTINEOPLASTIC AGENT; CALCIUM; HYDROCORTISONE; MORPHINE; TESTOSTERONE; THYROTROPIN; VITAMIN D;

ADULT; ADVANCED CANCER; AGED; ANOREXIA; ANXIETY; CACHEXIA; CONTROLLED STUDY; DECREASED APPETITE; DEPRESSION; DIGESTIVE SYSTEM CANCER; DROWSINESS; DYSPNEA; FATIGUE; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPOGONADISM; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; NAUSEA; PAIN; PREVALENCE; PRIORITY JOURNAL; RACE DIFFERENCE; RETROSPECTIVE STUDY; REVIEW; SCORING SYSTEM; SEX DIFFERENCE; SLEEP; SYMPTOMATOLOGY; TESTOSTERONE BLOOD LEVEL; THYROTROPIN BLOOD LEVEL; VITAMIN D DEFICIENCY; VITAMIN SUPPLEMENTATION; WELLBEING;

ADULT; AGED; AGED, 80 AND OVER; ANOREXIA; FATIGUE; FEMALE; HUMANS; HYDROCORTISONE; MALE; MIDDLE AGED; NEOPLASMS; RETROSPECTIVE STUDIES; TESTOSTERONE; THYROTROPIN; VITAMIN D; VITAMIN D DEFICIENCY; YOUNG ADULT;

EID: 82355187864     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2011-0151     Document Type: Review

References (36)

1. Heidari B, Shirvani JS, Firouzjahi A et al. Association between nonspecific skeletal pain and vitamin D deficiency. Int J Rheum Dis 2010;13:340-346.
2. Montero-Odasso M, Duque G. Vitamin D in the aging musculoskeletal system: An authentic strength preserving hormone. Mol Aspects Med 2005;26:203-219.
3. Barnard K, Colón-Emeric C. Extraskeletal effects of vitamin D in older adults: Cardiovascular disease, mortality, mood, and cognition. Am J Geriatr Pharmacother 2010;8:4-33.
4. Walsh D, Rybicki L. Symptom clustering in advanced cancer. Support Care Cancer 2006;14:831-836.
5. Chang VT, Hwang SS, Feruerman M. Validation of the Edmonton Symptom Assessment Scale. Cancer 2000;88:2164-2171.
6. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-281.
7. Rosner W, Auchus RJ, Azziz R et al. Position statement: Utility, limitations, and pitfalls in measuring testosterone: An Endocrine Society position statement. J Clin Endocrinol Metab 2007;92:405-413.
8. Wang C, Nieschlag E, Swerdloff R et al. Investigation, treatment and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA and ASA recommendations. Eur J Endocrinol 2008;159:507-514.
9. Fakih MG, Trump DL, Johnson CS et al. Chemotherapy is linked to severe vitamin D deficiency in patients with colorectal cancer. Int J Colorectal Dis 2009;24:219-224.
10. Neuhouser ML, Sorensen B, Hollis BW et al. Vitamin D insufficiency in a multiethnic cohort of breast cancer survivors. Am J Clin Nutr 2008;88:133-139.
11. Stone CA, Kenny RA, Healy M et al. Vitamin D depletion: Of clinical significance in advanced cancer? Support Care Cancer 2011;19:865-67.
12. Vashi PG, Trukova K, Lammersfeld CA et al. Impact of oral vitamin D supplementation on serum 25-hydroxyvitamin D levels in oncology. Nutr J 2010;9:60.
13. Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res 2011;31:48-54.
14. Chel VG, Ooms ME, Pavel S et al. Prevention and treatment of vitamin D deficiency in Dutch psychogeratric nursing home residents by weekly half-body UVB exposure after showering: A pilot study. Age Ageing 2011;40:211-214.
15. Chel VG, Ooms ME, Popp-Snijders C et al. Ultraviolet irradiation corrects vitamin D deficiency and suppresses secondary hyperparathy roidism in the elderly. J Bone Miner Res 1998;13: 1238-1242.
16. Corless D, Gupta SP, Switala S et al. Response of plasma-25-hydroxyvitamin D to ultraviolet irradiation in long-stay geriatric patients. Lancet 1978;2:649-651.
17. Sambrook PN, Cameron ID, Chen JS et al. Does increased sunlight exposure work as a strategy to improve vitamin D status in the elderly: A cluster randomised controlled trial. Osteoporos Int 2011 Mar 3 [Epub ahead of print].
18. Zhou W, Heist RS, Liu G et al. Circulating 25-hydroxyvitamin D levels predict survival in early-stage non-small cell lung cancer patients. J Clin Oncol 2007;25:479-485.
19. Goodwin PJ, Ennis M, Pritchard KI et al. Prognostic effects of 25-hydroxyvitamin D levels in early breast cancer. J Clin Oncol 2009;27:3757-3763.
20. Tretli S, Hernes E, Berg JP et al. Association between serum 25(OH)D and death from prostate cancer. Br J Cancer 2009;100:450-454.
21. Heist RS, Zhou W, Wang Z et al. Circulating 25-hydroxyvitamin D, VDR polymorphisms, and survival in advanced non-small-cell lung cancer. J Clin Oncol 2008;26:5596-5602.
22. Wehr E, Pilz S, Boehm BO et al. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf) 2010;73:243-248.
23. Pilz S, Frisch S, Koertke H et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res 2011;43:223-225.
24. Rajagopal A, Vassilopoulou-Sellin R, Palmer JL et al. Symptomatic hypogonadism in male survivors of cancer with chronic exposure to opioids. Cancer 2004;15:100:851-858.
25. Grossberg AJ, Scarlett JM, Marks DL. Hypothalamic mechanisms in cachexia. Physiol Behav 2010;100:478-489.
26. von Hurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient-a ran-domised, placebo-controlled trial. Br J Nutr 2010; 103:549-555.
27. Malkin CJ, Jones TH, Channer KS. The effect of testosterone on insulin sensitivity in men with heart failure. Eur J Heart Fail 2007;9:44-50.
28. McMillan DC. Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care 2009;12:223-226.
29. To T. Vitamin D deficiency in an Australian inpatient hospice population. J Pain Symptom Manage 2010;Nov 1 [Epub ahead of print].
30. Zhu K, Austin N, Devine A et al. A randomized controlled trial of the effects of vitamin D on muscle strength and mobility in older women with vitamin D insufficiency. J Am Geriatr Soc 2010;58: 2063-2068.
31. Broe KE, Chen TC, Weinberg J et al. A higher dose of vitamin D reduces the risk of falls in nursing home residents: A randomized, multiple-dose study. J Am Geriatr Soc 2007;55:234-239.
32. Bischoff-Ferrari HA, Orav EJ, Dawson-Hughes B. Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: A 3-year randomized controlled trial. Arch Intern Med 2006;166:424-430.
33. Flicker L, MacInnis RJ, Stein MS et al. Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. J Am Geriatr Soc 2005;53:1881-1888.
34. Sanders KM, Stuart AL, Williamson EJ et al. Annual high-dose oral vitamin D and falls and fractures in older women: A randomized controlled trial. JAMA 2010;303:1815-1822.
35. Bischoff-Ferrari HA, Orav EJ, Dawson- Hughes B. Additive benefit of higher testosterone levels and vitamin D plus calcium supplementation in regard to fall risk reduction among older men and women. Osteoporos Int 2008;19:1307-1314.
36. Amrein K, Sourij H, Wagner G et al. Short-term effects of high-dose oral vitamin D3 in critically ill vitamin D deficient patients: A randomized, double-blind, placebo-controlled pilot study. Crit Care 2011;15:R104.