Missing Heritability in the tails of quantitative traits? A simulation study on the impact of slightly altered true genetic models

Human Heredity

Volumn 72, Issue 3, 2011, Pages 173-181

  Pütter, Carolin ^a   Pechlivanis, Sonali ^a   Nöthen, Markus M ^b   Jöckel, Karl Heinz ^a   Wichmann, Heinz Erich ^c,d   Scherag, André ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Genetic association studies; Heritability; Mixture distribution; Selective sampling

Indexed keywords

ARTICLE; CASE CONTROL STUDY; DATA ANALYSIS; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC MODEL; GENETIC VARIABILITY; HERITABILITY; HUMAN; LINEAR REGRESSION ANALYSIS; LOGISTIC REGRESSION ANALYSIS; PHENOTYPE; QUANTITATIVE TRAIT; SIMULATION; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL DISTRIBUTION; STUDY DESIGN;

BODY MASS INDEX; CASE-CONTROL STUDIES; COMPUTER SIMULATION; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; INHERITANCE PATTERNS; MODELS, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT, HERITABLE;

EID: 82255183115     PISSN: 00015652     EISSN: 14230062     Source Type: Journal    
DOI: 10.1159/000332824     Document Type: Article

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