The 5-HT1A agonism potential of substituted piperazine-ethyl- amide derivatives is conserved in the hexyl homologues: Molecular modeling and pharmacological evaluation

Journal of Chemical Information and Modeling

Volumn 51, Issue 11, 2011, Pages 2961-2966

  Dilly, Sébastien ^a   Scuvée Moreau, Jacqueline ^a   Wouters, Johan ^b   Liégeois, Jean François ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF NAMUR   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ELECTROPHYSIOLOGY;

CARBOXAMIDES; DOCKING STUDIES; HIGH AFFINITY;

AMIDES;

AMIDE; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN AGONIST;

ACTION POTENTIAL; ANIMAL; ARTICLE; BRAIN STEM; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECT; HUMAN; IC 50; KINETICS; MALE; METABOLISM; MICROTOMY; PHYSIOLOGY; RAT; SEQUENCE ALIGNMENT; SEROTONINERGIC NERVE CELL; STRUCTURE ACTIVITY RELATION; TURKEY (BIRD); WISTAR RAT; X RAY CRYSTALLOGRAPHY;

ACTION POTENTIALS; AMIDES; ANIMALS; BRAIN STEM; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; MALE; MICROTOMY; PIPERAZINES; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; SEQUENCE ALIGNMENT; SEROTONERGIC NEURONS; SEROTONIN RECEPTOR AGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; TURKEYS;

EID: 82355160707     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci200313r     Document Type: Article

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