Antibody-mediated osseous regeneration: A novel strategy for bioengineering bone by immobilized anti-bone morphogenetic protein-2 antibodies

Tissue Engineering - Part A

Volumn 17, Issue 23-24, 2011, Pages 2911-2918

  Freire, Marcelo O ^a   You, Huyng Keun ^b   Kook, Joong Ki ^a,c   Choi, Jeong Ho ^a,d   Zadeh, Homayoun H ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Wonkwang University   (South Korea)

^c Chosun University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; BIOASSAY; COMPUTERIZED TOMOGRAPHY; MONOCLONAL ANTIBODIES; TISSUE; TISSUE ENGINEERING;

BONE REGENERATION; CALVARIAL DEFECTS; CELLULAR RECEPTORS; COLLAGEN SPONGE; EXOGENOUS GROWTH; FOOD AND DRUG ADMINISTRATION; HUMAN BONE MORPHOGENETIC PROTEIN; IMMUNE COMPLEX; IMMUNOHISTOCHEMISTRY; IN-SITU; IN-VITRO; IN-VIVO; MICROCOMPUTED TOMOGRAPHY; NOVEL STRATEGIES; OSTEOCALCIN; OSTEOGENESIS; PROOF OF CONCEPT; THERAPEUTIC METHOD;

BONE;

ANIMALIA; MURINAE; RATTUS;

ANTIBODY; BONE MORPHOGENETIC PROTEIN 2; IMMOBILIZED PROTEIN; OSTEOCALCIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2; RECOMBINANT PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL; ARTICLE; BIOENGINEERING; BONE; BONE REGENERATION; CELL LINE; DRUG EFFECT; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMPLANT; METABOLISM; METHODOLOGY; MICRO-COMPUTED TOMOGRAPHY; MOUSE; PATHOLOGY; PHYSIOLOGY; PROTEIN BINDING; RADIOGRAPHY; RAT; SKULL;

ANIMALS; ANTIBODIES; BIOENGINEERING; BONE AND BONES; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CELL LINE; FLOW CYTOMETRY; HUMANS; IMMOBILIZED PROTEINS; IMMUNOHISTOCHEMISTRY; IMPLANTS, EXPERIMENTAL; MICE; OSTEOCALCIN; PROTEIN BINDING; RATS; RECOMBINANT PROTEINS; SKULL; TRANSFORMING GROWTH FACTOR BETA; X-RAY MICROTOMOGRAPHY;

EID: 82355181432     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2010.0584     Document Type: Article

References (24)

1. Chin, M., Ng, T., Tom, W., and Carstens, M. Repair of alveolar clefts with recombinant human bone morphogenetic protein (rhBMP-2) in patients with clefts. J Craniofac Surg 16, 778, 2005.
2. Khan, S., and Lane, J. The use of recombinant human bone morphogenetic protein-2 (rhBMP-2) in orthopaedic applications. Expert Opin Biol Ther 4, 741, 2004.
3. Wikesjö , U., Polimeni, G., and Qahash, M. Tissue engineering with recombinant human bone morphogenetic protein-2 for alveolar augmentation and oral implant osseointegration: experimental observations and clinical perspectives. Clin Implant Dent Relat Res 7, 112, 2005.
4. Ishikawa, H., Kitoh, H., Sugiura, F., and Ishiguro, N. The effect of recombinant human bone morphogenetic protein-2 on the osteogenic potential of rat mesenchymal stem cells after several passages. Acta Orthop 78, 285, 2007.
5. Oldham, J., Lu, L., Zhu, X., Porter, B., Hefferan, T., Larson, D., et al. Biological activity of rhBMP-2 released from PLGA microspheres. J Biomech Eng 122, 289, 2000.
6. Chen, D., Zhao, M., and Mundy, G. Bone morphogenetic proteins. Growth Factors 22, 233, 2004.
7. Bosch, C., Melsen, B., and Vargervik, K. Importance of the critical-size bone defect in testing bone-regenerating materials. J Craniofac Surg 9, 310, 1998.
8. Cowan, C., Shi, Y., Aalami, O., Chou, Y., Mari, C., Thomas, R., et al. Adipose-derived adult stromal cells heal critical-size mouse calvarial defects. Nat Biotechnol 22, 560, 2004.
9. Miyazono, K., Maeda, S., and Imamura, T. Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins. Oncogene 23, 4232, 2004.
10. Nakashima, K., Zhou, X., Kunkel, G., Zhang, Z., Deng, J., Behringer, R., et al. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell 108, 17, 2002.
11. Hilton, M., Tu, X., Wu, X., Bai, S., Zhao, H., Kobayashi, T., et al. Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med 14, 306, 2008.
12. Kronenberg, H. Developmental regulation of the growth plate. Nature 423, 332, 2003.
13. Kitisin, K., Saha, T., Blake, T., Golestaneh, N., Deng, M., Kim, C., et al. Tgf-Beta signaling in development. Sci STKE 2007, cm1, 2007.
14. Koga, T., Matsui, Y., Asagiri, M., Kodama, T., de Crombrugghe, B., Nakashima, K., et al. NFAT and Osterix cooperatively regulate bone formation. Nat Med 11, 880, 2005.
15. Tsuji, K., Bandyopadhyay, A., Harfe, B., Cox, K., Kakar, S., Gerstenfeld, L., et al. BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing. Nat Genet 38, 1424, 2006.
16. Nakashima, M., and Reddi, A. The application of bone morphogenetic proteins to dental tissue engineering. Nat Biotechnol 21, 1025, 2003.
17. Sebald, W., Nickel, J., Zhang, J., and Mueller, T. Molecular recognition in bone morphogenetic protein (BMP)/receptor interaction. Biol Chem 385, 697, 2004.
18. Nickel, J., Dreyer, M., Kirsch, T., and Sebald, W. The crystal structure of the BMP-2: BMPR-IA complex and the generation of BMP-2 antagonists. J Bone Joint Surg Am 83-A Suppl 1, S7, 2001.
19. Zhao, B., Katagiri, T., Toyoda, H., Takada, T., Yanai, T., Fukuda, T., et al. Heparin potentiates the in vivo ectopic bone formation induced by bone morphogenetic protein-2. J Biol Chem 281, 23246, 2006.
20. Eddleston, A., Marenzana, M., Moore, A., Stephens, P., Muzylak, M., Marshall, D., et al. A short treatment with an antibody to sclerostin can inhibit bone loss in an ongoing model of colitis. J Bone Miner Res 24, 1662, 2009.
21. Reichert, J., Rosensweig, C., Faden, L., and Dewitz, M. Monoclonal antibody successes in the clinic. Nat Biotechnol 23, 1073, 2005.
22. Reichert, J., and Valge-Archer, V. Development trends for monoclonal antibody cancer therapeutics. Nat Rev Drug Discov 6, 349, 2007.
23. Reichert, J. Global antibody development trends. MAbs 1, 86, 2009.
24. Ominsky, M., Vlasseros, F., Jolette, J., Smith, S., Stouch, B., Doellgast, G., et al. Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength. J Bone Miner Res 25, 948, 2010.