Evaluation of a standardized protocol using lepirudin or argatroban for heparin-induced thrombocytopenia

Cardiovascular and Hematological Agents in Medicinal Chemistry

Volumn 9, Issue 4, 2011, Pages 262-268

  Kennedy, Kenneth ^a   Steinke, Doug ^b   King, Shawn ^c   Poe, Kevin ^c   Reeves, Jordan ^c   Short, Marintha ^c  

^a UNIVERSITY OF KENTUCKY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c Saint Joseph Hospital Lexington   (United States)

Author keywords

Activated partial thromboplastin time; aPTT; Argatroban; Heparin induced thrombocytopenia; HIT; Lepirudin; Post; Pre; Protocol; Standardized; Treatment

Indexed keywords

ARGATROBAN; HEPARIN; LEPIRUDIN;

ARTICLE; BLEEDING; CLINICAL ARTICLE; CLINICAL PROTOCOL; CONTROLLED STUDY; FEMALE; HEPARIN INDUCED THROMBOCYTOPENIA; HUMAN; LENGTH OF STAY; MALE; MEDICAL RECORD REVIEW; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; STANDARDIZATION; THROMBOCYTOPENIA; THROMBOSIS; TREATMENT RESPONSE;

AGED; ANTICOAGULANTS; ANTITHROMBINS; FEMALE; HEPARIN; HIRUDINS; HUMANS; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PIPECOLIC ACIDS; PLATELET AGGREGATION INHIBITORS; RECOMBINANT PROTEINS; THROMBOCYTOPENIA; TREATMENT OUTCOME;

EID: 82255181274     PISSN: 18715257     EISSN: 18756182     Source Type: Journal    
DOI: 10.2174/187152511798120886     Document Type: Article

References (16)

1. Jang, I.-K.; Hursting, M.J. When heparins promote thrombosis: review of heparin-induced thrombocytopenia. Circulation, 2005, 111(20), 2671-2683.
2. Kelton, J.G.; Warkentin, T.E., Heparin-induced thrombocytopenia: a historical perspective. Blood, 2008, 112(7), 2607-2616.
3. Warkentin, T.E.; Sheppard, J.I.; Moore, J.C.; Moore, K.M.; Sigouin, C.S.; Kelton, J.G. Laboratory testing for the antibodies that cause heparin-induced thrombocytopenia: How much class do we need? J. Lab. Clin. Med., 2005, 146(6), 341-346.
4. Warkentin, T.E.; Greinacher, A.; Koster, A.; Lincoff, A.M. Treatment and prevention of heparin-induced thrombocytopenia. Chest, 2008, 133(Suppl. 6), 340S-380S.
5. Shantsila, E.; Lip, G.Y.H.; Chong, B.H. Heparin-induced thrombocytopenia. Chest, 2009, 135(6), 1651-1664.
6. Dang, C.H.; Durkalski, V.L.; Nappi, J.M. Evaluation of treatment with direct thrombin inhibitors in patients with heparin-induced thrombocytopenia. Pharmacotherapy, 2006, 26(4), 461-468.
7. Cohen, M.; Demers, C.; Gurfinkel, E.; Turpie, A.; Fromell, G.; Goodman, S.; Langer, A.; Califf, R.M.; Fox, K.A.; Premmereur, J.; Bigonzi, F.; Stephens, J.; Weatherley, B. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. NEJM, 1997, 337(7), 447-452.
8. Kiser, T.H.; Mann, A.M.; Trujillo, T.C.; Hassell, K.L. Evaluation of empiric versus nomogram-based direct thrombin inhibitor management in patients with suspected heparin-induced thrombocytopenia. Am. J. Hematol., 2011, 86(3), 267-272.
9. To, L.; Schillig, J.M.; DeSmet, B.D.; Kuriakose, P.; Szandzik, E.G.; Kalus, J.S. Impact of a pharmacist-directed anticoagulation service on the quality and safety of heparin-induced thrombo- cytopenia management. Ann. Pharmacother., 2011, 45(2), 195-200.
10. Ansara, A.J.; Arif, S.; Warhurst, R.D. Weight-based argatroban dosing nomogram for treatment of heparin-induced thrombo- cytopenia. Ann. Pharmacother., 2009, 43(1), 9-18.
11. Smythe, M.A.; Koerber, J.M.; Forsyth, L.L.; Priziola, J.L.; Balasubramaniam, M.; Mattson, J.C. Argatroban dosage require- ments and outcomes in intensive care versus non-intensive care patients. Pharmacotherapy., 2009, 29 (9), 1073-1081.
12. Tschudi, M.; Lammle, B.; Alberio, L. Dosing lepirudin in patients with heparin-induced thrombocytopenia and normal or impaired renal function: a single-center experience with 68 patients. Blood, 2009, 113(11), 2402-2409.
13. Gosselin, R.C.; King, J.H.; Janatpour, K.A.; Dager, W.E.; Larkin, E.C.; Owings, J.T. Comparing direct thrombin inhibitors using aPTT, ecarin clotting times, and thrombin inhibitor management testing. Ann. Pharmacother., 2004, 38(9), 1383-1388.
14. Hafner, G.; Roser, M.; Nauck, M. Methods for the monitoring of direct thrombin inhibitors. Semin. Thromb. Hemost., 2002, 28(5), 425-430.
15. Love, J.E.; Ferrell, F.C., Chandler, W.L. Monitoring direct thrombin inhibitors with a plasma diluted thrombin time. Thromb. Haemost., 2007, 98, 234-242.
16. Lange, U.; Nowak, G.; Bucha, E. Ecarin chromogenic assay-a new method for quantitative determination of direct thrombin inhibitors like hirudin. Pathophysiol. Haemost. Thromb., 2003, 33(4), 184-191.