Immunohistochemical characterization of the cellular infiltrate in discoid lupus erythematosus

BioScience Trends

Volumn 5, Issue 2, 2011, Pages 83-88

  Xie, Yong ^a   Jinnin, Masatoshi ^a   Zhang, Xiaoyong ^a   Wakasugi, Shoji ^a   Makino, Takamitsu ^a   Inoue, Yuji ^a   Fukushima, Satoshi ^a   Masuguchi, Shinichi ^a   Sakai, Keisuke ^a   Ihn, Hironobu ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

B cells; CD panel antibodies; Immunohistochemistry; Natural killer cells; T cells

Indexed keywords

DISCOIDAE;

LEUKOCYTE ANTIGEN; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; CD4 CD8 RATIO; DISCOID LUPUS ERYTHEMATOSUS; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; MALE; PATHOLOGY;

ADULT; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; CD4-CD8 RATIO; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUPUS ERYTHEMATOSUS, DISCOID; MALE;

EID: 82255182559     PISSN: 18817815     EISSN: 18817823     Source Type: Journal    
DOI: 10.5582/bst.2011.v5.2.83     Document Type: Article

References (23)

1. Kaposi M. Pathologic und Therapie der Hautkrankeiten. 2nd ed., Urban and Schwarzenberg, Vienna, Austria, 1882.
2. Watson R. Cutaneous lesions in systemic lupus erythematosus. Med Clin North Am. 1989; 73:1091-1111.
3. Hymes SR, Jordon RE. Chronic cutaneous lupus erythematosus. Med Clin North Am. 1989; 73:1055-1071.
4. Peterson R, Good V. Lupus erythematosus. Pediatr Clin North Am. 1963; 10:941-978.
5. Prystowsky SD, Herndon JH Jr, Gilliam JN. Chronic cutaneous lupus erythematosus (DLE) - a clinical and laboratory investigation of 80 patients. Medicine (Baltimore). 1976; 55:183-191.
6. Wangel AG, Johansson E, Ranki A. Polyclonal B-cell activation and increased lymphocyte helper-suppressor ratios in discoid lupus erythematosus. Br J Dermatol. 1984; 110:665-669.
7. Kind P, Lipsky PE, Sontheimer RD. Circulating T- and B-cell abnormalities in cutaneous lupus erythematosus. J Invest Dermatol. 1986; 86:235-239.
8. Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, eds. Fitzpatrick's Dermatology in General Medicine. 6th ed., Mcgraw-Hill, New York, NY, USA, 2003.
9. Elder DE, Elenitsas R, Johnson BL Jr, Murphy GF, eds. Lever's Histopathology of the Skin. 9th ed., Lippincott Williams & Wilkins, Philadelphia, PA, USA, 2005.
10. Amoura Z, Combadiere C, Faure S, Parizot C, Miyara M, Raphaël D, Ghillani P, Debre P, Piette JC, Gorochov G. Roles of CCR2 and CXCR3 in the T cell-mediated response occurring during lupus flares. Arthritis Rheum. 2003; 48:3487-3496.
11. Tebbe B, Mazur L, Stadler R, Orfanos CE. Immunohistochemical analysis of chronic discoid and subacute cutaneous lupus erythematosus - relation to immunopathological mechanisms. Br J Dermatol. 1995; 132:25-31.
12. Wenzel J, Uerlich M, Wörrenkämper E, Freutel S, Bieber T, Tüting T. Scarring skin lesions of discoid lupus erythematosus are characterized by high numbers of skin-homing cytotoxic lymphocytes associated with strong expression of the type I interferon-induced protein MxA. Br J Dermatol. 2005; 153:1011-1015.
13. Wenzel J, Henze S, Wörenkämper E, Basner-Tschakarjan E, Sokolowska-Wojdylo M, Steitz J, Bieber T, Tüting T. Role of the chemokine receptor CCR4 and its ligand thymus- and activation-regulated chemokine/CCL17 for lymphocyte recruitment in cutaneous lupus erythematosus. J Invest Dermatol. 2005; 124:1241-1248.
14. Wouters CH, Diegenant C, Ceuppens JL, Degreef H, Stevens EA. The circulating lymphocyte profiles in patients with discoid lupus erythematosus and systemic lupus erythematosus suggest a pathogenetic relationship. Br J Dermatol. 2004; 150:693-700.
15. Mason DY, Comans-Bitter WM, Cordell JL, Verhoeven MA, van Dongen JJ. Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen. Am J Pathol. 1990; 136:1215-1222.
16. Moretti S, Amato L, Massi D, Bianchi B, Gallerani I, Fabbri P. Evaluation of inflammatory infiltrate and fibrogenic cytokines in pseudopelade of Brocq suggests the involvement of T-helper 2 and 3 cytokines. Br J Dermatol. 2004; 151:84-90.
17. Andrews BS, Schenk A, Barr R, Friou G, Mirick G, Ross P. Immunopathology of cutaneous human lupus erythematosus defined by murine monoclonal antibodies. J Am Acad Dermatol. 1986; 15:474-481.
18. Lee MS, Wilkinson B, Doyle JA, Kossard S. A comparative immunohistochemical study of lichen planus and discoid lupus erythematosus. Australas J Dermatol. 1996; 37:188-192.
19. Akasu R, Kahn HJ, From L. Lymphocyte markers on formalin fixed tissue in Jessner's lymphocytic infiltrate and lupus erythematosus. J Cutan Pathol. 1992; 19:59-65.
20. Bergroth V, Konttinen YT, Piirainen H, Johansson E, Nordström D, Malmström M. Evaluation of lymphocyte activation in skin lesions of patients with mixed connective tissue disease and discoid lupus erythematosus. Arch Dermatol Res. 1988; 280:1-4.
21. Sundqvist KG, Wanger L. Expression of lymphocyte activation markers in benign cutaneous T cell infiltrates. Discoid lupus erythematosus versus lichen ruber planus. Acta Derm Vnereol. 1989; 69:292-295.
22. + cells producing Th2-type cytokines. FASEB J. 1995; 9:81-86.
23. Kimata H, Shanahan F, Brogan M, Targan S, Saxon A. Modulation of ongoing human immunoglobulin synthesis bynatural killer cells. Cell Immunol. 1987; 107:74-88.